Epidemiological and virological characterization of 2009 pandemic influenza A virus subtype H1N1 in Madagascar.
Identifieur interne : 000082 ( Hal/Corpus ); précédent : 000081; suivant : 000083Epidemiological and virological characterization of 2009 pandemic influenza A virus subtype H1N1 in Madagascar.
Auteurs : Arnaud Orelle ; Norosoa Harline Razanajatovo ; Soatiana Rajatonirina ; Jonathan Hoffmann ; Laurence Randrianasolo ; Girard Marcellin Razafitrimo ; Dhamari Naidoo ; Vincent Richard ; Jean-Michel HeraudSource :
- Journal of Infectious Diseases [ 0022-1899 ] ; 2012-12-15.
Abstract
BACKGROUND: Madagascar was one of the first African countries to be affected by the 2009 pandemic of influenza A virus subtype H1N1 [A(H1N1)pdm2009] infection. The outbreak started in the capital city, Antananarivo, and then spread throughout the country from October 2009 through February 2010. METHODS: Specimens from patients presenting with influenza-like illness were collected and shipped to the National Influenza Center in Madagascar for analyses, together with forms containing patient demographic and clinical information. RESULTS: Of the 2303 specimens tested, 1016 (44.1%) and 131 (5.7%) yielded A(H1N1)pdm09 and seasonal influenza virus, respectively. Most specimens (42.0%) received were collected from patients <10 years old. Patients <20 years old were more likely than patients >50 years old to be infected with A(H1N1)pdm09 (odds ratio, 2.1; 95% confidence interval, 1.7-2.6; P < .01). Although phylogenetic analyses of A(H1N1)pdm09 suggested multiple introductions of the virus into Madagascar, no antigenic differences between A(H1N1)pdm09 viruses recovered in Madagascar and those that circulated worldwide were observed. CONCLUSIONS: The high proportion of respiratory specimens positive for A(H1N1)pdm09 is consistent with a widespread transmission of the pandemic in Madagascar. The age distribution of cases of A(H1N1)pdm09 infection suggests that children and young adults could be targeted for interventions that aim to reduce transmission during an influenza pandemic.
Url:
DOI: 10.1093/infdis/jis533
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<orgName>Institut Pasteur de Madagascar</orgName> <desc> <address> <addrLine>B.P. 1274 Antananarivo</addrLine> <country key="MG"></country> </address> <ref type="url">http://www.pasteur.mg</ref> </desc> <listRelation> <relation active="#struct-301247" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-301247" type="direct"><org type="regroupinstitution" xml:id="struct-301247" status="VALID"> <orgName>Réseau International des Instituts Pasteur</orgName> <orgName type="acronym">RIIP</orgName> <desc> <address> <addrLine>25, rue du Dr Roux 75724 Paris Cedex 15</addrLine> <country key="FR"></country> </address> <ref type="url">https://research.pasteur.fr/ip-network</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Razanajatovo, Norosoa Harline" sort="Razanajatovo, Norosoa Harline" uniqKey="Razanajatovo N" first="Norosoa Harline" last="Razanajatovo">Norosoa Harline Razanajatovo</name><affiliation><hal:affiliation type="institution" xml:id="struct-55578" status="VALID"> <orgName>Institut Pasteur de Madagascar</orgName> <desc> <address> <addrLine>B.P. 1274 Antananarivo</addrLine> <country key="MG"></country> </address> <ref type="url">http://www.pasteur.mg</ref> </desc> <listRelation> <relation active="#struct-301247" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-301247" type="direct"><org type="regroupinstitution" xml:id="struct-301247" status="VALID"> <orgName>Réseau International des Instituts Pasteur</orgName> <orgName type="acronym">RIIP</orgName> <desc> <address> <addrLine>25, rue du Dr Roux 75724 Paris Cedex 15</addrLine> <country key="FR"></country> </address> <ref type="url">https://research.pasteur.fr/ip-network</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Rajatonirina, Soatiana" sort="Rajatonirina, Soatiana" uniqKey="Rajatonirina S" first="Soatiana" last="Rajatonirina">Soatiana Rajatonirina</name><affiliation><hal:affiliation type="institution" xml:id="struct-55578" status="VALID"> <orgName>Institut Pasteur de Madagascar</orgName> <desc> <address> <addrLine>B.P. 1274 Antananarivo</addrLine> <country key="MG"></country> </address> <ref type="url">http://www.pasteur.mg</ref> </desc> <listRelation> <relation active="#struct-301247" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-301247" type="direct"><org type="regroupinstitution" xml:id="struct-301247" status="VALID"> <orgName>Réseau International des Instituts Pasteur</orgName> <orgName type="acronym">RIIP</orgName> <desc> <address> <addrLine>25, rue du Dr Roux 75724 Paris Cedex 15</addrLine> <country key="FR"></country> </address> <ref type="url">https://research.pasteur.fr/ip-network</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Hoffmann, Jonathan" sort="Hoffmann, Jonathan" uniqKey="Hoffmann J" first="Jonathan" last="Hoffmann">Jonathan Hoffmann</name><affiliation><hal:affiliation type="institution" xml:id="struct-55578" status="VALID"> <orgName>Institut Pasteur de Madagascar</orgName> <desc> <address> <addrLine>B.P. 1274 Antananarivo</addrLine> <country key="MG"></country> </address> <ref type="url">http://www.pasteur.mg</ref> </desc> <listRelation> <relation active="#struct-301247" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-301247" type="direct"><org type="regroupinstitution" xml:id="struct-301247" status="VALID"> <orgName>Réseau International des Instituts Pasteur</orgName> <orgName type="acronym">RIIP</orgName> <desc> <address> <addrLine>25, rue du Dr Roux 75724 Paris Cedex 15</addrLine> <country key="FR"></country> </address> <ref type="url">https://research.pasteur.fr/ip-network</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Randrianasolo, Laurence" sort="Randrianasolo, Laurence" uniqKey="Randrianasolo L" first="Laurence" last="Randrianasolo">Laurence Randrianasolo</name><affiliation><hal:affiliation type="institution" xml:id="struct-55578" status="VALID"> <orgName>Institut Pasteur de Madagascar</orgName> <desc> <address> <addrLine>B.P. 1274 Antananarivo</addrLine> <country key="MG"></country> </address> <ref type="url">http://www.pasteur.mg</ref> </desc> <listRelation> <relation active="#struct-301247" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-301247" type="direct"><org type="regroupinstitution" xml:id="struct-301247" status="VALID"> <orgName>Réseau International des Instituts Pasteur</orgName> <orgName type="acronym">RIIP</orgName> <desc> <address> <addrLine>25, rue du Dr Roux 75724 Paris Cedex 15</addrLine> <country key="FR"></country> </address> <ref type="url">https://research.pasteur.fr/ip-network</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Razafitrimo, Girard Marcellin" sort="Razafitrimo, Girard Marcellin" uniqKey="Razafitrimo G" first="Girard Marcellin" last="Razafitrimo">Girard Marcellin Razafitrimo</name><affiliation><hal:affiliation type="institution" xml:id="struct-55578" status="VALID"> <orgName>Institut Pasteur de Madagascar</orgName> <desc> <address> <addrLine>B.P. 1274 Antananarivo</addrLine> <country key="MG"></country> </address> <ref type="url">http://www.pasteur.mg</ref> </desc> <listRelation> <relation active="#struct-301247" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-301247" type="direct"><org type="regroupinstitution" xml:id="struct-301247" status="VALID"> <orgName>Réseau International des Instituts Pasteur</orgName> <orgName type="acronym">RIIP</orgName> <desc> <address> <addrLine>25, rue du Dr Roux 75724 Paris Cedex 15</addrLine> <country key="FR"></country> </address> <ref type="url">https://research.pasteur.fr/ip-network</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Naidoo, Dhamari" sort="Naidoo, Dhamari" uniqKey="Naidoo D" first="Dhamari" last="Naidoo">Dhamari Naidoo</name></author><author><name sortKey="Richard, Vincent" sort="Richard, Vincent" uniqKey="Richard V" first="Vincent" last="Richard">Vincent Richard</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-217849" status="VALID"> <orgName>Unité d'Epidémiologie des Maladies Infectieuses</orgName> <desc> <address> <addrLine>36, Avenue Pasteur B.P. 220 - Dakar</addrLine> <country key="SN"></country> </address> </desc> <listRelation> <relation active="#struct-42095" type="direct"></relation> <relation active="#struct-301247" type="indirect"></relation> </listRelation> <tutelles><tutelle active="#struct-42095" type="direct"><org type="institution" xml:id="struct-42095" status="VALID"> <orgName>Institut Pasteur de Dakar</orgName> <desc> <address> <addrLine>B.P. 220 Dakar</addrLine> <country key="SN"></country> </address> <ref type="url">http://www.pasteur.sn/</ref> </desc> <listRelation> <relation active="#struct-301247" type="direct"></relation> </listRelation> </org></tutelle><tutelle active="#struct-301247" type="indirect"><org type="regroupinstitution" xml:id="struct-301247" status="VALID"> <orgName>Réseau International des Instituts Pasteur</orgName> <orgName type="acronym">RIIP</orgName> <desc> <address> <addrLine>25, rue du Dr Roux 75724 Paris Cedex 15</addrLine> <country key="FR"></country> </address> <ref type="url">https://research.pasteur.fr/ip-network</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Heraud, Jean Michel" sort="Heraud, Jean Michel" uniqKey="Heraud J" first="Jean-Michel" last="Heraud">Jean-Michel Heraud</name><affiliation><hal:affiliation type="institution" xml:id="struct-55578" status="VALID"> <orgName>Institut Pasteur de Madagascar</orgName> <desc> <address> <addrLine>B.P. 1274 Antananarivo</addrLine> <country key="MG"></country> </address> <ref type="url">http://www.pasteur.mg</ref> </desc> <listRelation> <relation active="#struct-301247" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-301247" type="direct"><org type="regroupinstitution" xml:id="struct-301247" status="VALID"> <orgName>Réseau International des Instituts Pasteur</orgName> <orgName type="acronym">RIIP</orgName> <desc> <address> <addrLine>25, rue du Dr Roux 75724 Paris Cedex 15</addrLine> <country key="FR"></country> </address> <ref type="url">https://research.pasteur.fr/ip-network</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author></analytic><idno type="DOI">10.1093/infdis/jis533</idno><series><title level="j">Journal of Infectious Diseases</title><idno type="ISSN">0022-1899</idno><imprint><date type="datePub">2012-12-15</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"> <p>BACKGROUND: Madagascar was one of the first African countries to be affected by the 2009 pandemic of influenza A virus subtype H1N1 [A(H1N1)pdm2009] infection. The outbreak started in the capital city, Antananarivo, and then spread throughout the country from October 2009 through February 2010. METHODS: Specimens from patients presenting with influenza-like illness were collected and shipped to the National Influenza Center in Madagascar for analyses, together with forms containing patient demographic and clinical information. RESULTS: Of the 2303 specimens tested, 1016 (44.1%) and 131 (5.7%) yielded A(H1N1)pdm09 and seasonal influenza virus, respectively. Most specimens (42.0%) received were collected from patients <10 years old. Patients <20 years old were more likely than patients >50 years old to be infected with A(H1N1)pdm09 (odds ratio, 2.1; 95% confidence interval, 1.7-2.6; P < .01). Although phylogenetic analyses of A(H1N1)pdm09 suggested multiple introductions of the virus into Madagascar, no antigenic differences between A(H1N1)pdm09 viruses recovered in Madagascar and those that circulated worldwide were observed. CONCLUSIONS: The high proportion of respiratory specimens positive for A(H1N1)pdm09 is consistent with a widespread transmission of the pandemic in Madagascar. The age distribution of cases of A(H1N1)pdm09 infection suggests that children and young adults could be targeted for interventions that aim to reduce transmission during an influenza pandemic.</p> </div></front></TEI><hal api="V3"> <titleStmt> <title xml:lang="en">Epidemiological and virological characterization of 2009 pandemic influenza A virus subtype H1N1 in Madagascar.</title> <author role="aut"> <persName> <forename type="first">Arnaud</forename> <surname>Orelle</surname> </persName> <idno type="halauthorid">725150</idno> <affiliation ref="#struct-55578"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Norosoa Harline</forename> <surname>Razanajatovo</surname> </persName> <idno type="halauthorid">603951</idno> <affiliation ref="#struct-55578"></affiliation> </author> <author role="crp"> <persName> <forename type="first">Soatiana</forename> <forename type="middle">Cathycia</forename> <surname>Rajatonirina</surname> </persName> <email type="md5">610c3705e43a6ffe3d9856fb1025a55f</email> <email type="domain">pasteur.mg</email> <idno type="halauthorid">862156</idno> <affiliation ref="#struct-55578"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Jonathan</forename> <surname>Hoffmann</surname> </persName> <idno type="halauthorid">603952</idno> <affiliation ref="#struct-55578"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Laurence</forename> <surname>Randrianasolo</surname> </persName> <idno type="halauthorid">604039</idno> <affiliation ref="#struct-55578"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Girard Marcellin</forename> <surname>Razafitrimo</surname> </persName> <idno type="halauthorid">603953</idno> <affiliation ref="#struct-55578"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Dhamari</forename> <surname>Naidoo</surname> </persName> <idno type="halauthorid">862157</idno> </author> <author role="aut"> <persName> <forename type="first">Vincent</forename> <surname>Richard</surname> </persName> <idno type="halauthorid">517925</idno> <affiliation ref="#struct-217849"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Jean-Michel</forename> <surname>Heraud</surname> </persName> <email type="md5">1849a0600a4a62c48f329d055ab8ca5b</email> <email type="domain">pasteur.mg</email> <ptr type="url" target="http://publicationslist.org/jmheraud"></ptr> <idno type="idhal" notation="string">jmheraud</idno> <idno type="idhal" notation="numeric">13240</idno> <idno type="halauthorid">861799</idno> <idno type="ORCID">https://orcid.org/0000-0003-1107-0859</idno> <idno type="ResearcherId">http://www.researcherid.com/rid/O-1464-2013</idno> <affiliation ref="#struct-55578"></affiliation> </author> <editor role="depositor"> <persName> <forename>Princy</forename> <surname>Rakotoarison</surname> </persName> <email type="md5">6d1db8f8601833ff8a69bd85b11e61f2</email> <email type="domain">pasteur.mg</email> </editor> </titleStmt> <editionStmt> <edition n="v1" type="current"> <date type="whenSubmitted">2013-06-20 15:23:09</date> <date type="whenModified">2018-10-16 15:40:03</date> <date type="whenReleased">2013-06-20 15:23:09</date> <date type="whenProduced">2012-12-15</date> <ref type="externalLink" target="https://academic.oup.com/jid/article-pdf/206/suppl_1/S140/17408890/jis533.pdf"></ref> </edition> <respStmt> <resp>contributor</resp> <name key="184166"> <persName> <forename>Princy</forename> <surname>Rakotoarison</surname> </persName> <email type="md5">6d1db8f8601833ff8a69bd85b11e61f2</email> <email type="domain">pasteur.mg</email> </name> </respStmt> </editionStmt> <publicationStmt> <distributor>CCSD</distributor> <idno type="halId">pasteur-00836153</idno> <idno type="halUri">https://hal-riip.archives-ouvertes.fr/pasteur-00836153</idno> <idno type="halBibtex">orelle:pasteur-00836153</idno> <idno type="halRefHtml">Journal of Infectious Diseases, Oxford University Press (OUP), 2012, 206 Suppl 1, pp.S140-7. ⟨10.1093/infdis/jis533⟩</idno> <idno type="halRef">Journal of Infectious Diseases, Oxford University Press (OUP), 2012, 206 Suppl 1, pp.S140-7. ⟨10.1093/infdis/jis533⟩</idno> </publicationStmt> <seriesStmt> <idno type="stamp" n="RIIP_MADAGASCAR" corresp="RIIP">Institut Pasteur de Madagascar</idno> <idno type="stamp" n="RIIP">Institut Pasteur RIIP (Réseau International)</idno> <idno type="stamp" n="RIIP_DAKAR" corresp="RIIP">Institut Pasteur de Dakar</idno> </seriesStmt> <notesStmt> <note type="audience" n="2">International</note> <note type="popular" n="0">No</note> <note type="peer" n="1">Yes</note> </notesStmt> <sourceDesc> <biblStruct> <analytic> <title xml:lang="en">Epidemiological and virological characterization of 2009 pandemic influenza A virus subtype H1N1 in Madagascar.</title> <author role="aut"> <persName> <forename type="first">Arnaud</forename> <surname>Orelle</surname> </persName> <idno type="halauthorid">725150</idno> <affiliation ref="#struct-55578"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Norosoa Harline</forename> <surname>Razanajatovo</surname> </persName> <idno type="halauthorid">603951</idno> <affiliation ref="#struct-55578"></affiliation> </author> <author role="crp"> <persName> <forename type="first">Soatiana</forename> <forename type="middle">Cathycia</forename> <surname>Rajatonirina</surname> </persName> <email type="md5">610c3705e43a6ffe3d9856fb1025a55f</email> <email type="domain">pasteur.mg</email> <idno type="halauthorid">862156</idno> <affiliation ref="#struct-55578"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Jonathan</forename> <surname>Hoffmann</surname> </persName> <idno type="halauthorid">603952</idno> <affiliation ref="#struct-55578"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Laurence</forename> <surname>Randrianasolo</surname> </persName> <idno type="halauthorid">604039</idno> <affiliation ref="#struct-55578"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Girard Marcellin</forename> <surname>Razafitrimo</surname> </persName> <idno type="halauthorid">603953</idno> <affiliation ref="#struct-55578"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Dhamari</forename> <surname>Naidoo</surname> </persName> <idno type="halauthorid">862157</idno> </author> <author role="aut"> <persName> <forename type="first">Vincent</forename> <surname>Richard</surname> </persName> <idno type="halauthorid">517925</idno> <affiliation ref="#struct-217849"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Jean-Michel</forename> <surname>Heraud</surname> </persName> <email type="md5">1849a0600a4a62c48f329d055ab8ca5b</email> <email type="domain">pasteur.mg</email> <ptr type="url" target="http://publicationslist.org/jmheraud"></ptr> <idno type="idhal" notation="string">jmheraud</idno> <idno type="idhal" notation="numeric">13240</idno> <idno type="halauthorid">861799</idno> <idno type="ORCID">https://orcid.org/0000-0003-1107-0859</idno> <idno type="ResearcherId">http://www.researcherid.com/rid/O-1464-2013</idno> <affiliation ref="#struct-55578"></affiliation> </author> </analytic> <monogr> <idno type="halJournalId" status="VALID">16582</idno> <idno type="issn">0022-1899</idno> <idno type="eissn">1537-6613</idno> <title level="j">Journal of Infectious Diseases</title> <imprint> <publisher>Oxford University Press (OUP)</publisher> <biblScope unit="volume">206 Suppl 1</biblScope> <biblScope unit="pp">S140-7</biblScope> <date type="datePub">2012-12-15</date> </imprint> </monogr> <idno type="doi">10.1093/infdis/jis533</idno> <idno type="pubmed">23169961</idno> </biblStruct> </sourceDesc> <profileDesc> <langUsage> <language ident="en">English</language> </langUsage> <textClass> <classCode scheme="mesh">Adolescent</classCode> <classCode scheme="mesh">Adult</classCode> <classCode scheme="mesh">Influenza A Virus, H1N1 Subtype</classCode> <classCode scheme="mesh">Influenza, Human</classCode> <classCode scheme="mesh">Madagascar</classCode> <classCode scheme="mesh">Male</classCode> <classCode scheme="mesh">Middle Aged</classCode> <classCode scheme="mesh">Molecular Epidemiology</classCode> <classCode scheme="mesh">Molecular Sequence Data</classCode> <classCode scheme="mesh">Pandemics</classCode> <classCode scheme="mesh">Phylogeny</classCode> <classCode scheme="mesh">RNA, Viral</classCode> <classCode scheme="mesh">Age Distribution</classCode> <classCode scheme="mesh">Sequence Analysis, DNA</classCode> <classCode scheme="mesh">Young Adult</classCode> <classCode scheme="mesh">Aged</classCode> <classCode scheme="mesh">Child</classCode> <classCode scheme="mesh">Child, Preschool</classCode> <classCode scheme="mesh">Female</classCode> <classCode scheme="mesh">Genotype</classCode> <classCode scheme="mesh">Humans</classCode> <classCode scheme="mesh">Infant</classCode> <classCode scheme="halDomain" n="sdv">Life Sciences [q-bio]</classCode> <classCode scheme="halTypology" n="ART">Journal articles</classCode> </textClass> <abstract xml:lang="en"> <p>BACKGROUND: Madagascar was one of the first African countries to be affected by the 2009 pandemic of influenza A virus subtype H1N1 [A(H1N1)pdm2009] infection. The outbreak started in the capital city, Antananarivo, and then spread throughout the country from October 2009 through February 2010. METHODS: Specimens from patients presenting with influenza-like illness were collected and shipped to the National Influenza Center in Madagascar for analyses, together with forms containing patient demographic and clinical information. RESULTS: Of the 2303 specimens tested, 1016 (44.1%) and 131 (5.7%) yielded A(H1N1)pdm09 and seasonal influenza virus, respectively. Most specimens (42.0%) received were collected from patients <10 years old. Patients <20 years old were more likely than patients >50 years old to be infected with A(H1N1)pdm09 (odds ratio, 2.1; 95% confidence interval, 1.7-2.6; P < .01). Although phylogenetic analyses of A(H1N1)pdm09 suggested multiple introductions of the virus into Madagascar, no antigenic differences between A(H1N1)pdm09 viruses recovered in Madagascar and those that circulated worldwide were observed. CONCLUSIONS: The high proportion of respiratory specimens positive for A(H1N1)pdm09 is consistent with a widespread transmission of the pandemic in Madagascar. The age distribution of cases of A(H1N1)pdm09 infection suggests that children and young adults could be targeted for interventions that aim to reduce transmission during an influenza pandemic.</p> </abstract> </profileDesc> </hal></record>Pour manipuler ce document sous Unix (Dilib)
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