H2N2V1, Hal, Checkpoint, bibRecord, 000285

A probiotic fermented dairy drink improves antibody response to influenza vaccination in the elderly in two randomised controlled trials.

Identifieur interne : 000285 ( Hal/Checkpoint ); précédent : 000284; suivant : 000286

A probiotic fermented dairy drink improves antibody response to influenza vaccination in the elderly in two randomised controlled trials.

Auteurs : Thierry Boge [France] ; Michel Rémigy [France] ; Sarah Vaudaine [France] ; Jérôme Tanguy [France] ; Raphaëlle Bourdet-Sicard [France] ; Sylvie Van Der Werf [France]

Source :

Vaccine [ 0264-410X ] ; 2009-09-18.

RBID : Hal:pasteur-00457701

Abstract

BACKGROUND: Influenza vaccination is recommended for the elderly in many countries, but immune responses are weaker compared to younger adults. OBJECTIVE: To investigate the impact of daily consumption of a probiotic dairy drink on the immune response to influenza vaccination in an elderly population of healthy volunteers over 70 years of age. DESIGN: Two randomised, multicentre, double-blind, controlled studies were conducted during two vaccination seasons in 2005-2006 (pilot) and 2006-2007 (confirmatory). Eighty-six and 222 elderly volunteers consumed either a fermented dairy drink, containing the probiotic strain Lactobacillus casei DN-114 001 and yoghurt ferments (Actimel, or a non-fermented control dairy product twice daily for a period of 7 weeks (pilot) or 13 weeks (confirmatory). Vaccination occurred after 4 weeks of product consumption. Geometric mean antibody titres (GMT) against the 3 viral strains composing the vaccine (H1N1, H3N2, and B) were measured at several time intervals post-vaccination by haemagglutination inhibition test. RESULTS: In the pilot study, the influenza-specific antibody titres increased after vaccination, being consistently higher in the probiotic product group compared to the control group under product consumption. Similarly, in the confirmatory study, titres against the B strain increased significantly more in the probiotic group than in the control group at 3, 6 and 9 weeks post-vaccination under product consumption (p=0.020). Significant differences in seroconversion between the groups by intended to treat analysis were still found 5 months after vaccination. Similar GMT results were observed for the H3N2 strain and H1N1 strain, confirming the results of the pilot study. CONCLUSION: These studies demonstrate that daily consumption of this particular probiotic product increased relevant specific antibody responses to influenza vaccination in individuals of over 70 years of age and may therefore provide a health benefit in this population.

Url:

https://hal-pasteur.archives-ouvertes.fr/pasteur-00457701

DOI: 10.1016/j.vaccine.2009.06.094

Links toward previous steps (curation, corpus...)

to stream Hal, to step Corpus: 000010
to stream Hal, to step Curation: 000010

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Hal:pasteur-00457701

Le document en format XML

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<front><div type="abstract" xml:lang="en">              <p>BACKGROUND: Influenza vaccination is recommended for the elderly in many countries, but immune responses are weaker compared to younger adults. OBJECTIVE: To investigate the impact of daily consumption of a probiotic dairy drink on the immune response to influenza vaccination in an elderly population of healthy volunteers over 70 years of age. DESIGN: Two randomised, multicentre, double-blind, controlled studies were conducted during two vaccination seasons in 2005-2006 (pilot) and 2006-2007 (confirmatory). Eighty-six and 222 elderly volunteers consumed either a fermented dairy drink, containing the probiotic strain Lactobacillus casei DN-114 001 and yoghurt ferments (Actimel, or a non-fermented control dairy product twice daily for a period of 7 weeks (pilot) or 13 weeks (confirmatory). Vaccination occurred after 4 weeks of product consumption. Geometric mean antibody titres (GMT) against the 3 viral strains composing the vaccine (H1N1, H3N2, and B) were measured at several time intervals post-vaccination by haemagglutination inhibition test. RESULTS: In the pilot study, the influenza-specific antibody titres increased after vaccination, being consistently higher in the probiotic product group compared to the control group under product consumption. Similarly, in the confirmatory study, titres against the B strain increased significantly more in the probiotic group than in the control group at 3, 6 and 9 weeks post-vaccination under product consumption (p=0.020). Significant differences in seroconversion between the groups by intended to treat analysis were still found 5 months after vaccination. Similar GMT results were observed for the H3N2 strain and H1N1 strain, confirming the results of the pilot study. CONCLUSION: These studies demonstrate that daily consumption of this particular probiotic product increased relevant specific antibody responses to influenza vaccination in individuals of over 70 years of age and may therefore provide a health benefit in this population.</p>
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          <seriesStmt>            <idno type="stamp" n="PASTEUR">Institut Pasteur</idno>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="RIIP_PARIS">Institut Pasteur de Paris</idno>
            <idno type="stamp" n="UNIV-PARIS7" corresp="UNIV-PARIS">Université Denis Diderot - Paris VII</idno>
            <idno type="stamp" n="USPC">Université Sorbonne Paris Cité</idno>
            <idno type="stamp" n="UNIV-PARIS">Université de Paris</idno>
          </seriesStmt>
          <notesStmt>            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>            <biblStruct>              <analytic>                <title xml:lang="en">A probiotic fermented dairy drink improves antibody response to influenza vaccination in the elderly in two randomised controlled trials.</title>
                <author role="aut">                  <persName>                    <forename type="first">Thierry</forename>
                    <surname>Boge</surname>
                  </persName>
                  <idno type="halauthorid">468127</idno>
                  <affiliation ref="#struct-108489"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Michel</forename>
                    <surname>Rémigy</surname>
                  </persName>
                  <idno type="halauthorid">468128</idno>
                  <affiliation ref="#struct-108490"></affiliation>
                </author>
                <author role="crp">                  <persName>                    <forename type="first">Sarah</forename>
                    <surname>Vaudaine</surname>
                  </persName>
                  <email type="md5">3cb14bcce5cad6624ca459aed7f4aa85</email>
                  <email type="domain">danone.com</email>
                  <idno type="halauthorid">468129</idno>
                  <affiliation ref="#struct-51299"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Jérôme</forename>
                    <surname>Tanguy</surname>
                  </persName>
                  <idno type="halauthorid">468130</idno>
                  <affiliation ref="#struct-51299"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Raphaëlle</forename>
                    <surname>Bourdet-Sicard</surname>
                  </persName>
                  <idno type="halauthorid">468131</idno>
                  <affiliation ref="#struct-51299"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Sylvie</forename>
                    <surname>Van Der Werf</surname>
                  </persName>
                  <idno type="halauthorid">202082</idno>
                  <affiliation ref="#struct-35815"></affiliation>
                </author>
              </analytic>
              <monogr>                <idno type="halJournalId" status="VALID">19820</idno>
                <idno type="issn">0264-410X</idno>
                <idno type="eissn">0264-410X</idno>
                <title level="j">Vaccine</title>
                <imprint>                  <publisher>Elsevier</publisher>
                  <biblScope unit="volume">27</biblScope>
                  <biblScope unit="issue">41</biblScope>
                  <biblScope unit="pp">5677-84</biblScope>
                  <date type="datePub">2009-09-18</date>
                  <date type="dateEpub">2009-07-16</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1016/j.vaccine.2009.06.094</idno>
              <idno type="pubmed">19615959</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>            <langUsage>              <language ident="en">English</language>
            </langUsage>
            <textClass>              <classCode scheme="mesh">Aged</classCode>
              <classCode scheme="mesh">Aged, 80 and over</classCode>
              <classCode scheme="mesh">Influenza A Virus, H3N2 Subtype</classCode>
              <classCode scheme="mesh">Influenza B virus</classCode>
              <classCode scheme="mesh">Influenza Vaccines</classCode>
              <classCode scheme="mesh">Lactobacillus casei</classCode>
              <classCode scheme="mesh">Male</classCode>
              <classCode scheme="mesh">Placebos</classCode>
              <classCode scheme="mesh">Probiotics</classCode>
              <classCode scheme="mesh">Antibodies, Viral</classCode>
              <classCode scheme="mesh">Dairy Products</classCode>
              <classCode scheme="mesh">Double-Blind Method</classCode>
              <classCode scheme="mesh">Female</classCode>
              <classCode scheme="mesh">Hemagglutination Inhibition Tests</classCode>
              <classCode scheme="mesh">Humans</classCode>
              <classCode scheme="mesh">Immunologic Factors</classCode>
              <classCode scheme="mesh">Influenza A Virus, H1N1 Subtype</classCode>
              <classCode scheme="halDomain" n="sdv.mp.par">Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">              <p>BACKGROUND: Influenza vaccination is recommended for the elderly in many countries, but immune responses are weaker compared to younger adults. OBJECTIVE: To investigate the impact of daily consumption of a probiotic dairy drink on the immune response to influenza vaccination in an elderly population of healthy volunteers over 70 years of age. DESIGN: Two randomised, multicentre, double-blind, controlled studies were conducted during two vaccination seasons in 2005-2006 (pilot) and 2006-2007 (confirmatory). Eighty-six and 222 elderly volunteers consumed either a fermented dairy drink, containing the probiotic strain Lactobacillus casei DN-114 001 and yoghurt ferments (Actimel, or a non-fermented control dairy product twice daily for a period of 7 weeks (pilot) or 13 weeks (confirmatory). Vaccination occurred after 4 weeks of product consumption. Geometric mean antibody titres (GMT) against the 3 viral strains composing the vaccine (H1N1, H3N2, and B) were measured at several time intervals post-vaccination by haemagglutination inhibition test. RESULTS: In the pilot study, the influenza-specific antibody titres increased after vaccination, being consistently higher in the probiotic product group compared to the control group under product consumption. Similarly, in the confirmatory study, titres against the B strain increased significantly more in the probiotic group than in the control group at 3, 6 and 9 weeks post-vaccination under product consumption (p=0.020). Significant differences in seroconversion between the groups by intended to treat analysis were still found 5 months after vaccination. Similar GMT results were observed for the H3N2 strain and H1N1 strain, confirming the results of the pilot study. CONCLUSION: These studies demonstrate that daily consumption of this particular probiotic product increased relevant specific antibody responses to influenza vaccination in individuals of over 70 years of age and may therefore provide a health benefit in this population.</p>
            </abstract>
          </profileDesc>
        </hal>
</record>

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A probiotic fermented dairy drink improves antibody response to influenza vaccination in the elderly in two randomised controlled trials.

A probiotic fermented dairy drink improves antibody response to influenza vaccination in the elderly in two randomised controlled trials.

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