Experimental infection with H1N1 European swine influenza virus protects pigs from an infection with the 2009 pandemic H1N1 human influenza virus
Identifieur interne : 000274 ( Hal/Checkpoint ); précédent : 000273; suivant : 000275Experimental infection with H1N1 European swine influenza virus protects pigs from an infection with the 2009 pandemic H1N1 human influenza virus
Auteurs : Núria Busquets ; Joaquim Segalés ; Lorena C Rdoba ; Tufaria Mussá ; Elisa Crisci ; Gerard E. Martín-Valls ; Meritxell Simon-Grifé ; Marta Pérez-Sim ; Monica Pérez-Maíllo ; Jose I. Nú Ez ; Francesc X. Abad ; Lorenzo Fraile ; Sonia Pina ; Natalia Maj ; Albert Bensaid ; Mariano Domingo ; María MontoyaSource :
- Veterinary Research [ 0928-4249 ] ; 2010.
English descriptors
Abstract
The recent pandemic caused by human influenza virus A(H1N1) 2009 contains ancestral gene segments from North American and Eurasian swine lineages as well as from avian and human influenza lineages. The emergence of this A(H1N1) 2009 poses a potential global threat for human health and the fact that it can infect other species, like pigs, favours a possible encounter with other influenza viruses circulating in swine herds. In Europe, H1N1, H1N2 and H3N2 subtypes of swine influenza virus currently have a high prevalence in commercial farms. To better assess the risk posed by the A(H1N1) 2009 in the actual situation of swine farms, we sought to analyze whether a previous infection with a circulating European avian-like swine A/Swine/Spain/53207/2004 (H1N1) influenza virus (hereafter referred to as SwH1N1) generated or not cross-protective immunity against a subsequent infection with the new human pandemic A/Catalonia/63/2009 (H1N1) influenza virus (hereafter referred to as pH1N1) 21 days apart. Pigs infected only with pH1N1 had mild to moderate pathological findings, consisting on broncho-interstitial pneumonia. However, pigs inoculated with SwH1N1 virus and subsequently infected with pH1N1 had very mild lung lesions, apparently attributed to the remaining lesions caused by SwH1N1 infection. These later pigs also exhibited boosted levels of specific antibodies. Finally, animals firstly infected with SwH1N1 virus and latter infected with pH1N1 exhibited undetectable viral RNA load in nasal swabs and lungs after challenge with pH1N1, indicating a cross-protective effect between both strains.
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DOI: 10.1051/vetres/2010046
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Martín-Valls</name></author><author><name sortKey="Simon Grife, Meritxell" sort="Simon Grife, Meritxell" uniqKey="Simon Grife M" first="Meritxell" last="Simon-Grifé">Meritxell Simon-Grifé</name></author><author><name sortKey="Perez Sim, Marta" sort="Perez Sim, Marta" uniqKey="Perez Sim M" first="Marta" last="Pérez-Sim">Marta Pérez-Sim</name></author><author><name sortKey="Perez Maillo, Monica" sort="Perez Maillo, Monica" uniqKey="Perez Maillo M" first="Monica" last="Pérez-Maíllo">Monica Pérez-Maíllo</name></author><author><name sortKey="Nu Ez, Jose I" sort="Nu Ez, Jose I" uniqKey="Nu Ez J" first="Jose I." last="Nú Ez">Jose I. Nú Ez</name></author><author><name sortKey="Abad, Francesc X" sort="Abad, Francesc X" uniqKey="Abad F" first="Francesc X." last="Abad">Francesc X. Abad</name></author><author><name sortKey="Fraile, Lorenzo" sort="Fraile, Lorenzo" uniqKey="Fraile L" first="Lorenzo" last="Fraile">Lorenzo Fraile</name></author><author><name sortKey="Pina, Sonia" sort="Pina, Sonia" uniqKey="Pina S" first="Sonia" last="Pina">Sonia Pina</name></author><author><name sortKey="Maj, Natalia" sort="Maj, Natalia" uniqKey="Maj N" first="Natalia" last="Maj">Natalia Maj</name></author><author><name sortKey="Bensaid, Albert" sort="Bensaid, Albert" uniqKey="Bensaid A" first="Albert" last="Bensaid">Albert Bensaid</name></author><author><name sortKey="Domingo, Mariano" sort="Domingo, Mariano" uniqKey="Domingo M" first="Mariano" last="Domingo">Mariano Domingo</name></author><author><name sortKey="Montoya, Maria" sort="Montoya, Maria" uniqKey="Montoya M" first="María" last="Montoya">María Montoya</name></author></analytic><idno type="DOI">10.1051/vetres/2010046</idno><series><title level="j">Veterinary Research</title><idno type="ISSN">0928-4249</idno><imprint><date type="datePub">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="mix" xml:lang="en"><term>cross-protection</term><term>human A(H1N1) 2009</term><term>influenza virus</term><term>swine H1N1</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"> <p>The recent pandemic caused by human influenza virus A(H1N1) 2009 contains ancestral gene segments from North American and Eurasian swine lineages as well as from avian and human influenza lineages. The emergence of this A(H1N1) 2009 poses a potential global threat for human health and the fact that it can infect other species, like pigs, favours a possible encounter with other influenza viruses circulating in swine herds. In Europe, H1N1, H1N2 and H3N2 subtypes of swine influenza virus currently have a high prevalence in commercial farms. To better assess the risk posed by the A(H1N1) 2009 in the actual situation of swine farms, we sought to analyze whether a previous infection with a circulating European avian-like swine A/Swine/Spain/53207/2004 (H1N1) influenza virus (hereafter referred to as SwH1N1) generated or not cross-protective immunity against a subsequent infection with the new human pandemic A/Catalonia/63/2009 (H1N1) influenza virus (hereafter referred to as pH1N1) 21 days apart. Pigs infected only with pH1N1 had mild to moderate pathological findings, consisting on broncho-interstitial pneumonia. However, pigs inoculated with SwH1N1 virus and subsequently infected with pH1N1 had very mild lung lesions, apparently attributed to the remaining lesions caused by SwH1N1 infection. These later pigs also exhibited boosted levels of specific antibodies. 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type="halRefHtml">Veterinary Research, BioMed Central, 2010, 41 (5), ⟨10.1051/vetres/2010046⟩</idno> <idno type="halRef">Veterinary Research, BioMed Central, 2010, 41 (5), ⟨10.1051/vetres/2010046⟩</idno> </publicationStmt> <seriesStmt> <idno type="stamp" n="ARINRA-VETR" corresp="ARINRA">Veterinary research</idno> <idno type="stamp" n="ARINRA">Archives des revues INRA</idno> <idno type="stamp" n="SANTE_PUB_INSERM" corresp="INSERM">Santé Publique à l'Inserm</idno> </seriesStmt> <notesStmt> <note type="audience" n="2">International</note> <note type="popular" n="0">No</note> <note type="peer" n="1">Yes</note> </notesStmt> <sourceDesc> <biblStruct> <analytic> <title xml:lang="en">Experimental infection with H1N1 European swine influenza virus protects pigs from an infection with the 2009 pandemic H1N1 human influenza virus</title> <author role="aut"> <persName> <forename type="first">Núria</forename> <surname>Busquets</surname> </persName> <idno type="halauthorid">941711</idno> </author> <author role="aut"> <persName> <forename type="first">Joaquim</forename> <surname>Segalés</surname> </persName> <idno type="halauthorid">499323</idno> </author> <author role="aut"> <persName> <forename type="first">Lorena</forename> <surname>Córdoba</surname> </persName> <email type="md5">e82032a7492d3f00f8ab716f24b3d200</email> <email type="domain">gmail.com</email> <idno type="idhal" notation="string">lorena-cordoba</idno> <idno type="idhal" notation="numeric">170625</idno> <idno type="halauthorid">941712</idno> <idno type="ORCID">https://orcid.org/0000-0002-0648-5024</idno> <idno type="ResearcherId">http://www.researcherid.com/rid/N-4113-2016</idno> </author> <author role="aut"> <persName> <forename type="first">Tufaria</forename> <surname>Mussá</surname> </persName> <idno type="halauthorid">941713</idno> </author> <author role="aut"> <persName> <forename type="first">Elisa</forename> <surname>Crisci</surname> </persName> <idno type="halauthorid">941714</idno> </author> <author role="aut"> <persName> <forename type="first">Gerard E.</forename> <surname>Martín-Valls</surname> </persName> <idno type="halauthorid">941715</idno> </author> <author role="aut"> <persName> <forename type="first">Meritxell</forename> <surname>Simon-Grifé</surname> </persName> <idno type="halauthorid">941716</idno> </author> <author role="aut"> <persName> <forename type="first">Marta</forename> <surname>Pérez-Simó</surname> </persName> <idno type="halauthorid">941600</idno> </author> <author role="aut"> <persName> <forename type="first">Monica</forename> <surname>Pérez-Maíllo</surname> </persName> <idno type="halauthorid">941717</idno> </author> <author role="aut"> <persName> <forename type="first">Jose I.</forename> <surname>Núñez</surname> </persName> <idno type="halauthorid">941718</idno> </author> <author role="aut"> <persName> <forename type="first">Francesc X.</forename> <surname>Abad</surname> </persName> <idno type="halauthorid">941719</idno> </author> <author role="aut"> <persName> <forename type="first">Lorenzo</forename> <surname>Fraile</surname> </persName> <idno type="halauthorid">541864</idno> </author> <author role="aut"> <persName> <forename type="first">Sonia</forename> <surname>Pina</surname> </persName> <idno type="halauthorid">495128</idno> </author> <author role="aut"> <persName> <forename type="first">Natalia</forename> <surname>Majó</surname> </persName> <idno type="halauthorid">941720</idno> </author> <author role="aut"> <persName> <forename type="first">Albert</forename> <surname>Bensaid</surname> </persName> <idno type="halauthorid">941601</idno> </author> <author role="aut"> <persName> <forename type="first">Mariano</forename> <surname>Domingo</surname> </persName> <idno type="halauthorid">940446</idno> </author> <author role="aut"> <persName> <forename type="first">María</forename> <surname>Montoya</surname> </persName> <idno type="halauthorid">941721</idno> </author> </analytic> <monogr> <idno type="halJournalId" status="VALID">19840</idno> <idno type="issn">0928-4249</idno> <idno type="eissn">1297-9716</idno> <title level="j">Veterinary Research</title> <imprint> <publisher>BioMed Central</publisher> <biblScope unit="volume">41</biblScope> <biblScope unit="issue">5</biblScope> <date type="datePub">2010</date> </imprint> </monogr> <idno type="doi">10.1051/vetres/2010046</idno> </biblStruct> </sourceDesc> <profileDesc> <langUsage> <language ident="en">English</language> </langUsage> <textClass> <keywords scheme="author"> <term xml:lang="en">influenza virus</term> <term xml:lang="en">swine H1N1</term> <term xml:lang="en">human A(H1N1) 2009</term> <term xml:lang="en">cross-protection</term> </keywords> <classCode scheme="halDomain" n="sdv.bbm.bm">Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology</classCode> <classCode scheme="halDomain" n="sdv.gen.ga">Life Sciences [q-bio]/Genetics/Animal genetics</classCode> <classCode scheme="halDomain" n="sdv.bc">Life Sciences [q-bio]/Cellular Biology</classCode> <classCode scheme="halDomain" n="sdv.bc.ic">Life Sciences [q-bio]/Cellular Biology/Cell Behavior [q-bio.CB]</classCode> <classCode scheme="halDomain" n="sdv.mp">Life Sciences [q-bio]/Microbiology and Parasitology</classCode> <classCode scheme="halDomain" n="sdv.imm">Life Sciences [q-bio]/Immunology</classCode> <classCode scheme="halDomain" n="sdv.neu">Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]</classCode> <classCode scheme="halDomain" n="sdv.spee">Life Sciences [q-bio]/Santé publique et épidémiologie</classCode> <classCode scheme="halDomain" n="sdv.ba">Life Sciences [q-bio]/Animal biology</classCode> <classCode scheme="halTypology" n="ART">Journal articles</classCode> </textClass> <abstract xml:lang="en"> <p>The recent pandemic caused by human influenza virus A(H1N1) 2009 contains ancestral gene segments from North American and Eurasian swine lineages as well as from avian and human influenza lineages. The emergence of this A(H1N1) 2009 poses a potential global threat for human health and the fact that it can infect other species, like pigs, favours a possible encounter with other influenza viruses circulating in swine herds. In Europe, H1N1, H1N2 and H3N2 subtypes of swine influenza virus currently have a high prevalence in commercial farms. To better assess the risk posed by the A(H1N1) 2009 in the actual situation of swine farms, we sought to analyze whether a previous infection with a circulating European avian-like swine A/Swine/Spain/53207/2004 (H1N1) influenza virus (hereafter referred to as SwH1N1) generated or not cross-protective immunity against a subsequent infection with the new human pandemic A/Catalonia/63/2009 (H1N1) influenza virus (hereafter referred to as pH1N1) 21 days apart. Pigs infected only with pH1N1 had mild to moderate pathological findings, consisting on broncho-interstitial pneumonia. However, pigs inoculated with SwH1N1 virus and subsequently infected with pH1N1 had very mild lung lesions, apparently attributed to the remaining lesions caused by SwH1N1 infection. These later pigs also exhibited boosted levels of specific antibodies. Finally, animals firstly infected with SwH1N1 virus and latter infected with pH1N1 exhibited undetectable viral RNA load in nasal swabs and lungs after challenge with pH1N1, indicating a cross-protective effect between both strains.</p> </abstract> </profileDesc> </hal></record>Pour manipuler ce document sous Unix (Dilib)
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