2009 A(H1N1) Seroconversion Rates and Risk Factors among the General Population in Vientiane Capital, Laos
Identifieur interne : 000001 ( Hal/Corpus ); précédent : 000000; suivant : 0000022009 A(H1N1) Seroconversion Rates and Risk Factors among the General Population in Vientiane Capital, Laos
Auteurs : Alexia Kieffer ; Phimpha Paboriboune ; Pascal Crepey ; Bruno Flaissier ; Vimalay Souvong ; Nicolas Steenkeste ; Nicolas Salez ; François-Xavier Babin ; Christophe Longuet ; Fabrice Carrat ; Antoine Flahault ; Xavier De LamballerieSource :
- PLoS ONE [ 1932-6203 ] ; 2013.
English descriptors
- mix :
Abstract
Objective: To assess 2009 A(H1N1) seroconversion rates and their determinants within an unvaccinated population in Vientiane Capital, Laos. Methods: CoPanFlu Laos, a general population cohort of 807 households and 4,072 participants was established in March 2010. Sociodemographic data, epidemiological data, and capillary blood samples were collected from all the household members in March, and again in October 2010, in order to assess the level of antibodies to 2009 A(H1N1) with the haemagglutination inhibition assay. 2009 A(H1N1) seroconversion was defined as a fourfold or greater increase in titre between inclusion and follow-up. Determinants for pandemic influenza infection were studied using the generalized estimating equations model, taking household clustering into account. Results: Between March and November 2010, 3,524 paired sera were tested. Prior to the pandemic, our cohort was almost completely vaccine-naive for seasonal influenza. The overall seroconversion rate among nonvaccinated individuals (n = 2,810) was 14.3% (95%CI [13.0, 15.6]), with the highest rate for participants under 20 yo (19.8%, 95%CI [17.4, 22.4]) and the lowest rate for participants over 60 yo (6.5%, 95%CI [3.7, 10.4]). Participants with lower baseline titres had significantly higher infection rates, with a dose-effect relationship. Odds ratios (ORs) ranged from 76.5 (95%CI [27.1, 215.8]), for those with a titre at inclusion of 1:10, to 8.1 (95%CI [3.3, 20.4]), for those with a titre of 1:40. Having another household member with a titre $1:80 was associated with a higher likelihood of immunity (OR = 3.3, 95%CI [2.8, 3.9]). Conclusion: The determinants and age distribution for seroconversion within a vaccine-naive population were similar to those found in developed countries. This pandemic was characterized by strong epidemiological determinants, regardless of geographical zone and level of development. Moreover, we detected pre-existing cross-reacting antibodies in participants over 60 yo, which could not have originated from former multiple vaccination as has been suggested elsewhere.
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DOI: 10.1371/journal.pone.0061909
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Hôpitaux de Marseille</orgName> <orgName type="acronym">APHM</orgName> <desc> <address> <addrLine>Direction générale AP-HM80, rue Brochier13 354 Marseille Cedex 5</addrLine> <country key="FR"></country> </address> <ref type="url">http://fr.ap-hm.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Paboriboune, Phimpha" sort="Paboriboune, Phimpha" uniqKey="Paboriboune P" first="Phimpha" last="Paboriboune">Phimpha Paboriboune</name><affiliation><hal:affiliation type="institution" xml:id="struct-556250" status="INCOMING"> <orgName>Center of Infectiology Lao-Christophe Mérieux</orgName> <orgName type="acronym">CILM</orgName> <desc> <address> <addrLine>Samsenthai Road, Kaoyot Village,Sisathanak District, Vientiane CapitalLao P.D.R</addrLine> <country key="LA"></country> </address> <ref type="url">http://www.ccm-laos.org/</ref> </desc> </hal:affiliation></affiliation></author><author><name sortKey="Crepey, Pascal" sort="Crepey, Pascal" uniqKey="Crepey P" first="Pascal" last="Crepey">Pascal Crepey</name><affiliation><hal:affiliation type="institution" xml:id="struct-301986" status="VALID"> <orgName>École des Hautes Études en Santé Publique [EHESP]</orgName> <orgName type="acronym">EHESP</orgName> <date type="start">2016-06-20</date> <desc> <address> <addrLine>15, avenue du Pr. Léon Bernard - 35043 Rennes Cedex</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.ehesp.fr/</ref> </desc> </hal:affiliation></affiliation></author><author><name sortKey="Flaissier, Bruno" sort="Flaissier, Bruno" uniqKey="Flaissier B" first="Bruno" last="Flaissier">Bruno Flaissier</name><affiliation><hal:affiliation type="institution" xml:id="struct-301986" status="VALID"> <orgName>École des Hautes Études en Santé Publique [EHESP]</orgName> <orgName type="acronym">EHESP</orgName> <date type="start">2016-06-20</date> <desc> <address> <addrLine>15, avenue du Pr. Léon Bernard - 35043 Rennes Cedex</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.ehesp.fr/</ref> </desc> </hal:affiliation></affiliation></author><author><name sortKey="Souvong, Vimalay" sort="Souvong, Vimalay" uniqKey="Souvong V" first="Vimalay" last="Souvong">Vimalay Souvong</name><affiliation><hal:affiliation type="institution" xml:id="struct-556250" status="INCOMING"> <orgName>Center of Infectiology Lao-Christophe Mérieux</orgName> <orgName type="acronym">CILM</orgName> <desc> <address> <addrLine>Samsenthai Road, Kaoyot Village,Sisathanak District, Vientiane CapitalLao P.D.R</addrLine> <country key="LA"></country> </address> <ref type="url">http://www.ccm-laos.org/</ref> </desc> </hal:affiliation></affiliation></author><author><name sortKey="Steenkeste, Nicolas" sort="Steenkeste, Nicolas" uniqKey="Steenkeste N" first="Nicolas" last="Steenkeste">Nicolas Steenkeste</name><affiliation><hal:affiliation type="institution" xml:id="struct-348225" status="VALID"> <orgName>Fondation Mérieux</orgName> <desc> <address> <addrLine>17, rue Bourgelat 69002 Lyon, France</addrLine> <country key="FR"></country> </address> <ref type="url">https://www.fondation-merieux.org/</ref> </desc> </hal:affiliation></affiliation></author><author><name sortKey="Salez, Nicolas" sort="Salez, Nicolas" uniqKey="Salez N" first="Nicolas" last="Salez">Nicolas Salez</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-86891" status="OLD"> <idno type="IdRef">124942504</idno> <idno type="RNSR">200817677J</idno> <orgName>Emergence des Pathologies Virales</orgName> <orgName type="acronym">EPV</orgName> <date type="start">2008</date> <date type="end">2017-12-31</date> <desc> <address> <addrLine>Faculté de médecine27 Bd jean Moulin13385 Marseille Cedex 5</addrLine> <country key="FR"></country> </address> <ref type="url">https://www.ird.fr/la-recherche/liste-des-unites-de-recherche/190-emergence-des-pathologies-virales</ref> </desc> <listRelation> <relation name="UMR_D 190" active="#struct-303623" type="direct"></relation> <relation name="UMR_D 190" active="#struct-67872" type="direct"></relation> <relation name="UMR_D 190" active="#struct-198056" type="direct"></relation> <relation name="UMR_D 190" active="#struct-300073" type="direct"></relation> </listRelation> <tutelles><tutelle name="UMR_D 190" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc> </org></tutelle><tutelle name="UMR_D 190" active="#struct-67872" type="direct"><org type="institution" xml:id="struct-67872" status="VALID"> <orgName>Institut de Recherche pour le Développement</orgName> <orgName type="acronym">IRD</orgName> <desc> <address> <addrLine>SiègeLe Sextant 44, bd de DunkerqueCS 9000913572 Marseille cedex 02</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.ird.fr/</ref> </desc> </org></tutelle><tutelle name="UMR_D 190" active="#struct-198056" type="direct"><org type="institution" xml:id="struct-198056" status="VALID"> <idno type="IdRef">15863621X</idno> <idno type="ISNI">0000 0001 2176 4817</idno> <orgName>Aix Marseille Université</orgName> <orgName type="acronym">AMU</orgName> <date type="start">2012-01-01</date> <desc> <address> <addrLine>Aix-Marseille UniversitéJardins du Pharo58 Boulevard Charles Livon13284 Marseille cedex 7</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-amu.fr/</ref> </desc> </org></tutelle><tutelle name="UMR_D 190" active="#struct-300073" type="direct"><org type="institution" xml:id="struct-300073" status="VALID"> <orgName>Assistance Publique - Hôpitaux de Marseille</orgName> <orgName type="acronym">APHM</orgName> <desc> <address> <addrLine>Direction générale AP-HM80, rue Brochier13 354 Marseille Cedex 5</addrLine> <country key="FR"></country> </address> <ref type="url">http://fr.ap-hm.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Babin, Francois Xavier" sort="Babin, Francois Xavier" uniqKey="Babin F" first="François-Xavier" last="Babin">François-Xavier Babin</name><affiliation><hal:affiliation type="institution" xml:id="struct-348225" status="VALID"> <orgName>Fondation Mérieux</orgName> <desc> <address> <addrLine>17, rue Bourgelat 69002 Lyon, France</addrLine> <country key="FR"></country> </address> <ref type="url">https://www.fondation-merieux.org/</ref> </desc> </hal:affiliation></affiliation></author><author><name sortKey="Longuet, Christophe" sort="Longuet, Christophe" uniqKey="Longuet C" first="Christophe" last="Longuet">Christophe Longuet</name><affiliation><hal:affiliation type="institution" xml:id="struct-348225" status="VALID"> <orgName>Fondation Mérieux</orgName> <desc> <address> <addrLine>17, rue Bourgelat 69002 Lyon, France</addrLine> <country key="FR"></country> </address> <ref type="url">https://www.fondation-merieux.org/</ref> </desc> </hal:affiliation></affiliation></author><author><name sortKey="Carrat, Fabrice" sort="Carrat, Fabrice" uniqKey="Carrat F" first="Fabrice" last="Carrat">Fabrice Carrat</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-3065" status="OLD"> <orgName>Epidémiologie des maladies infectieuses et modélisation</orgName> <orgName type="acronym">ESIM</orgName> <desc> <address> <addrLine>Faculte de Médecine Saint-Antoine 27, Rue Chaligny 75571 Paris Cedex 12</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.u707.jussieu.fr</ref> </desc> <listRelation> <relation active="#struct-93591" type="direct"></relation> <relation name="U707" active="#struct-303623" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-93591" type="direct"><org type="institution" xml:id="struct-93591" status="OLD"> <orgName>Université Pierre et Marie Curie - Paris 6</orgName> <orgName type="acronym">UPMC</orgName> <date type="end">2017-12-31</date> <desc> <address> <addrLine>4 place Jussieu - 75005 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.upmc.fr/</ref> </desc> </org></tutelle><tutelle name="U707" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Flahault, Antoine" sort="Flahault, Antoine" uniqKey="Flahault A" first="Antoine" last="Flahault">Antoine Flahault</name><affiliation><hal:affiliation type="institution" xml:id="struct-301986" status="VALID"> <orgName>École des Hautes Études en Santé Publique [EHESP]</orgName> <orgName type="acronym">EHESP</orgName> <date type="start">2016-06-20</date> <desc> <address> <addrLine>15, avenue du Pr. Léon Bernard - 35043 Rennes Cedex</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.ehesp.fr/</ref> </desc> </hal:affiliation></affiliation></author><author><name sortKey="Lamballerie, Xavier De" sort="Lamballerie, Xavier De" uniqKey="Lamballerie X" first="Xavier De" last="Lamballerie">Xavier De Lamballerie</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-86891" status="OLD"> <idno type="IdRef">124942504</idno> <idno type="RNSR">200817677J</idno> <orgName>Emergence des Pathologies Virales</orgName> <orgName type="acronym">EPV</orgName> <date type="start">2008</date> <date type="end">2017-12-31</date> <desc> <address> <addrLine>Faculté de médecine27 Bd jean Moulin13385 Marseille Cedex 5</addrLine> <country key="FR"></country> </address> <ref type="url">https://www.ird.fr/la-recherche/liste-des-unites-de-recherche/190-emergence-des-pathologies-virales</ref> </desc> <listRelation> <relation name="UMR_D 190" active="#struct-303623" type="direct"></relation> <relation name="UMR_D 190" active="#struct-67872" type="direct"></relation> <relation name="UMR_D 190" active="#struct-198056" type="direct"></relation> <relation name="UMR_D 190" active="#struct-300073" type="direct"></relation> </listRelation> <tutelles><tutelle name="UMR_D 190" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc> </org></tutelle><tutelle name="UMR_D 190" active="#struct-67872" type="direct"><org type="institution" xml:id="struct-67872" status="VALID"> <orgName>Institut de Recherche pour le Développement</orgName> <orgName type="acronym">IRD</orgName> <desc> <address> <addrLine>SiègeLe Sextant 44, bd de DunkerqueCS 9000913572 Marseille cedex 02</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.ird.fr/</ref> </desc> </org></tutelle><tutelle name="UMR_D 190" active="#struct-198056" type="direct"><org type="institution" xml:id="struct-198056" status="VALID"> <idno type="IdRef">15863621X</idno> <idno type="ISNI">0000 0001 2176 4817</idno> <orgName>Aix Marseille Université</orgName> <orgName type="acronym">AMU</orgName> <date type="start">2012-01-01</date> <desc> <address> <addrLine>Aix-Marseille UniversitéJardins du Pharo58 Boulevard Charles Livon13284 Marseille cedex 7</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-amu.fr/</ref> </desc> </org></tutelle><tutelle name="UMR_D 190" active="#struct-300073" type="direct"><org type="institution" xml:id="struct-300073" status="VALID"> <orgName>Assistance Publique - Hôpitaux de Marseille</orgName> <orgName type="acronym">APHM</orgName> <desc> <address> <addrLine>Direction générale AP-HM80, rue Brochier13 354 Marseille Cedex 5</addrLine> <country key="FR"></country> </address> <ref type="url">http://fr.ap-hm.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author></analytic><idno type="DOI">10.1371/journal.pone.0061909</idno><series><title level="j">PLoS ONE</title><idno type="ISSN">1932-6203</idno><imprint><date type="datePub">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="mix" xml:lang="en"><term>Age groups</term><term>Antibodies</term><term>Epidemiology</term><term>Influenza</term><term>Influenza viruses</term><term>Laos</term><term>Serology</term><term>Vaccination and immunization</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"> <p>Objective: To assess 2009 A(H1N1) seroconversion rates and their determinants within an unvaccinated population in Vientiane Capital, Laos. Methods: CoPanFlu Laos, a general population cohort of 807 households and 4,072 participants was established in March 2010. Sociodemographic data, epidemiological data, and capillary blood samples were collected from all the household members in March, and again in October 2010, in order to assess the level of antibodies to 2009 A(H1N1) with the haemagglutination inhibition assay. 2009 A(H1N1) seroconversion was defined as a fourfold or greater increase in titre between inclusion and follow-up. Determinants for pandemic influenza infection were studied using the generalized estimating equations model, taking household clustering into account. Results: Between March and November 2010, 3,524 paired sera were tested. Prior to the pandemic, our cohort was almost completely vaccine-naive for seasonal influenza. The overall seroconversion rate among nonvaccinated individuals (n = 2,810) was 14.3% (95%CI [13.0, 15.6]), with the highest rate for participants under 20 yo (19.8%, 95%CI [17.4, 22.4]) and the lowest rate for participants over 60 yo (6.5%, 95%CI [3.7, 10.4]). Participants with lower baseline titres had significantly higher infection rates, with a dose-effect relationship. Odds ratios (ORs) ranged from 76.5 (95%CI [27.1, 215.8]), for those with a titre at inclusion of 1:10, to 8.1 (95%CI [3.3, 20.4]), for those with a titre of 1:40. Having another household member with a titre $1:80 was associated with a higher likelihood of immunity (OR = 3.3, 95%CI [2.8, 3.9]). Conclusion: The determinants and age distribution for seroconversion within a vaccine-naive population were similar to those found in developed countries. This pandemic was characterized by strong epidemiological determinants, regardless of geographical zone and level of development. Moreover, we detected pre-existing cross-reacting antibodies in participants over 60 yo, which could not have originated from former multiple vaccination as has been suggested elsewhere.</p> </div></front></TEI><hal api="V3"> <titleStmt> <title xml:lang="en">2009 A(H1N1) Seroconversion Rates and Risk Factors among the General Population in Vientiane Capital, Laos</title> <author role="aut"> <persName> <forename type="first">Alexia</forename> <surname>Kieffer</surname> </persName> <email type="md5">fd103f3400d84a02c08707f4970471a9</email> <email type="domain">gmail.com</email> <idno type="halauthorid">987069</idno> <affiliation ref="#struct-86891"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Phimpha</forename> <surname>Paboriboune</surname> </persName> <idno type="halauthorid">1008931</idno> <affiliation ref="#struct-556250"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Pascal</forename> <surname>Crepey</surname> </persName> <email type="md5">a7ef101bad2e46c40f6f235ee0f9fcfa</email> <email type="domain">ehesp.fr</email> <idno type="idhal" notation="string">pascal-crepey</idno> <idno type="idhal" notation="numeric">14363</idno> <idno type="halauthorid">987068</idno> <idno type="ORCID">https://orcid.org/0000-0003-1852-0752</idno> <idno type="ResearcherId">http://www.researcherid.com/rid/G-5422-2011</idno> <affiliation ref="#struct-301986"></affiliation> <affiliation ref="#struct-86891"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Bruno</forename> <surname>Flaissier</surname> </persName> <idno type="halauthorid">11184827</idno> <affiliation ref="#struct-301986"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Vimalay</forename> <surname>Souvong</surname> </persName> <email type="md5">b02973c1c5dc6c07da6f93ede3322424</email> <email type="domain">yahoo.com</email> <idno type="halauthorid">822759</idno> <affiliation ref="#struct-556250"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Nicolas</forename> <surname>Steenkeste</surname> </persName> <idno type="halauthorid">772000</idno> <affiliation ref="#struct-348225"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Nicolas</forename> <surname>Salez</surname> </persName> <idno type="halauthorid">629657</idno> <affiliation ref="#struct-86891"></affiliation> </author> <author role="aut"> <persName> <forename type="first">François-Xavier</forename> <surname>Babin</surname> </persName> <idno type="halauthorid">11184828</idno> <affiliation ref="#struct-348225"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Christophe</forename> <surname>LONGUET</surname> </persName> <email type="md5">609705456502e0acfaf7344e8f5432fc</email> <email type="domain">fondation-merieux.org</email> <idno type="halauthorid">1008404</idno> <affiliation ref="#struct-348225"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Fabrice</forename> <surname>Carrat</surname> </persName> <email type="md5">d3fac14bbecb5ab5a5029e3cc79cb4ca</email> <email type="domain">iplesp.upmc.fr</email> <idno type="idhal" notation="string">fabrice-carrat</idno> <idno type="idhal" notation="numeric">181388</idno> <idno type="halauthorid">422828</idno> <idno type="ORCID">https://orcid.org/0000-0002-8672-7918</idno> <idno type="ResearcherId">http://www.researcherid.com/rid/P-6177-2017</idno> <affiliation ref="#struct-3065"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Antoine</forename> <surname>Flahault</surname> </persName> <idno type="halauthorid">119515</idno> <affiliation ref="#struct-301986"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Xavier de</forename> <surname>Lamballerie</surname> </persName> <idno type="halauthorid">1556585</idno> <affiliation ref="#struct-86891"></affiliation> </author> <editor role="depositor"> <persName> <forename>Administrateur</forename> <surname>HAL AMU</surname> </persName> <email type="md5">15be4914e109ecac893c50bb8b1cb1b0</email> <email type="domain">univ-amu.fr</email> </editor> </titleStmt> <editionStmt> <edition n="v1" type="current"> <date type="whenSubmitted">2018-04-19 15:49:57</date> <date type="whenModified">2020-01-14 10:14:02</date> <date type="whenReleased">2018-04-24 14:28:28</date> <date type="whenProduced">2013</date> <date type="whenEndEmbargoed">2018-04-19</date> <ref type="file" target="https://hal-amu.archives-ouvertes.fr/hal-01771560/document"> <date notBefore="2018-04-19"></date> </ref> <ref type="file" subtype="publisherPaid" n="1" target="https://hal-amu.archives-ouvertes.fr/hal-01771560/file/journal.pone.0061909.PDF"> <date notBefore="2018-04-19"></date> </ref> <ref type="externalLink" target="https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0061909&type=printable"></ref> </edition> <respStmt> <resp>contributor</resp> <name key="321208"> <persName> <forename>Administrateur</forename> <surname>HAL AMU</surname> </persName> <email type="md5">15be4914e109ecac893c50bb8b1cb1b0</email> <email type="domain">univ-amu.fr</email> </name> </respStmt> </editionStmt> <publicationStmt> <distributor>CCSD</distributor> <idno type="halId">hal-01771560</idno> <idno type="halUri">https://hal-amu.archives-ouvertes.fr/hal-01771560</idno> <idno type="halBibtex">kieffer:hal-01771560</idno> <idno type="halRefHtml">PLoS ONE, Public Library of Science, 2013, 8, pp.61909 - 61909. ⟨10.1371/journal.pone.0061909⟩</idno> <idno type="halRef">PLoS ONE, Public Library of Science, 2013, 8, pp.61909 - 61909. ⟨10.1371/journal.pone.0061909⟩</idno> <availability status="restricted"> <licence target="http://creativecommons.org/licenses/by/">Attribution</licence> </availability> </publicationStmt> <seriesStmt> <idno type="stamp" n="UNIV-AMU">Aix Marseille Université</idno> <idno type="stamp" n="UPMC" corresp="SORBONNE-UNIVERSITE">Université Pierre et Marie Curie</idno> <idno type="stamp" n="COPANFLU" corresp="INSERM">Cohorte des 1000 ménages pour le suivi de la pandémie de grippe H1N1</idno> <idno type="stamp" n="IRD">IRD - Institut de recherche pour le développement</idno> <idno type="stamp" n="EHESP">École des hautes études en santé publique</idno> <idno type="stamp" n="TEST-AMU">Espace de test AMU</idno> <idno type="stamp" n="USPC">Université Sorbonne Paris Cité</idno> <idno type="stamp" n="INSERM">INSERM - Institut national de la santé et de la recherche médicale</idno> <idno type="stamp" n="SORBONNE-UNIVERSITE">Sorbonne Université</idno> </seriesStmt> <notesStmt> <note type="audience" n="2">International</note> <note type="popular" n="0">No</note> <note type="peer" n="1">Yes</note> </notesStmt> <sourceDesc> <biblStruct> <analytic> <title xml:lang="en">2009 A(H1N1) Seroconversion Rates and Risk Factors among the General Population in Vientiane Capital, Laos</title> <author role="aut"> <persName> <forename type="first">Alexia</forename> <surname>Kieffer</surname> </persName> <email type="md5">fd103f3400d84a02c08707f4970471a9</email> <email type="domain">gmail.com</email> <idno type="halauthorid">987069</idno> <affiliation ref="#struct-86891"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Phimpha</forename> <surname>Paboriboune</surname> </persName> <idno type="halauthorid">1008931</idno> <affiliation ref="#struct-556250"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Pascal</forename> <surname>Crepey</surname> </persName> <email type="md5">a7ef101bad2e46c40f6f235ee0f9fcfa</email> <email type="domain">ehesp.fr</email> <idno type="idhal" notation="string">pascal-crepey</idno> <idno type="idhal" notation="numeric">14363</idno> <idno type="halauthorid">987068</idno> <idno type="ORCID">https://orcid.org/0000-0003-1852-0752</idno> <idno type="ResearcherId">http://www.researcherid.com/rid/G-5422-2011</idno> <affiliation ref="#struct-301986"></affiliation> <affiliation ref="#struct-86891"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Bruno</forename> <surname>Flaissier</surname> </persName> <idno type="halauthorid">11184827</idno> <affiliation ref="#struct-301986"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Vimalay</forename> <surname>Souvong</surname> </persName> <email type="md5">b02973c1c5dc6c07da6f93ede3322424</email> <email type="domain">yahoo.com</email> <idno type="halauthorid">822759</idno> <affiliation ref="#struct-556250"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Nicolas</forename> <surname>Steenkeste</surname> </persName> <idno type="halauthorid">772000</idno> <affiliation ref="#struct-348225"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Nicolas</forename> <surname>Salez</surname> </persName> <idno type="halauthorid">629657</idno> <affiliation ref="#struct-86891"></affiliation> </author> <author role="aut"> <persName> <forename type="first">François-Xavier</forename> <surname>Babin</surname> </persName> <idno type="halauthorid">11184828</idno> <affiliation ref="#struct-348225"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Christophe</forename> <surname>LONGUET</surname> </persName> <email type="md5">609705456502e0acfaf7344e8f5432fc</email> <email type="domain">fondation-merieux.org</email> <idno type="halauthorid">1008404</idno> <affiliation ref="#struct-348225"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Fabrice</forename> <surname>Carrat</surname> </persName> <email type="md5">d3fac14bbecb5ab5a5029e3cc79cb4ca</email> <email type="domain">iplesp.upmc.fr</email> <idno type="idhal" notation="string">fabrice-carrat</idno> <idno type="idhal" notation="numeric">181388</idno> <idno type="halauthorid">422828</idno> <idno type="ORCID">https://orcid.org/0000-0002-8672-7918</idno> <idno type="ResearcherId">http://www.researcherid.com/rid/P-6177-2017</idno> <affiliation ref="#struct-3065"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Antoine</forename> <surname>Flahault</surname> </persName> <idno type="halauthorid">119515</idno> <affiliation ref="#struct-301986"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Xavier de</forename> <surname>Lamballerie</surname> </persName> <idno type="halauthorid">1556585</idno> <affiliation ref="#struct-86891"></affiliation> </author> </analytic> <monogr> <idno type="halJournalId" status="VALID">28700</idno> <idno type="issn">1932-6203</idno> <idno type="eissn">1932-6203</idno> <title level="j">PLoS ONE</title> <imprint> <publisher>Public Library of Science</publisher> <biblScope unit="volume">8</biblScope> <biblScope unit="pp">61909 - 61909</biblScope> <date type="datePub">2013</date> </imprint> </monogr> <idno type="doi">10.1371/journal.pone.0061909</idno> </biblStruct> </sourceDesc> <profileDesc> <langUsage> <language ident="en">English</language> </langUsage> <textClass> <keywords scheme="author"> <term xml:lang="en">Antibodies</term> <term xml:lang="en">Age groups</term> <term xml:lang="en">Influenza</term> <term xml:lang="en">Influenza viruses</term> <term xml:lang="en">Vaccination and immunization</term> <term xml:lang="en">Epidemiology</term> <term xml:lang="en">Serology</term> <term xml:lang="en">Laos</term> </keywords> <classCode scheme="halDomain" n="sdv.mp">Life Sciences [q-bio]/Microbiology and Parasitology</classCode> <classCode scheme="halTypology" n="ART">Journal articles</classCode> </textClass> <abstract xml:lang="en"> <p>Objective: To assess 2009 A(H1N1) seroconversion rates and their determinants within an unvaccinated population in Vientiane Capital, Laos. Methods: CoPanFlu Laos, a general population cohort of 807 households and 4,072 participants was established in March 2010. Sociodemographic data, epidemiological data, and capillary blood samples were collected from all the household members in March, and again in October 2010, in order to assess the level of antibodies to 2009 A(H1N1) with the haemagglutination inhibition assay. 2009 A(H1N1) seroconversion was defined as a fourfold or greater increase in titre between inclusion and follow-up. Determinants for pandemic influenza infection were studied using the generalized estimating equations model, taking household clustering into account. Results: Between March and November 2010, 3,524 paired sera were tested. Prior to the pandemic, our cohort was almost completely vaccine-naive for seasonal influenza. The overall seroconversion rate among nonvaccinated individuals (n = 2,810) was 14.3% (95%CI [13.0, 15.6]), with the highest rate for participants under 20 yo (19.8%, 95%CI [17.4, 22.4]) and the lowest rate for participants over 60 yo (6.5%, 95%CI [3.7, 10.4]). Participants with lower baseline titres had significantly higher infection rates, with a dose-effect relationship. Odds ratios (ORs) ranged from 76.5 (95%CI [27.1, 215.8]), for those with a titre at inclusion of 1:10, to 8.1 (95%CI [3.3, 20.4]), for those with a titre of 1:40. Having another household member with a titre $1:80 was associated with a higher likelihood of immunity (OR = 3.3, 95%CI [2.8, 3.9]). Conclusion: The determinants and age distribution for seroconversion within a vaccine-naive population were similar to those found in developed countries. This pandemic was characterized by strong epidemiological determinants, regardless of geographical zone and level of development. Moreover, we detected pre-existing cross-reacting antibodies in participants over 60 yo, which could not have originated from former multiple vaccination as has been suggested elsewhere.</p> </abstract> </profileDesc> </hal></record>Pour manipuler ce document sous Unix (Dilib)
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