H2N2V1, Hal, Checkpoint, bibRecord, 000062

Antiviral activity of Formyl Peptide Receptor 2 antagonists against influenza viruses

Identifieur interne : 000062 ( Hal/Checkpoint ); précédent : 000061; suivant : 000063

Antiviral activity of Formyl Peptide Receptor 2 antagonists against influenza viruses

Auteurs : Noemie Courtin [France] ; Aurelien Fotso Fotso [France] ; Pierre Fautrad [France] ; Floriane Mas [France] ; Marie-Christine Alessi [France] ; Beatrice Riteau [France]

Source :

Antiviral Research [ 0166-3542 ] ; 2017.

RBID : Hal:hal-01755130

English descriptors

mix :
- Antiviral, Formyl peptide receptor 2, Influenza virus.

Abstract

Influenza viruses are one of the most important respiratory pathogens worldwide, causing both epidemic and pandemic infections. The aim of the study was to evaluate the effect of FPR2 antagonists PBP10 and BOC2 on influenza virus replication. We determined that these molecules exhibit antiviral effects against influenza A (H1N1, H3N2, H6N2) and B viruses. FPR2 antagonists used in combination with oseltamivir showed additive antiviral effects. Mechanistically, the antiviral effect of PBP10 and BOC2 is mediated through early inhibition of virus-induced ERK activation. Finally, our preclinical studies showed that FPR2 antagonists protected mice from lethal infections induced by influenza, both in a prophylactic and therapeutic manner. Thus, FPR2 antagonists might be explored for novel treatments against influenza.

Url:

https://hal-amu.archives-ouvertes.fr/hal-01755130

DOI: 10.1016/j.antiviral.2017.05.001

Links toward previous steps (curation, corpus...)

to stream Hal, to step Corpus: 000021
to stream Hal, to step Curation: 000021

Links to Exploration step

Hal:hal-01755130

Le document en format XML

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<idno type="DOI">10.1016/j.antiviral.2017.05.001</idno>
<series><title level="j">Antiviral Research</title>
<idno type="ISSN">0166-3542</idno>
<imprint><date type="datePub">2017</date>
</imprint>
</series>
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</fileDesc>
<profileDesc><textClass><keywords scheme="mix" xml:lang="en"><term>Antiviral</term>
<term>Formyl peptide receptor 2</term>
<term>Influenza virus</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">              <p>Influenza viruses are one of the most important respiratory pathogens worldwide, causing both epidemic and pandemic infections. The aim of the study was to evaluate the effect of FPR2 antagonists PBP10 and BOC2 on influenza virus replication. We determined that these molecules exhibit antiviral effects against influenza A (H1N1, H3N2, H6N2) and B viruses. FPR2 antagonists used in combination with oseltamivir showed additive antiviral effects. Mechanistically, the antiviral effect of PBP10 and BOC2 is mediated through early inhibition of virus-induced ERK activation. Finally, our preclinical studies showed that FPR2 antagonists protected mice from lethal infections induced by influenza, both in a prophylactic and therapeutic manner. Thus, FPR2 antagonists might be explored for novel treatments against influenza.</p>
            </div>
</front>
</TEI>
<hal api="V3">          <titleStmt>            <title xml:lang="en">Antiviral activity of Formyl Peptide Receptor 2 antagonists against influenza viruses</title>
            <author role="aut">              <persName>                <forename type="first">Noemie</forename>
                <surname>Courtin</surname>
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            <author role="aut">              <persName>                <forename type="first">Pierre</forename>
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            <author role="aut">              <persName>                <forename type="first">Marie-Christine</forename>
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            <editor role="depositor">              <persName>                <forename>Marie-Christine</forename>
                <surname>ALESSI</surname>
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            <funder>ANR  ANR-13-BSV3-0011,  Fondation de France 00066467, FVLM RF20160501641  SA17 Sud-Est, 789-SA-16-UAM </funder>
          </titleStmt>
          <editionStmt>            <edition n="v1" type="current">              <date type="whenSubmitted">2018-03-30 14:14:58</date>
              <date type="whenModified">2020-03-17 02:54:55</date>
              <date type="whenReleased">2018-03-30 14:21:27</date>
              <date type="whenProduced">2017</date>
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            <idno type="halBibtex">courtin:hal-01755130</idno>
            <idno type="halRefHtml">Antiviral Research, Elsevier Masson, 2017, 143, pp.252-261. ⟨10.1016/j.antiviral.2017.05.001⟩</idno>
            <idno type="halRef">Antiviral Research, Elsevier Masson, 2017, 143, pp.252-261. ⟨10.1016/j.antiviral.2017.05.001⟩</idno>
          </publicationStmt>
          <seriesStmt>            <idno type="stamp" n="UNIV-AMU">Aix Marseille Université</idno>
            <idno type="stamp" n="INRA">INRA - Institut national de la recherche agronomique</idno>
            <idno type="stamp" n="AGREENIUM">Archive ouverte en agrobiosciences</idno>
            <idno type="stamp" n="TEST-AMU">Espace de test AMU</idno>
            <idno type="stamp" n="INSERM">INSERM - Institut national de la santé et de la recherche médicale</idno>
            <idno type="stamp" n="INRAE">Institut National de Recherche en Agriculture, Alimentation et Environnement</idno>
          </seriesStmt>
          <notesStmt>            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
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          <sourceDesc>            <biblStruct>              <analytic>                <title xml:lang="en">Antiviral activity of Formyl Peptide Receptor 2 antagonists against influenza viruses</title>
                <author role="aut">                  <persName>                    <forename type="first">Noemie</forename>
                    <surname>Courtin</surname>
                  </persName>
                  <idno type="halauthorid">1637512</idno>
                  <affiliation ref="#struct-180118"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Aurelien Fotso</forename>
                    <surname>Fotso</surname>
                  </persName>
                  <idno type="halauthorid">1481781</idno>
                  <affiliation ref="#struct-180118"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Pierre</forename>
                    <surname>Fautrad</surname>
                  </persName>
                  <idno type="halauthorid">1637513</idno>
                  <affiliation ref="#struct-180118"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Floriane</forename>
                    <surname>Mas</surname>
                  </persName>
                  <idno type="halauthorid">1637514</idno>
                  <affiliation ref="#struct-180118"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Marie-Christine</forename>
                    <surname>Alessi</surname>
                  </persName>
                  <email type="md5">279f3d58b01a03fd7bf7cd6b2684b605</email>
                  <email type="domain">univ-amu.fr</email>
                  <idno type="idhal" notation="string">marie-christine-alessi</idno>
                  <idno type="idhal" notation="numeric">12718</idno>
                  <idno type="halauthorid">1432571</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-3927-5792</idno>
                  <affiliation ref="#struct-180118"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Beatrice</forename>
                    <surname>Riteau</surname>
                  </persName>
                  <email type="md5">529e865f909afe6a0f0e1893c4729205</email>
                  <email type="domain">laposte.net</email>
                  <idno type="halauthorid">1540322</idno>
                  <affiliation ref="#struct-180118"></affiliation>
                </author>
              </analytic>
              <monogr>                <idno type="halJournalId" status="VALID">10572</idno>
                <idno type="issn">0166-3542</idno>
                <title level="j">Antiviral Research</title>
                <imprint>                  <publisher>Elsevier Masson</publisher>
                  <biblScope unit="volume">143</biblScope>
                  <biblScope unit="pp">252-261</biblScope>
                  <date type="datePub">2017</date>
                  <date type="dateEpub">2017-05-05</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1016/j.antiviral.2017.05.001</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>            <langUsage>              <language ident="en">English</language>
            </langUsage>
            <textClass>              <keywords scheme="author">                <term xml:lang="en">Formyl peptide receptor 2</term>
                <term xml:lang="en">Influenza virus</term>
                <term xml:lang="en">Antiviral</term>
              </keywords>
              <classCode scheme="halDomain" n="sdv.sp.pharma">Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology</classCode>
              <classCode scheme="halDomain" n="sdv.mhep.mi">Life Sciences [q-bio]/Human health and pathology/Infectious diseases</classCode>
              <classCode scheme="halDomain" n="sdv.mp.vir">Life Sciences [q-bio]/Microbiology and Parasitology/Virology</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">              <p>Influenza viruses are one of the most important respiratory pathogens worldwide, causing both epidemic and pandemic infections. The aim of the study was to evaluate the effect of FPR2 antagonists PBP10 and BOC2 on influenza virus replication. We determined that these molecules exhibit antiviral effects against influenza A (H1N1, H3N2, H6N2) and B viruses. FPR2 antagonists used in combination with oseltamivir showed additive antiviral effects. Mechanistically, the antiviral effect of PBP10 and BOC2 is mediated through early inhibition of virus-induced ERK activation. Finally, our preclinical studies showed that FPR2 antagonists protected mice from lethal infections induced by influenza, both in a prophylactic and therapeutic manner. Thus, FPR2 antagonists might be explored for novel treatments against influenza.</p>
            </abstract>
          </profileDesc>
        </hal>
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Antiviral activity of Formyl Peptide Receptor 2 antagonists against influenza viruses

Antiviral activity of Formyl Peptide Receptor 2 antagonists against influenza viruses

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