Long-term immunogenicity of two doses of 2009 A/H1N1v vaccine with and without AS03(A) adjuvant in HIV-1-infected adults.
Identifieur interne : 000191 ( Hal/Corpus ); précédent : 000190; suivant : 000192Long-term immunogenicity of two doses of 2009 A/H1N1v vaccine with and without AS03(A) adjuvant in HIV-1-infected adults.
Auteurs : Christine Durier ; Corinne Desaint ; Frédéric Lucht ; Pierre-Marie Girard ; Yves Lévy ; Thierry May ; Christian Michelet ; Agathe Rami ; François Roman ; Jean-François Delfraissy ; Jean-Pierre Aboulker ; Odile LaunaySource :
- AIDS [ 0269-9370 ] ; 2013-01-02.
Abstract
OBJECTIVE: In immunocompromised patients, alternative schedules more immunogenic than the standard influenza vaccine regimen are necessary to enhance and prolong vaccine efficacy. We previously reported that the AS03A-adjuvanted 2009 A/H1N1v vaccine yielded a higher short-term immune response than the nonadjuvanted one in HIV-1-infected adults. This study reports the long-term persistence of the immune response. DESIGN AND METHODS: In a prospective, multicenter, randomized, patient-blinded trial, two doses of AS03A-adjuvanted H1N1v vaccine containing 3.75 μg haemagglutinin (n = 155; group A) or nonadjuvanted H1N1v vaccine containing 15 μg haemagglutinin (n = 151; group B), were administered 21 days apart. Haemagglutination inhibition and neutralizing antibodies were assessed 6 and 12 months after vaccination. RESULTS: In group A and B, the seroprotection rates were 83.7 and 59.4% at month 6, and 70.4 and 49.3 at month 12, respectively. In a multivariate analysis, persistence of seroprotection 12 months after vaccination was negatively associated with current smoking (odds ratio = 0.6, P = 0.03) and positively related with the AS03A-adjuvanted H1N1v vaccine (odds ratio = 2.7, P = 0.0002). CONCLUSION: In HIV-1-infected adults, two doses of adjuvanted influenza vaccine induce long-term persistence of immune response up to 1 year after vaccination.
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DOI: 10.1097/QAD.0b013e328359f27a
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Hal:hal-00875148Le document en format XML
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Paris 11</orgName> <orgName type="acronym">UP11</orgName> <desc> <address> <addrLine>Bâtiment 300 - 91405 Orsay cedex</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.u-psud.fr/</ref> </desc> </org></tutelle><tutelle name="SC10" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Desaint, Corinne" sort="Desaint, Corinne" uniqKey="Desaint C" first="Corinne" last="Desaint">Corinne Desaint</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-2593" status="OLD"> <orgName>CIC - Biotherapie - AP-HP (cochin - 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40 Rue de Rennes, BP 73532 - 49035 Angers CEDEX 01</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-angers.fr/</ref> </desc> </org></tutelle><tutelle active="#struct-105160" type="direct"><org type="institution" xml:id="struct-105160" status="VALID"> <orgName>Université de Rennes 1</orgName> <orgName type="acronym">UR1</orgName> <desc> <address> <addrLine>2 rue du Thabor - CS 46510 - 35065 Rennes cedex</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-rennes1.fr/</ref> </desc> <listRelation> <relation active="#struct-528860" type="direct"></relation> </listRelation> </org></tutelle><tutelle active="#struct-528860" type="indirect"><org type="regroupinstitution" xml:id="struct-528860" status="VALID"> <orgName>Université de Rennes</orgName> <orgName type="acronym">UNIV-RENNES</orgName> <date type="start">2018-01-01</date> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-301986" type="direct"><org type="institution" xml:id="struct-301986" status="VALID"> <orgName>École des Hautes Études en Santé Publique [EHESP]</orgName> <orgName type="acronym">EHESP</orgName> <date type="start">2016-06-20</date> <desc> <address> <addrLine>15, avenue du Pr. Léon Bernard - 35043 Rennes Cedex</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.ehesp.fr/</ref> </desc> </org></tutelle><tutelle name="U1085" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc> </org></tutelle><tutelle active="#struct-453207" type="direct"><org type="institution" xml:id="struct-453207" status="VALID"> <orgName>Structure Fédérative de Recherche en Biologie et Santé de Rennes </orgName> <orgName type="acronym"> Biosit : Biologie - Santé - Innovation Technologique </orgName> <desc> <address> <addrLine>Université Rennes 1 - Campus Santé Villejean - 2, avenue Professeur Léon Bernard 35043 Rennes cedex</addrLine> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Rami, Agathe" sort="Rami, Agathe" uniqKey="Rami A" first="Agathe" last="Rami">Agathe Rami</name></author><author><name sortKey="Roman, Francois" sort="Roman, Francois" uniqKey="Roman F" first="François" last="Roman">François Roman</name></author><author><name sortKey="Delfraissy, Jean Francois" sort="Delfraissy, Jean Francois" uniqKey="Delfraissy J" first="Jean-François" last="Delfraissy">Jean-François Delfraissy</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-33891" status="VALID"> <orgName>Service de médecine interne et maladies infectieuses</orgName> <desc> <address> <addrLine>Le Kremlin-Bicêtre</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-92966" type="direct"></relation> <relation active="#struct-300068" type="direct"></relation> <relation active="#struct-300148" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-92966" type="direct"><org type="institution" xml:id="struct-92966" status="VALID"> <orgName>Université Paris-Sud - Paris 11</orgName> <orgName type="acronym">UP11</orgName> <desc> <address> <addrLine>Bâtiment 300 - 91405 Orsay cedex</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.u-psud.fr/</ref> </desc> </org></tutelle><tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID"> <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName> <orgName type="acronym">APHP</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-300148" type="direct"><org type="institution" xml:id="struct-300148" status="VALID"> <orgName>Hôpital Bicêtre</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Aboulker, Jean Pierre" sort="Aboulker, Jean Pierre" uniqKey="Aboulker J" first="Jean-Pierre" last="Aboulker">Jean-Pierre Aboulker</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-2794" status="OLD"> <orgName>Essais Therapeutiques et Infection Par Le Vih</orgName> <date type="end">2012</date> <desc> <address> <addrLine>Centre de Recherche Inserm PARIS XI 16, Avenue Paul Vaillant-Couturier 94807 VILLEJUIF CEDEX</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-92966" type="direct"></relation> <relation name="SC10" active="#struct-303623" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-92966" type="direct"><org type="institution" xml:id="struct-92966" status="VALID"> <orgName>Université Paris-Sud - Paris 11</orgName> <orgName type="acronym">UP11</orgName> <desc> <address> <addrLine>Bâtiment 300 - 91405 Orsay cedex</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.u-psud.fr/</ref> </desc> </org></tutelle><tutelle name="SC10" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Launay, Odile" sort="Launay, Odile" uniqKey="Launay O" first="Odile" last="Launay">Odile Launay</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-2593" status="OLD"> <orgName>CIC - Biotherapie - AP-HP (cochin - Pasteur)</orgName> <desc> <address> <addrLine>Hopital Cochin PARIS V 27, Rue du Faubourg Saint-Jacques 75679 PARIS CEDEX 14</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation name="CBT505" active="#struct-303623" type="direct"></relation> </listRelation> <tutelles><tutelle name="CBT505" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author></analytic><idno type="DOI">10.1097/QAD.0b013e328359f27a</idno><series><title level="j">AIDS</title><idno type="ISSN">0269-9370</idno><imprint><date type="datePub">2013-01-02</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"> <p>OBJECTIVE: In immunocompromised patients, alternative schedules more immunogenic than the standard influenza vaccine regimen are necessary to enhance and prolong vaccine efficacy. We previously reported that the AS03A-adjuvanted 2009 A/H1N1v vaccine yielded a higher short-term immune response than the nonadjuvanted one in HIV-1-infected adults. This study reports the long-term persistence of the immune response. DESIGN AND METHODS: In a prospective, multicenter, randomized, patient-blinded trial, two doses of AS03A-adjuvanted H1N1v vaccine containing 3.75 μg haemagglutinin (n = 155; group A) or nonadjuvanted H1N1v vaccine containing 15 μg haemagglutinin (n = 151; group B), were administered 21 days apart. Haemagglutination inhibition and neutralizing antibodies were assessed 6 and 12 months after vaccination. RESULTS: In group A and B, the seroprotection rates were 83.7 and 59.4% at month 6, and 70.4 and 49.3 at month 12, respectively. In a multivariate analysis, persistence of seroprotection 12 months after vaccination was negatively associated with current smoking (odds ratio = 0.6, P = 0.03) and positively related with the AS03A-adjuvanted H1N1v vaccine (odds ratio = 2.7, P = 0.0002). CONCLUSION: In HIV-1-infected adults, two doses of adjuvanted influenza vaccine induce long-term persistence of immune response up to 1 year after vaccination.</p> </div></front></TEI><hal api="V3"> <titleStmt> <title xml:lang="en">Long-term immunogenicity of two doses of 2009 A/H1N1v vaccine with and without AS03(A) adjuvant in HIV-1-infected adults.</title> <author role="aut"> <persName> <forename type="first">Christine</forename> <surname>Durier</surname> </persName> <idno type="halauthorid">707354</idno> <affiliation ref="#struct-2794"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Corinne</forename> <surname>Desaint</surname> </persName> <idno type="halauthorid">707355</idno> <affiliation ref="#struct-2593"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Frédéric</forename> <surname>Lucht</surname> </persName> <idno type="halauthorid">391768</idno> <affiliation ref="#struct-3137"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Pierre-Marie</forename> <surname>Girard</surname> </persName> <idno type="halauthorid">140048</idno> </author> <author role="aut"> <persName> <forename type="first">Yves</forename> <surname>Lévy</surname> </persName> <idno type="halauthorid">316376</idno> <affiliation ref="#struct-266797"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Thierry</forename> <surname>May</surname> </persName> <idno type="halauthorid">366388</idno> <affiliation ref="#struct-245658"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Christian</forename> <surname>Michelet</surname> </persName> <idno type="halauthorid">516156</idno> <affiliation ref="#struct-182194"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Agathe</forename> <surname>Rami</surname> </persName> <idno type="halauthorid">901925</idno> </author> <author role="aut"> <persName> <forename type="first">François</forename> <surname>Roman</surname> </persName> <idno type="halauthorid">901926</idno> </author> <author role="aut"> <persName> <forename type="first">Jean-François</forename> <surname>Delfraissy</surname> </persName> <idno type="halauthorid">85735</idno> <affiliation ref="#struct-33891"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Jean-Pierre</forename> <surname>Aboulker</surname> </persName> <idno type="halauthorid">707359</idno> <affiliation ref="#struct-2794"></affiliation> </author> <author role="crp"> <persName> <forename type="first">Odile</forename> <surname>Launay</surname> </persName> <email type="md5">3a9306133151a9800c3d9ad5e5f025d0</email> <email type="domain">cch.aphp.fr</email> <idno type="halauthorid">632155</idno> <affiliation ref="#struct-2593"></affiliation> </author> <editor role="depositor"> <persName> <forename>Morgane</forename> <surname>Le Corre</surname> </persName> <email type="md5">8503b29898396526c56d96d8ae07e3e5</email> <email type="domain">univ-rennes1.fr</email> </editor> <funder>French National Agency for Research on AIDS and Viral Hepatitis (ANRS, Paris, France)</funder> </titleStmt> <editionStmt> <edition n="v1" type="current"> <date type="whenSubmitted">2013-10-21 11:57:25</date> <date type="whenModified">2019-11-29 01:47:42</date> <date type="whenReleased">2013-10-21 11:57:25</date> <date type="whenProduced">2013-01-02</date> </edition> <respStmt> <resp>contributor</resp> <name key="186196"> <persName> <forename>Morgane</forename> <surname>Le Corre</surname> </persName> <email type="md5">8503b29898396526c56d96d8ae07e3e5</email> <email type="domain">univ-rennes1.fr</email> </name> </respStmt> </editionStmt> <publicationStmt> <distributor>CCSD</distributor> <idno type="halId">hal-00875148</idno> <idno type="halUri">https://hal.archives-ouvertes.fr/hal-00875148</idno> <idno type="halBibtex">durier:hal-00875148</idno> <idno type="halRefHtml">AIDS, Lippincott, Williams & Wilkins, 2013, 27 (1), pp.87-93. ⟨10.1097/QAD.0b013e328359f27a⟩</idno> <idno type="halRef">AIDS, Lippincott, Williams & Wilkins, 2013, 27 (1), pp.87-93. ⟨10.1097/QAD.0b013e328359f27a⟩</idno> </publicationStmt> <seriesStmt> <idno type="stamp" n="UNIV-ST-ETIENNE">Université Jean Monnet - Saint-Etienne</idno> <idno type="stamp" n="IFR140">SFR Biosit - Biologie et Santé CNRS UMS 3480</idno> <idno type="stamp" n="IMRB" corresp="INSERM">Institut Mondor de Recherche Biomédicale</idno> <idno type="stamp" n="UNIV-RENNES1">Université de Rennes 1</idno> <idno type="stamp" n="IRSET">Institut de Recherche en Santé, Environnement et Travail</idno> <idno type="stamp" n="APHP" corresp="INSERM">AP-HP</idno> <idno type="stamp" n="IRSET-HIAEC" corresp="IRSET">HEPATOTROPIC INFECTIOUS AGENTS AND ENVIRONMENTAL COFACTORS</idno> <idno type="stamp" n="BIOSIT">SFR Biosit - Biologie et Santé CNRS UMS 3480</idno> <idno type="stamp" n="UPEC-UPEM">UPEC-UPEM</idno> <idno type="stamp" n="UR1-UFR-SVE">UFR SVE Sciences de la vie et de l'environnement</idno> <idno type="stamp" n="STATS-UR1">Statistiques-HAL-UR1</idno> <idno type="stamp" n="UR1-HAL">Publications labos UR1 dans HAL-Rennes 1</idno> <idno type="stamp" n="UR1-SDV">UR1 - publications SDV</idno> <idno type="stamp" n="IRSET-2" corresp="IRSET">SAMSON - Infection, immunité, facteurs environnementaux et foie (2IFEF) </idno> <idno type="stamp" n="UNIV-ANGERS">Université d'Angers</idno> <idno type="stamp" n="UNIV-PSUD">Université Paris Sud - Paris XI</idno> <idno type="stamp" n="TEST-UNIV-RENNES">TEST Université de Rennes</idno> <idno type="stamp" n="TEST-UR-CSS">TEST Université de Rennes CSS</idno> <idno type="stamp" n="UNIV-RENNES">Université de Rennes</idno> <idno type="stamp" n="UPEC" corresp="UPEC-UPEM">Université Paris-Est Créteil Val-de-Marne</idno> <idno type="stamp" n="UDL">UDL</idno> <idno type="stamp" n="UNIV-LYON">Université de Lyon</idno> <idno type="stamp" n="IRSET-SMS" corresp="IRSET">STRESS, MEMBRANE AND SIGNALING</idno> <idno type="stamp" n="IRSET-CCII" corresp="IRSET">CHEMICAL CONTAMINANTS, IMMUNITY AND INFLAMMATION</idno> <idno type="stamp" n="IRSET-TREC" corresp="IRSET">TRANSCRIPTION, ENVIRONMENT and CANCER (TREC)</idno> <idno type="stamp" n="IRSET-SMLF" corresp="IRSET">SIGNALING AND MODELING IN LIVER FIBROSIS</idno> <idno type="stamp" n="IRSET-ERD" corresp="IRSET">EPIDEMIOLOGICAL RESEARCH ON ENVIRONMENT, REPRODUCTION AND DEVELOPMENT</idno> <idno type="stamp" n="IRSET-VCER" corresp="IRSET">ENVIRONMENT VIRAL ET CHIMIQUE & REPRODUCTION</idno> <idno type="stamp" n="IRSET-NEED" corresp="IRSET">NEUROENDOCRINE EFFECTS OF ENDOCRINE DISRUPTORS</idno> <idno type="stamp" n="IRSET-TNGC" corresp="IRSET">Recherches épidémiologiques sur l'environnement, la reproduction et le développement</idno> </seriesStmt> <notesStmt> <note type="audience" n="2">International</note> <note type="popular" n="0">No</note> <note type="peer" n="1">Yes</note> </notesStmt> <sourceDesc> <biblStruct> <analytic> <title xml:lang="en">Long-term immunogenicity of two doses of 2009 A/H1N1v vaccine with and without AS03(A) adjuvant in HIV-1-infected adults.</title> <author role="aut"> <persName> <forename type="first">Christine</forename> <surname>Durier</surname> </persName> <idno type="halauthorid">707354</idno> <affiliation ref="#struct-2794"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Corinne</forename> <surname>Desaint</surname> </persName> <idno type="halauthorid">707355</idno> <affiliation ref="#struct-2593"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Frédéric</forename> <surname>Lucht</surname> </persName> <idno type="halauthorid">391768</idno> <affiliation ref="#struct-3137"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Pierre-Marie</forename> <surname>Girard</surname> </persName> <idno type="halauthorid">140048</idno> </author> <author role="aut"> <persName> <forename type="first">Yves</forename> <surname>Lévy</surname> </persName> <idno type="halauthorid">316376</idno> <affiliation ref="#struct-266797"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Thierry</forename> <surname>May</surname> </persName> <idno type="halauthorid">366388</idno> <affiliation ref="#struct-245658"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Christian</forename> <surname>Michelet</surname> </persName> <idno type="halauthorid">516156</idno> <affiliation ref="#struct-182194"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Agathe</forename> <surname>Rami</surname> </persName> <idno type="halauthorid">901925</idno> </author> <author role="aut"> <persName> <forename type="first">François</forename> <surname>Roman</surname> </persName> <idno type="halauthorid">901926</idno> </author> <author role="aut"> <persName> <forename type="first">Jean-François</forename> <surname>Delfraissy</surname> </persName> <idno type="halauthorid">85735</idno> <affiliation ref="#struct-33891"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Jean-Pierre</forename> <surname>Aboulker</surname> </persName> <idno type="halauthorid">707359</idno> <affiliation ref="#struct-2794"></affiliation> </author> <author role="crp"> <persName> <forename type="first">Odile</forename> <surname>Launay</surname> </persName> <email type="md5">3a9306133151a9800c3d9ad5e5f025d0</email> <email type="domain">cch.aphp.fr</email> <idno type="halauthorid">632155</idno> <affiliation ref="#struct-2593"></affiliation> </author> </analytic> <monogr> <idno type="halJournalId" status="VALID">10293</idno> <idno type="issn">0269-9370</idno> <title level="j">AIDS</title> <imprint> <publisher>Lippincott, Williams & Wilkins</publisher> <biblScope unit="volume">27</biblScope> <biblScope unit="issue">1</biblScope> <biblScope unit="pp">87-93</biblScope> <date type="datePub">2013-01-02</date> </imprint> </monogr> <idno type="pubmed">23018437</idno> <idno type="doi">10.1097/QAD.0b013e328359f27a</idno> </biblStruct> </sourceDesc> <profileDesc> <langUsage> <language ident="en">English</language> </langUsage> <textClass> <classCode scheme="mesh">Adjuvants, Immunologic</classCode> <classCode scheme="mesh">Antibodies, Neutralizing</classCode> <classCode scheme="mesh">Hemagglutinins</classCode> <classCode scheme="mesh">Humans</classCode> <classCode scheme="mesh">Influenza A Virus, H1N1 Subtype</classCode> <classCode scheme="mesh">Influenza Vaccines</classCode> <classCode scheme="mesh">Influenza, Human</classCode> <classCode scheme="mesh">Male</classCode> <classCode scheme="mesh">Polysorbates</classCode> <classCode scheme="mesh">Prospective Studies</classCode> <classCode scheme="mesh">Single-Blind Method</classCode> <classCode scheme="mesh">Smoking</classCode> <classCode scheme="mesh">Antibodies, Viral</classCode> <classCode scheme="mesh">Squalene</classCode> <classCode scheme="mesh">Time Factors</classCode> <classCode scheme="mesh">alpha-Tocopherol</classCode> <classCode scheme="mesh">Antibody Formation</classCode> <classCode scheme="mesh">Drug Combinations</classCode> <classCode scheme="mesh">Female</classCode> <classCode scheme="mesh">France</classCode> <classCode scheme="mesh">HIV Infections</classCode> <classCode scheme="mesh">HIV-1</classCode> <classCode scheme="mesh">Hemagglutination Inhibition Tests</classCode> <classCode scheme="halDomain" n="sdv.imm.vac">Life Sciences [q-bio]/Immunology/Vaccinology</classCode> <classCode scheme="halTypology" n="ART">Journal articles</classCode> </textClass> <abstract xml:lang="en"> <p>OBJECTIVE: In immunocompromised patients, alternative schedules more immunogenic than the standard influenza vaccine regimen are necessary to enhance and prolong vaccine efficacy. We previously reported that the AS03A-adjuvanted 2009 A/H1N1v vaccine yielded a higher short-term immune response than the nonadjuvanted one in HIV-1-infected adults. This study reports the long-term persistence of the immune response. DESIGN AND METHODS: In a prospective, multicenter, randomized, patient-blinded trial, two doses of AS03A-adjuvanted H1N1v vaccine containing 3.75 μg haemagglutinin (n = 155; group A) or nonadjuvanted H1N1v vaccine containing 15 μg haemagglutinin (n = 151; group B), were administered 21 days apart. Haemagglutination inhibition and neutralizing antibodies were assessed 6 and 12 months after vaccination. RESULTS: In group A and B, the seroprotection rates were 83.7 and 59.4% at month 6, and 70.4 and 49.3 at month 12, respectively. In a multivariate analysis, persistence of seroprotection 12 months after vaccination was negatively associated with current smoking (odds ratio = 0.6, P = 0.03) and positively related with the AS03A-adjuvanted H1N1v vaccine (odds ratio = 2.7, P = 0.0002). CONCLUSION: In HIV-1-infected adults, two doses of adjuvanted influenza vaccine induce long-term persistence of immune response up to 1 year after vaccination.</p> </abstract> <particDesc> <org type="consortium">ANRS 151 study group and the REIVAC network</org> </particDesc> </profileDesc> </hal></record>Pour manipuler ce document sous Unix (Dilib)
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