Genetic evolution of equine influenza virus strains (H3N8) isolated in France from 1967 to 2015 and the implications of several potential pathogenic factors
Identifieur interne : 000116 ( Hal/Curation ); précédent : 000115; suivant : 000117Genetic evolution of equine influenza virus strains (H3N8) isolated in France from 1967 to 2015 and the implications of several potential pathogenic factors
Auteurs : Stéphanie Fougerolle [France] ; Loïc Legrand [France] ; Fanny Lecouturier [France] ; Corinne Sailleau [France] ; Romain Paillot [Royaume-Uni] ; Aymeric Hans [France] ; Stéphane Pronost [France]Source :
- Virology [ 0042-6822 ] ; 2017-05.
Abstract
Equine influenza virus (EIV) is a major respiratory pathogen of horses despite the availability of equine influenza vaccines. This study aimed to determine genetic evolution of EIV strains in France between 1967 to present. A whole genome comparative analysis was also conducted on recent French strains in order to identify potential factors of pathogenicity. Comparison of French EIV sequences with vaccine and worldwide epidemic strains revealed amino acid substitutions in both haemagglutinin (HA) and neuraminidase, especially within the antigenic sites and/or close to receptor binding sites (HA). Amino acid substitutions were also identified in other genes, mainly the polymerase complex proteins and PB1-F2. Viruses belonging to Eurasian and American lineages have circulated until 2003 and Florida sub-lineage Clade 2 strains predominates since 2005. The last French strain (2015) displayed several specificities in HA suggesting the occurrence of antigenic drift with presence of pathogenic markers in the PA and PB1-F2 genes.
Url:
DOI: 10.1016/j.virol.2017.02.003
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<front><div type="abstract" xml:lang="en"> <p>Equine influenza virus (EIV) is a major respiratory pathogen of horses despite the availability of equine influenza vaccines. This study aimed to determine genetic evolution of EIV strains in France between 1967 to present. A whole genome comparative analysis was also conducted on recent French strains in order to identify potential factors of pathogenicity. Comparison of French EIV sequences with vaccine and worldwide epidemic strains revealed amino acid substitutions in both haemagglutinin (HA) and neuraminidase, especially within the antigenic sites and/or close to receptor binding sites (HA). Amino acid substitutions were also identified in other genes, mainly the polymerase complex proteins and PB1-F2. Viruses belonging to Eurasian and American lineages have circulated until 2003 and Florida sub-lineage Clade 2 strains predominates since 2005. The last French strain (2015) displayed several specificities in HA suggesting the occurrence of antigenic drift with presence of pathogenic markers in the PA and PB1-F2 genes.</p>
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<editionStmt> <edition n="v1" type="current"> <date type="whenSubmitted">2019-06-28 14:53:33</date>
<date type="whenModified">2020-03-17 02:09:19</date>
<date type="whenReleased">2019-07-04 12:01:04</date>
<date type="whenProduced">2017-05</date>
<date type="whenEndEmbargoed">2019-06-28</date>
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<name key="477685"> <persName> <forename>Erika</forename>
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<email type="domain">laboratoire-labeo.fr</email>
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<idno type="halRefHtml">Virology, Elsevier, 2017, 505, pp.210-217. ⟨10.1016/j.virol.2017.02.003⟩</idno>
<idno type="halRef">Virology, Elsevier, 2017, 505, pp.210-217. ⟨10.1016/j.virol.2017.02.003⟩</idno>
</publicationStmt>
<seriesStmt> <idno type="stamp" n="COMUE-NORMANDIE">Normandie Université</idno>
<idno type="stamp" n="LABEO">LABÉO, Pôle d’analyses et de recherche de Normandie </idno>
<idno type="stamp" n="INRA">INRA - Institut national de la recherche agronomique</idno>
<idno type="stamp" n="ANSES">Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail</idno>
<idno type="stamp" n="AGREENIUM">Archive ouverte en agrobiosciences</idno>
<idno type="stamp" n="UNICAEN" corresp="COMUE-NORMANDIE">Université de Caen Normandie</idno>
<idno type="stamp" n="ENVA">Ecole Nationale Vétérinaire d'Alfort</idno>
<idno type="stamp" n="BIOTARGEN-MECIIR" corresp="BIOTARGEN">MÉcanisme et Contrôle des Infections et Inflammation Respiratoire</idno>
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<sourceDesc> <biblStruct> <analytic> <title xml:lang="en">Genetic evolution of equine influenza virus strains (H3N8) isolated in France from 1967 to 2015 and the implications of several potential pathogenic factors</title>
<author role="aut"> <persName> <forename type="first">Stéphanie</forename>
<surname>Fougerolle</surname>
</persName>
<email type="md5">cbcc5957f65b17e31c159964b7b076c5</email>
<email type="domain">laboratoire-labeo.fr</email>
<idno type="idhal" notation="string">stephanie-fougerolle</idno>
<idno type="idhal" notation="numeric">176285</idno>
<idno type="halauthorid">11521172</idno>
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<affiliation ref="#struct-550525"></affiliation>
<affiliation ref="#struct-257103"></affiliation>
</author>
<author role="aut"> <persName> <forename type="first">Loïc</forename>
<surname>Legrand</surname>
</persName>
<email type="md5">fbd52426e6d1ef2156f81a90eb354cb3</email>
<email type="domain">laboratoire-labeo.fr</email>
<idno type="idhal" notation="string">loic-legrand</idno>
<idno type="idhal" notation="numeric">180916</idno>
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<affiliation ref="#struct-550525"></affiliation>
<affiliation ref="#struct-257103"></affiliation>
</author>
<author role="aut"> <persName> <forename type="first">Fanny</forename>
<surname>Lecouturier</surname>
</persName>
<idno type="halauthorid">11521630</idno>
<affiliation ref="#struct-122682"></affiliation>
<affiliation ref="#struct-550525"></affiliation>
</author>
<author role="aut"> <persName> <forename type="first">Corinne</forename>
<surname>Sailleau</surname>
</persName>
<idno type="halauthorid">881666</idno>
<affiliation ref="#struct-37913"></affiliation>
</author>
<author role="aut"> <persName> <forename type="first">Romain</forename>
<surname>Paillot</surname>
</persName>
<email type="md5">b74b1feeed284e13ab628acb81f09135</email>
<email type="domain">laboratoire-labeo.fr</email>
<idno type="idhal" notation="string">romain-paillot</idno>
<idno type="idhal" notation="numeric">180281</idno>
<idno type="halauthorid">499352</idno>
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<affiliation ref="#struct-257103"></affiliation>
<affiliation ref="#struct-550525"></affiliation>
</author>
<author role="aut"> <persName> <forename type="first">Aymeric</forename>
<surname>Hans</surname>
</persName>
<idno type="halauthorid">1205193</idno>
<affiliation ref="#struct-122682"></affiliation>
<affiliation ref="#struct-550525"></affiliation>
</author>
<author role="aut"> <persName> <forename type="first">Stéphane</forename>
<surname>Pronost</surname>
</persName>
<email type="md5">472529cace87f067b350c9dcba4f34bb</email>
<email type="domain">laboratoire-labeo.fr</email>
<idno type="idhal" notation="string">stephane-pronost</idno>
<idno type="idhal" notation="numeric">172991</idno>
<idno type="halauthorid">528764</idno>
<affiliation ref="#struct-431062"></affiliation>
<affiliation ref="#struct-257103"></affiliation>
<affiliation ref="#struct-550525"></affiliation>
</author>
</analytic>
<monogr> <idno type="halJournalId" status="VALID">9192</idno>
<idno type="issn">0042-6822</idno>
<idno type="eissn">1096-0341</idno>
<title level="j">Virology</title>
<imprint> <publisher>Elsevier</publisher>
<biblScope unit="volume">505</biblScope>
<biblScope unit="pp">210-217</biblScope>
<date type="datePub">2017-05</date>
</imprint>
</monogr>
<idno type="doi">10.1016/j.virol.2017.02.003</idno>
</biblStruct>
</sourceDesc>
<profileDesc> <langUsage> <language ident="en">English</language>
</langUsage>
<textClass> <classCode scheme="halDomain" n="sdv.ba">Life Sciences [q-bio]/Animal biology</classCode>
<classCode scheme="halDomain" n="sdv.ba.mvsa">Life Sciences [q-bio]/Animal biology/Veterinary medicine and animal Health</classCode>
<classCode scheme="halTypology" n="ART">Journal articles</classCode>
</textClass>
<abstract xml:lang="en"> <p>Equine influenza virus (EIV) is a major respiratory pathogen of horses despite the availability of equine influenza vaccines. This study aimed to determine genetic evolution of EIV strains in France between 1967 to present. A whole genome comparative analysis was also conducted on recent French strains in order to identify potential factors of pathogenicity. Comparison of French EIV sequences with vaccine and worldwide epidemic strains revealed amino acid substitutions in both haemagglutinin (HA) and neuraminidase, especially within the antigenic sites and/or close to receptor binding sites (HA). Amino acid substitutions were also identified in other genes, mainly the polymerase complex proteins and PB1-F2. Viruses belonging to Eurasian and American lineages have circulated until 2003 and Florida sub-lineage Clade 2 strains predominates since 2005. The last French strain (2015) displayed several specificities in HA suggesting the occurrence of antigenic drift with presence of pathogenic markers in the PA and PB1-F2 genes.</p>
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