H2N2V1, Hal, Checkpoint, bibRecord, 000335

Genetic analysis of the compatibility between polymerase proteins from human and avian strains of influenza A viruses

Identifieur interne : 000335 ( Hal/Checkpoint ); précédent : 000334; suivant : 000336

Genetic analysis of the compatibility between polymerase proteins from human and avian strains of influenza A viruses

Auteurs : Nadia Naffakh [France] ; Pascale Massin [France] ; Nicolas Escriou [France] ; Bernadette Crescenzo-Chaigne [France] ; Sylvie Van Der Werf [France]

Source :

Journal of General Virology [ 0022-1317 ] ; 2000-05-01.

RBID : Hal:pasteur-01611108

English descriptors

mix :
- RNA Viruses.

Abstract

In order to determine how efficiently the polymerase proteins derived from human and avian influenza A viruses can interact with each other in the context of a mammalian cell, a genetic system that allows the in vivo reconstitution of active ribonucleoproteins was used. The ability to achieve replication of a viral-like reporter RNA in COS-1 cells was examined with heterospecific mixtures of the core proteins (PB1, PB2, PA and NP) from two strains of human viruses (A/Puerto Rico/8/34 and A/Victoria/3/75), two strains of avian viruses (A/Mallard/NY/6750/78 and A/FPV/-Rostock/34), and a strain of avian origin (A/Hong Kong/156/97) that was isolated from the first human case of H5N1 influenza in Hong Kong in 1997. In accordance with published observations on reassortant viruses, PB2 amino acid 627 was identified as a major determinant of the replication efficiency of heterospecific complexes in COS-1 cells. Moreover, the results showed that replication of the viral-like reporter RNA was more efficient when PB2 and NP were both derived from the same avian or human virus or when PB1 was derived from an avian virus, whatever the origin of the other proteins. Furthermore, the PB1 and PB2 proteins from the A/Hong-Kong/156/97 virus exhibited intermediate properties with respect to the corresponding proteins from avian or human influenza viruses, suggesting that some molecular characteristics of PB1 and PB2 proteins might at least partially account for the ability of the A/Hong Kong/156/97 virus to replicate in humans.

Url:

https://hal-pasteur.archives-ouvertes.fr/pasteur-01611108

DOI: 10.1099/0022-1317-81-5-1283

Links toward previous steps (curation, corpus...)

to stream Hal, to step Corpus: 000113
to stream Hal, to step Curation: 000113

Links to Exploration step

Hal:pasteur-01611108

Le document en format XML

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<front><div type="abstract" xml:lang="en">              <p>In order to determine how efficiently the polymerase proteins derived from human and avian influenza A viruses can interact with each other in the context of a mammalian cell, a genetic system that allows the in vivo reconstitution of active ribonucleoproteins was used. The ability to achieve replication of a viral-like reporter RNA in COS-1 cells was examined with heterospecific mixtures of the core proteins (PB1, PB2, PA and NP) from two strains of human viruses (A/Puerto Rico/8/34 and A/Victoria/3/75), two strains of avian viruses (A/Mallard/NY/6750/78 and A/FPV/-Rostock/34), and a strain of avian origin (A/Hong Kong/156/97) that was isolated from the first human case of H5N1 influenza in Hong Kong in 1997. In accordance with published observations on reassortant viruses, PB2 amino acid 627 was identified as a major determinant of the replication efficiency of heterospecific complexes in COS-1 cells. Moreover, the results showed that replication of the viral-like reporter RNA was more efficient when PB2 and NP were both derived from the same avian or human virus or when PB1 was derived from an avian virus, whatever the origin of the other proteins. Furthermore, the PB1 and PB2 proteins from the A/Hong-Kong/156/97 virus exhibited intermediate properties with respect to the corresponding proteins from avian or human influenza viruses, suggesting that some molecular characteristics of PB1 and PB2 proteins might at least partially account for the ability of the A/Hong Kong/156/97 virus to replicate in humans.</p>
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            <funder>This work was supported in part by the Ministère de l’Education Nationale, de la Recherche et de la Technologie (EA 302).</funder>
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                </author>
                <author role="aut">                  <persName>                    <forename type="first">Nicolas</forename>
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                <title level="j">Journal of General Virology</title>
                <imprint>                  <publisher>Microbiology Society</publisher>
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            <textClass>              <keywords scheme="author">                <term xml:lang="en">RNA Viruses</term>
              </keywords>
              <classCode scheme="mesh">Animals</classCode>
              <classCode scheme="mesh">COS Cells</classCode>
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              <classCode scheme="mesh">Plasmids</classCode>
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            <abstract xml:lang="en">              <p>In order to determine how efficiently the polymerase proteins derived from human and avian influenza A viruses can interact with each other in the context of a mammalian cell, a genetic system that allows the in vivo reconstitution of active ribonucleoproteins was used. The ability to achieve replication of a viral-like reporter RNA in COS-1 cells was examined with heterospecific mixtures of the core proteins (PB1, PB2, PA and NP) from two strains of human viruses (A/Puerto Rico/8/34 and A/Victoria/3/75), two strains of avian viruses (A/Mallard/NY/6750/78 and A/FPV/-Rostock/34), and a strain of avian origin (A/Hong Kong/156/97) that was isolated from the first human case of H5N1 influenza in Hong Kong in 1997. In accordance with published observations on reassortant viruses, PB2 amino acid 627 was identified as a major determinant of the replication efficiency of heterospecific complexes in COS-1 cells. Moreover, the results showed that replication of the viral-like reporter RNA was more efficient when PB2 and NP were both derived from the same avian or human virus or when PB1 was derived from an avian virus, whatever the origin of the other proteins. Furthermore, the PB1 and PB2 proteins from the A/Hong-Kong/156/97 virus exhibited intermediate properties with respect to the corresponding proteins from avian or human influenza viruses, suggesting that some molecular characteristics of PB1 and PB2 proteins might at least partially account for the ability of the A/Hong Kong/156/97 virus to replicate in humans.</p>
            </abstract>
            <particDesc>              <org type="consortium">The authors are very grateful to J. Pavlovic for providing the pHMG recombinant plasmids, to A. Portela for providing the pGEM recombinant plasmids, to P. Palese for providing plasmid pPolI-CAT-RT, and to J. Ortin for providing polyclonal sera specific for PB1, PB2 and PA proteins. They are grateful to A. Hay for providing the A/FPV/Rostock/34 and A/Hong Kong/156/97 viruses, and R. Webster for providing the A/Mallard/NY/6750/78 virus. The technical assistance of Ida Rijks and Claudine Rousseaux for the production of influenza viruses is gratefully acknowledged. We thank Cécile Quemin for contribution to the initial cloning of the A/Hong Kong/156/97 cDNAs, and Marco Vignuzzi for critical reading of the manuscript. </org>
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Genetic analysis of the compatibility between polymerase proteins from human and avian strains of influenza A viruses

Genetic analysis of the compatibility between polymerase proteins from human and avian strains of influenza A viruses

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