The metabolic checkpoint kinase mTOR is essential for IL-15 signaling during the development and activation of NK cells
Identifieur interne : 000294 ( Hal/Corpus ); précédent : 000293; suivant : 000295The metabolic checkpoint kinase mTOR is essential for IL-15 signaling during the development and activation of NK cells
Auteurs : Antoine Marçais ; Julien Cherfils-Vicini ; Charlotte Viant ; Sophie Degouve ; Sébastien Viel ; Aurore Fenis ; Jessica Rabilloud ; Katia Mayol ; Armelle Tavares ; Jacques Bienvenu ; Yann-Gaël Gangloff ; Eric Gilson ; Eric Vivier ; Thierry WalzerSource :
- Nature Immunology [ 1529-2908 ] ; 2014-08.
English descriptors
- mix :
- Animals, Cell Proliferation, Cells, Cultured, H1N1 Subtype, Herpesviridae Infections, Humans, Immunosuppressive Agents, Inbred C57BL, Inflammation, Influenza A Virus, Interleukin-15, Killer Cells, Knockout, Lymphocyte Activation, Mechanistic Target of Rapamycin Complex 1, Mechanistic Target of Rapamycin Complex 2, Mice, Multiprotein Complexes, Muromegalovirus, Natural, Orthomyxoviridae Infections, Poly I-C, STAT5 Transcription Factor, Signal Transduction, Sirolimus, TOR Serine-Threonine Kinases.
Abstract
Interleukin 15 (IL-15) controls both the homeostasis and the peripheral activation of natural killer (NK) cells. The molecular basis for this duality of action remains unknown. Here we found that the metabolic checkpoint kinase mTOR was activated and boosted bioenergetic metabolism after exposure of NK cells to high concentrations of IL-15, whereas low doses of IL-15 triggered only phosphorylation of the transcription factor STAT5. mTOR stimulated the growth and nutrient uptake of NK cells and positively fed back on the receptor for IL-15. This process was essential for sustaining NK cell proliferation during development and the acquisition of cytolytic potential during inflammation or viral infection. The mTORC1 inhibitor rapamycin inhibited NK cell cytotoxicity both in mice and humans; this probably contributes to the immunosuppressive activity of this drug in different clinical settings.
Url:
DOI: 10.1038/ni.2936
Links to Exploration step
Hal:hal-01911540Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The metabolic checkpoint kinase mTOR is essential for IL-15 signaling during the development and activation of NK cells</title><author><name sortKey="Marcais, Antoine" sort="Marcais, Antoine" uniqKey="Marcais A" first="Antoine" last="Marçais">Antoine Marçais</name><affiliation><hal:affiliation type="researchteam" xml:id="struct-543610" status="VALID"> <orgName>Réponse immunitaire innée dans les maladies infectieuses et auto-immunes – Innate immunity in infectious and autoimmune diseases </orgName> <date type="start">2013-01-01</date> <desc> <address> <addrLine>« Tour CERVI»21 avenue Tony Garnier69007 Lyon</addrLine> <country key="FR"></country> </address> <ref type="url">http://ciri.inserm.fr/</ref> </desc> <listRelation> <relation active="#struct-222995" type="direct"></relation> <relation name="U1111" active="#struct-303623" type="indirect"></relation> <relation active="#struct-6818" type="indirect"></relation> <relation active="#struct-194495" type="indirect"></relation> <relation active="#struct-301088" type="indirect"></relation> <relation name="UMR5308" active="#struct-441569" type="indirect"></relation> </listRelation> <tutelles><tutelle active="#struct-222995" type="direct"><org type="regrouplaboratory" xml:id="struct-222995" status="VALID"> <idno type="IdRef">17825696X</idno> <idno type="RNSR">201320572J</idno> <orgName>Centre International de Recherche en Infectiologie - UMR</orgName> <orgName type="acronym">CIRI</orgName> <date type="start">2013-01-01</date> <desc> <address> <addrLine>21 avenue Tony Garnier 69365 Lyon Cedex 07</addrLine> <country key="FR"></country> </address> <ref type="url">http://ciri.inserm.fr/</ref> </desc> <listRelation> <relation name="U1111" active="#struct-303623" type="direct"></relation> <relation active="#struct-6818" type="direct"></relation> <relation active="#struct-194495" type="direct"></relation> <relation active="#struct-301088" type="indirect"></relation> <relation name="UMR5308" active="#struct-441569" type="direct"></relation> </listRelation> </org></tutelle><tutelle name="U1111" active="#struct-303623" type="indirect"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc> </org></tutelle><tutelle active="#struct-6818" type="indirect"><org type="institution" xml:id="struct-6818" status="VALID"> <idno type="IdRef">149154992</idno> <orgName>École normale supérieure - Lyon</orgName> <orgName type="acronym">ENS Lyon</orgName> <desc> <address> <addrLine>15 parvis René Descartes - BP 7000 - 69342 Lyon Cedex 07</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.ens-lyon.eu/</ref> </desc> </org></tutelle><tutelle active="#struct-194495" type="indirect"><org type="institution" xml:id="struct-194495" status="VALID"> <idno type="IdRef">026402823</idno> <idno type="ISNI">0000000121686185</idno> <orgName>Université Claude Bernard Lyon 1</orgName> <orgName type="acronym">UCBL</orgName> <desc> <address> <addrLine>43, boulevard du 11 novembre 1918, 69622 Villeurbanne cedex</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-lyon1.fr/</ref> </desc> <listRelation> <relation active="#struct-301088" type="direct"></relation> </listRelation> </org></tutelle><tutelle active="#struct-301088" type="indirect"><org type="regroupinstitution" xml:id="struct-301088" status="VALID"> <orgName>Université de Lyon</orgName> <desc> <address> <addrLine>92 rue Pasteur - CS 30122, 69361 Lyon Cedex 07</addrLine> <country key="FR"></country> </address> <ref type="url">https://www.universite-lyon.fr/</ref> </desc> </org></tutelle><tutelle name="UMR5308" active="#struct-441569" type="indirect"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno> <idno type="ISNI">0000000122597504</idno> <orgName>Centre National de la Recherche Scientifique</orgName> <orgName type="acronym">CNRS</orgName> <date type="start">1939-10-19</date> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://www.cnrs.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Cherfils Vicini, Julien" sort="Cherfils Vicini, Julien" uniqKey="Cherfils Vicini J" first="Julien" last="Cherfils-Vicini">Julien Cherfils-Vicini</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-182186" status="VALID"> <orgName>Institut de Recherche sur le Cancer et le Vieillissement</orgName> <orgName type="acronym">IRCAN</orgName> <desc> <address> <addrLine>Faculté de médecine, 28 avenue de Valombrose 06107 Nice Cedex 2</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation name="UMR7284" active="#struct-441569" type="direct"></relation> <relation name="U1081" active="#struct-303623" type="direct"></relation> <relation active="#struct-117617" type="direct"></relation> <relation active="#struct-523042" type="indirect"></relation> </listRelation> <tutelles><tutelle name="UMR7284" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno> <idno type="ISNI">0000000122597504</idno> <orgName>Centre National de la Recherche Scientifique</orgName> <orgName type="acronym">CNRS</orgName> <date type="start">1939-10-19</date> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://www.cnrs.fr/</ref> </desc> </org></tutelle><tutelle name="U1081" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc> </org></tutelle><tutelle active="#struct-117617" type="direct"><org type="institution" xml:id="struct-117617" status="VALID"> <orgName>Université Nice Sophia Antipolis (... - 2019)</orgName> <orgName type="acronym">UNS</orgName> <desc> <address> <addrLine>Parc Valrose - BP 2135 - 06103 Nice cedex 2</addrLine> <country key="FR"></country> </address> <ref type="url">http://unice.fr/</ref> </desc> <listRelation> <relation active="#struct-523042" type="direct"></relation> </listRelation> </org></tutelle><tutelle active="#struct-523042" type="indirect"><org type="regroupinstitution" xml:id="struct-523042" status="VALID"> <orgName>Université Côte d'Azur </orgName> <orgName type="acronym">UCA</orgName> <date type="start">2015-03-01</date> <desc> <address> <addrLine>Parc Valrose, 28 avenue Valrose 06108 Nice Cedex 2 </addrLine> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Viant, Charlotte" sort="Viant, Charlotte" uniqKey="Viant C" first="Charlotte" last="Viant">Charlotte Viant</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-182245" status="VALID"> <idno type="IdRef">150044909</idno> <idno type="RNSR">200017461J</idno> <orgName>Centre d'Immunologie de Marseille - Luminy</orgName> <orgName type="acronym">CIML</orgName> <date type="start">2012-01-01</date> <desc> <address> <addrLine>Parc scientifique et technologique de Luminy - 163, avenue de Luminy - Case 906 - 13288 Marseille cedex 09</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation name="UM 2" active="#struct-198056" type="direct"></relation> <relation name="UMR_S 1104" active="#struct-303623" type="direct"></relation> <relation name="UMR7280" active="#struct-441569" type="direct"></relation> </listRelation> <tutelles><tutelle name="UM 2" active="#struct-198056" type="direct"><org type="institution" xml:id="struct-198056" status="VALID"> <idno type="IdRef">15863621X</idno> <idno type="ISNI">0000 0001 2176 4817</idno> <orgName>Aix Marseille Université</orgName> <orgName type="acronym">AMU</orgName> <date type="start">2012-01-01</date> <desc> <address> <addrLine>Aix-Marseille UniversitéJardins du Pharo58 Boulevard Charles Livon13284 Marseille cedex 7</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-amu.fr/</ref> </desc> </org></tutelle><tutelle name="UMR_S 1104" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc> </org></tutelle><tutelle name="UMR7280" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno> <idno type="ISNI">0000000122597504</idno> <orgName>Centre National de la Recherche Scientifique</orgName> <orgName type="acronym">CNRS</orgName> <date type="start">1939-10-19</date> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://www.cnrs.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Degouve, Sophie" sort="Degouve, Sophie" uniqKey="Degouve S" first="Sophie" last="Degouve">Sophie Degouve</name><affiliation><hal:affiliation type="researchteam" xml:id="struct-543610" status="VALID"> <orgName>Réponse immunitaire innée dans les maladies infectieuses et auto-immunes – Innate immunity in infectious and autoimmune diseases </orgName> <date type="start">2013-01-01</date> <desc> <address> <addrLine>« Tour CERVI»21 avenue Tony Garnier69007 Lyon</addrLine> <country key="FR"></country> </address> <ref type="url">http://ciri.inserm.fr/</ref> </desc> <listRelation> <relation active="#struct-222995" type="direct"></relation> <relation name="U1111" active="#struct-303623" type="indirect"></relation> <relation active="#struct-6818" type="indirect"></relation> <relation active="#struct-194495" type="indirect"></relation> <relation active="#struct-301088" type="indirect"></relation> <relation name="UMR5308" active="#struct-441569" type="indirect"></relation> </listRelation> <tutelles><tutelle active="#struct-222995" type="direct"><org type="regrouplaboratory" xml:id="struct-222995" status="VALID"> <idno type="IdRef">17825696X</idno> <idno type="RNSR">201320572J</idno> <orgName>Centre International de Recherche en Infectiologie - UMR</orgName> <orgName type="acronym">CIRI</orgName> <date type="start">2013-01-01</date> <desc> <address> <addrLine>21 avenue Tony Garnier 69365 Lyon Cedex 07</addrLine> <country key="FR"></country> </address> <ref type="url">http://ciri.inserm.fr/</ref> </desc> <listRelation> <relation name="U1111" active="#struct-303623" type="direct"></relation> <relation active="#struct-6818" type="direct"></relation> <relation active="#struct-194495" type="direct"></relation> <relation active="#struct-301088" type="indirect"></relation> <relation name="UMR5308" active="#struct-441569" type="direct"></relation> </listRelation> </org></tutelle><tutelle name="U1111" active="#struct-303623" type="indirect"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc> </org></tutelle><tutelle active="#struct-6818" type="indirect"><org type="institution" xml:id="struct-6818" status="VALID"> <idno type="IdRef">149154992</idno> <orgName>École normale supérieure - Lyon</orgName> <orgName type="acronym">ENS Lyon</orgName> <desc> <address> <addrLine>15 parvis René Descartes - BP 7000 - 69342 Lyon Cedex 07</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.ens-lyon.eu/</ref> </desc> </org></tutelle><tutelle active="#struct-194495" type="indirect"><org type="institution" xml:id="struct-194495" status="VALID"> <idno type="IdRef">026402823</idno> <idno type="ISNI">0000000121686185</idno> <orgName>Université Claude Bernard Lyon 1</orgName> <orgName type="acronym">UCBL</orgName> <desc> <address> <addrLine>43, boulevard du 11 novembre 1918, 69622 Villeurbanne cedex</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-lyon1.fr/</ref> </desc> <listRelation> <relation active="#struct-301088" type="direct"></relation> </listRelation> </org></tutelle><tutelle active="#struct-301088" type="indirect"><org type="regroupinstitution" xml:id="struct-301088" status="VALID"> <orgName>Université de Lyon</orgName> <desc> <address> <addrLine>92 rue Pasteur - CS 30122, 69361 Lyon Cedex 07</addrLine> <country key="FR"></country> </address> <ref type="url">https://www.universite-lyon.fr/</ref> </desc> </org></tutelle><tutelle name="UMR5308" active="#struct-441569" type="indirect"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno> <idno type="ISNI">0000000122597504</idno> <orgName>Centre National de la Recherche Scientifique</orgName> <orgName type="acronym">CNRS</orgName> <date type="start">1939-10-19</date> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://www.cnrs.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Viel, Sebastien" sort="Viel, Sebastien" uniqKey="Viel S" first="Sébastien" last="Viel">Sébastien Viel</name><affiliation><hal:affiliation type="researchteam" xml:id="struct-543610" status="VALID"> <orgName>Réponse immunitaire innée dans les maladies infectieuses et auto-immunes – Innate immunity in infectious and autoimmune diseases </orgName> <date type="start">2013-01-01</date> <desc> <address> <addrLine>« Tour CERVI»21 avenue Tony Garnier69007 Lyon</addrLine> <country key="FR"></country> </address> <ref type="url">http://ciri.inserm.fr/</ref> </desc> <listRelation> <relation active="#struct-222995" type="direct"></relation> <relation name="U1111" active="#struct-303623" type="indirect"></relation> <relation active="#struct-6818" type="indirect"></relation> <relation active="#struct-194495" type="indirect"></relation> <relation active="#struct-301088" type="indirect"></relation> <relation name="UMR5308" active="#struct-441569" type="indirect"></relation> </listRelation> <tutelles><tutelle active="#struct-222995" type="direct"><org type="regrouplaboratory" xml:id="struct-222995" status="VALID"> <idno type="IdRef">17825696X</idno> <idno type="RNSR">201320572J</idno> <orgName>Centre International de Recherche en Infectiologie - UMR</orgName> <orgName type="acronym">CIRI</orgName> <date type="start">2013-01-01</date> <desc> <address> <addrLine>21 avenue Tony Garnier 69365 Lyon Cedex 07</addrLine> <country key="FR"></country> </address> <ref type="url">http://ciri.inserm.fr/</ref> </desc> <listRelation> <relation name="U1111" active="#struct-303623" type="direct"></relation> <relation active="#struct-6818" type="direct"></relation> <relation active="#struct-194495" type="direct"></relation> <relation active="#struct-301088" type="indirect"></relation> <relation name="UMR5308" active="#struct-441569" type="direct"></relation> </listRelation> </org></tutelle><tutelle name="U1111" active="#struct-303623" type="indirect"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc> </org></tutelle><tutelle active="#struct-6818" type="indirect"><org type="institution" xml:id="struct-6818" status="VALID"> <idno type="IdRef">149154992</idno> <orgName>École normale supérieure - Lyon</orgName> <orgName type="acronym">ENS Lyon</orgName> <desc> <address> <addrLine>15 parvis René Descartes - BP 7000 - 69342 Lyon Cedex 07</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.ens-lyon.eu/</ref> </desc> </org></tutelle><tutelle active="#struct-194495" type="indirect"><org type="institution" xml:id="struct-194495" status="VALID"> <idno type="IdRef">026402823</idno> <idno type="ISNI">0000000121686185</idno> <orgName>Université Claude Bernard Lyon 1</orgName> <orgName type="acronym">UCBL</orgName> <desc> <address> <addrLine>43, boulevard du 11 novembre 1918, 69622 Villeurbanne cedex</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-lyon1.fr/</ref> </desc> <listRelation> <relation active="#struct-301088" type="direct"></relation> </listRelation> </org></tutelle><tutelle active="#struct-301088" type="indirect"><org type="regroupinstitution" xml:id="struct-301088" status="VALID"> <orgName>Université de Lyon</orgName> <desc> <address> <addrLine>92 rue Pasteur - CS 30122, 69361 Lyon Cedex 07</addrLine> <country key="FR"></country> </address> <ref type="url">https://www.universite-lyon.fr/</ref> </desc> </org></tutelle><tutelle name="UMR5308" active="#struct-441569" type="indirect"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno> <idno type="ISNI">0000000122597504</idno> <orgName>Centre National de la Recherche Scientifique</orgName> <orgName type="acronym">CNRS</orgName> <date type="start">1939-10-19</date> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://www.cnrs.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Fenis, Aurore" sort="Fenis, Aurore" uniqKey="Fenis A" first="Aurore" last="Fenis">Aurore Fenis</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-182245" status="VALID"> <idno type="IdRef">150044909</idno> <idno type="RNSR">200017461J</idno> <orgName>Centre d'Immunologie de Marseille - Luminy</orgName> <orgName type="acronym">CIML</orgName> <date type="start">2012-01-01</date> <desc> <address> <addrLine>Parc scientifique et technologique de Luminy - 163, avenue de Luminy - Case 906 - 13288 Marseille cedex 09</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation name="UM 2" active="#struct-198056" type="direct"></relation> <relation name="UMR_S 1104" active="#struct-303623" type="direct"></relation> <relation name="UMR7280" active="#struct-441569" type="direct"></relation> </listRelation> <tutelles><tutelle name="UM 2" active="#struct-198056" type="direct"><org type="institution" xml:id="struct-198056" status="VALID"> <idno type="IdRef">15863621X</idno> <idno type="ISNI">0000 0001 2176 4817</idno> <orgName>Aix Marseille Université</orgName> <orgName type="acronym">AMU</orgName> <date type="start">2012-01-01</date> <desc> <address> <addrLine>Aix-Marseille UniversitéJardins du Pharo58 Boulevard Charles Livon13284 Marseille cedex 7</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-amu.fr/</ref> </desc> </org></tutelle><tutelle name="UMR_S 1104" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc> </org></tutelle><tutelle name="UMR7280" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno> <idno type="ISNI">0000000122597504</idno> <orgName>Centre National de la Recherche Scientifique</orgName> <orgName type="acronym">CNRS</orgName> <date type="start">1939-10-19</date> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://www.cnrs.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Rabilloud, Jessica" sort="Rabilloud, Jessica" uniqKey="Rabilloud J" first="Jessica" last="Rabilloud">Jessica Rabilloud</name><affiliation><hal:affiliation type="researchteam" xml:id="struct-543610" status="VALID"> <orgName>Réponse immunitaire innée dans les maladies infectieuses et auto-immunes – Innate immunity in infectious and autoimmune diseases </orgName> <date type="start">2013-01-01</date> <desc> <address> <addrLine>« Tour CERVI»21 avenue Tony Garnier69007 Lyon</addrLine> <country key="FR"></country> </address> <ref type="url">http://ciri.inserm.fr/</ref> </desc> <listRelation> <relation active="#struct-222995" type="direct"></relation> <relation name="U1111" active="#struct-303623" type="indirect"></relation> <relation active="#struct-6818" type="indirect"></relation> <relation active="#struct-194495" type="indirect"></relation> <relation active="#struct-301088" type="indirect"></relation> <relation name="UMR5308" active="#struct-441569" type="indirect"></relation> </listRelation> <tutelles><tutelle active="#struct-222995" type="direct"><org type="regrouplaboratory" xml:id="struct-222995" status="VALID"> <idno type="IdRef">17825696X</idno> <idno type="RNSR">201320572J</idno> <orgName>Centre International de Recherche en Infectiologie - UMR</orgName> <orgName type="acronym">CIRI</orgName> <date type="start">2013-01-01</date> <desc> <address> <addrLine>21 avenue Tony Garnier 69365 Lyon Cedex 07</addrLine> <country key="FR"></country> </address> <ref type="url">http://ciri.inserm.fr/</ref> </desc> <listRelation> <relation name="U1111" active="#struct-303623" type="direct"></relation> <relation active="#struct-6818" type="direct"></relation> <relation active="#struct-194495" type="direct"></relation> <relation active="#struct-301088" type="indirect"></relation> <relation name="UMR5308" active="#struct-441569" type="direct"></relation> </listRelation> </org></tutelle><tutelle name="U1111" active="#struct-303623" type="indirect"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc> </org></tutelle><tutelle active="#struct-6818" type="indirect"><org type="institution" xml:id="struct-6818" status="VALID"> <idno type="IdRef">149154992</idno> <orgName>École normale supérieure - Lyon</orgName> <orgName type="acronym">ENS Lyon</orgName> <desc> <address> <addrLine>15 parvis René Descartes - BP 7000 - 69342 Lyon Cedex 07</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.ens-lyon.eu/</ref> </desc> </org></tutelle><tutelle active="#struct-194495" type="indirect"><org type="institution" xml:id="struct-194495" status="VALID"> <idno type="IdRef">026402823</idno> <idno type="ISNI">0000000121686185</idno> <orgName>Université Claude Bernard Lyon 1</orgName> <orgName type="acronym">UCBL</orgName> <desc> <address> <addrLine>43, boulevard du 11 novembre 1918, 69622 Villeurbanne cedex</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-lyon1.fr/</ref> </desc> <listRelation> <relation active="#struct-301088" type="direct"></relation> </listRelation> </org></tutelle><tutelle active="#struct-301088" type="indirect"><org type="regroupinstitution" xml:id="struct-301088" status="VALID"> <orgName>Université de Lyon</orgName> <desc> <address> <addrLine>92 rue Pasteur - CS 30122, 69361 Lyon Cedex 07</addrLine> <country key="FR"></country> </address> <ref type="url">https://www.universite-lyon.fr/</ref> </desc> </org></tutelle><tutelle name="UMR5308" active="#struct-441569" type="indirect"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno> <idno type="ISNI">0000000122597504</idno> <orgName>Centre National de la Recherche Scientifique</orgName> <orgName type="acronym">CNRS</orgName> <date type="start">1939-10-19</date> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://www.cnrs.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Mayol, Katia" sort="Mayol, Katia" uniqKey="Mayol K" first="Katia" last="Mayol">Katia Mayol</name><affiliation><hal:affiliation type="researchteam" xml:id="struct-543610" status="VALID"> <orgName>Réponse immunitaire innée dans les maladies infectieuses et auto-immunes – Innate immunity in infectious and autoimmune diseases </orgName> <date type="start">2013-01-01</date> <desc> <address> <addrLine>« Tour CERVI»21 avenue Tony Garnier69007 Lyon</addrLine> <country key="FR"></country> </address> <ref type="url">http://ciri.inserm.fr/</ref> </desc> <listRelation> <relation active="#struct-222995" type="direct"></relation> <relation name="U1111" active="#struct-303623" type="indirect"></relation> <relation active="#struct-6818" type="indirect"></relation> <relation active="#struct-194495" type="indirect"></relation> <relation active="#struct-301088" type="indirect"></relation> <relation name="UMR5308" active="#struct-441569" type="indirect"></relation> </listRelation> <tutelles><tutelle active="#struct-222995" type="direct"><org type="regrouplaboratory" xml:id="struct-222995" status="VALID"> <idno type="IdRef">17825696X</idno> <idno type="RNSR">201320572J</idno> <orgName>Centre International de Recherche en Infectiologie - UMR</orgName> <orgName type="acronym">CIRI</orgName> <date type="start">2013-01-01</date> <desc> <address> <addrLine>21 avenue Tony Garnier 69365 Lyon Cedex 07</addrLine> <country key="FR"></country> </address> <ref type="url">http://ciri.inserm.fr/</ref> </desc> <listRelation> <relation name="U1111" active="#struct-303623" type="direct"></relation> <relation active="#struct-6818" type="direct"></relation> <relation active="#struct-194495" type="direct"></relation> <relation active="#struct-301088" type="indirect"></relation> <relation name="UMR5308" active="#struct-441569" type="direct"></relation> </listRelation> </org></tutelle><tutelle name="U1111" active="#struct-303623" type="indirect"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc> </org></tutelle><tutelle active="#struct-6818" type="indirect"><org type="institution" xml:id="struct-6818" status="VALID"> <idno type="IdRef">149154992</idno> <orgName>École normale supérieure - Lyon</orgName> <orgName type="acronym">ENS Lyon</orgName> <desc> <address> <addrLine>15 parvis René Descartes - BP 7000 - 69342 Lyon Cedex 07</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.ens-lyon.eu/</ref> </desc> </org></tutelle><tutelle active="#struct-194495" type="indirect"><org type="institution" xml:id="struct-194495" status="VALID"> <idno type="IdRef">026402823</idno> <idno type="ISNI">0000000121686185</idno> <orgName>Université Claude Bernard Lyon 1</orgName> <orgName type="acronym">UCBL</orgName> <desc> <address> <addrLine>43, boulevard du 11 novembre 1918, 69622 Villeurbanne cedex</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-lyon1.fr/</ref> </desc> <listRelation> <relation active="#struct-301088" type="direct"></relation> </listRelation> </org></tutelle><tutelle active="#struct-301088" type="indirect"><org type="regroupinstitution" xml:id="struct-301088" status="VALID"> <orgName>Université de Lyon</orgName> <desc> <address> <addrLine>92 rue Pasteur - CS 30122, 69361 Lyon Cedex 07</addrLine> <country key="FR"></country> </address> <ref type="url">https://www.universite-lyon.fr/</ref> </desc> </org></tutelle><tutelle name="UMR5308" active="#struct-441569" type="indirect"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno> <idno type="ISNI">0000000122597504</idno> <orgName>Centre National de la Recherche Scientifique</orgName> <orgName type="acronym">CNRS</orgName> <date type="start">1939-10-19</date> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://www.cnrs.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Tavares, Armelle" sort="Tavares, Armelle" uniqKey="Tavares A" first="Armelle" last="Tavares">Armelle Tavares</name><affiliation><hal:affiliation type="researchteam" xml:id="struct-543610" status="VALID"> <orgName>Réponse immunitaire innée dans les maladies infectieuses et auto-immunes – Innate immunity in infectious and autoimmune diseases </orgName> <date type="start">2013-01-01</date> <desc> <address> <addrLine>« Tour CERVI»21 avenue Tony Garnier69007 Lyon</addrLine> <country key="FR"></country> </address> <ref type="url">http://ciri.inserm.fr/</ref> </desc> <listRelation> <relation active="#struct-222995" type="direct"></relation> <relation name="U1111" active="#struct-303623" type="indirect"></relation> <relation active="#struct-6818" type="indirect"></relation> <relation active="#struct-194495" type="indirect"></relation> <relation active="#struct-301088" type="indirect"></relation> <relation name="UMR5308" active="#struct-441569" type="indirect"></relation> </listRelation> <tutelles><tutelle active="#struct-222995" type="direct"><org type="regrouplaboratory" xml:id="struct-222995" status="VALID"> <idno type="IdRef">17825696X</idno> <idno type="RNSR">201320572J</idno> <orgName>Centre International de Recherche en Infectiologie - UMR</orgName> <orgName type="acronym">CIRI</orgName> <date type="start">2013-01-01</date> <desc> <address> <addrLine>21 avenue Tony Garnier 69365 Lyon Cedex 07</addrLine> <country key="FR"></country> </address> <ref type="url">http://ciri.inserm.fr/</ref> </desc> <listRelation> <relation name="U1111" active="#struct-303623" type="direct"></relation> <relation active="#struct-6818" type="direct"></relation> <relation active="#struct-194495" type="direct"></relation> <relation active="#struct-301088" type="indirect"></relation> <relation name="UMR5308" active="#struct-441569" type="direct"></relation> </listRelation> </org></tutelle><tutelle name="U1111" active="#struct-303623" type="indirect"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc> </org></tutelle><tutelle active="#struct-6818" type="indirect"><org type="institution" xml:id="struct-6818" status="VALID"> <idno type="IdRef">149154992</idno> <orgName>École normale supérieure - Lyon</orgName> <orgName type="acronym">ENS Lyon</orgName> <desc> <address> <addrLine>15 parvis René Descartes - BP 7000 - 69342 Lyon Cedex 07</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.ens-lyon.eu/</ref> </desc> </org></tutelle><tutelle active="#struct-194495" type="indirect"><org type="institution" xml:id="struct-194495" status="VALID"> <idno type="IdRef">026402823</idno> <idno type="ISNI">0000000121686185</idno> <orgName>Université Claude Bernard Lyon 1</orgName> <orgName type="acronym">UCBL</orgName> <desc> <address> <addrLine>43, boulevard du 11 novembre 1918, 69622 Villeurbanne cedex</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-lyon1.fr/</ref> </desc> <listRelation> <relation active="#struct-301088" type="direct"></relation> </listRelation> </org></tutelle><tutelle active="#struct-301088" type="indirect"><org type="regroupinstitution" xml:id="struct-301088" status="VALID"> <orgName>Université de Lyon</orgName> <desc> <address> <addrLine>92 rue Pasteur - CS 30122, 69361 Lyon Cedex 07</addrLine> <country key="FR"></country> </address> <ref type="url">https://www.universite-lyon.fr/</ref> </desc> </org></tutelle><tutelle name="UMR5308" active="#struct-441569" type="indirect"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno> <idno type="ISNI">0000000122597504</idno> <orgName>Centre National de la Recherche Scientifique</orgName> <orgName type="acronym">CNRS</orgName> <date type="start">1939-10-19</date> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://www.cnrs.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Bienvenu, Jacques" sort="Bienvenu, Jacques" uniqKey="Bienvenu J" first="Jacques" last="Bienvenu">Jacques Bienvenu</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-157369" status="VALID"> <orgName>Service d'immunologie [Centre Hospitalier Lyon Sud - HCL]</orgName> <desc> <address> <addrLine>165, chemin du Grand-Revoyet, 69495 Pierre-Bénite, France</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-353860" type="direct"></relation> <relation active="#struct-300074" type="indirect"></relation> </listRelation> <tutelles><tutelle active="#struct-353860" type="direct"><org type="institution" xml:id="struct-353860" status="VALID"> <orgName>Centre Hospitalier Lyon Sud [CHU - HCL]</orgName> <orgName type="acronym">CHLS</orgName> <desc> <address> <addrLine>165 Chemin du Grand Revoyet69495 Pierre-Bénite</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.chu-lyon.fr/fr/centre-hospitalier-lyon-sud</ref> </desc> <listRelation> <relation active="#struct-300074" type="direct"></relation> </listRelation> </org></tutelle><tutelle active="#struct-300074" type="indirect"><org type="regroupinstitution" xml:id="struct-300074" status="VALID"> <idno type="IdRef">026534657</idno> <orgName>Hospices Civils de Lyon</orgName> <orgName type="acronym">HCL</orgName> <desc> <address> <addrLine>3 Quai des Célestins69002 Lyon </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.chu-lyon.fr/fr/hospices-civils-de-lyon-hcl</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Gangloff, Yann Gael" sort="Gangloff, Yann Gael" uniqKey="Gangloff Y" first="Yann-Gaël" last="Gangloff">Yann-Gaël Gangloff</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-489487" status="VALID"> <idno type="IdRef">166612049</idno> <idno type="RNSR">200711906R</idno> <orgName>Laboratoire de biologie et modélisation de la cellule</orgName> <orgName type="acronym">LBMC UMR 5239</orgName> <date type="start">2007-01-01</date> <desc> <address> <addrLine>Ecole Normale Supérieure46 Allée d'Italie69364 Lyon Cedex 07</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.ens-lyon.fr/LBMC/</ref> </desc> <listRelation> <relation active="#struct-194495" type="direct"></relation> <relation active="#struct-301088" type="indirect"></relation> <relation active="#struct-6818" type="direct"></relation> <relation name="UMR 5239" active="#struct-441569" type="direct"></relation> <relation name="U1210" active="#struct-303623" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-194495" type="direct"><org type="institution" xml:id="struct-194495" status="VALID"> <idno type="IdRef">026402823</idno> <idno type="ISNI">0000000121686185</idno> <orgName>Université Claude Bernard Lyon 1</orgName> <orgName type="acronym">UCBL</orgName> <desc> <address> <addrLine>43, boulevard du 11 novembre 1918, 69622 Villeurbanne cedex</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-lyon1.fr/</ref> </desc> <listRelation> <relation active="#struct-301088" type="direct"></relation> </listRelation> </org></tutelle><tutelle active="#struct-301088" type="indirect"><org type="regroupinstitution" xml:id="struct-301088" status="VALID"> <orgName>Université de Lyon</orgName> <desc> <address> <addrLine>92 rue Pasteur - CS 30122, 69361 Lyon Cedex 07</addrLine> <country key="FR"></country> </address> <ref type="url">https://www.universite-lyon.fr/</ref> </desc> </org></tutelle><tutelle active="#struct-6818" type="direct"><org type="institution" xml:id="struct-6818" status="VALID"> <idno type="IdRef">149154992</idno> <orgName>École normale supérieure - Lyon</orgName> <orgName type="acronym">ENS Lyon</orgName> <desc> <address> <addrLine>15 parvis René Descartes - BP 7000 - 69342 Lyon Cedex 07</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.ens-lyon.eu/</ref> </desc> </org></tutelle><tutelle name="UMR 5239" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno> <idno type="ISNI">0000000122597504</idno> <orgName>Centre National de la Recherche Scientifique</orgName> <orgName type="acronym">CNRS</orgName> <date type="start">1939-10-19</date> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://www.cnrs.fr/</ref> </desc> </org></tutelle><tutelle name="U1210" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Gilson, Eric" sort="Gilson, Eric" uniqKey="Gilson E" first="Eric" last="Gilson">Eric Gilson</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-182186" status="VALID"> <orgName>Institut de Recherche sur le Cancer et le Vieillissement</orgName> <orgName type="acronym">IRCAN</orgName> <desc> <address> <addrLine>Faculté de médecine, 28 avenue de Valombrose 06107 Nice Cedex 2</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation name="UMR7284" active="#struct-441569" type="direct"></relation> <relation name="U1081" active="#struct-303623" type="direct"></relation> <relation active="#struct-117617" type="direct"></relation> <relation active="#struct-523042" type="indirect"></relation> </listRelation> <tutelles><tutelle name="UMR7284" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno> <idno type="ISNI">0000000122597504</idno> <orgName>Centre National de la Recherche Scientifique</orgName> <orgName type="acronym">CNRS</orgName> <date type="start">1939-10-19</date> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://www.cnrs.fr/</ref> </desc> </org></tutelle><tutelle name="U1081" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc> </org></tutelle><tutelle active="#struct-117617" type="direct"><org type="institution" xml:id="struct-117617" status="VALID"> <orgName>Université Nice Sophia Antipolis (... - 2019)</orgName> <orgName type="acronym">UNS</orgName> <desc> <address> <addrLine>Parc Valrose - BP 2135 - 06103 Nice cedex 2</addrLine> <country key="FR"></country> </address> <ref type="url">http://unice.fr/</ref> </desc> <listRelation> <relation active="#struct-523042" type="direct"></relation> </listRelation> </org></tutelle><tutelle active="#struct-523042" type="indirect"><org type="regroupinstitution" xml:id="struct-523042" status="VALID"> <orgName>Université Côte d'Azur </orgName> <orgName type="acronym">UCA</orgName> <date type="start">2015-03-01</date> <desc> <address> <addrLine>Parc Valrose, 28 avenue Valrose 06108 Nice Cedex 2 </addrLine> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Vivier, Eric" sort="Vivier, Eric" uniqKey="Vivier E" first="Eric" last="Vivier">Eric Vivier</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-182245" status="VALID"> <idno type="IdRef">150044909</idno> <idno type="RNSR">200017461J</idno> <orgName>Centre d'Immunologie de Marseille - Luminy</orgName> <orgName type="acronym">CIML</orgName> <date type="start">2012-01-01</date> <desc> <address> <addrLine>Parc scientifique et technologique de Luminy - 163, avenue de Luminy - Case 906 - 13288 Marseille cedex 09</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation name="UM 2" active="#struct-198056" type="direct"></relation> <relation name="UMR_S 1104" active="#struct-303623" type="direct"></relation> <relation name="UMR7280" active="#struct-441569" type="direct"></relation> </listRelation> <tutelles><tutelle name="UM 2" active="#struct-198056" type="direct"><org type="institution" xml:id="struct-198056" status="VALID"> <idno type="IdRef">15863621X</idno> <idno type="ISNI">0000 0001 2176 4817</idno> <orgName>Aix Marseille Université</orgName> <orgName type="acronym">AMU</orgName> <date type="start">2012-01-01</date> <desc> <address> <addrLine>Aix-Marseille UniversitéJardins du Pharo58 Boulevard Charles Livon13284 Marseille cedex 7</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-amu.fr/</ref> </desc> </org></tutelle><tutelle name="UMR_S 1104" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc> </org></tutelle><tutelle name="UMR7280" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno> <idno type="ISNI">0000000122597504</idno> <orgName>Centre National de la Recherche Scientifique</orgName> <orgName type="acronym">CNRS</orgName> <date type="start">1939-10-19</date> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://www.cnrs.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Walzer, Thierry" sort="Walzer, Thierry" uniqKey="Walzer T" first="Thierry" last="Walzer">Thierry Walzer</name><affiliation><hal:affiliation type="researchteam" xml:id="struct-543610" status="VALID"> <orgName>Réponse immunitaire innée dans les maladies infectieuses et auto-immunes – Innate immunity in infectious and autoimmune diseases </orgName> <date type="start">2013-01-01</date> <desc> <address> <addrLine>« Tour CERVI»21 avenue Tony Garnier69007 Lyon</addrLine> <country key="FR"></country> </address> <ref type="url">http://ciri.inserm.fr/</ref> </desc> <listRelation> <relation active="#struct-222995" type="direct"></relation> <relation name="U1111" active="#struct-303623" type="indirect"></relation> <relation active="#struct-6818" type="indirect"></relation> <relation active="#struct-194495" type="indirect"></relation> <relation active="#struct-301088" type="indirect"></relation> <relation name="UMR5308" active="#struct-441569" type="indirect"></relation> </listRelation> <tutelles><tutelle active="#struct-222995" type="direct"><org type="regrouplaboratory" xml:id="struct-222995" status="VALID"> <idno type="IdRef">17825696X</idno> <idno type="RNSR">201320572J</idno> <orgName>Centre International de Recherche en Infectiologie - UMR</orgName> <orgName type="acronym">CIRI</orgName> <date type="start">2013-01-01</date> <desc> <address> <addrLine>21 avenue Tony Garnier 69365 Lyon Cedex 07</addrLine> <country key="FR"></country> </address> <ref type="url">http://ciri.inserm.fr/</ref> </desc> <listRelation> <relation name="U1111" active="#struct-303623" type="direct"></relation> <relation active="#struct-6818" type="direct"></relation> <relation active="#struct-194495" type="direct"></relation> <relation active="#struct-301088" type="indirect"></relation> <relation name="UMR5308" active="#struct-441569" type="direct"></relation> </listRelation> </org></tutelle><tutelle name="U1111" active="#struct-303623" type="indirect"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc> </org></tutelle><tutelle active="#struct-6818" type="indirect"><org type="institution" xml:id="struct-6818" status="VALID"> <idno type="IdRef">149154992</idno> <orgName>École normale supérieure - Lyon</orgName> <orgName type="acronym">ENS Lyon</orgName> <desc> <address> <addrLine>15 parvis René Descartes - BP 7000 - 69342 Lyon Cedex 07</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.ens-lyon.eu/</ref> </desc> </org></tutelle><tutelle active="#struct-194495" type="indirect"><org type="institution" xml:id="struct-194495" status="VALID"> <idno type="IdRef">026402823</idno> <idno type="ISNI">0000000121686185</idno> <orgName>Université Claude Bernard Lyon 1</orgName> <orgName type="acronym">UCBL</orgName> <desc> <address> <addrLine>43, boulevard du 11 novembre 1918, 69622 Villeurbanne cedex</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-lyon1.fr/</ref> </desc> <listRelation> <relation active="#struct-301088" type="direct"></relation> </listRelation> </org></tutelle><tutelle active="#struct-301088" type="indirect"><org type="regroupinstitution" xml:id="struct-301088" status="VALID"> <orgName>Université de Lyon</orgName> <desc> <address> <addrLine>92 rue Pasteur - CS 30122, 69361 Lyon Cedex 07</addrLine> <country key="FR"></country> </address> <ref type="url">https://www.universite-lyon.fr/</ref> </desc> </org></tutelle><tutelle name="UMR5308" active="#struct-441569" type="indirect"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno> <idno type="ISNI">0000000122597504</idno> <orgName>Centre National de la Recherche Scientifique</orgName> <orgName type="acronym">CNRS</orgName> <date type="start">1939-10-19</date> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://www.cnrs.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">HAL</idno><idno type="RBID">Hal:hal-01911540</idno><idno type="halId">hal-01911540</idno><idno type="halUri">https://hal.archives-ouvertes.fr/hal-01911540</idno><idno type="url">https://hal.archives-ouvertes.fr/hal-01911540</idno><idno type="doi">10.1038/ni.2936</idno><date when="2014-08">2014-08</date><idno type="wicri:Area/Hal/Corpus">000294</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">The metabolic checkpoint kinase mTOR is essential for IL-15 signaling during the development and activation of NK cells</title><author><name sortKey="Marcais, Antoine" sort="Marcais, Antoine" uniqKey="Marcais A" first="Antoine" last="Marçais">Antoine Marçais</name><affiliation><hal:affiliation type="researchteam" xml:id="struct-543610" status="VALID"> <orgName>Réponse immunitaire innée dans les maladies infectieuses et auto-immunes – Innate immunity in infectious and autoimmune diseases </orgName> <date type="start">2013-01-01</date> <desc> <address> <addrLine>« Tour CERVI»21 avenue Tony Garnier69007 Lyon</addrLine> <country key="FR"></country> </address> <ref type="url">http://ciri.inserm.fr/</ref> </desc> <listRelation> <relation active="#struct-222995" type="direct"></relation> <relation name="U1111" active="#struct-303623" type="indirect"></relation> <relation active="#struct-6818" type="indirect"></relation> <relation active="#struct-194495" type="indirect"></relation> <relation active="#struct-301088" type="indirect"></relation> <relation name="UMR5308" active="#struct-441569" type="indirect"></relation> </listRelation> <tutelles><tutelle active="#struct-222995" type="direct"><org type="regrouplaboratory" xml:id="struct-222995" status="VALID"> <idno type="IdRef">17825696X</idno> <idno type="RNSR">201320572J</idno> <orgName>Centre International de Recherche en Infectiologie - UMR</orgName> <orgName type="acronym">CIRI</orgName> <date type="start">2013-01-01</date> <desc> <address> <addrLine>21 avenue Tony Garnier 69365 Lyon Cedex 07</addrLine> <country key="FR"></country> </address> <ref type="url">http://ciri.inserm.fr/</ref> </desc> <listRelation> <relation name="U1111" active="#struct-303623" type="direct"></relation> <relation active="#struct-6818" type="direct"></relation> <relation active="#struct-194495" type="direct"></relation> <relation active="#struct-301088" type="indirect"></relation> <relation name="UMR5308" active="#struct-441569" type="direct"></relation> </listRelation> </org></tutelle><tutelle name="U1111" active="#struct-303623" type="indirect"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc> </org></tutelle><tutelle active="#struct-6818" type="indirect"><org type="institution" xml:id="struct-6818" status="VALID"> <idno type="IdRef">149154992</idno> <orgName>École normale supérieure - Lyon</orgName> <orgName type="acronym">ENS Lyon</orgName> <desc> <address> <addrLine>15 parvis René Descartes - BP 7000 - 69342 Lyon Cedex 07</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.ens-lyon.eu/</ref> </desc> </org></tutelle><tutelle active="#struct-194495" type="indirect"><org type="institution" xml:id="struct-194495" status="VALID"> <idno type="IdRef">026402823</idno> <idno type="ISNI">0000000121686185</idno> <orgName>Université Claude Bernard Lyon 1</orgName> <orgName type="acronym">UCBL</orgName> <desc> <address> <addrLine>43, boulevard du 11 novembre 1918, 69622 Villeurbanne cedex</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-lyon1.fr/</ref> </desc> <listRelation> <relation active="#struct-301088" type="direct"></relation> </listRelation> </org></tutelle><tutelle active="#struct-301088" type="indirect"><org type="regroupinstitution" xml:id="struct-301088" status="VALID"> <orgName>Université de Lyon</orgName> <desc> <address> <addrLine>92 rue Pasteur - CS 30122, 69361 Lyon Cedex 07</addrLine> <country key="FR"></country> </address> <ref type="url">https://www.universite-lyon.fr/</ref> </desc> </org></tutelle><tutelle name="UMR5308" active="#struct-441569" type="indirect"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno> <idno type="ISNI">0000000122597504</idno> <orgName>Centre National de la Recherche Scientifique</orgName> <orgName type="acronym">CNRS</orgName> <date type="start">1939-10-19</date> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://www.cnrs.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Cherfils Vicini, Julien" sort="Cherfils Vicini, Julien" uniqKey="Cherfils Vicini J" first="Julien" last="Cherfils-Vicini">Julien Cherfils-Vicini</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-182186" status="VALID"> <orgName>Institut de Recherche sur le Cancer et le Vieillissement</orgName> <orgName type="acronym">IRCAN</orgName> <desc> <address> <addrLine>Faculté de médecine, 28 avenue de Valombrose 06107 Nice Cedex 2</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation name="UMR7284" active="#struct-441569" type="direct"></relation> <relation name="U1081" active="#struct-303623" type="direct"></relation> <relation active="#struct-117617" type="direct"></relation> <relation active="#struct-523042" type="indirect"></relation> </listRelation> <tutelles><tutelle name="UMR7284" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno> <idno type="ISNI">0000000122597504</idno> <orgName>Centre National de la Recherche Scientifique</orgName> <orgName type="acronym">CNRS</orgName> <date type="start">1939-10-19</date> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://www.cnrs.fr/</ref> </desc> </org></tutelle><tutelle name="U1081" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc> </org></tutelle><tutelle active="#struct-117617" type="direct"><org type="institution" xml:id="struct-117617" status="VALID"> <orgName>Université Nice Sophia Antipolis (... - 2019)</orgName> <orgName type="acronym">UNS</orgName> <desc> <address> <addrLine>Parc Valrose - BP 2135 - 06103 Nice cedex 2</addrLine> <country key="FR"></country> </address> <ref type="url">http://unice.fr/</ref> </desc> <listRelation> <relation active="#struct-523042" type="direct"></relation> </listRelation> </org></tutelle><tutelle active="#struct-523042" type="indirect"><org type="regroupinstitution" xml:id="struct-523042" status="VALID"> <orgName>Université Côte d'Azur </orgName> <orgName type="acronym">UCA</orgName> <date type="start">2015-03-01</date> <desc> <address> <addrLine>Parc Valrose, 28 avenue Valrose 06108 Nice Cedex 2 </addrLine> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Viant, Charlotte" sort="Viant, Charlotte" uniqKey="Viant C" first="Charlotte" last="Viant">Charlotte Viant</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-182245" status="VALID"> <idno type="IdRef">150044909</idno> <idno type="RNSR">200017461J</idno> <orgName>Centre d'Immunologie de Marseille - Luminy</orgName> <orgName type="acronym">CIML</orgName> <date type="start">2012-01-01</date> <desc> <address> <addrLine>Parc scientifique et technologique de Luminy - 163, avenue de Luminy - Case 906 - 13288 Marseille cedex 09</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation name="UM 2" active="#struct-198056" type="direct"></relation> <relation name="UMR_S 1104" active="#struct-303623" type="direct"></relation> <relation name="UMR7280" active="#struct-441569" type="direct"></relation> </listRelation> <tutelles><tutelle name="UM 2" active="#struct-198056" type="direct"><org type="institution" xml:id="struct-198056" status="VALID"> <idno type="IdRef">15863621X</idno> <idno type="ISNI">0000 0001 2176 4817</idno> <orgName>Aix Marseille Université</orgName> <orgName type="acronym">AMU</orgName> <date type="start">2012-01-01</date> <desc> <address> <addrLine>Aix-Marseille UniversitéJardins du Pharo58 Boulevard Charles Livon13284 Marseille cedex 7</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-amu.fr/</ref> </desc> </org></tutelle><tutelle name="UMR_S 1104" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc> </org></tutelle><tutelle name="UMR7280" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno> <idno type="ISNI">0000000122597504</idno> <orgName>Centre National de la Recherche Scientifique</orgName> <orgName type="acronym">CNRS</orgName> <date type="start">1939-10-19</date> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://www.cnrs.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Degouve, Sophie" sort="Degouve, Sophie" uniqKey="Degouve S" first="Sophie" last="Degouve">Sophie Degouve</name><affiliation><hal:affiliation type="researchteam" xml:id="struct-543610" status="VALID"> <orgName>Réponse immunitaire innée dans les maladies infectieuses et auto-immunes – Innate immunity in infectious and autoimmune diseases </orgName> <date type="start">2013-01-01</date> <desc> <address> <addrLine>« Tour CERVI»21 avenue Tony Garnier69007 Lyon</addrLine> <country key="FR"></country> </address> <ref type="url">http://ciri.inserm.fr/</ref> </desc> <listRelation> <relation active="#struct-222995" type="direct"></relation> <relation name="U1111" active="#struct-303623" type="indirect"></relation> <relation active="#struct-6818" type="indirect"></relation> <relation active="#struct-194495" type="indirect"></relation> <relation active="#struct-301088" type="indirect"></relation> <relation name="UMR5308" active="#struct-441569" type="indirect"></relation> </listRelation> <tutelles><tutelle active="#struct-222995" type="direct"><org type="regrouplaboratory" xml:id="struct-222995" status="VALID"> <idno type="IdRef">17825696X</idno> <idno type="RNSR">201320572J</idno> <orgName>Centre International de Recherche en Infectiologie - UMR</orgName> <orgName type="acronym">CIRI</orgName> <date type="start">2013-01-01</date> <desc> <address> <addrLine>21 avenue Tony Garnier 69365 Lyon Cedex 07</addrLine> <country key="FR"></country> </address> <ref type="url">http://ciri.inserm.fr/</ref> </desc> <listRelation> <relation name="U1111" active="#struct-303623" type="direct"></relation> <relation active="#struct-6818" type="direct"></relation> <relation active="#struct-194495" type="direct"></relation> <relation active="#struct-301088" type="indirect"></relation> <relation name="UMR5308" active="#struct-441569" type="direct"></relation> </listRelation> </org></tutelle><tutelle name="U1111" active="#struct-303623" type="indirect"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc> </org></tutelle><tutelle active="#struct-6818" type="indirect"><org type="institution" xml:id="struct-6818" status="VALID"> <idno type="IdRef">149154992</idno> <orgName>École normale supérieure - Lyon</orgName> <orgName type="acronym">ENS Lyon</orgName> <desc> <address> <addrLine>15 parvis René Descartes - BP 7000 - 69342 Lyon Cedex 07</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.ens-lyon.eu/</ref> </desc> </org></tutelle><tutelle active="#struct-194495" type="indirect"><org type="institution" xml:id="struct-194495" status="VALID"> <idno type="IdRef">026402823</idno> <idno type="ISNI">0000000121686185</idno> <orgName>Université Claude Bernard Lyon 1</orgName> <orgName type="acronym">UCBL</orgName> <desc> <address> <addrLine>43, boulevard du 11 novembre 1918, 69622 Villeurbanne cedex</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-lyon1.fr/</ref> </desc> <listRelation> <relation active="#struct-301088" type="direct"></relation> </listRelation> </org></tutelle><tutelle active="#struct-301088" type="indirect"><org type="regroupinstitution" xml:id="struct-301088" status="VALID"> <orgName>Université de Lyon</orgName> <desc> <address> <addrLine>92 rue Pasteur - CS 30122, 69361 Lyon Cedex 07</addrLine> <country key="FR"></country> </address> <ref type="url">https://www.universite-lyon.fr/</ref> </desc> </org></tutelle><tutelle name="UMR5308" active="#struct-441569" type="indirect"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno> <idno type="ISNI">0000000122597504</idno> <orgName>Centre National de la Recherche Scientifique</orgName> <orgName type="acronym">CNRS</orgName> <date type="start">1939-10-19</date> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://www.cnrs.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Viel, Sebastien" sort="Viel, Sebastien" uniqKey="Viel S" first="Sébastien" last="Viel">Sébastien Viel</name><affiliation><hal:affiliation type="researchteam" xml:id="struct-543610" status="VALID"> <orgName>Réponse immunitaire innée dans les maladies infectieuses et auto-immunes – Innate immunity in infectious and autoimmune diseases </orgName> <date type="start">2013-01-01</date> <desc> <address> <addrLine>« Tour CERVI»21 avenue Tony Garnier69007 Lyon</addrLine> <country key="FR"></country> </address> <ref type="url">http://ciri.inserm.fr/</ref> </desc> <listRelation> <relation active="#struct-222995" type="direct"></relation> <relation name="U1111" active="#struct-303623" type="indirect"></relation> <relation active="#struct-6818" type="indirect"></relation> <relation active="#struct-194495" type="indirect"></relation> <relation active="#struct-301088" type="indirect"></relation> <relation name="UMR5308" active="#struct-441569" type="indirect"></relation> </listRelation> <tutelles><tutelle active="#struct-222995" type="direct"><org type="regrouplaboratory" xml:id="struct-222995" status="VALID"> <idno type="IdRef">17825696X</idno> <idno type="RNSR">201320572J</idno> <orgName>Centre International de Recherche en Infectiologie - UMR</orgName> <orgName type="acronym">CIRI</orgName> <date type="start">2013-01-01</date> <desc> <address> <addrLine>21 avenue Tony Garnier 69365 Lyon Cedex 07</addrLine> <country key="FR"></country> </address> <ref type="url">http://ciri.inserm.fr/</ref> </desc> <listRelation> <relation name="U1111" active="#struct-303623" type="direct"></relation> <relation active="#struct-6818" type="direct"></relation> <relation active="#struct-194495" type="direct"></relation> <relation active="#struct-301088" type="indirect"></relation> <relation name="UMR5308" active="#struct-441569" type="direct"></relation> </listRelation> </org></tutelle><tutelle name="U1111" active="#struct-303623" type="indirect"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc> </org></tutelle><tutelle active="#struct-6818" type="indirect"><org type="institution" xml:id="struct-6818" status="VALID"> <idno type="IdRef">149154992</idno> <orgName>École normale supérieure - Lyon</orgName> <orgName type="acronym">ENS Lyon</orgName> <desc> <address> <addrLine>15 parvis René Descartes - BP 7000 - 69342 Lyon Cedex 07</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.ens-lyon.eu/</ref> </desc> </org></tutelle><tutelle active="#struct-194495" type="indirect"><org type="institution" xml:id="struct-194495" status="VALID"> <idno type="IdRef">026402823</idno> <idno type="ISNI">0000000121686185</idno> <orgName>Université Claude Bernard Lyon 1</orgName> <orgName type="acronym">UCBL</orgName> <desc> <address> <addrLine>43, boulevard du 11 novembre 1918, 69622 Villeurbanne cedex</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-lyon1.fr/</ref> </desc> <listRelation> <relation active="#struct-301088" type="direct"></relation> </listRelation> </org></tutelle><tutelle active="#struct-301088" type="indirect"><org type="regroupinstitution" xml:id="struct-301088" status="VALID"> <orgName>Université de Lyon</orgName> <desc> <address> <addrLine>92 rue Pasteur - CS 30122, 69361 Lyon Cedex 07</addrLine> <country key="FR"></country> </address> <ref type="url">https://www.universite-lyon.fr/</ref> </desc> </org></tutelle><tutelle name="UMR5308" active="#struct-441569" type="indirect"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno> <idno type="ISNI">0000000122597504</idno> <orgName>Centre National de la Recherche Scientifique</orgName> <orgName type="acronym">CNRS</orgName> <date type="start">1939-10-19</date> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://www.cnrs.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Fenis, Aurore" sort="Fenis, Aurore" uniqKey="Fenis A" first="Aurore" last="Fenis">Aurore Fenis</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-182245" status="VALID"> <idno type="IdRef">150044909</idno> <idno type="RNSR">200017461J</idno> <orgName>Centre d'Immunologie de Marseille - Luminy</orgName> <orgName type="acronym">CIML</orgName> <date type="start">2012-01-01</date> <desc> <address> <addrLine>Parc scientifique et technologique de Luminy - 163, avenue de Luminy - Case 906 - 13288 Marseille cedex 09</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation name="UM 2" active="#struct-198056" type="direct"></relation> <relation name="UMR_S 1104" active="#struct-303623" type="direct"></relation> <relation name="UMR7280" active="#struct-441569" type="direct"></relation> </listRelation> <tutelles><tutelle name="UM 2" active="#struct-198056" type="direct"><org type="institution" xml:id="struct-198056" status="VALID"> <idno type="IdRef">15863621X</idno> <idno type="ISNI">0000 0001 2176 4817</idno> <orgName>Aix Marseille Université</orgName> <orgName type="acronym">AMU</orgName> <date type="start">2012-01-01</date> <desc> <address> <addrLine>Aix-Marseille UniversitéJardins du Pharo58 Boulevard Charles Livon13284 Marseille cedex 7</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-amu.fr/</ref> </desc> </org></tutelle><tutelle name="UMR_S 1104" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc> </org></tutelle><tutelle name="UMR7280" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno> <idno type="ISNI">0000000122597504</idno> <orgName>Centre National de la Recherche Scientifique</orgName> <orgName type="acronym">CNRS</orgName> <date type="start">1939-10-19</date> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://www.cnrs.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Rabilloud, Jessica" sort="Rabilloud, Jessica" uniqKey="Rabilloud J" first="Jessica" last="Rabilloud">Jessica Rabilloud</name><affiliation><hal:affiliation type="researchteam" xml:id="struct-543610" status="VALID"> <orgName>Réponse immunitaire innée dans les maladies infectieuses et auto-immunes – Innate immunity in infectious and autoimmune diseases </orgName> <date type="start">2013-01-01</date> <desc> <address> <addrLine>« Tour CERVI»21 avenue Tony Garnier69007 Lyon</addrLine> <country key="FR"></country> </address> <ref type="url">http://ciri.inserm.fr/</ref> </desc> <listRelation> <relation active="#struct-222995" type="direct"></relation> <relation name="U1111" active="#struct-303623" type="indirect"></relation> <relation active="#struct-6818" type="indirect"></relation> <relation active="#struct-194495" type="indirect"></relation> <relation active="#struct-301088" type="indirect"></relation> <relation name="UMR5308" active="#struct-441569" type="indirect"></relation> </listRelation> <tutelles><tutelle active="#struct-222995" type="direct"><org type="regrouplaboratory" xml:id="struct-222995" status="VALID"> <idno type="IdRef">17825696X</idno> <idno type="RNSR">201320572J</idno> <orgName>Centre International de Recherche en Infectiologie - UMR</orgName> <orgName type="acronym">CIRI</orgName> <date type="start">2013-01-01</date> <desc> <address> <addrLine>21 avenue Tony Garnier 69365 Lyon Cedex 07</addrLine> <country key="FR"></country> </address> <ref type="url">http://ciri.inserm.fr/</ref> </desc> <listRelation> <relation name="U1111" active="#struct-303623" type="direct"></relation> <relation active="#struct-6818" type="direct"></relation> <relation active="#struct-194495" type="direct"></relation> <relation active="#struct-301088" type="indirect"></relation> <relation name="UMR5308" active="#struct-441569" type="direct"></relation> </listRelation> </org></tutelle><tutelle name="U1111" active="#struct-303623" type="indirect"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc> </org></tutelle><tutelle active="#struct-6818" type="indirect"><org type="institution" xml:id="struct-6818" status="VALID"> <idno type="IdRef">149154992</idno> <orgName>École normale supérieure - Lyon</orgName> <orgName type="acronym">ENS Lyon</orgName> <desc> <address> <addrLine>15 parvis René Descartes - BP 7000 - 69342 Lyon Cedex 07</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.ens-lyon.eu/</ref> </desc> </org></tutelle><tutelle active="#struct-194495" type="indirect"><org type="institution" xml:id="struct-194495" status="VALID"> <idno type="IdRef">026402823</idno> <idno type="ISNI">0000000121686185</idno> <orgName>Université Claude Bernard Lyon 1</orgName> <orgName type="acronym">UCBL</orgName> <desc> <address> <addrLine>43, boulevard du 11 novembre 1918, 69622 Villeurbanne cedex</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-lyon1.fr/</ref> </desc> <listRelation> <relation active="#struct-301088" type="direct"></relation> </listRelation> </org></tutelle><tutelle active="#struct-301088" type="indirect"><org type="regroupinstitution" xml:id="struct-301088" status="VALID"> <orgName>Université de Lyon</orgName> <desc> <address> <addrLine>92 rue Pasteur - CS 30122, 69361 Lyon Cedex 07</addrLine> <country key="FR"></country> </address> <ref type="url">https://www.universite-lyon.fr/</ref> </desc> </org></tutelle><tutelle name="UMR5308" active="#struct-441569" type="indirect"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno> <idno type="ISNI">0000000122597504</idno> <orgName>Centre National de la Recherche Scientifique</orgName> <orgName type="acronym">CNRS</orgName> <date type="start">1939-10-19</date> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://www.cnrs.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Mayol, Katia" sort="Mayol, Katia" uniqKey="Mayol K" first="Katia" last="Mayol">Katia Mayol</name><affiliation><hal:affiliation type="researchteam" xml:id="struct-543610" status="VALID"> <orgName>Réponse immunitaire innée dans les maladies infectieuses et auto-immunes – Innate immunity in infectious and autoimmune diseases </orgName> <date type="start">2013-01-01</date> <desc> <address> <addrLine>« Tour CERVI»21 avenue Tony Garnier69007 Lyon</addrLine> <country key="FR"></country> </address> <ref type="url">http://ciri.inserm.fr/</ref> </desc> <listRelation> <relation active="#struct-222995" type="direct"></relation> <relation name="U1111" active="#struct-303623" type="indirect"></relation> <relation active="#struct-6818" type="indirect"></relation> <relation active="#struct-194495" type="indirect"></relation> <relation active="#struct-301088" type="indirect"></relation> <relation name="UMR5308" active="#struct-441569" type="indirect"></relation> </listRelation> <tutelles><tutelle active="#struct-222995" type="direct"><org type="regrouplaboratory" xml:id="struct-222995" status="VALID"> <idno type="IdRef">17825696X</idno> <idno type="RNSR">201320572J</idno> <orgName>Centre International de Recherche en Infectiologie - UMR</orgName> <orgName type="acronym">CIRI</orgName> <date type="start">2013-01-01</date> <desc> <address> <addrLine>21 avenue Tony Garnier 69365 Lyon Cedex 07</addrLine> <country key="FR"></country> </address> <ref type="url">http://ciri.inserm.fr/</ref> </desc> <listRelation> <relation name="U1111" active="#struct-303623" type="direct"></relation> <relation active="#struct-6818" type="direct"></relation> <relation active="#struct-194495" type="direct"></relation> <relation active="#struct-301088" type="indirect"></relation> <relation name="UMR5308" active="#struct-441569" type="direct"></relation> </listRelation> </org></tutelle><tutelle name="U1111" active="#struct-303623" type="indirect"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc> </org></tutelle><tutelle active="#struct-6818" type="indirect"><org type="institution" xml:id="struct-6818" status="VALID"> <idno type="IdRef">149154992</idno> <orgName>École normale supérieure - Lyon</orgName> <orgName type="acronym">ENS Lyon</orgName> <desc> <address> <addrLine>15 parvis René Descartes - BP 7000 - 69342 Lyon Cedex 07</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.ens-lyon.eu/</ref> </desc> </org></tutelle><tutelle active="#struct-194495" type="indirect"><org type="institution" xml:id="struct-194495" status="VALID"> <idno type="IdRef">026402823</idno> <idno type="ISNI">0000000121686185</idno> <orgName>Université Claude Bernard Lyon 1</orgName> <orgName type="acronym">UCBL</orgName> <desc> <address> <addrLine>43, boulevard du 11 novembre 1918, 69622 Villeurbanne cedex</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-lyon1.fr/</ref> </desc> <listRelation> <relation active="#struct-301088" type="direct"></relation> </listRelation> </org></tutelle><tutelle active="#struct-301088" type="indirect"><org type="regroupinstitution" xml:id="struct-301088" status="VALID"> <orgName>Université de Lyon</orgName> <desc> <address> <addrLine>92 rue Pasteur - CS 30122, 69361 Lyon Cedex 07</addrLine> <country key="FR"></country> </address> <ref type="url">https://www.universite-lyon.fr/</ref> </desc> </org></tutelle><tutelle name="UMR5308" active="#struct-441569" type="indirect"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno> <idno type="ISNI">0000000122597504</idno> <orgName>Centre National de la Recherche Scientifique</orgName> <orgName type="acronym">CNRS</orgName> <date type="start">1939-10-19</date> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://www.cnrs.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Tavares, Armelle" sort="Tavares, Armelle" uniqKey="Tavares A" first="Armelle" last="Tavares">Armelle Tavares</name><affiliation><hal:affiliation type="researchteam" xml:id="struct-543610" status="VALID"> <orgName>Réponse immunitaire innée dans les maladies infectieuses et auto-immunes – Innate immunity in infectious and autoimmune diseases </orgName> <date type="start">2013-01-01</date> <desc> <address> <addrLine>« Tour CERVI»21 avenue Tony Garnier69007 Lyon</addrLine> <country key="FR"></country> </address> <ref type="url">http://ciri.inserm.fr/</ref> </desc> <listRelation> <relation active="#struct-222995" type="direct"></relation> <relation name="U1111" active="#struct-303623" type="indirect"></relation> <relation active="#struct-6818" type="indirect"></relation> <relation active="#struct-194495" type="indirect"></relation> <relation active="#struct-301088" type="indirect"></relation> <relation name="UMR5308" active="#struct-441569" type="indirect"></relation> </listRelation> <tutelles><tutelle active="#struct-222995" type="direct"><org type="regrouplaboratory" xml:id="struct-222995" status="VALID"> <idno type="IdRef">17825696X</idno> <idno type="RNSR">201320572J</idno> <orgName>Centre International de Recherche en Infectiologie - UMR</orgName> <orgName type="acronym">CIRI</orgName> <date type="start">2013-01-01</date> <desc> <address> <addrLine>21 avenue Tony Garnier 69365 Lyon Cedex 07</addrLine> <country key="FR"></country> </address> <ref type="url">http://ciri.inserm.fr/</ref> </desc> <listRelation> <relation name="U1111" active="#struct-303623" type="direct"></relation> <relation active="#struct-6818" type="direct"></relation> <relation active="#struct-194495" type="direct"></relation> <relation active="#struct-301088" type="indirect"></relation> <relation name="UMR5308" active="#struct-441569" type="direct"></relation> </listRelation> </org></tutelle><tutelle name="U1111" active="#struct-303623" type="indirect"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc> </org></tutelle><tutelle active="#struct-6818" type="indirect"><org type="institution" xml:id="struct-6818" status="VALID"> <idno type="IdRef">149154992</idno> <orgName>École normale supérieure - Lyon</orgName> <orgName type="acronym">ENS Lyon</orgName> <desc> <address> <addrLine>15 parvis René Descartes - BP 7000 - 69342 Lyon Cedex 07</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.ens-lyon.eu/</ref> </desc> </org></tutelle><tutelle active="#struct-194495" type="indirect"><org type="institution" xml:id="struct-194495" status="VALID"> <idno type="IdRef">026402823</idno> <idno type="ISNI">0000000121686185</idno> <orgName>Université Claude Bernard Lyon 1</orgName> <orgName type="acronym">UCBL</orgName> <desc> <address> <addrLine>43, boulevard du 11 novembre 1918, 69622 Villeurbanne cedex</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-lyon1.fr/</ref> </desc> <listRelation> <relation active="#struct-301088" type="direct"></relation> </listRelation> </org></tutelle><tutelle active="#struct-301088" type="indirect"><org type="regroupinstitution" xml:id="struct-301088" status="VALID"> <orgName>Université de Lyon</orgName> <desc> <address> <addrLine>92 rue Pasteur - CS 30122, 69361 Lyon Cedex 07</addrLine> <country key="FR"></country> </address> <ref type="url">https://www.universite-lyon.fr/</ref> </desc> </org></tutelle><tutelle name="UMR5308" active="#struct-441569" type="indirect"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno> <idno type="ISNI">0000000122597504</idno> <orgName>Centre National de la Recherche Scientifique</orgName> <orgName type="acronym">CNRS</orgName> <date type="start">1939-10-19</date> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://www.cnrs.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Bienvenu, Jacques" sort="Bienvenu, Jacques" uniqKey="Bienvenu J" first="Jacques" last="Bienvenu">Jacques Bienvenu</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-157369" status="VALID"> <orgName>Service d'immunologie [Centre Hospitalier Lyon Sud - HCL]</orgName> <desc> <address> <addrLine>165, chemin du Grand-Revoyet, 69495 Pierre-Bénite, France</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-353860" type="direct"></relation> <relation active="#struct-300074" type="indirect"></relation> </listRelation> <tutelles><tutelle active="#struct-353860" type="direct"><org type="institution" xml:id="struct-353860" status="VALID"> <orgName>Centre Hospitalier Lyon Sud [CHU - HCL]</orgName> <orgName type="acronym">CHLS</orgName> <desc> <address> <addrLine>165 Chemin du Grand Revoyet69495 Pierre-Bénite</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.chu-lyon.fr/fr/centre-hospitalier-lyon-sud</ref> </desc> <listRelation> <relation active="#struct-300074" type="direct"></relation> </listRelation> </org></tutelle><tutelle active="#struct-300074" type="indirect"><org type="regroupinstitution" xml:id="struct-300074" status="VALID"> <idno type="IdRef">026534657</idno> <orgName>Hospices Civils de Lyon</orgName> <orgName type="acronym">HCL</orgName> <desc> <address> <addrLine>3 Quai des Célestins69002 Lyon </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.chu-lyon.fr/fr/hospices-civils-de-lyon-hcl</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Gangloff, Yann Gael" sort="Gangloff, Yann Gael" uniqKey="Gangloff Y" first="Yann-Gaël" last="Gangloff">Yann-Gaël Gangloff</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-489487" status="VALID"> <idno type="IdRef">166612049</idno> <idno type="RNSR">200711906R</idno> <orgName>Laboratoire de biologie et modélisation de la cellule</orgName> <orgName type="acronym">LBMC UMR 5239</orgName> <date type="start">2007-01-01</date> <desc> <address> <addrLine>Ecole Normale Supérieure46 Allée d'Italie69364 Lyon Cedex 07</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.ens-lyon.fr/LBMC/</ref> </desc> <listRelation> <relation active="#struct-194495" type="direct"></relation> <relation active="#struct-301088" type="indirect"></relation> <relation active="#struct-6818" type="direct"></relation> <relation name="UMR 5239" active="#struct-441569" type="direct"></relation> <relation name="U1210" active="#struct-303623" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-194495" type="direct"><org type="institution" xml:id="struct-194495" status="VALID"> <idno type="IdRef">026402823</idno> <idno type="ISNI">0000000121686185</idno> <orgName>Université Claude Bernard Lyon 1</orgName> <orgName type="acronym">UCBL</orgName> <desc> <address> <addrLine>43, boulevard du 11 novembre 1918, 69622 Villeurbanne cedex</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-lyon1.fr/</ref> </desc> <listRelation> <relation active="#struct-301088" type="direct"></relation> </listRelation> </org></tutelle><tutelle active="#struct-301088" type="indirect"><org type="regroupinstitution" xml:id="struct-301088" status="VALID"> <orgName>Université de Lyon</orgName> <desc> <address> <addrLine>92 rue Pasteur - CS 30122, 69361 Lyon Cedex 07</addrLine> <country key="FR"></country> </address> <ref type="url">https://www.universite-lyon.fr/</ref> </desc> </org></tutelle><tutelle active="#struct-6818" type="direct"><org type="institution" xml:id="struct-6818" status="VALID"> <idno type="IdRef">149154992</idno> <orgName>École normale supérieure - Lyon</orgName> <orgName type="acronym">ENS Lyon</orgName> <desc> <address> <addrLine>15 parvis René Descartes - BP 7000 - 69342 Lyon Cedex 07</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.ens-lyon.eu/</ref> </desc> </org></tutelle><tutelle name="UMR 5239" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno> <idno type="ISNI">0000000122597504</idno> <orgName>Centre National de la Recherche Scientifique</orgName> <orgName type="acronym">CNRS</orgName> <date type="start">1939-10-19</date> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://www.cnrs.fr/</ref> </desc> </org></tutelle><tutelle name="U1210" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Gilson, Eric" sort="Gilson, Eric" uniqKey="Gilson E" first="Eric" last="Gilson">Eric Gilson</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-182186" status="VALID"> <orgName>Institut de Recherche sur le Cancer et le Vieillissement</orgName> <orgName type="acronym">IRCAN</orgName> <desc> <address> <addrLine>Faculté de médecine, 28 avenue de Valombrose 06107 Nice Cedex 2</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation name="UMR7284" active="#struct-441569" type="direct"></relation> <relation name="U1081" active="#struct-303623" type="direct"></relation> <relation active="#struct-117617" type="direct"></relation> <relation active="#struct-523042" type="indirect"></relation> </listRelation> <tutelles><tutelle name="UMR7284" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno> <idno type="ISNI">0000000122597504</idno> <orgName>Centre National de la Recherche Scientifique</orgName> <orgName type="acronym">CNRS</orgName> <date type="start">1939-10-19</date> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://www.cnrs.fr/</ref> </desc> </org></tutelle><tutelle name="U1081" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc> </org></tutelle><tutelle active="#struct-117617" type="direct"><org type="institution" xml:id="struct-117617" status="VALID"> <orgName>Université Nice Sophia Antipolis (... - 2019)</orgName> <orgName type="acronym">UNS</orgName> <desc> <address> <addrLine>Parc Valrose - BP 2135 - 06103 Nice cedex 2</addrLine> <country key="FR"></country> </address> <ref type="url">http://unice.fr/</ref> </desc> <listRelation> <relation active="#struct-523042" type="direct"></relation> </listRelation> </org></tutelle><tutelle active="#struct-523042" type="indirect"><org type="regroupinstitution" xml:id="struct-523042" status="VALID"> <orgName>Université Côte d'Azur </orgName> <orgName type="acronym">UCA</orgName> <date type="start">2015-03-01</date> <desc> <address> <addrLine>Parc Valrose, 28 avenue Valrose 06108 Nice Cedex 2 </addrLine> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Vivier, Eric" sort="Vivier, Eric" uniqKey="Vivier E" first="Eric" last="Vivier">Eric Vivier</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-182245" status="VALID"> <idno type="IdRef">150044909</idno> <idno type="RNSR">200017461J</idno> <orgName>Centre d'Immunologie de Marseille - Luminy</orgName> <orgName type="acronym">CIML</orgName> <date type="start">2012-01-01</date> <desc> <address> <addrLine>Parc scientifique et technologique de Luminy - 163, avenue de Luminy - Case 906 - 13288 Marseille cedex 09</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation name="UM 2" active="#struct-198056" type="direct"></relation> <relation name="UMR_S 1104" active="#struct-303623" type="direct"></relation> <relation name="UMR7280" active="#struct-441569" type="direct"></relation> </listRelation> <tutelles><tutelle name="UM 2" active="#struct-198056" type="direct"><org type="institution" xml:id="struct-198056" status="VALID"> <idno type="IdRef">15863621X</idno> <idno type="ISNI">0000 0001 2176 4817</idno> <orgName>Aix Marseille Université</orgName> <orgName type="acronym">AMU</orgName> <date type="start">2012-01-01</date> <desc> <address> <addrLine>Aix-Marseille UniversitéJardins du Pharo58 Boulevard Charles Livon13284 Marseille cedex 7</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-amu.fr/</ref> </desc> </org></tutelle><tutelle name="UMR_S 1104" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc> </org></tutelle><tutelle name="UMR7280" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno> <idno type="ISNI">0000000122597504</idno> <orgName>Centre National de la Recherche Scientifique</orgName> <orgName type="acronym">CNRS</orgName> <date type="start">1939-10-19</date> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://www.cnrs.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Walzer, Thierry" sort="Walzer, Thierry" uniqKey="Walzer T" first="Thierry" last="Walzer">Thierry Walzer</name><affiliation><hal:affiliation type="researchteam" xml:id="struct-543610" status="VALID"> <orgName>Réponse immunitaire innée dans les maladies infectieuses et auto-immunes – Innate immunity in infectious and autoimmune diseases </orgName> <date type="start">2013-01-01</date> <desc> <address> <addrLine>« Tour CERVI»21 avenue Tony Garnier69007 Lyon</addrLine> <country key="FR"></country> </address> <ref type="url">http://ciri.inserm.fr/</ref> </desc> <listRelation> <relation active="#struct-222995" type="direct"></relation> <relation name="U1111" active="#struct-303623" type="indirect"></relation> <relation active="#struct-6818" type="indirect"></relation> <relation active="#struct-194495" type="indirect"></relation> <relation active="#struct-301088" type="indirect"></relation> <relation name="UMR5308" active="#struct-441569" type="indirect"></relation> </listRelation> <tutelles><tutelle active="#struct-222995" type="direct"><org type="regrouplaboratory" xml:id="struct-222995" status="VALID"> <idno type="IdRef">17825696X</idno> <idno type="RNSR">201320572J</idno> <orgName>Centre International de Recherche en Infectiologie - UMR</orgName> <orgName type="acronym">CIRI</orgName> <date type="start">2013-01-01</date> <desc> <address> <addrLine>21 avenue Tony Garnier 69365 Lyon Cedex 07</addrLine> <country key="FR"></country> </address> <ref type="url">http://ciri.inserm.fr/</ref> </desc> <listRelation> <relation name="U1111" active="#struct-303623" type="direct"></relation> <relation active="#struct-6818" type="direct"></relation> <relation active="#struct-194495" type="direct"></relation> <relation active="#struct-301088" type="indirect"></relation> <relation name="UMR5308" active="#struct-441569" type="direct"></relation> </listRelation> </org></tutelle><tutelle name="U1111" active="#struct-303623" type="indirect"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc> </org></tutelle><tutelle active="#struct-6818" type="indirect"><org type="institution" xml:id="struct-6818" status="VALID"> <idno type="IdRef">149154992</idno> <orgName>École normale supérieure - Lyon</orgName> <orgName type="acronym">ENS Lyon</orgName> <desc> <address> <addrLine>15 parvis René Descartes - BP 7000 - 69342 Lyon Cedex 07</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.ens-lyon.eu/</ref> </desc> </org></tutelle><tutelle active="#struct-194495" type="indirect"><org type="institution" xml:id="struct-194495" status="VALID"> <idno type="IdRef">026402823</idno> <idno type="ISNI">0000000121686185</idno> <orgName>Université Claude Bernard Lyon 1</orgName> <orgName type="acronym">UCBL</orgName> <desc> <address> <addrLine>43, boulevard du 11 novembre 1918, 69622 Villeurbanne cedex</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-lyon1.fr/</ref> </desc> <listRelation> <relation active="#struct-301088" type="direct"></relation> </listRelation> </org></tutelle><tutelle active="#struct-301088" type="indirect"><org type="regroupinstitution" xml:id="struct-301088" status="VALID"> <orgName>Université de Lyon</orgName> <desc> <address> <addrLine>92 rue Pasteur - CS 30122, 69361 Lyon Cedex 07</addrLine> <country key="FR"></country> </address> <ref type="url">https://www.universite-lyon.fr/</ref> </desc> </org></tutelle><tutelle name="UMR5308" active="#struct-441569" type="indirect"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno> <idno type="ISNI">0000000122597504</idno> <orgName>Centre National de la Recherche Scientifique</orgName> <orgName type="acronym">CNRS</orgName> <date type="start">1939-10-19</date> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://www.cnrs.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author></analytic><idno type="DOI">10.1038/ni.2936</idno><series><title level="j">Nature Immunology</title><idno type="ISSN">1529-2908</idno><imprint><date type="datePub">2014-08</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="mix" xml:lang="en"><term>Animals</term><term>Cell Proliferation</term><term>Cells</term><term>Cultured</term><term>H1N1 Subtype</term><term>Herpesviridae Infections</term><term>Humans</term><term>Immunosuppressive Agents</term><term>Inbred C57BL</term><term>Inflammation</term><term>Influenza A Virus</term><term>Interleukin-15</term><term>Killer Cells</term><term>Knockout</term><term>Lymphocyte Activation</term><term>Mechanistic Target of Rapamycin Complex 1</term><term>Mechanistic Target of Rapamycin Complex 2</term><term>Mice</term><term>Multiprotein Complexes</term><term>Muromegalovirus</term><term>Natural</term><term>Orthomyxoviridae Infections</term><term>Poly I-C</term><term>STAT5 Transcription Factor</term><term>Signal Transduction</term><term>Sirolimus</term><term>TOR Serine-Threonine Kinases</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"> <p>Interleukin 15 (IL-15) controls both the homeostasis and the peripheral activation of natural killer (NK) cells. The molecular basis for this duality of action remains unknown. Here we found that the metabolic checkpoint kinase mTOR was activated and boosted bioenergetic metabolism after exposure of NK cells to high concentrations of IL-15, whereas low doses of IL-15 triggered only phosphorylation of the transcription factor STAT5. mTOR stimulated the growth and nutrient uptake of NK cells and positively fed back on the receptor for IL-15. This process was essential for sustaining NK cell proliferation during development and the acquisition of cytolytic potential during inflammation or viral infection. The mTORC1 inhibitor rapamycin inhibited NK cell cytotoxicity both in mice and humans; this probably contributes to the immunosuppressive activity of this drug in different clinical settings.</p> </div></front></TEI><hal api="V3"> <titleStmt> <title xml:lang="en">The metabolic checkpoint kinase mTOR is essential for IL-15 signaling during the development and activation of NK cells</title> <author role="aut"> <persName> <forename type="first">Antoine</forename> <surname>Marçais</surname> </persName> <idno type="halauthorid">1008681</idno> <affiliation ref="#struct-543610"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Julien</forename> <surname>Cherfils-Vicini</surname> </persName> <email type="md5">031138379033ad8e92c8f49525f0be29</email> <email type="domain">unice.fr</email> <idno type="idhal" notation="string">julien-cherfils-vicini</idno> <idno type="idhal" notation="numeric">180846</idno> <idno type="halauthorid">1479703</idno> <idno type="ORCID">https://orcid.org/0000-0001-7813-1527</idno> <affiliation ref="#struct-182186"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Charlotte</forename> <surname>Viant</surname> </persName> <idno type="halauthorid">1457456</idno> <affiliation ref="#struct-182245"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Sophie</forename> <surname>Degouve</surname> </persName> <idno type="halauthorid">11178067</idno> <affiliation ref="#struct-543610"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Sébastien</forename> <surname>Viel</surname> </persName> <idno type="halauthorid">1008668</idno> <affiliation ref="#struct-543610"></affiliation> <affiliation ref="#struct-157369"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Aurore</forename> <surname>Fenis</surname> </persName> <idno type="halauthorid">626940</idno> <affiliation ref="#struct-182245"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Jessica</forename> <surname>Rabilloud</surname> </persName> <idno type="halauthorid">11204887</idno> <affiliation ref="#struct-543610"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Katia</forename> <surname>Mayol</surname> </persName> <idno type="halauthorid">479916</idno> <affiliation ref="#struct-543610"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Armelle</forename> <surname>Tavares</surname> </persName> <idno type="halauthorid">11310320</idno> <affiliation ref="#struct-543610"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Jacques</forename> <surname>Bienvenu</surname> </persName> <idno type="halauthorid">843125</idno> <affiliation ref="#struct-157369"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Yann-Gaël</forename> <surname>Gangloff</surname> </persName> <email type="md5">82cc74be286a616c9055feb51066c718</email> <email type="domain">univ-lyon1.fr</email> <idno type="idhal" notation="string">yann-gael-gangloff</idno> <idno type="idhal" notation="numeric">175042</idno> <idno type="halauthorid">11241688</idno> <idno type="ORCID">https://orcid.org/0000-0001-9031-1184</idno> <idno type="ResearcherId">http://www.researcherid.com/rid/I-2161-2014</idno> <affiliation ref="#struct-489487"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Eric</forename> <surname>Gilson</surname> </persName> <idno type="halauthorid">94075</idno> <affiliation ref="#struct-182186"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Eric</forename> <surname>Vivier</surname> </persName> <email type="md5">5bfb77e73d4fd86616173673fdef6ee1</email> <email type="domain">ciml.univ-mrs.fr</email> <idno type="idhal" notation="string">eric-vivier</idno> <idno type="idhal" notation="numeric">17342</idno> <idno type="halauthorid">1412263</idno> <idno type="ResearcherId">http://www.researcherid.com/rid/F-8939-2010</idno> <affiliation ref="#struct-182245"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Thierry</forename> <surname>Walzer</surname> </persName> <idno type="halauthorid">199434</idno> <affiliation ref="#struct-543610"></affiliation> </author> <editor role="depositor"> <persName> <forename>Laure-Hélène</forename> <surname>Davoine</surname> </persName> <email type="md5">298592f97559bb3f7b468a5c0a91041b</email> <email type="domain">univ-lyon1.fr</email> </editor> <funder ref="#projeurop-87274"></funder> </titleStmt> <editionStmt> <edition n="v1" type="current"> <date type="whenSubmitted">2018-11-02 19:34:36</date> <date type="whenModified">2020-03-05 12:20:34</date> <date type="whenReleased">2018-11-02 19:34:36</date> <date type="whenProduced">2014-08</date> <ref type="externalLink" target="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4110708/pdf"></ref> </edition> <respStmt> <resp>contributor</resp> <name key="458178"> <persName> <forename>Laure-Hélène</forename> <surname>Davoine</surname> </persName> <email type="md5">298592f97559bb3f7b468a5c0a91041b</email> <email type="domain">univ-lyon1.fr</email> </name> </respStmt> </editionStmt> <publicationStmt> <distributor>CCSD</distributor> <idno type="halId">hal-01911540</idno> <idno type="halUri">https://hal.archives-ouvertes.fr/hal-01911540</idno> <idno type="halBibtex">marcais:hal-01911540</idno> <idno type="halRefHtml">Nature Immunology, Nature Publishing Group, 2014, 15 (8), pp.749-757. ⟨10.1038/ni.2936⟩</idno> <idno type="halRef">Nature Immunology, Nature Publishing Group, 2014, 15 (8), pp.749-757. ⟨10.1038/ni.2936⟩</idno> </publicationStmt> <seriesStmt> <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno> <idno type="stamp" n="UNIV-LYON1">Université Claude Bernard - Lyon I</idno> <idno type="stamp" n="CIRI" corresp="UNIV-LYON1">Centre International de Recherche en Infectiologie</idno> <idno type="stamp" n="CIRI-REPONSE-IMMUNITAIRE-INNEE-DANS-LES-MALADIES-INFECTIEUSES-ET-AUTO-IMMUNES" corresp="CIRI">CIRI-Réponse immunitaire innée dans les maladies infectieuses et auto-immunes-Innate Immunity in infectious and autoimmune diseases</idno> <idno type="stamp" n="ENS-LYON">École Normale Supérieure de Lyon</idno> <idno type="stamp" n="UNIV-AMU">Aix Marseille Université</idno> <idno type="stamp" n="CERCLE">Publications des lauréats des projets ERC financés sur le site Aix Marseille</idno> <idno type="stamp" n="OPENAIRE">OpenAIRE</idno> <idno type="stamp" n="TEST-AMU">Espace de test AMU</idno> <idno type="stamp" n="UDL">UDL</idno> <idno type="stamp" n="UNIV-LYON">Université de Lyon</idno> <idno type="stamp" n="HCL">Hospices Civils de Lyon</idno> <idno type="stamp" n="CHLS" corresp="HCL">Centre Hospitalier Lyon Sud</idno> <idno type="stamp" n="UNICE">Université Nice Sophia Antipolis</idno> <idno type="stamp" n="UCA-TEST">UCA-TEST</idno> <idno type="stamp" n="UNIV-COTEDAZUR">Université Côte d'Azur</idno> </seriesStmt> <notesStmt> <note type="audience" n="2">International</note> <note type="popular" n="0">No</note> <note type="peer" n="1">Yes</note> </notesStmt> <sourceDesc> <biblStruct> <analytic> <title xml:lang="en">The metabolic checkpoint kinase mTOR is essential for IL-15 signaling during the development and activation of NK cells</title> <author role="aut"> <persName> <forename type="first">Antoine</forename> <surname>Marçais</surname> </persName> <idno type="halauthorid">1008681</idno> <affiliation ref="#struct-543610"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Julien</forename> <surname>Cherfils-Vicini</surname> </persName> <email type="md5">031138379033ad8e92c8f49525f0be29</email> <email type="domain">unice.fr</email> <idno type="idhal" notation="string">julien-cherfils-vicini</idno> <idno type="idhal" notation="numeric">180846</idno> <idno type="halauthorid">1479703</idno> <idno type="ORCID">https://orcid.org/0000-0001-7813-1527</idno> <affiliation ref="#struct-182186"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Charlotte</forename> <surname>Viant</surname> </persName> <idno type="halauthorid">1457456</idno> <affiliation ref="#struct-182245"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Sophie</forename> <surname>Degouve</surname> </persName> <idno type="halauthorid">11178067</idno> <affiliation ref="#struct-543610"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Sébastien</forename> <surname>Viel</surname> </persName> <idno type="halauthorid">1008668</idno> <affiliation ref="#struct-543610"></affiliation> <affiliation ref="#struct-157369"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Aurore</forename> <surname>Fenis</surname> </persName> <idno type="halauthorid">626940</idno> <affiliation ref="#struct-182245"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Jessica</forename> <surname>Rabilloud</surname> </persName> <idno type="halauthorid">11204887</idno> <affiliation ref="#struct-543610"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Katia</forename> <surname>Mayol</surname> </persName> <idno type="halauthorid">479916</idno> <affiliation ref="#struct-543610"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Armelle</forename> <surname>Tavares</surname> </persName> <idno type="halauthorid">11310320</idno> <affiliation ref="#struct-543610"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Jacques</forename> <surname>Bienvenu</surname> </persName> <idno type="halauthorid">843125</idno> <affiliation ref="#struct-157369"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Yann-Gaël</forename> <surname>Gangloff</surname> </persName> <email type="md5">82cc74be286a616c9055feb51066c718</email> <email type="domain">univ-lyon1.fr</email> <idno type="idhal" notation="string">yann-gael-gangloff</idno> <idno type="idhal" notation="numeric">175042</idno> <idno type="halauthorid">11241688</idno> <idno type="ORCID">https://orcid.org/0000-0001-9031-1184</idno> <idno type="ResearcherId">http://www.researcherid.com/rid/I-2161-2014</idno> <affiliation ref="#struct-489487"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Eric</forename> <surname>Gilson</surname> </persName> <idno type="halauthorid">94075</idno> <affiliation ref="#struct-182186"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Eric</forename> <surname>Vivier</surname> </persName> <email type="md5">5bfb77e73d4fd86616173673fdef6ee1</email> <email type="domain">ciml.univ-mrs.fr</email> <idno type="idhal" notation="string">eric-vivier</idno> <idno type="idhal" notation="numeric">17342</idno> <idno type="halauthorid">1412263</idno> <idno type="ResearcherId">http://www.researcherid.com/rid/F-8939-2010</idno> <affiliation ref="#struct-182245"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Thierry</forename> <surname>Walzer</surname> </persName> <idno type="halauthorid">199434</idno> <affiliation ref="#struct-543610"></affiliation> </author> </analytic> <monogr> <idno type="halJournalId" status="VALID">17319</idno> <idno type="issn">1529-2908</idno> <idno type="eissn">1529-2916</idno> <title level="j">Nature Immunology</title> <imprint> <publisher>Nature Publishing Group</publisher> <biblScope unit="volume">15</biblScope> <biblScope unit="issue">8</biblScope> <biblScope unit="pp">749-757</biblScope> <date type="datePub">2014-08</date> </imprint> </monogr> <idno type="doi">10.1038/ni.2936</idno> <idno type="pubmed">24973821</idno> <idno type="pubmedcentral">PMC4110708</idno> </biblStruct> </sourceDesc> <profileDesc> <langUsage> <language ident="en">English</language> </langUsage> <textClass> <keywords scheme="author"> <term xml:lang="en">Orthomyxoviridae Infections</term> <term xml:lang="en">Muromegalovirus</term> <term xml:lang="en">Animals</term> <term xml:lang="en">Cell Proliferation</term> <term xml:lang="en">Mechanistic Target of Rapamycin Complex 2</term> <term xml:lang="en">Mechanistic Target of Rapamycin Complex 1</term> <term xml:lang="en">Lymphocyte Activation</term> <term xml:lang="en">Natural</term> <term xml:lang="en">Killer Cells</term> <term xml:lang="en">Interleukin-15</term> <term xml:lang="en">H1N1 Subtype</term> <term xml:lang="en">Influenza A Virus</term> <term xml:lang="en">Inflammation</term> <term xml:lang="en">Immunosuppressive Agents</term> <term xml:lang="en">Knockout</term> <term xml:lang="en">Multiprotein Complexes</term> <term xml:lang="en">Inbred C57BL</term> <term xml:lang="en">Mice</term> <term xml:lang="en">Cells</term> <term xml:lang="en">Cultured</term> <term xml:lang="en">Herpesviridae Infections</term> <term xml:lang="en">Humans</term> <term xml:lang="en">Poly I-C</term> <term xml:lang="en">Signal Transduction</term> <term xml:lang="en">Sirolimus</term> <term xml:lang="en">STAT5 Transcription Factor</term> <term xml:lang="en">TOR Serine-Threonine Kinases</term> </keywords> <classCode scheme="halDomain" n="sdv.imm">Life Sciences [q-bio]/Immunology</classCode> <classCode scheme="halDomain" n="sdv.mp.bac">Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology</classCode> <classCode scheme="halDomain" n="sdv.mp.vir">Life Sciences [q-bio]/Microbiology and Parasitology/Virology</classCode> <classCode scheme="halTypology" n="ART">Journal articles</classCode> </textClass> <abstract xml:lang="en"> <p>Interleukin 15 (IL-15) controls both the homeostasis and the peripheral activation of natural killer (NK) cells. The molecular basis for this duality of action remains unknown. Here we found that the metabolic checkpoint kinase mTOR was activated and boosted bioenergetic metabolism after exposure of NK cells to high concentrations of IL-15, whereas low doses of IL-15 triggered only phosphorylation of the transcription factor STAT5. mTOR stimulated the growth and nutrient uptake of NK cells and positively fed back on the receptor for IL-15. This process was essential for sustaining NK cell proliferation during development and the acquisition of cytolytic potential during inflammation or viral infection. The mTORC1 inhibitor rapamycin inhibited NK cell cytotoxicity both in mice and humans; this probably contributes to the immunosuppressive activity of this drug in different clinical settings.</p> </abstract> </profileDesc> </hal></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/Hal/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000294 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Hal/Corpus/biblio.hfd -nk 000294 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= H2N2V1
|flux= Hal
|étape= Corpus
|type= RBID
|clé= Hal:hal-01911540
|texte= The metabolic checkpoint kinase mTOR is essential for IL-15 signaling during the development and activation of NK cells
}}
| This area was generated with Dilib version V0.6.33. |  |