H2N2V1, Hal, Corpus, bibRecord, 000063

Dual functions of ginsenosides in protecting human endothelial cells against influenza H9N2-induced inflammation and apoptosis.

Identifieur interne : 000063 ( Hal/Corpus ); précédent : 000062; suivant : 000064

Dual functions of ginsenosides in protecting human endothelial cells against influenza H9N2-induced inflammation and apoptosis.

Auteurs : Lok Yung Chan ; Hoi Hin Kwok ; Renee Wan Yi Chan ; Malik Joseph Sriyal Peiris ; Nai Ki Mak ; Ricky Ngok Shun Wong ; Michael Chi Wai Chan ; Patrick Ying Kit Yue

Source :

Journal of Ethnopharmacology [ 0378-8741 ] ; 2011-08-22.

RBID : Hal:pasteur-00623719

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE: Panax ginseng is a precious traditional Chinese herbal medicine which has been utilized as herbal tonic for improving immunity. The active component, ginsenosides have been shown to possess various pharmacological functions including immunomodulation and cardiovascular protection. AIM OF THE STUDY: To investigate the immunomodulatory effect and anti-apoptotic effect of ginsenosides on avian influenza-infected human endothelial cells, and to present evidence for the cardiovascular protection by ginseng during influenza infection. MATERIALS AND METHODS: Human umbilical vein endothelial cells (HUVECs) were infected with avian influenza H9N2/G1 to induce IP-10 production and cell death, cells were then incubated with ginsenosides PPT and Re. The level of IP-10 and microRNA was determined by ELISA and real-time PCR respectively. Cell death was determined by MTT, TUNEL and flow cytometry. RESULTS: Ginsenoside metabolite protopanaxatriol showed significant suppression effect on IP-10 production upon H9N2/G1 infection through up-regulation of miR-15b expression. In addition, ginsenoside-induced cytoprotection was reflected in the increase of cell viability. Data from flow cytometry analysis and TUNEL assay also showed that ginsenoside Re could protect ECs from H9N2/G1-induced apoptosis and DNA damage. CONCLUSIONS: This report further supports the traditional belief for immunomodulatory effects of ginseng, also demonstrated the partial protective mechanism of ginsenosides on avian influenza infection and its related endothelial dysfunction.

Url:

https://hal-riip.archives-ouvertes.fr/pasteur-00623719

DOI: 10.1016/j.jep.2011.08.022

Links to Exploration step

Hal:pasteur-00623719

Le document en format XML

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<front><div type="abstract" xml:lang="en">              <p>ETHNOPHARMACOLOGICAL RELEVANCE: Panax ginseng is a precious traditional Chinese herbal medicine which has been utilized as herbal tonic for improving immunity. The active component, ginsenosides have been shown to possess various pharmacological functions including immunomodulation and cardiovascular protection. AIM OF THE STUDY: To investigate the immunomodulatory effect and anti-apoptotic effect of ginsenosides on avian influenza-infected human endothelial cells, and to present evidence for the cardiovascular protection by ginseng during influenza infection. MATERIALS AND METHODS: Human umbilical vein endothelial cells (HUVECs) were infected with avian influenza H9N2/G1 to induce IP-10 production and cell death, cells were then incubated with ginsenosides PPT and Re. The level of IP-10 and microRNA was determined by ELISA and real-time PCR respectively. Cell death was determined by MTT, TUNEL and flow cytometry. RESULTS: Ginsenoside metabolite protopanaxatriol showed significant suppression effect on IP-10 production upon H9N2/G1 infection through up-regulation of miR-15b expression. In addition, ginsenoside-induced cytoprotection was reflected in the increase of cell viability. Data from flow cytometry analysis and TUNEL assay also showed that ginsenoside Re could protect ECs from H9N2/G1-induced apoptosis and DNA damage. CONCLUSIONS: This report further supports the traditional belief for immunomodulatory effects of ginseng, also demonstrated the partial protective mechanism of ginsenosides on avian influenza infection and its related endothelial dysfunction.</p>
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                  <email type="md5">db6294369232523cfd6bc751b89c3327</email>
                  <email type="domain">hkbu.edu.hk</email>
                  <idno type="halauthorid">642461</idno>
                  <affiliation ref="#struct-93486"></affiliation>
                </author>
              </analytic>
              <monogr>                <idno type="halJournalId" status="VALID">13269</idno>
                <idno type="issn">0378-8741</idno>
                <title level="j">Journal of Ethnopharmacology</title>
                <imprint>                  <publisher>Elsevier</publisher>
                  <biblScope unit="pp">epub ahead of print</biblScope>
                  <date type="datePub">2011-08-22</date>
                  <date type="dateEpub">2011-08-22</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1016/j.jep.2011.08.022</idno>
              <idno type="pubmed">21872652</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>            <langUsage>              <language ident="en">English</language>
            </langUsage>
            <textClass>              <classCode scheme="halDomain" n="sdv.mp.vir">Life Sciences [q-bio]/Microbiology and Parasitology/Virology</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">              <p>ETHNOPHARMACOLOGICAL RELEVANCE: Panax ginseng is a precious traditional Chinese herbal medicine which has been utilized as herbal tonic for improving immunity. The active component, ginsenosides have been shown to possess various pharmacological functions including immunomodulation and cardiovascular protection. AIM OF THE STUDY: To investigate the immunomodulatory effect and anti-apoptotic effect of ginsenosides on avian influenza-infected human endothelial cells, and to present evidence for the cardiovascular protection by ginseng during influenza infection. MATERIALS AND METHODS: Human umbilical vein endothelial cells (HUVECs) were infected with avian influenza H9N2/G1 to induce IP-10 production and cell death, cells were then incubated with ginsenosides PPT and Re. The level of IP-10 and microRNA was determined by ELISA and real-time PCR respectively. Cell death was determined by MTT, TUNEL and flow cytometry. RESULTS: Ginsenoside metabolite protopanaxatriol showed significant suppression effect on IP-10 production upon H9N2/G1 infection through up-regulation of miR-15b expression. In addition, ginsenoside-induced cytoprotection was reflected in the increase of cell viability. Data from flow cytometry analysis and TUNEL assay also showed that ginsenoside Re could protect ECs from H9N2/G1-induced apoptosis and DNA damage. CONCLUSIONS: This report further supports the traditional belief for immunomodulatory effects of ginseng, also demonstrated the partial protective mechanism of ginsenosides on avian influenza infection and its related endothelial dysfunction.</p>
            </abstract>
          </profileDesc>
        </hal>
</record>

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Dual functions of ginsenosides in protecting human endothelial cells against influenza H9N2-induced inflammation and apoptosis.

Dual functions of ginsenosides in protecting human endothelial cells against influenza H9N2-induced inflammation and apoptosis.

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