Divergent genetic evolution of hemagglutinin in influenza A H1N1 and A H1N2 subtypes isolated in the south-France since the winter of 2001-2002.
Identifieur interne : 000061 ( Hal/Corpus ); précédent : 000060; suivant : 000062Divergent genetic evolution of hemagglutinin in influenza A H1N1 and A H1N2 subtypes isolated in the south-France since the winter of 2001-2002.
Auteurs : S. Al Faress ; G. Cartet ; O. Ferraris ; H. Norder ; M. Valette ; B. LinaSource :
English descriptors
- mix :
- Animals, Cell Line, DNA, Dogs, Evolution, France, H1N1 Subtype, Hemagglutination Inhibition Tests, Hemagglutinin Glycoproteins, Human/virology, Humans, Influenza, Influenza A Virus, Influenza A virus/*classification/*genetics/isolation & purification, Influenza Virus/*genetics, Molecular, Phylogeny, Sequence Analysis.
Abstract
BACKGROUND: Influenza A viruses are divided into subtypes based on their hemagglutinin (H1 to H15) and neuraminidase (N1 to N9) glycoproteins. Of these, three A subtypes H1N1, H3N2 and H1N2 circulate in the human population. Influenza A viruses display a high antigenic variability called "antigenic drift" which allows the virus to escape antibody neutralization. OBJECTIVES: Evaluate the mutations apparition that might predict a divergent antigenic evolution of hemagglutinin in influenza A H1N1 and A H1N2 viruses. STUDY DESIGN: During the three winters of 2001-2002 to 2003-2004, 58 A H1N1 and 23 A H1N2 subtypes have been isolated from patients with influenza-like illness in the south of France. The HA1 region was analyzed by RT-PCR and subsequently sequenced to compare the HA1 genetic evolution of influenza A H1N1 and A H1N2 subtypes. RESULTS: Our results showed that 28 amino acid substitutions have accumulated in the HA1 region since the circulation of A/New Caledonia/20/99-like viruses in France. Of these, fifteen were located in four antigenic sites (B, C, D and E). Six of them were observed only in the A H1N2 isolates, six only in the A H1N1 isolates and three in both subtypes. Furthermore, nine of twenty two A H1N2 isolates from the winter of 2002-2003 shared a T90A amino acid change which has not been observed in any A H1N1 isolate; resulting in the introduction of a new glycosylation site close to the antigenic site E. This might mask some antigenic E determinants and therefore, modify the A H1N2 antigenicity. CONCLUSIONS: The divergent genetic evolution of hemagglutinin may ultimately lead to a significant different antigenicity between A H1N1 and A H1N2 subtypes that would require the introduction of a new subtype in the vaccine batches.
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Hal:hal-00125068Le document en format XML
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<author><name sortKey="Lina, B" sort="Lina, B" uniqKey="Lina B" first="B." last="Lina">B. Lina</name>
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<front><div type="abstract" xml:lang="en"> <p>BACKGROUND: Influenza A viruses are divided into subtypes based on their hemagglutinin (H1 to H15) and neuraminidase (N1 to N9) glycoproteins. Of these, three A subtypes H1N1, H3N2 and H1N2 circulate in the human population. Influenza A viruses display a high antigenic variability called "antigenic drift" which allows the virus to escape antibody neutralization. OBJECTIVES: Evaluate the mutations apparition that might predict a divergent antigenic evolution of hemagglutinin in influenza A H1N1 and A H1N2 viruses. STUDY DESIGN: During the three winters of 2001-2002 to 2003-2004, 58 A H1N1 and 23 A H1N2 subtypes have been isolated from patients with influenza-like illness in the south of France. The HA1 region was analyzed by RT-PCR and subsequently sequenced to compare the HA1 genetic evolution of influenza A H1N1 and A H1N2 subtypes. RESULTS: Our results showed that 28 amino acid substitutions have accumulated in the HA1 region since the circulation of A/New Caledonia/20/99-like viruses in France. Of these, fifteen were located in four antigenic sites (B, C, D and E). Six of them were observed only in the A H1N2 isolates, six only in the A H1N1 isolates and three in both subtypes. Furthermore, nine of twenty two A H1N2 isolates from the winter of 2002-2003 shared a T90A amino acid change which has not been observed in any A H1N1 isolate; resulting in the introduction of a new glycosylation site close to the antigenic site E. This might mask some antigenic E determinants and therefore, modify the A H1N2 antigenicity. CONCLUSIONS: The divergent genetic evolution of hemagglutinin may ultimately lead to a significant different antigenicity between A H1N1 and A H1N2 subtypes that would require the introduction of a new subtype in the vaccine batches.</p>
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<hal api="V3"> <titleStmt> <title xml:lang="en">Divergent genetic evolution of hemagglutinin in influenza A H1N1 and A H1N2 subtypes isolated in the south-France since the winter of 2001-2002.</title>
<author role="aut"> <persName> <forename type="first">S.</forename>
<surname>Al Faress</surname>
</persName>
<idno type="halauthorid">158318</idno>
<affiliation ref="#struct-714"></affiliation>
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<author role="aut"> <persName> <forename type="first">G.</forename>
<surname>Cartet</surname>
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<idno type="halauthorid">158319</idno>
<affiliation ref="#struct-714"></affiliation>
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<author role="aut"> <persName> <forename type="first">O.</forename>
<surname>Ferraris</surname>
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<idno type="halauthorid">157038</idno>
<affiliation ref="#struct-714"></affiliation>
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<author role="aut"> <persName> <forename type="first">H.</forename>
<surname>Norder</surname>
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<idno type="halauthorid">155217</idno>
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</author>
<author role="aut"> <persName> <forename type="first">M.</forename>
<surname>Valette</surname>
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<idno type="halauthorid">155263</idno>
<affiliation ref="#struct-714"></affiliation>
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<author role="crp"> <persName> <forename type="first">B.</forename>
<surname>Lina</surname>
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<email type="md5">dd510e30bc5b7784041e5bfdd42d0574</email>
<email type="domain">univ-lyon1.fr</email>
<idno type="halauthorid">158320</idno>
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<editor role="depositor"> <persName> <forename>Bertrand</forename>
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<email type="domain">sante.univ-lyon1.fr</email>
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<funder>We thank all members who participated in National In- fluenza Surveillance in the south-France for their contribution by isolating and supplying viruses. We are also grateful to A. Hay and Yi-Pu Lin, National Institute for Medical Research, London, UK, for providing the primer sequences for the identification of AH1 isolates.</funder>
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<name key="114260"> <persName> <forename>Bertrand</forename>
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<abstract xml:lang="en"> <p>BACKGROUND: Influenza A viruses are divided into subtypes based on their hemagglutinin (H1 to H15) and neuraminidase (N1 to N9) glycoproteins. Of these, three A subtypes H1N1, H3N2 and H1N2 circulate in the human population. Influenza A viruses display a high antigenic variability called "antigenic drift" which allows the virus to escape antibody neutralization. OBJECTIVES: Evaluate the mutations apparition that might predict a divergent antigenic evolution of hemagglutinin in influenza A H1N1 and A H1N2 viruses. STUDY DESIGN: During the three winters of 2001-2002 to 2003-2004, 58 A H1N1 and 23 A H1N2 subtypes have been isolated from patients with influenza-like illness in the south of France. The HA1 region was analyzed by RT-PCR and subsequently sequenced to compare the HA1 genetic evolution of influenza A H1N1 and A H1N2 subtypes. RESULTS: Our results showed that 28 amino acid substitutions have accumulated in the HA1 region since the circulation of A/New Caledonia/20/99-like viruses in France. Of these, fifteen were located in four antigenic sites (B, C, D and E). Six of them were observed only in the A H1N2 isolates, six only in the A H1N1 isolates and three in both subtypes. Furthermore, nine of twenty two A H1N2 isolates from the winter of 2002-2003 shared a T90A amino acid change which has not been observed in any A H1N1 isolate; resulting in the introduction of a new glycosylation site close to the antigenic site E. This might mask some antigenic E determinants and therefore, modify the A H1N2 antigenicity. CONCLUSIONS: The divergent genetic evolution of hemagglutinin may ultimately lead to a significant different antigenicity between A H1N1 and A H1N2 subtypes that would require the introduction of a new subtype in the vaccine batches.</p>
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