2015/16 I-MOVE/I-MOVE+ multicentre case-control study in Europe: Moderate vaccine effectiveness estimates against influenza A(H1N1)pdm09 and low estimates against lineage-mismatched influenza B among children
Identifieur interne : 000003 ( Hal/Corpus ); précédent : 000002; suivant : 0000042015/16 I-MOVE/I-MOVE+ multicentre case-control study in Europe: Moderate vaccine effectiveness estimates against influenza A(H1N1)pdm09 and low estimates against lineage-mismatched influenza B among children
Auteurs : Esther Kissling ; Marta Valenciano ; Francisco Pozo ; Ana-Maria Vilcu ; Annicka Reuss ; Caterina Rizzo ; Amparo Larrauri ; Judit Krisztina Horváth ; Mia Brytting ; Lisa Domegan ; Monika Korczy Ska ; Adam Meijer ; Ausenda Machado ; Alina Ivanciuc ; Vesna Višekruna Vu Ina ; Sylvie Van Der Werf ; Brunhilde Schweiger ; Antonino Bella ; Alin Gherasim ; Annamária Ferenczi ; Katherina Zakikhany ; Joan O Onnell ; Iwona Paradowska-Stankiewicz ; Frederika Dijkstra ; Raquel Guiomar ; Mihaela Lazar ; Sanja Kure I Filipovi ; Kari Johansen ; Alain MorenSource :
- Influenza and Other Respiratory Viruses [ 1750-2640 ] ; 2018.
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Abstract
BACKGROUND: During the 2015/16 influenza season in Europe, the cocirculating influenza viruses were A(H1N1)pdm09 and B/Victoria, which was antigenically distinct from the B/Yamagata component in the trivalent influenza vaccine.METHODS: We used the test-negative design in a multicentre case-control study in twelve European countries to measure 2015/16 influenza vaccine effectiveness (VE) against medically attended influenza-like illness (ILI) laboratory-confirmed as influenza. General practitioners swabbed a systematic sample of consulting ILI patients and a random sample of influenza-positive swabs was sequenced. We calculated adjusted VE against influenza A(H1N1)pdm09, A(H1N1)pdm09 genetic group 6B.1 and influenza B overall and by age group.RESULTS: We included 11 430 ILI patients, of which 2272 were influenza A(H1N1)pdm09 and 2901 were influenza B cases. Overall VE against influenza A(H1N1)pdm09 was 32.9% (95% CI: 15.5-46.7). Among those aged 0-14, 15-64 and ≥65 years, VE against A(H1N1)pdm09 was 31.9% (95% CI: -32.3 to 65.0), 41.4% (95% CI: 20.5-56.7) and 13.2% (95% CI: -38.0 to 45.3), respectively. Overall VE against influenza A(H1N1)pdm09 genetic group 6B.1 was 32.8% (95% CI: -4.1 to 56.7). Among those aged 0-14, 15-64 and ≥65 years, VE against influenza B was -47.6% (95% CI: -124.9 to 3.1), 27.3% (95% CI: -4.6 to 49.4) and 9.3% (95% CI: -44.1 to 42.9), respectively.CONCLUSIONS: Vaccine effectiveness (VE) against influenza A(H1N1)pdm09 and its genetic group 6B.1 was moderate in children and adults, and low among individuals ≥65 years. Vaccine effectiveness (VE) against influenza B was low and heterogeneous among age groups. More information on effects of previous vaccination and previous infection is needed to understand the VE results against influenza B in the context of a mismatched vaccine.
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DOI: 10.1111/irv.12520
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Hal:hal-02102565Le document en format XML
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CIBERNED. Carlos III Institute of Health, Madrid</orgName> <desc> <address> <country key="ES"></country> </address> </desc> <listRelation> <relation active="#struct-301916" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-301916" type="direct"><org type="institution" xml:id="struct-301916" status="VALID"> <orgName>CIBER de Enfermedades Neurodegenerativas (CIBERNED)</orgName> <desc> <address> <country key="ES"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Ferenczi, Annamaria" sort="Ferenczi, Annamaria" uniqKey="Ferenczi A" first="Annamária" last="Ferenczi">Annamária Ferenczi</name><affiliation><hal:affiliation type="institution" xml:id="struct-1003256" status="INCOMING"> <orgName>National Centre for Epidemiology [Budapest]</orgName> <desc> <address> <country key="HU"></country> </address> </desc> </hal:affiliation></affiliation></author><author><name sortKey="Zakikhany, Katherina" sort="Zakikhany, Katherina" uniqKey="Zakikhany K" first="Katherina" last="Zakikhany">Katherina Zakikhany</name><affiliation><hal:affiliation type="institution" xml:id="struct-455778" status="VALID"> <orgName>Public Health Agency of Sweden</orgName> <desc> <address> <addrLine>Solna</addrLine> <country key="SE"></country> </address> </desc> </hal:affiliation></affiliation></author><author><name sortKey="O Onnell, Joan" sort="O Onnell, Joan" uniqKey="O Onnell J" first="Joan" last="O Onnell">Joan O Onnell</name><affiliation><hal:affiliation type="institution" xml:id="struct-343970" status="VALID"> <orgName>Health Protection Surveillance Centre</orgName> <orgName type="acronym">HPSC</orgName> <desc> <address> <addrLine>25-27 Middle Gardiner St, Dublin 1 Ireland</addrLine> <country key="IE"></country> </address> <ref type="url">https://www.hpsc.ie/</ref> </desc> </hal:affiliation></affiliation></author><author><name sortKey="Paradowska Stankiewicz, Iwona" sort="Paradowska Stankiewicz, Iwona" uniqKey="Paradowska Stankiewicz I" first="Iwona" last="Paradowska-Stankiewicz">Iwona Paradowska-Stankiewicz</name><affiliation><hal:affiliation type="institution" xml:id="struct-507010" status="INCOMING"> <orgName>National Institute of Public Health – National Institute of Hygiene [Varsovie]</orgName> <desc> <address> <addrLine>Varsovie</addrLine> <country key="PL"></country> </address> </desc> </hal:affiliation></affiliation></author><author><name sortKey="Dijkstra, Frederika" sort="Dijkstra, Frederika" uniqKey="Dijkstra F" first="Frederika" last="Dijkstra">Frederika Dijkstra</name><affiliation><hal:affiliation type="institution" xml:id="struct-453112" status="VALID"> <orgName>National Institute for Public Health and the Environment [Bilthoven]</orgName> <orgName type="acronym">RIVM</orgName> <desc> <address> <addrLine>Antonie van Leeuwenhoeklaan 9, 3721 MA, Bilthoven / PO Box 1, 3720 BA Bilthoven</addrLine> <country key="NL"></country> </address> <ref type="url">http://www.rivm.nl/en</ref> </desc> </hal:affiliation></affiliation></author><author><name sortKey="Guiomar, Raquel" sort="Guiomar, Raquel" uniqKey="Guiomar R" first="Raquel" last="Guiomar">Raquel Guiomar</name><affiliation><hal:affiliation type="institution" xml:id="struct-310652" status="VALID"> <orgName>Instituto Nacional de Saùde Dr Ricardo Jorge [Portugal]</orgName> <orgName type="acronym">INSA</orgName> <desc> <address> <addrLine>Lisboa</addrLine> <country key="PT"></country> </address> <ref type="url">http://www.insa.pt/</ref> </desc> </hal:affiliation></affiliation></author><author><name sortKey="Lazar, Mihaela" sort="Lazar, Mihaela" uniqKey="Lazar M" first="Mihaela" last="Lazar">Mihaela Lazar</name><affiliation><hal:affiliation type="institution" xml:id="struct-344082" status="VALID"> <orgName>Cantacuzino Institute [Romania]</orgName> <desc> <address> <addrLine>103, Spl. Independentei, sector 5, 050096 Bucarest, Romania</addrLine> <country key="RO"></country> </address> <ref type="url">https://www.cantacuzino.ro/</ref> </desc> <listRelation> <relation active="#struct-301247" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-301247" type="direct"><org type="regroupinstitution" xml:id="struct-301247" status="VALID"> <orgName>Réseau International des Instituts Pasteur</orgName> <orgName type="acronym">RIIP</orgName> <desc> <address> <addrLine>25, rue du Dr Roux 75724 Paris Cedex 15</addrLine> <country key="FR"></country> </address> <ref type="url">https://research.pasteur.fr/ip-network</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Kure I Filipovi, Sanja" sort="Kure I Filipovi, Sanja" uniqKey="Kure I Filipovi S" first="Sanja" last="Kure I Filipovi">Sanja Kure I Filipovi</name><affiliation><hal:affiliation type="institution" xml:id="struct-521164" status="VALID"> <orgName>Croatian Institute of Public Health [Zagreb]</orgName> <orgName type="acronym">CIPH</orgName> <desc> <address> <addrLine>Rockefeller str. 7, 10000 Zagreb</addrLine> <country key="HR"></country> </address> <ref type="url">https://www.hzjz.hr/en/directorate/croatian-institute-of-public-health/</ref> </desc> </hal:affiliation></affiliation></author><author><name sortKey="Johansen, Kari" sort="Johansen, Kari" uniqKey="Johansen K" first="Kari" last="Johansen">Kari Johansen</name><affiliation><hal:affiliation type="institution" xml:id="struct-339705" status="VALID"> <orgName>European Centre for Disease Prevention and Control</orgName> <orgName type="acronym">ECDC</orgName> <desc> <address> <addrLine>Stokholm</addrLine> <country key="SE"></country> </address> </desc> </hal:affiliation></affiliation></author><author><name sortKey="Moren, Alain" sort="Moren, Alain" uniqKey="Moren A" first="Alain" last="Moren">Alain Moren</name><affiliation><hal:affiliation type="institution" xml:id="struct-534644" status="INCOMING"> <orgName>EpiConcept [Paris]</orgName> <desc> <address> <addrLine>Paris.</addrLine> <country key="FR"></country> </address> </desc> </hal:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">HAL</idno><idno type="RBID">Hal:hal-02102565</idno><idno type="halId">hal-02102565</idno><idno type="halUri">https://hal.sorbonne-universite.fr/hal-02102565</idno><idno type="url">https://hal.sorbonne-universite.fr/hal-02102565</idno><idno type="doi">10.1111/irv.12520</idno><date when="2018">2018</date><idno type="wicri:Area/Hal/Corpus">000003</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">2015/16 I-MOVE/I-MOVE+ multicentre case-control study in Europe: Moderate vaccine effectiveness estimates against influenza A(H1N1)pdm09 and low estimates against lineage-mismatched influenza B among children</title><author><name sortKey="Kissling, Esther" sort="Kissling, Esther" uniqKey="Kissling E" first="Esther" last="Kissling">Esther Kissling</name><affiliation><hal:affiliation type="institution" xml:id="struct-534644" status="INCOMING"> <orgName>EpiConcept [Paris]</orgName> <desc> <address> <addrLine>Paris.</addrLine> <country key="FR"></country> </address> </desc> </hal:affiliation></affiliation></author><author><name sortKey="Valenciano, Marta" sort="Valenciano, Marta" uniqKey="Valenciano M" first="Marta" last="Valenciano">Marta Valenciano</name><affiliation><hal:affiliation type="institution" xml:id="struct-534644" status="INCOMING"> <orgName>EpiConcept [Paris]</orgName> <desc> <address> <addrLine>Paris.</addrLine> <country key="FR"></country> </address> </desc> </hal:affiliation></affiliation></author><author><name sortKey="Pozo, Francisco" sort="Pozo, Francisco" uniqKey="Pozo F" first="Francisco" last="Pozo">Francisco Pozo</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-1003254" status="INCOMING"> <orgName>National Centre for Microbiology [Madrid]</orgName> <desc> <address> <country key="ES"></country> </address> </desc> <listRelation> <relation active="#struct-308343" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-308343" type="direct"><org type="institution" xml:id="struct-308343" status="VALID"> <orgName>Instituto de Salud Carlos III</orgName> <orgName type="acronym">ISC</orgName> <desc> <address> <addrLine> Carretera de Majadahonda - Pozuelo, 28220 Majadahonda, Madrid, Espagne</addrLine> <country key="ES"></country> </address> <ref type="url">http://www.isciii.es/</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Vilcu, Ana Maria" sort="Vilcu, Ana Maria" uniqKey="Vilcu A" first="Ana-Maria" last="Vilcu">Ana-Maria Vilcu</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-542132" status="VALID"> <idno type="RNSR">201420917E</idno> <orgName>Institut Pierre Louis d'Epidémiologie et de Santé Publique</orgName> <orgName type="acronym">iPLESP</orgName> <desc> <address> <addrLine>56, boulevard Vincent Auriol - CS 81393 - 75646 Paris Cedex 13</addrLine> <country key="FR"></country> </address> <ref type="url">https://www.iplesp.upmc.fr/</ref> </desc> <listRelation> <relation name="U1136" active="#struct-303623" type="direct"></relation> <relation active="#struct-413221" type="direct"></relation> </listRelation> <tutelles><tutelle name="U1136" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc> </org></tutelle><tutelle active="#struct-413221" type="direct"><org type="institution" xml:id="struct-413221" status="VALID"> <orgName>Sorbonne Université</orgName> <orgName type="acronym">SU</orgName> <date type="start">2018-01-01</date> <desc> <address> <addrLine>21 rue de l’École de médecine - 75006 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.sorbonne-universite.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Reuss, Annicka" sort="Reuss, Annicka" uniqKey="Reuss A" first="Annicka" last="Reuss">Annicka Reuss</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-1003255" status="INCOMING"> <orgName>Department for Infectious Disease Epidemiology [Berlin]</orgName> <desc> <address> <addrLine>Berlin</addrLine> <country key="DE"></country> </address> </desc> <listRelation> <relation active="#struct-478253" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-478253" type="direct"><org type="institution" xml:id="struct-478253" status="VALID"> <orgName>Robert Koch Institute [Berlin]</orgName> <orgName type="acronym">RKI</orgName> <desc> <address> <addrLine>Nordufer 20, 13353 Berlin, Germany</addrLine> <country key="DE"></country> </address> <ref type="url">http://www.rki.de/EN/Home/homepage_node.html</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Rizzo, Caterina" sort="Rizzo, Caterina" uniqKey="Rizzo C" first="Caterina" last="Rizzo">Caterina Rizzo</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-480496" status="INCOMING"> <orgName>Department of Infectious Diseases [Rome, Italy]</orgName> <desc> <address> <country key="IT"></country> </address> </desc> <listRelation> <relation active="#struct-480495" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-480495" type="direct"><org type="institution" xml:id="struct-480495" status="INCOMING"> <orgName>Istituto Superiore di Sanita</orgName> <desc> <address> <addrLine>Rome</addrLine> <country key="IT"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Larrauri, Amparo" sort="Larrauri, Amparo" uniqKey="Larrauri A" first="Amparo" last="Larrauri">Amparo Larrauri</name><affiliation><hal:affiliation type="institution" xml:id="struct-301929" status="VALID"> <orgName>CIBER de Epidemiología y Salud Pública (CIBERESP)</orgName> <desc> <address> <addrLine>Madrid </addrLine> <country key="ES"></country> </address> </desc> </hal:affiliation></affiliation></author><author><name sortKey="Horvath, Judit Krisztina" sort="Horvath, Judit Krisztina" uniqKey="Horvath J" first="Judit Krisztina" last="Horváth">Judit Krisztina Horváth</name><affiliation><hal:affiliation type="institution" xml:id="struct-1003256" status="INCOMING"> <orgName>National Centre for Epidemiology [Budapest]</orgName> <desc> <address> <country key="HU"></country> </address> </desc> </hal:affiliation></affiliation></author><author><name sortKey="Brytting, Mia" sort="Brytting, Mia" uniqKey="Brytting M" first="Mia" last="Brytting">Mia Brytting</name><affiliation><hal:affiliation type="institution" xml:id="struct-455778" status="VALID"> <orgName>Public Health Agency of Sweden</orgName> <desc> <address> <addrLine>Solna</addrLine> <country key="SE"></country> </address> </desc> </hal:affiliation></affiliation></author><author><name sortKey="Domegan, Lisa" sort="Domegan, Lisa" uniqKey="Domegan L" first="Lisa" last="Domegan">Lisa Domegan</name><affiliation><hal:affiliation type="institution" xml:id="struct-343970" status="VALID"> <orgName>Health Protection Surveillance Centre</orgName> <orgName type="acronym">HPSC</orgName> <desc> <address> <addrLine>25-27 Middle Gardiner St, Dublin 1 Ireland</addrLine> <country key="IE"></country> </address> <ref type="url">https://www.hpsc.ie/</ref> </desc> </hal:affiliation></affiliation></author><author><name sortKey="Korczy Ska, Monika" sort="Korczy Ska, Monika" uniqKey="Korczy Ska M" first="Monika" last="Korczy Ska">Monika Korczy Ska</name><affiliation><hal:affiliation type="institution" xml:id="struct-507010" status="INCOMING"> <orgName>National Institute of Public Health – National Institute of Hygiene [Varsovie]</orgName> <desc> <address> <addrLine>Varsovie</addrLine> <country key="PL"></country> </address> </desc> </hal:affiliation></affiliation></author><author><name sortKey="Meijer, Adam" sort="Meijer, Adam" uniqKey="Meijer A" first="Adam" last="Meijer">Adam Meijer</name><affiliation><hal:affiliation type="institution" xml:id="struct-453112" status="VALID"> <orgName>National Institute for Public Health and the Environment [Bilthoven]</orgName> <orgName type="acronym">RIVM</orgName> <desc> <address> <addrLine>Antonie van Leeuwenhoeklaan 9, 3721 MA, Bilthoven / PO Box 1, 3720 BA Bilthoven</addrLine> <country key="NL"></country> </address> <ref type="url">http://www.rivm.nl/en</ref> </desc> </hal:affiliation></affiliation></author><author><name sortKey="Machado, Ausenda" sort="Machado, Ausenda" uniqKey="Machado A" first="Ausenda" last="Machado">Ausenda Machado</name><affiliation><hal:affiliation type="institution" xml:id="struct-511550" status="VALID"> <orgName>Instituto Nacional de Saúde Doutor Ricardo Jorge [Lisboa]</orgName> <desc> <address> <country key="PT"></country> </address> </desc> </hal:affiliation></affiliation></author><author><name sortKey="Ivanciuc, Alina" sort="Ivanciuc, Alina" uniqKey="Ivanciuc A" first="Alina" last="Ivanciuc">Alina Ivanciuc</name><affiliation><hal:affiliation type="institution" xml:id="struct-344082" status="VALID"> <orgName>Cantacuzino Institute [Romania]</orgName> <desc> <address> <addrLine>103, Spl. Independentei, sector 5, 050096 Bucarest, Romania</addrLine> <country key="RO"></country> </address> <ref type="url">https://www.cantacuzino.ro/</ref> </desc> <listRelation> <relation active="#struct-301247" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-301247" type="direct"><org type="regroupinstitution" xml:id="struct-301247" status="VALID"> <orgName>Réseau International des Instituts Pasteur</orgName> <orgName type="acronym">RIIP</orgName> <desc> <address> <addrLine>25, rue du Dr Roux 75724 Paris Cedex 15</addrLine> <country key="FR"></country> </address> <ref type="url">https://research.pasteur.fr/ip-network</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Visekruna Vu Ina, Vesna" sort="Visekruna Vu Ina, Vesna" uniqKey="Visekruna Vu Ina V" first="Vesna" last="Višekruna Vu Ina">Vesna Višekruna Vu Ina</name><affiliation><hal:affiliation type="institution" xml:id="struct-521164" status="VALID"> <orgName>Croatian Institute of Public Health [Zagreb]</orgName> <orgName type="acronym">CIPH</orgName> <desc> <address> <addrLine>Rockefeller str. 7, 10000 Zagreb</addrLine> <country key="HR"></country> </address> <ref type="url">https://www.hzjz.hr/en/directorate/croatian-institute-of-public-health/</ref> </desc> </hal:affiliation></affiliation></author><author><name sortKey="Van Der Werf, Sylvie" sort="Van Der Werf, Sylvie" uniqKey="Van Der Werf S" first="Sylvie" last="Van Der Werf">Sylvie Van Der Werf</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-525918" status="OLD"> <idno type="RNSR">200818198A</idno> <orgName>Génétique moléculaire des virus à ARN</orgName> <orgName type="acronym">(U-Pasteur_ 2 / UMR_3569)</orgName> <date type="end">2019-12-31</date> <desc> <address> <addrLine>Institut Pasteur25-28 rue du Docteur ROUX75724 Paris Cedex 15</addrLine> <country key="FR"></country> </address> <ref type="url">https://www.pasteur.fr/fr/sante-publique/centres-nationaux-reference/cnr/virus-infections-respiratoires-dont-grippe</ref> </desc> <listRelation> <relation active="#struct-300027" type="direct"></relation> <relation name="U-Pasteur_ 2" active="#struct-300301" type="direct"></relation> <relation name="UMR_3569" active="#struct-441569" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300027" type="direct"><org type="institution" xml:id="struct-300027" status="VALID"> <idno type="IdRef">027936643</idno> <idno type="ISNI">0000 0001 2353 6535</idno> <orgName>Institut Pasteur [Paris]</orgName> <date type="start">1887-06-04</date> <desc> <address> <addrLine>25-28, rue du docteur Roux, 75724 Paris cedex 15</addrLine> <country key="FR"></country> </address> <ref type="url">https://www.pasteur.fr</ref> </desc> </org></tutelle><tutelle name="U-Pasteur_ 2" active="#struct-300301" type="direct"><org type="institution" xml:id="struct-300301" status="OLD"> <idno type="ISNI">0000000121514068</idno> <idno type="IdRef">027542084</idno> <orgName>Université Paris Diderot - Paris 7</orgName> <orgName type="acronym">UPD7</orgName> <date type="end">2019-12-31</date> <desc> <address> <addrLine>5 rue Thomas-Mann - 75205 Paris cedex 13</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-paris-diderot.fr</ref> </desc> </org></tutelle><tutelle name="UMR_3569" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno> <idno type="ISNI">0000000122597504</idno> <orgName>Centre National de la Recherche Scientifique</orgName> <orgName type="acronym">CNRS</orgName> <date type="start">1939-10-19</date> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://www.cnrs.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Schweiger, Brunhilde" sort="Schweiger, Brunhilde" uniqKey="Schweiger B" first="Brunhilde" last="Schweiger">Brunhilde Schweiger</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-1003257" status="INCOMING"> <orgName>National Reference Centre for Influenza [Berlin]</orgName> <desc> <address> <country key="DE"></country> </address> </desc> <listRelation> <relation active="#struct-478253" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-478253" type="direct"><org type="institution" xml:id="struct-478253" status="VALID"> <orgName>Robert Koch Institute [Berlin]</orgName> <orgName type="acronym">RKI</orgName> <desc> <address> <addrLine>Nordufer 20, 13353 Berlin, Germany</addrLine> <country key="DE"></country> </address> <ref type="url">http://www.rki.de/EN/Home/homepage_node.html</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Bella, Antonino" sort="Bella, Antonino" uniqKey="Bella A" first="Antonino" last="Bella">Antonino Bella</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-480496" status="INCOMING"> <orgName>Department of Infectious Diseases [Rome, Italy]</orgName> <desc> <address> <country key="IT"></country> </address> </desc> <listRelation> <relation active="#struct-480495" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-480495" type="direct"><org type="institution" xml:id="struct-480495" status="INCOMING"> <orgName>Istituto Superiore di Sanita</orgName> <desc> <address> <addrLine>Rome</addrLine> <country key="IT"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Gherasim, Alin" sort="Gherasim, Alin" uniqKey="Gherasim A" first="Alin" last="Gherasim">Alin Gherasim</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-140739" status="INCOMING"> <orgName>National Centre for Epidemiology. CIBERNED. Carlos III Institute of Health, Madrid</orgName> <desc> <address> <country key="ES"></country> </address> </desc> <listRelation> <relation active="#struct-301916" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-301916" type="direct"><org type="institution" xml:id="struct-301916" status="VALID"> <orgName>CIBER de Enfermedades Neurodegenerativas (CIBERNED)</orgName> <desc> <address> <country key="ES"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Ferenczi, Annamaria" sort="Ferenczi, Annamaria" uniqKey="Ferenczi A" first="Annamária" last="Ferenczi">Annamária Ferenczi</name><affiliation><hal:affiliation type="institution" xml:id="struct-1003256" status="INCOMING"> <orgName>National Centre for Epidemiology [Budapest]</orgName> <desc> <address> <country key="HU"></country> </address> </desc> </hal:affiliation></affiliation></author><author><name sortKey="Zakikhany, Katherina" sort="Zakikhany, Katherina" uniqKey="Zakikhany K" first="Katherina" last="Zakikhany">Katherina Zakikhany</name><affiliation><hal:affiliation type="institution" xml:id="struct-455778" status="VALID"> <orgName>Public Health Agency of Sweden</orgName> <desc> <address> <addrLine>Solna</addrLine> <country key="SE"></country> </address> </desc> </hal:affiliation></affiliation></author><author><name sortKey="O Onnell, Joan" sort="O Onnell, Joan" uniqKey="O Onnell J" first="Joan" last="O Onnell">Joan O Onnell</name><affiliation><hal:affiliation type="institution" xml:id="struct-343970" status="VALID"> <orgName>Health Protection Surveillance Centre</orgName> <orgName type="acronym">HPSC</orgName> <desc> <address> <addrLine>25-27 Middle Gardiner St, Dublin 1 Ireland</addrLine> <country key="IE"></country> </address> <ref type="url">https://www.hpsc.ie/</ref> </desc> </hal:affiliation></affiliation></author><author><name sortKey="Paradowska Stankiewicz, Iwona" sort="Paradowska Stankiewicz, Iwona" uniqKey="Paradowska Stankiewicz I" first="Iwona" last="Paradowska-Stankiewicz">Iwona Paradowska-Stankiewicz</name><affiliation><hal:affiliation type="institution" xml:id="struct-507010" status="INCOMING"> <orgName>National Institute of Public Health – National Institute of Hygiene [Varsovie]</orgName> <desc> <address> <addrLine>Varsovie</addrLine> <country key="PL"></country> </address> </desc> </hal:affiliation></affiliation></author><author><name sortKey="Dijkstra, Frederika" sort="Dijkstra, Frederika" uniqKey="Dijkstra F" first="Frederika" last="Dijkstra">Frederika Dijkstra</name><affiliation><hal:affiliation type="institution" xml:id="struct-453112" status="VALID"> <orgName>National Institute for Public Health and the Environment [Bilthoven]</orgName> <orgName type="acronym">RIVM</orgName> <desc> <address> <addrLine>Antonie van Leeuwenhoeklaan 9, 3721 MA, Bilthoven / PO Box 1, 3720 BA Bilthoven</addrLine> <country key="NL"></country> </address> <ref type="url">http://www.rivm.nl/en</ref> </desc> </hal:affiliation></affiliation></author><author><name sortKey="Guiomar, Raquel" sort="Guiomar, Raquel" uniqKey="Guiomar R" first="Raquel" last="Guiomar">Raquel Guiomar</name><affiliation><hal:affiliation type="institution" xml:id="struct-310652" status="VALID"> <orgName>Instituto Nacional de Saùde Dr Ricardo Jorge [Portugal]</orgName> <orgName type="acronym">INSA</orgName> <desc> <address> <addrLine>Lisboa</addrLine> <country key="PT"></country> </address> <ref type="url">http://www.insa.pt/</ref> </desc> </hal:affiliation></affiliation></author><author><name sortKey="Lazar, Mihaela" sort="Lazar, Mihaela" uniqKey="Lazar M" first="Mihaela" last="Lazar">Mihaela Lazar</name><affiliation><hal:affiliation type="institution" xml:id="struct-344082" status="VALID"> <orgName>Cantacuzino Institute [Romania]</orgName> <desc> <address> <addrLine>103, Spl. Independentei, sector 5, 050096 Bucarest, Romania</addrLine> <country key="RO"></country> </address> <ref type="url">https://www.cantacuzino.ro/</ref> </desc> <listRelation> <relation active="#struct-301247" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-301247" type="direct"><org type="regroupinstitution" xml:id="struct-301247" status="VALID"> <orgName>Réseau International des Instituts Pasteur</orgName> <orgName type="acronym">RIIP</orgName> <desc> <address> <addrLine>25, rue du Dr Roux 75724 Paris Cedex 15</addrLine> <country key="FR"></country> </address> <ref type="url">https://research.pasteur.fr/ip-network</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Kure I Filipovi, Sanja" sort="Kure I Filipovi, Sanja" uniqKey="Kure I Filipovi S" first="Sanja" last="Kure I Filipovi">Sanja Kure I Filipovi</name><affiliation><hal:affiliation type="institution" xml:id="struct-521164" status="VALID"> <orgName>Croatian Institute of Public Health [Zagreb]</orgName> <orgName type="acronym">CIPH</orgName> <desc> <address> <addrLine>Rockefeller str. 7, 10000 Zagreb</addrLine> <country key="HR"></country> </address> <ref type="url">https://www.hzjz.hr/en/directorate/croatian-institute-of-public-health/</ref> </desc> </hal:affiliation></affiliation></author><author><name sortKey="Johansen, Kari" sort="Johansen, Kari" uniqKey="Johansen K" first="Kari" last="Johansen">Kari Johansen</name><affiliation><hal:affiliation type="institution" xml:id="struct-339705" status="VALID"> <orgName>European Centre for Disease Prevention and Control</orgName> <orgName type="acronym">ECDC</orgName> <desc> <address> <addrLine>Stokholm</addrLine> <country key="SE"></country> </address> </desc> </hal:affiliation></affiliation></author><author><name sortKey="Moren, Alain" sort="Moren, Alain" uniqKey="Moren A" first="Alain" last="Moren">Alain Moren</name><affiliation><hal:affiliation type="institution" xml:id="struct-534644" status="INCOMING"> <orgName>EpiConcept [Paris]</orgName> <desc> <address> <addrLine>Paris.</addrLine> <country key="FR"></country> </address> </desc> </hal:affiliation></affiliation></author></analytic><idno type="DOI">10.1111/irv.12520</idno><series><title level="j">Influenza and Other Respiratory Viruses</title><idno type="ISSN">1750-2640</idno><imprint><date type="datePub">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="mix" xml:lang="en"><term>case-control study</term><term>case‐control study</term><term>influenza</term><term>influenza vaccine</term><term>multicentre study</term><term>vaccine effectiveness</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"> <p>BACKGROUND: During the 2015/16 influenza season in Europe, the cocirculating influenza viruses were A(H1N1)pdm09 and B/Victoria, which was antigenically distinct from the B/Yamagata component in the trivalent influenza vaccine.METHODS: We used the test-negative design in a multicentre case-control study in twelve European countries to measure 2015/16 influenza vaccine effectiveness (VE) against medically attended influenza-like illness (ILI) laboratory-confirmed as influenza. General practitioners swabbed a systematic sample of consulting ILI patients and a random sample of influenza-positive swabs was sequenced. We calculated adjusted VE against influenza A(H1N1)pdm09, A(H1N1)pdm09 genetic group 6B.1 and influenza B overall and by age group.RESULTS: We included 11 430 ILI patients, of which 2272 were influenza A(H1N1)pdm09 and 2901 were influenza B cases. Overall VE against influenza A(H1N1)pdm09 was 32.9% (95% CI: 15.5-46.7). Among those aged 0-14, 15-64 and ≥65 years, VE against A(H1N1)pdm09 was 31.9% (95% CI: -32.3 to 65.0), 41.4% (95% CI: 20.5-56.7) and 13.2% (95% CI: -38.0 to 45.3), respectively. Overall VE against influenza A(H1N1)pdm09 genetic group 6B.1 was 32.8% (95% CI: -4.1 to 56.7). Among those aged 0-14, 15-64 and ≥65 years, VE against influenza B was -47.6% (95% CI: -124.9 to 3.1), 27.3% (95% CI: -4.6 to 49.4) and 9.3% (95% CI: -44.1 to 42.9), respectively.CONCLUSIONS: Vaccine effectiveness (VE) against influenza A(H1N1)pdm09 and its genetic group 6B.1 was moderate in children and adults, and low among individuals ≥65 years. Vaccine effectiveness (VE) against influenza B was low and heterogeneous among age groups. More information on effects of previous vaccination and previous infection is needed to understand the VE results against influenza B in the context of a mismatched vaccine.</p> </div></front></TEI><hal api="V3"> <titleStmt> <title xml:lang="en">2015/16 I-MOVE/I-MOVE+ multicentre case-control study in Europe: Moderate vaccine effectiveness estimates against influenza A(H1N1)pdm09 and low estimates against lineage-mismatched influenza B among children</title> <author role="aut"> <persName> <forename type="first">Esther</forename> <surname>Kissling</surname> </persName> <idno type="halauthorid">1626879</idno> <affiliation ref="#struct-534644"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Marta</forename> <surname>Valenciano</surname> </persName> <idno type="halauthorid">1626880</idno> <affiliation ref="#struct-534644"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Francisco</forename> <surname>Pozo</surname> </persName> <idno type="halauthorid">638445</idno> <affiliation ref="#struct-1003254"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Ana-Maria</forename> <surname>Vilcu</surname> </persName> <idno type="halauthorid">1607342</idno> <affiliation ref="#struct-542132"></affiliation> <affiliation ref="#struct-413221"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Annicka</forename> <surname>Reuss</surname> </persName> <idno type="halauthorid">1626881</idno> <affiliation ref="#struct-1003255"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Caterina</forename> <surname>Rizzo</surname> </persName> <email type="md5">d1599be641b7fd7a7e3bb382739b2f60</email> <email type="domain">iss.it</email> <idno type="halauthorid">1015661</idno> <affiliation ref="#struct-480496"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Amparo</forename> <surname>Larrauri</surname> </persName> <idno type="halauthorid">1626882</idno> <affiliation ref="#struct-301929"></affiliation> <affiliation ref="#struct-140739"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Judit Krisztina</forename> <surname>Horváth</surname> </persName> <idno type="halauthorid">1626890</idno> <affiliation ref="#struct-1003256"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Mia</forename> <surname>Brytting</surname> </persName> <idno type="halauthorid">11140924</idno> <affiliation ref="#struct-455778"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Lisa</forename> <surname>Domegan</surname> </persName> <idno type="halauthorid">1626886</idno> <affiliation ref="#struct-343970"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Monika</forename> <surname>Korczyńska</surname> </persName> <idno type="halauthorid">1626893</idno> <affiliation ref="#struct-507010"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Adam</forename> <surname>Meijer</surname> </persName> <email type="md5">220ec4279ea5f763d36b7b8b676e8d60</email> <email type="domain">rivm.nl</email> <idno type="halauthorid">400978</idno> <affiliation ref="#struct-453112"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Ausenda</forename> <surname>Machado</surname> </persName> <idno type="halauthorid">1626884</idno> <affiliation ref="#struct-511550"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Alina</forename> <surname>Ivanciuc</surname> </persName> <idno type="halauthorid">11462996</idno> <affiliation ref="#struct-344082"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Vesna</forename> <surname>Višekruna Vučina</surname> </persName> <idno type="halauthorid">11462997</idno> <affiliation ref="#struct-521164"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Sylvie</forename> <surname>Van Der Werf</surname> </persName> <idno type="halauthorid">202082</idno> <affiliation ref="#struct-525918"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Brunhilde</forename> <surname>Schweiger</surname> </persName> <idno type="halauthorid">400982</idno> <affiliation ref="#struct-1003257"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Antonino</forename> <surname>Bella</surname> </persName> <idno type="halauthorid">941308</idno> <affiliation ref="#struct-480496"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Alin</forename> <surname>Gherasim</surname> </persName> <idno type="halauthorid">1626889</idno> <affiliation ref="#struct-140739"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Annamária</forename> <surname>Ferenczi</surname> </persName> <idno type="halauthorid">1664150</idno> <affiliation ref="#struct-1003256"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Katherina</forename> <surname>Zakikhany</surname> </persName> <idno type="halauthorid">11377436</idno> <affiliation ref="#struct-455778"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Joan</forename> <surname>O′Donnell</surname> </persName> <idno type="halauthorid">11462998</idno> <affiliation ref="#struct-343970"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Iwona</forename> <surname>Paradowska-Stankiewicz</surname> </persName> <idno type="halauthorid">1626887</idno> <affiliation ref="#struct-507010"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Frederika</forename> <surname>Dijkstra</surname> </persName> <idno type="halauthorid">11462999</idno> <affiliation ref="#struct-453112"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Raquel</forename> <surname>Guiomar</surname> </persName> <idno type="halauthorid">1714425</idno> <affiliation ref="#struct-310652"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Mihaela</forename> <surname>Lazar</surname> </persName> <idno type="halauthorid">11463000</idno> <affiliation ref="#struct-344082"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Sanja</forename> <surname>Kurečić Filipović</surname> </persName> <idno type="halauthorid">11463001</idno> <affiliation ref="#struct-521164"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Kari</forename> <surname>Johansen</surname> </persName> <idno type="halauthorid">11463002</idno> <affiliation ref="#struct-339705"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Alain</forename> <surname>Moren</surname> </persName> <idno type="halauthorid">1626894</idno> <affiliation ref="#struct-534644"></affiliation> </author> <editor role="depositor"> <persName> <forename>Gestionnaire</forename> <surname>HAL-SU</surname> </persName> <email type="md5">20ce03d813b4e6b0eba84db23565c63b</email> <email type="domain">sorbonne-universite.fr</email> </editor> </titleStmt> <editionStmt> <edition n="v1" type="current"> <date type="whenSubmitted">2019-04-17 14:48:08</date> <date type="whenModified">2020-03-27 03:46:35</date> <date type="whenReleased">2019-04-17 15:00:59</date> <date type="whenProduced">2018</date> <date type="whenEndEmbargoed">2019-04-17</date> <ref type="file" target="https://hal.sorbonne-universite.fr/hal-02102565/document"> <date notBefore="2019-04-17"></date> </ref> <ref type="file" subtype="publisherPaid" n="1" target="https://hal.sorbonne-universite.fr/hal-02102565/file/Kissling_et_al-2018-Influenza_and_Other_Respiratory_Viruses.pdf"> <date notBefore="2019-04-17"></date> </ref> <ref type="externalLink" target="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6005601/pdf"></ref> </edition> <respStmt> <resp>contributor</resp> <name key="662159"> <persName> <forename>Gestionnaire</forename> <surname>HAL-SU</surname> </persName> <email type="md5">20ce03d813b4e6b0eba84db23565c63b</email> <email type="domain">sorbonne-universite.fr</email> </name> </respStmt> </editionStmt> <publicationStmt> <distributor>CCSD</distributor> <idno type="halId">hal-02102565</idno> <idno type="halUri">https://hal.sorbonne-universite.fr/hal-02102565</idno> <idno type="halBibtex">kissling:hal-02102565</idno> <idno type="halRefHtml">Influenza and Other Respiratory Viruses, Wiley Open Access, 2018, 12 (4), pp.423-437. ⟨10.1111/irv.12520⟩</idno> <idno type="halRef">Influenza and Other Respiratory Viruses, Wiley Open Access, 2018, 12 (4), pp.423-437. ⟨10.1111/irv.12520⟩</idno> </publicationStmt> <seriesStmt> <idno type="stamp" n="SORBONNE-UNIVERSITE">Sorbonne Université</idno> <idno type="stamp" n="SANTE_PUB_INSERM" corresp="INSERM">Santé Publique à l'Inserm</idno> <idno type="stamp" n="RIIP">Institut Pasteur RIIP (Réseau International)</idno> <idno type="stamp" n="SORBONNE-UNIV" corresp="SORBONNE-UNIVERSITE">Sorbonne Université 01/01/2018</idno> <idno type="stamp" n="IPLESP" corresp="SORBONNE-UNIVERSITE">Institut Pierre Louis d'Epidémiologie et de Santé Publique</idno> <idno type="stamp" n="SU-MEDECINE" corresp="SORBONNE-UNIVERSITE">Faculté de Médecine de Sorbonne Université</idno> <idno type="stamp" n="PASTEUR">Institut Pasteur</idno> <idno type="stamp" n="RIIP_PARIS">Institut Pasteur de Paris</idno> <idno type="stamp" n="UNIV-PARIS7" corresp="UNIV-PARIS">Université Denis Diderot - Paris VII</idno> <idno type="stamp" n="USPC">Université Sorbonne Paris Cité</idno> <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno> <idno type="stamp" n="UNIV-PARIS">Université de Paris</idno> </seriesStmt> <notesStmt> <note type="audience" n="2">International</note> <note type="popular" n="0">No</note> <note type="peer" n="1">Yes</note> </notesStmt> <sourceDesc> <biblStruct> <analytic> <title xml:lang="en">2015/16 I-MOVE/I-MOVE+ multicentre case-control study in Europe: Moderate vaccine effectiveness estimates against influenza A(H1N1)pdm09 and low estimates against lineage-mismatched influenza B among children</title> <author role="aut"> <persName> <forename type="first">Esther</forename> <surname>Kissling</surname> </persName> <idno type="halauthorid">1626879</idno> <affiliation ref="#struct-534644"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Marta</forename> <surname>Valenciano</surname> </persName> <idno type="halauthorid">1626880</idno> <affiliation ref="#struct-534644"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Francisco</forename> <surname>Pozo</surname> </persName> <idno type="halauthorid">638445</idno> <affiliation ref="#struct-1003254"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Ana-Maria</forename> <surname>Vilcu</surname> </persName> <idno type="halauthorid">1607342</idno> <affiliation ref="#struct-542132"></affiliation> <affiliation ref="#struct-413221"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Annicka</forename> <surname>Reuss</surname> </persName> <idno type="halauthorid">1626881</idno> <affiliation ref="#struct-1003255"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Caterina</forename> <surname>Rizzo</surname> </persName> <email type="md5">d1599be641b7fd7a7e3bb382739b2f60</email> <email type="domain">iss.it</email> <idno type="halauthorid">1015661</idno> <affiliation ref="#struct-480496"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Amparo</forename> <surname>Larrauri</surname> </persName> <idno type="halauthorid">1626882</idno> <affiliation ref="#struct-301929"></affiliation> <affiliation ref="#struct-140739"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Judit Krisztina</forename> <surname>Horváth</surname> </persName> <idno type="halauthorid">1626890</idno> <affiliation ref="#struct-1003256"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Mia</forename> <surname>Brytting</surname> </persName> <idno type="halauthorid">11140924</idno> <affiliation ref="#struct-455778"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Lisa</forename> <surname>Domegan</surname> </persName> <idno type="halauthorid">1626886</idno> <affiliation ref="#struct-343970"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Monika</forename> <surname>Korczyńska</surname> </persName> <idno type="halauthorid">1626893</idno> <affiliation ref="#struct-507010"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Adam</forename> <surname>Meijer</surname> </persName> <email type="md5">220ec4279ea5f763d36b7b8b676e8d60</email> <email type="domain">rivm.nl</email> <idno type="halauthorid">400978</idno> <affiliation ref="#struct-453112"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Ausenda</forename> <surname>Machado</surname> </persName> <idno type="halauthorid">1626884</idno> <affiliation ref="#struct-511550"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Alina</forename> <surname>Ivanciuc</surname> </persName> <idno type="halauthorid">11462996</idno> <affiliation ref="#struct-344082"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Vesna</forename> <surname>Višekruna Vučina</surname> </persName> <idno type="halauthorid">11462997</idno> <affiliation ref="#struct-521164"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Sylvie</forename> <surname>Van Der Werf</surname> </persName> <idno type="halauthorid">202082</idno> <affiliation ref="#struct-525918"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Brunhilde</forename> <surname>Schweiger</surname> </persName> <idno type="halauthorid">400982</idno> <affiliation ref="#struct-1003257"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Antonino</forename> <surname>Bella</surname> </persName> <idno type="halauthorid">941308</idno> <affiliation ref="#struct-480496"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Alin</forename> <surname>Gherasim</surname> </persName> <idno type="halauthorid">1626889</idno> <affiliation ref="#struct-140739"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Annamária</forename> <surname>Ferenczi</surname> </persName> <idno type="halauthorid">1664150</idno> <affiliation ref="#struct-1003256"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Katherina</forename> <surname>Zakikhany</surname> </persName> <idno type="halauthorid">11377436</idno> <affiliation ref="#struct-455778"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Joan</forename> <surname>O′Donnell</surname> </persName> <idno type="halauthorid">11462998</idno> <affiliation ref="#struct-343970"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Iwona</forename> <surname>Paradowska-Stankiewicz</surname> </persName> <idno type="halauthorid">1626887</idno> <affiliation ref="#struct-507010"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Frederika</forename> <surname>Dijkstra</surname> </persName> <idno type="halauthorid">11462999</idno> <affiliation ref="#struct-453112"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Raquel</forename> <surname>Guiomar</surname> </persName> <idno type="halauthorid">1714425</idno> <affiliation ref="#struct-310652"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Mihaela</forename> <surname>Lazar</surname> </persName> <idno type="halauthorid">11463000</idno> <affiliation ref="#struct-344082"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Sanja</forename> <surname>Kurečić Filipović</surname> </persName> <idno type="halauthorid">11463001</idno> <affiliation ref="#struct-521164"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Kari</forename> <surname>Johansen</surname> </persName> <idno type="halauthorid">11463002</idno> <affiliation ref="#struct-339705"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Alain</forename> <surname>Moren</surname> </persName> <idno type="halauthorid">1626894</idno> <affiliation ref="#struct-534644"></affiliation> </author> </analytic> <monogr> <idno type="halJournalId" status="VALID">39317</idno> <idno type="issn">1750-2640</idno> <idno type="eissn">1750-2659</idno> <title level="j">Influenza and Other Respiratory Viruses</title> <imprint> <publisher>Wiley Open Access</publisher> <biblScope unit="volume">12</biblScope> <biblScope unit="issue">4</biblScope> <biblScope unit="pp">423-437</biblScope> <date type="datePub">2018</date> </imprint> </monogr> <idno type="doi">10.1111/irv.12520</idno> <idno type="pubmed">29125681</idno> <idno type="pubmedcentral">PMC6005601</idno> </biblStruct> </sourceDesc> <profileDesc> <langUsage> <language ident="en">English</language> </langUsage> <textClass> <keywords scheme="author"> <term xml:lang="en">influenza</term> <term xml:lang="en">case-control study</term> <term xml:lang="en">influenza vaccine</term> <term xml:lang="en">vaccine effectiveness</term> <term xml:lang="en">case‐control study</term> <term xml:lang="en">multicentre study</term> </keywords> <classCode scheme="halDomain" n="sdv.spee">Life Sciences [q-bio]/Santé publique et épidémiologie</classCode> <classCode scheme="halDomain" n="sdv.imm.vac">Life Sciences [q-bio]/Immunology/Vaccinology</classCode> <classCode scheme="halTypology" n="ART">Journal articles</classCode> </textClass> <abstract xml:lang="en"> <p>BACKGROUND: During the 2015/16 influenza season in Europe, the cocirculating influenza viruses were A(H1N1)pdm09 and B/Victoria, which was antigenically distinct from the B/Yamagata component in the trivalent influenza vaccine.METHODS: We used the test-negative design in a multicentre case-control study in twelve European countries to measure 2015/16 influenza vaccine effectiveness (VE) against medically attended influenza-like illness (ILI) laboratory-confirmed as influenza. General practitioners swabbed a systematic sample of consulting ILI patients and a random sample of influenza-positive swabs was sequenced. We calculated adjusted VE against influenza A(H1N1)pdm09, A(H1N1)pdm09 genetic group 6B.1 and influenza B overall and by age group.RESULTS: We included 11 430 ILI patients, of which 2272 were influenza A(H1N1)pdm09 and 2901 were influenza B cases. Overall VE against influenza A(H1N1)pdm09 was 32.9% (95% CI: 15.5-46.7). Among those aged 0-14, 15-64 and ≥65 years, VE against A(H1N1)pdm09 was 31.9% (95% CI: -32.3 to 65.0), 41.4% (95% CI: 20.5-56.7) and 13.2% (95% CI: -38.0 to 45.3), respectively. Overall VE against influenza A(H1N1)pdm09 genetic group 6B.1 was 32.8% (95% CI: -4.1 to 56.7). Among those aged 0-14, 15-64 and ≥65 years, VE against influenza B was -47.6% (95% CI: -124.9 to 3.1), 27.3% (95% CI: -4.6 to 49.4) and 9.3% (95% CI: -44.1 to 42.9), respectively.CONCLUSIONS: Vaccine effectiveness (VE) against influenza A(H1N1)pdm09 and its genetic group 6B.1 was moderate in children and adults, and low among individuals ≥65 years. Vaccine effectiveness (VE) against influenza B was low and heterogeneous among age groups. More information on effects of previous vaccination and previous infection is needed to understand the VE results against influenza B in the context of a mismatched vaccine.</p> </abstract> </profileDesc> </hal></record>Pour manipuler ce document sous Unix (Dilib)
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