H2N2V1, Hal, Corpus, bibRecord, 000071

Effect of vitamin E and vitamin C combination on experimental influenza virus infection.

Identifieur interne : 000071 ( Hal/Corpus ); précédent : 000070; suivant : 000072

Effect of vitamin E and vitamin C combination on experimental influenza virus infection.

Auteurs : L. P. Tantcheva ; E. S. Stoeva ; A. S. Galabov ; A. A. Braykova ; V. M. Savov ; M. M. Mileva

Source :

Methods and findings in experimental and clinical pharmacology [ 0379-0355 ] ; 2003-05.

RBID : Hal:pasteur-00736450

Abstract

Successful antioxidant treatment of the so-called "free radical diseases" has been reported in the literature. In this study we examined the preventive effect of vitamin E and vitamin C, alone and in combination, on the damage caused by influenza virus infection (IVI). Male mice (ICR), infected with influenza virus A/2/68/(H3N2) (1.5 of LD(50)), were administered single once-daily doses of vitamin E (60 mg/kg b.w.) and vitamin C (80 mg/kg b.w.) intraperitoneally (3 days before virus inoculation). On the 5th and 7th day, respectively, after virus inoculation, animals were decapitated. Monooxygenase enzyme activity (ethylmorphine N-demethylase, amidopyrin N-demethylase, analgin N-demethylase, aniline hydroxylase, cytochrome P-450 content and NADPH-cytochrome C reductase [CCR]) was determined in liver 9000 x g supernatant. Primary and secondary products of lipid peroxidation (LPO; conjugated dienes [CD] and TBA-reactive substances) were measured in blood plasma, lung and liver 9000 x g supernatant. Vitamin E effectively restored LPO-levels increased by IVI. The effect of vitamin C was similar, but slighter. The combination (vitamin E + C) had greater effect on LPO levels than their separate administration. P-450-dependent monooxygenase activity was significantly restored and more pronounced cytochrome P-450 content and NADPH-CCR activity was noted. The preventive effect of vitamin E was stronger than the effect of vitamin C, but the combination (vitamin E + C) had the strongest effect. The superior protective effect of the combination is probably due to vitamin C's repairing effect on vitamin E's tocopheroxyl radical.

Url:

https://hal-riip.archives-ouvertes.fr/pasteur-00736450

DOI: 10.1358/mf.2003.25.4.769673

Links to Exploration step

Hal:pasteur-00736450

Le document en format XML

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<front><div type="abstract" xml:lang="en">              <p>Successful antioxidant treatment of the so-called "free radical diseases" has been reported in the literature. In this study we examined the preventive effect of vitamin E and vitamin C, alone and in combination, on the damage caused by influenza virus infection (IVI). Male mice (ICR), infected with influenza virus A/2/68/(H3N2) (1.5 of LD(50)), were administered single once-daily doses of vitamin E (60 mg/kg b.w.) and vitamin C (80 mg/kg b.w.) intraperitoneally (3 days before virus inoculation). On the 5th and 7th day, respectively, after virus inoculation, animals were decapitated. Monooxygenase enzyme activity (ethylmorphine N-demethylase, amidopyrin N-demethylase, analgin N-demethylase, aniline hydroxylase, cytochrome P-450 content and NADPH-cytochrome C reductase [CCR]) was determined in liver 9000 x g supernatant. Primary and secondary products of lipid peroxidation (LPO; conjugated dienes [CD] and TBA-reactive substances) were measured in blood plasma, lung and liver 9000 x g supernatant. Vitamin E effectively restored LPO-levels increased by IVI. The effect of vitamin C was similar, but slighter. The combination (vitamin E + C) had greater effect on LPO levels than their separate administration. P-450-dependent monooxygenase activity was significantly restored and more pronounced cytochrome P-450 content and NADPH-CCR activity was noted. The preventive effect of vitamin E was stronger than the effect of vitamin C, but the combination (vitamin E + C) had the strongest effect. The superior protective effect of the combination is probably due to vitamin C's repairing effect on vitamin E's tocopheroxyl radical.</p>
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            <textClass>              <classCode scheme="mesh">Animals</classCode>
              <classCode scheme="mesh">Antioxidants</classCode>
              <classCode scheme="mesh">Cytochrome P-450 Enzyme System</classCode>
              <classCode scheme="mesh">Drug Therapy, Combination</classCode>
              <classCode scheme="mesh">Influenza A virus</classCode>
              <classCode scheme="mesh">Injections, Intraperitoneal</classCode>
              <classCode scheme="mesh">Lipid Peroxidation</classCode>
              <classCode scheme="mesh">Liver</classCode>
              <classCode scheme="mesh">Lung</classCode>
              <classCode scheme="mesh">Male</classCode>
              <classCode scheme="mesh">Mice</classCode>
              <classCode scheme="mesh">Mice, Inbred ICR</classCode>
              <classCode scheme="mesh">Mixed Function Oxygenases</classCode>
              <classCode scheme="mesh">Orthomyxoviridae Infections</classCode>
              <classCode scheme="mesh">Thiobarbituric Acid Reactive Substances</classCode>
              <classCode scheme="mesh">Vitamin E</classCode>
              <classCode scheme="mesh">Ascorbic Acid</classCode>
              <classCode scheme="halDomain" n="sdv.mp.vir">Life Sciences [q-bio]/Microbiology and Parasitology/Virology</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">              <p>Successful antioxidant treatment of the so-called "free radical diseases" has been reported in the literature. In this study we examined the preventive effect of vitamin E and vitamin C, alone and in combination, on the damage caused by influenza virus infection (IVI). Male mice (ICR), infected with influenza virus A/2/68/(H3N2) (1.5 of LD(50)), were administered single once-daily doses of vitamin E (60 mg/kg b.w.) and vitamin C (80 mg/kg b.w.) intraperitoneally (3 days before virus inoculation). On the 5th and 7th day, respectively, after virus inoculation, animals were decapitated. Monooxygenase enzyme activity (ethylmorphine N-demethylase, amidopyrin N-demethylase, analgin N-demethylase, aniline hydroxylase, cytochrome P-450 content and NADPH-cytochrome C reductase [CCR]) was determined in liver 9000 x g supernatant. Primary and secondary products of lipid peroxidation (LPO; conjugated dienes [CD] and TBA-reactive substances) were measured in blood plasma, lung and liver 9000 x g supernatant. Vitamin E effectively restored LPO-levels increased by IVI. The effect of vitamin C was similar, but slighter. The combination (vitamin E + C) had greater effect on LPO levels than their separate administration. P-450-dependent monooxygenase activity was significantly restored and more pronounced cytochrome P-450 content and NADPH-CCR activity was noted. The preventive effect of vitamin E was stronger than the effect of vitamin C, but the combination (vitamin E + C) had the strongest effect. The superior protective effect of the combination is probably due to vitamin C's repairing effect on vitamin E's tocopheroxyl radical.</p>
            </abstract>
          </profileDesc>
        </hal>
</record>

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Effect of vitamin E and vitamin C combination on experimental influenza virus infection.

Effect of vitamin E and vitamin C combination on experimental influenza virus infection.

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