Checkpoint
Hal
Racine
Checkpoint
Hal
Exploration
Accueil
Racine
Racine

Serveur d'exploration H2N2

Attention, ce site est en cours de développement !
Attention, site généré par des moyens informatiques à partir de corpus bruts.
Les informations ne sont donc pas validées.

The Annexin A1 Receptor FPR2 Regulates the Endosomal Export of Influenza Virus

Identifieur interne : 000036 ( Hal/Checkpoint ); précédent : 000035; suivant : 000037

The Annexin A1 Receptor FPR2 Regulates the Endosomal Export of Influenza Virus

Auteurs : Fryad Rahman [France] ; Mohammad Chebbo [France] ; Noemie Courtin [France] ; Aurelien Fotso Fotso [France] ; Marie-Christine Alessi [France] ; Beatrice Riteau [France]

Source :

RBID : Hal:hal-02091328

English descriptors

Abstract

The Formyl Peptide Receptor 2 (FPR2) is a novel promising target for the treatment of influenza. During viral infection, FPR2 is activated by annexinA1, which is present in the envelope of influenza viruses; this activation promotes virus replication. Here, we investigated whether blockage of FPR2 would affect the genome trafficking of influenza virus. We found that, upon infection and cell treatment with the specific FPR2 antagonist WRW4 or the anti-FPR2 monoclonal antibody, FN-1D6-AI, influenza viruses were blocked into endosomes. This effect was independent on the strain and was observed for H1N1 and H3N2 viruses. In addition, blocking FPR2signaling in alveolar lung A549 epithelial cells with the monoclonal anti-FPR2 antibody significantly inhibited virus replication. Altogether, these results show that FPR2signaling interferes with the endosomal trafficking of influenza viruses and provides, for the first time, the proof of concept that monoclonal antibodies directed against FPR2 inhibit virus replication. Antibodies-based therapeutics have emerged as attractive reagents in infectious diseases. Thus, this study suggests that the use of anti-FPR2 antibodies against influenza hold great promise for the future.


Url:
DOI: 10.3390/ijms19051400

Links toward previous steps (curation, corpus...)

Links to Exploration step

Hal:hal-02091328

Le document en format XML

<record>
<TEI>
<teiHeader>
<fileDesc>
<titleStmt>
<title xml:lang="en">The Annexin A1 Receptor FPR2 Regulates the Endosomal Export of Influenza Virus</title>
<author>
<name sortKey="Rahman, Fryad" sort="Rahman, Fryad" uniqKey="Rahman F" first="Fryad" last="Rahman">Fryad Rahman</name>
<affiliation wicri:level="1">
<hal:affiliation type="laboratory" xml:id="struct-180118" status="OLD">
<idno type="RNSR">197417835D</idno>
<idno type="IdRef">123019265</idno>
<orgName>Nutrition, obésité et risque thrombotique</orgName>
<orgName type="acronym">NORT</orgName>
<date type="start">1974</date>
<date type="end">2017-12-31</date>
<desc>
<address>
<addrLine>Faculté de Médecine Timone - 27 Bd Jean Moulin 13385 Marseille Cedex 5</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://nort.univ-amu.fr/</ref>
</desc>
<listRelation>
<relation name="UMR_A1260" active="#struct-92114" type="direct"></relation>
<relation name="UMR_A1260" active="#struct-198056" type="direct"></relation>
<relation name="U1062" active="#struct-303623" type="direct"></relation>
</listRelation>
<tutelles>
<tutelle name="UMR_A1260" active="#struct-92114" type="direct">
<org type="institution" xml:id="struct-92114" status="OLD">
<orgName>Institut National de la Recherche Agronomique</orgName>
<orgName type="acronym">INRA</orgName>
<date type="start">1946-05-18</date>
<date type="end">2019-12-31</date>
<desc>
<address>
<country key="FR"></country>
</address>
<ref type="url">http://www.inra.fr</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR_A1260" active="#struct-198056" type="direct">
<org type="institution" xml:id="struct-198056" status="VALID">
<idno type="IdRef">15863621X</idno>
<idno type="ISNI">0000 0001 2176 4817</idno>
<orgName>Aix Marseille Université</orgName>
<orgName type="acronym">AMU</orgName>
<date type="start">2012-01-01</date>
<desc>
<address>
<addrLine>Aix-Marseille UniversitéJardins du Pharo58 Boulevard Charles Livon13284 Marseille cedex 7</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-amu.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="U1062" active="#struct-303623" type="direct">
<org type="institution" xml:id="struct-303623" status="VALID">
<idno type="IdRef">026388278</idno>
<orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
<orgName type="acronym">INSERM</orgName>
<desc>
<address>
<addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.inserm.fr</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName>
<settlement type="city">Marseille</settlement>
<region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
</placeName>
<orgName type="university">Université d'Aix-Marseille</orgName>
</affiliation>
</author>
<author>
<name sortKey="Chebbo, Mohammad" sort="Chebbo, Mohammad" uniqKey="Chebbo M" first="Mohammad" last="Chebbo">Mohammad Chebbo</name>
<affiliation wicri:level="1">
<hal:affiliation type="laboratory" xml:id="struct-527021" status="OLD">
<idno type="RNSR">201822670T</idno>
<orgName>Centre recherche en CardioVasculaire et Nutrition</orgName>
<orgName type="acronym">C2VN</orgName>
<date type="start">2018-01-01</date>
<date type="end">2019-12-31</date>
<desc>
<address>
<addrLine>Faculté de Pharmacie - Timone27, boulevard Jean Moulin13385 Marseille cedex 5</addrLine>
<country key="FR"></country>
</address>
</desc>
<listRelation>
<relation name="UMR_S1263" active="#struct-92114" type="direct"></relation>
<relation name="UMR_S1263" active="#struct-198056" type="direct"></relation>
<relation name="UMR_S1263" active="#struct-303623" type="direct"></relation>
</listRelation>
<tutelles>
<tutelle name="UMR_S1263" active="#struct-92114" type="direct">
<org type="institution" xml:id="struct-92114" status="OLD">
<orgName>Institut National de la Recherche Agronomique</orgName>
<orgName type="acronym">INRA</orgName>
<date type="start">1946-05-18</date>
<date type="end">2019-12-31</date>
<desc>
<address>
<country key="FR"></country>
</address>
<ref type="url">http://www.inra.fr</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR_S1263" active="#struct-198056" type="direct">
<org type="institution" xml:id="struct-198056" status="VALID">
<idno type="IdRef">15863621X</idno>
<idno type="ISNI">0000 0001 2176 4817</idno>
<orgName>Aix Marseille Université</orgName>
<orgName type="acronym">AMU</orgName>
<date type="start">2012-01-01</date>
<desc>
<address>
<addrLine>Aix-Marseille UniversitéJardins du Pharo58 Boulevard Charles Livon13284 Marseille cedex 7</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-amu.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR_S1263" active="#struct-303623" type="direct">
<org type="institution" xml:id="struct-303623" status="VALID">
<idno type="IdRef">026388278</idno>
<orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
<orgName type="acronym">INSERM</orgName>
<desc>
<address>
<addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.inserm.fr</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName>
<settlement type="city">Marseille</settlement>
<region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
</placeName>
<orgName type="university">Université d'Aix-Marseille</orgName>
</affiliation>
</author>
<author>
<name sortKey="Courtin, Noemie" sort="Courtin, Noemie" uniqKey="Courtin N" first="Noemie" last="Courtin">Noemie Courtin</name>
<affiliation wicri:level="1">
<hal:affiliation type="laboratory" xml:id="struct-180118" status="OLD">
<idno type="RNSR">197417835D</idno>
<idno type="IdRef">123019265</idno>
<orgName>Nutrition, obésité et risque thrombotique</orgName>
<orgName type="acronym">NORT</orgName>
<date type="start">1974</date>
<date type="end">2017-12-31</date>
<desc>
<address>
<addrLine>Faculté de Médecine Timone - 27 Bd Jean Moulin 13385 Marseille Cedex 5</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://nort.univ-amu.fr/</ref>
</desc>
<listRelation>
<relation name="UMR_A1260" active="#struct-92114" type="direct"></relation>
<relation name="UMR_A1260" active="#struct-198056" type="direct"></relation>
<relation name="U1062" active="#struct-303623" type="direct"></relation>
</listRelation>
<tutelles>
<tutelle name="UMR_A1260" active="#struct-92114" type="direct">
<org type="institution" xml:id="struct-92114" status="OLD">
<orgName>Institut National de la Recherche Agronomique</orgName>
<orgName type="acronym">INRA</orgName>
<date type="start">1946-05-18</date>
<date type="end">2019-12-31</date>
<desc>
<address>
<country key="FR"></country>
</address>
<ref type="url">http://www.inra.fr</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR_A1260" active="#struct-198056" type="direct">
<org type="institution" xml:id="struct-198056" status="VALID">
<idno type="IdRef">15863621X</idno>
<idno type="ISNI">0000 0001 2176 4817</idno>
<orgName>Aix Marseille Université</orgName>
<orgName type="acronym">AMU</orgName>
<date type="start">2012-01-01</date>
<desc>
<address>
<addrLine>Aix-Marseille UniversitéJardins du Pharo58 Boulevard Charles Livon13284 Marseille cedex 7</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-amu.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="U1062" active="#struct-303623" type="direct">
<org type="institution" xml:id="struct-303623" status="VALID">
<idno type="IdRef">026388278</idno>
<orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
<orgName type="acronym">INSERM</orgName>
<desc>
<address>
<addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.inserm.fr</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName>
<settlement type="city">Marseille</settlement>
<region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
</placeName>
<orgName type="university">Université d'Aix-Marseille</orgName>
</affiliation>
</author>
<author>
<name sortKey="Fotso, Aurelien Fotso" sort="Fotso, Aurelien Fotso" uniqKey="Fotso A" first="Aurelien Fotso" last="Fotso">Aurelien Fotso Fotso</name>
<affiliation wicri:level="1">
<hal:affiliation type="laboratory" xml:id="struct-180118" status="OLD">
<idno type="RNSR">197417835D</idno>
<idno type="IdRef">123019265</idno>
<orgName>Nutrition, obésité et risque thrombotique</orgName>
<orgName type="acronym">NORT</orgName>
<date type="start">1974</date>
<date type="end">2017-12-31</date>
<desc>
<address>
<addrLine>Faculté de Médecine Timone - 27 Bd Jean Moulin 13385 Marseille Cedex 5</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://nort.univ-amu.fr/</ref>
</desc>
<listRelation>
<relation name="UMR_A1260" active="#struct-92114" type="direct"></relation>
<relation name="UMR_A1260" active="#struct-198056" type="direct"></relation>
<relation name="U1062" active="#struct-303623" type="direct"></relation>
</listRelation>
<tutelles>
<tutelle name="UMR_A1260" active="#struct-92114" type="direct">
<org type="institution" xml:id="struct-92114" status="OLD">
<orgName>Institut National de la Recherche Agronomique</orgName>
<orgName type="acronym">INRA</orgName>
<date type="start">1946-05-18</date>
<date type="end">2019-12-31</date>
<desc>
<address>
<country key="FR"></country>
</address>
<ref type="url">http://www.inra.fr</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR_A1260" active="#struct-198056" type="direct">
<org type="institution" xml:id="struct-198056" status="VALID">
<idno type="IdRef">15863621X</idno>
<idno type="ISNI">0000 0001 2176 4817</idno>
<orgName>Aix Marseille Université</orgName>
<orgName type="acronym">AMU</orgName>
<date type="start">2012-01-01</date>
<desc>
<address>
<addrLine>Aix-Marseille UniversitéJardins du Pharo58 Boulevard Charles Livon13284 Marseille cedex 7</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-amu.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="U1062" active="#struct-303623" type="direct">
<org type="institution" xml:id="struct-303623" status="VALID">
<idno type="IdRef">026388278</idno>
<orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
<orgName type="acronym">INSERM</orgName>
<desc>
<address>
<addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.inserm.fr</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName>
<settlement type="city">Marseille</settlement>
<region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
</placeName>
<orgName type="university">Université d'Aix-Marseille</orgName>
</affiliation>
</author>
<author>
<name sortKey="Alessi, Marie Christine" sort="Alessi, Marie Christine" uniqKey="Alessi M" first="Marie-Christine" last="Alessi">Marie-Christine Alessi</name>
<affiliation wicri:level="1">
<hal:affiliation type="laboratory" xml:id="struct-180118" status="OLD">
<idno type="RNSR">197417835D</idno>
<idno type="IdRef">123019265</idno>
<orgName>Nutrition, obésité et risque thrombotique</orgName>
<orgName type="acronym">NORT</orgName>
<date type="start">1974</date>
<date type="end">2017-12-31</date>
<desc>
<address>
<addrLine>Faculté de Médecine Timone - 27 Bd Jean Moulin 13385 Marseille Cedex 5</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://nort.univ-amu.fr/</ref>
</desc>
<listRelation>
<relation name="UMR_A1260" active="#struct-92114" type="direct"></relation>
<relation name="UMR_A1260" active="#struct-198056" type="direct"></relation>
<relation name="U1062" active="#struct-303623" type="direct"></relation>
</listRelation>
<tutelles>
<tutelle name="UMR_A1260" active="#struct-92114" type="direct">
<org type="institution" xml:id="struct-92114" status="OLD">
<orgName>Institut National de la Recherche Agronomique</orgName>
<orgName type="acronym">INRA</orgName>
<date type="start">1946-05-18</date>
<date type="end">2019-12-31</date>
<desc>
<address>
<country key="FR"></country>
</address>
<ref type="url">http://www.inra.fr</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR_A1260" active="#struct-198056" type="direct">
<org type="institution" xml:id="struct-198056" status="VALID">
<idno type="IdRef">15863621X</idno>
<idno type="ISNI">0000 0001 2176 4817</idno>
<orgName>Aix Marseille Université</orgName>
<orgName type="acronym">AMU</orgName>
<date type="start">2012-01-01</date>
<desc>
<address>
<addrLine>Aix-Marseille UniversitéJardins du Pharo58 Boulevard Charles Livon13284 Marseille cedex 7</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-amu.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="U1062" active="#struct-303623" type="direct">
<org type="institution" xml:id="struct-303623" status="VALID">
<idno type="IdRef">026388278</idno>
<orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
<orgName type="acronym">INSERM</orgName>
<desc>
<address>
<addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.inserm.fr</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName>
<settlement type="city">Marseille</settlement>
<region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
</placeName>
<orgName type="university">Université d'Aix-Marseille</orgName>
</affiliation>
</author>
<author>
<name sortKey="Riteau, Beatrice" sort="Riteau, Beatrice" uniqKey="Riteau B" first="Beatrice" last="Riteau">Beatrice Riteau</name>
<affiliation wicri:level="1">
<hal:affiliation type="laboratory" xml:id="struct-180118" status="OLD">
<idno type="RNSR">197417835D</idno>
<idno type="IdRef">123019265</idno>
<orgName>Nutrition, obésité et risque thrombotique</orgName>
<orgName type="acronym">NORT</orgName>
<date type="start">1974</date>
<date type="end">2017-12-31</date>
<desc>
<address>
<addrLine>Faculté de Médecine Timone - 27 Bd Jean Moulin 13385 Marseille Cedex 5</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://nort.univ-amu.fr/</ref>
</desc>
<listRelation>
<relation name="UMR_A1260" active="#struct-92114" type="direct"></relation>
<relation name="UMR_A1260" active="#struct-198056" type="direct"></relation>
<relation name="U1062" active="#struct-303623" type="direct"></relation>
</listRelation>
<tutelles>
<tutelle name="UMR_A1260" active="#struct-92114" type="direct">
<org type="institution" xml:id="struct-92114" status="OLD">
<orgName>Institut National de la Recherche Agronomique</orgName>
<orgName type="acronym">INRA</orgName>
<date type="start">1946-05-18</date>
<date type="end">2019-12-31</date>
<desc>
<address>
<country key="FR"></country>
</address>
<ref type="url">http://www.inra.fr</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR_A1260" active="#struct-198056" type="direct">
<org type="institution" xml:id="struct-198056" status="VALID">
<idno type="IdRef">15863621X</idno>
<idno type="ISNI">0000 0001 2176 4817</idno>
<orgName>Aix Marseille Université</orgName>
<orgName type="acronym">AMU</orgName>
<date type="start">2012-01-01</date>
<desc>
<address>
<addrLine>Aix-Marseille UniversitéJardins du Pharo58 Boulevard Charles Livon13284 Marseille cedex 7</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-amu.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="U1062" active="#struct-303623" type="direct">
<org type="institution" xml:id="struct-303623" status="VALID">
<idno type="IdRef">026388278</idno>
<orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
<orgName type="acronym">INSERM</orgName>
<desc>
<address>
<addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.inserm.fr</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName>
<settlement type="city">Marseille</settlement>
<region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
</placeName>
<orgName type="university">Université d'Aix-Marseille</orgName>
</affiliation>
</author>
</titleStmt>
<publicationStmt>
<idno type="wicri:source">HAL</idno>
<idno type="RBID">Hal:hal-02091328</idno>
<idno type="halId">hal-02091328</idno>
<idno type="halUri">https://hal-amu.archives-ouvertes.fr/hal-02091328</idno>
<idno type="url">https://hal-amu.archives-ouvertes.fr/hal-02091328</idno>
<idno type="doi">10.3390/ijms19051400</idno>
<date when="2018">2018</date>
<idno type="wicri:Area/Hal/Corpus">000288</idno>
<idno type="wicri:Area/Hal/Curation">000288</idno>
<idno type="wicri:Area/Hal/Checkpoint">000036</idno>
<idno type="wicri:explorRef" wicri:stream="Hal" wicri:step="Checkpoint">000036</idno>
</publicationStmt>
<sourceDesc>
<biblStruct>
<analytic>
<title xml:lang="en">The Annexin A1 Receptor FPR2 Regulates the Endosomal Export of Influenza Virus</title>
<author>
<name sortKey="Rahman, Fryad" sort="Rahman, Fryad" uniqKey="Rahman F" first="Fryad" last="Rahman">Fryad Rahman</name>
<affiliation wicri:level="1">
<hal:affiliation type="laboratory" xml:id="struct-180118" status="OLD">
<idno type="RNSR">197417835D</idno>
<idno type="IdRef">123019265</idno>
<orgName>Nutrition, obésité et risque thrombotique</orgName>
<orgName type="acronym">NORT</orgName>
<date type="start">1974</date>
<date type="end">2017-12-31</date>
<desc>
<address>
<addrLine>Faculté de Médecine Timone - 27 Bd Jean Moulin 13385 Marseille Cedex 5</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://nort.univ-amu.fr/</ref>
</desc>
<listRelation>
<relation name="UMR_A1260" active="#struct-92114" type="direct"></relation>
<relation name="UMR_A1260" active="#struct-198056" type="direct"></relation>
<relation name="U1062" active="#struct-303623" type="direct"></relation>
</listRelation>
<tutelles>
<tutelle name="UMR_A1260" active="#struct-92114" type="direct">
<org type="institution" xml:id="struct-92114" status="OLD">
<orgName>Institut National de la Recherche Agronomique</orgName>
<orgName type="acronym">INRA</orgName>
<date type="start">1946-05-18</date>
<date type="end">2019-12-31</date>
<desc>
<address>
<country key="FR"></country>
</address>
<ref type="url">http://www.inra.fr</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR_A1260" active="#struct-198056" type="direct">
<org type="institution" xml:id="struct-198056" status="VALID">
<idno type="IdRef">15863621X</idno>
<idno type="ISNI">0000 0001 2176 4817</idno>
<orgName>Aix Marseille Université</orgName>
<orgName type="acronym">AMU</orgName>
<date type="start">2012-01-01</date>
<desc>
<address>
<addrLine>Aix-Marseille UniversitéJardins du Pharo58 Boulevard Charles Livon13284 Marseille cedex 7</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-amu.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="U1062" active="#struct-303623" type="direct">
<org type="institution" xml:id="struct-303623" status="VALID">
<idno type="IdRef">026388278</idno>
<orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
<orgName type="acronym">INSERM</orgName>
<desc>
<address>
<addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.inserm.fr</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName>
<settlement type="city">Marseille</settlement>
<region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
</placeName>
<orgName type="university">Université d'Aix-Marseille</orgName>
</affiliation>
</author>
<author>
<name sortKey="Chebbo, Mohammad" sort="Chebbo, Mohammad" uniqKey="Chebbo M" first="Mohammad" last="Chebbo">Mohammad Chebbo</name>
<affiliation wicri:level="1">
<hal:affiliation type="laboratory" xml:id="struct-527021" status="OLD">
<idno type="RNSR">201822670T</idno>
<orgName>Centre recherche en CardioVasculaire et Nutrition</orgName>
<orgName type="acronym">C2VN</orgName>
<date type="start">2018-01-01</date>
<date type="end">2019-12-31</date>
<desc>
<address>
<addrLine>Faculté de Pharmacie - Timone27, boulevard Jean Moulin13385 Marseille cedex 5</addrLine>
<country key="FR"></country>
</address>
</desc>
<listRelation>
<relation name="UMR_S1263" active="#struct-92114" type="direct"></relation>
<relation name="UMR_S1263" active="#struct-198056" type="direct"></relation>
<relation name="UMR_S1263" active="#struct-303623" type="direct"></relation>
</listRelation>
<tutelles>
<tutelle name="UMR_S1263" active="#struct-92114" type="direct">
<org type="institution" xml:id="struct-92114" status="OLD">
<orgName>Institut National de la Recherche Agronomique</orgName>
<orgName type="acronym">INRA</orgName>
<date type="start">1946-05-18</date>
<date type="end">2019-12-31</date>
<desc>
<address>
<country key="FR"></country>
</address>
<ref type="url">http://www.inra.fr</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR_S1263" active="#struct-198056" type="direct">
<org type="institution" xml:id="struct-198056" status="VALID">
<idno type="IdRef">15863621X</idno>
<idno type="ISNI">0000 0001 2176 4817</idno>
<orgName>Aix Marseille Université</orgName>
<orgName type="acronym">AMU</orgName>
<date type="start">2012-01-01</date>
<desc>
<address>
<addrLine>Aix-Marseille UniversitéJardins du Pharo58 Boulevard Charles Livon13284 Marseille cedex 7</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-amu.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR_S1263" active="#struct-303623" type="direct">
<org type="institution" xml:id="struct-303623" status="VALID">
<idno type="IdRef">026388278</idno>
<orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
<orgName type="acronym">INSERM</orgName>
<desc>
<address>
<addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.inserm.fr</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName>
<settlement type="city">Marseille</settlement>
<region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
</placeName>
<orgName type="university">Université d'Aix-Marseille</orgName>
</affiliation>
</author>
<author>
<name sortKey="Courtin, Noemie" sort="Courtin, Noemie" uniqKey="Courtin N" first="Noemie" last="Courtin">Noemie Courtin</name>
<affiliation wicri:level="1">
<hal:affiliation type="laboratory" xml:id="struct-180118" status="OLD">
<idno type="RNSR">197417835D</idno>
<idno type="IdRef">123019265</idno>
<orgName>Nutrition, obésité et risque thrombotique</orgName>
<orgName type="acronym">NORT</orgName>
<date type="start">1974</date>
<date type="end">2017-12-31</date>
<desc>
<address>
<addrLine>Faculté de Médecine Timone - 27 Bd Jean Moulin 13385 Marseille Cedex 5</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://nort.univ-amu.fr/</ref>
</desc>
<listRelation>
<relation name="UMR_A1260" active="#struct-92114" type="direct"></relation>
<relation name="UMR_A1260" active="#struct-198056" type="direct"></relation>
<relation name="U1062" active="#struct-303623" type="direct"></relation>
</listRelation>
<tutelles>
<tutelle name="UMR_A1260" active="#struct-92114" type="direct">
<org type="institution" xml:id="struct-92114" status="OLD">
<orgName>Institut National de la Recherche Agronomique</orgName>
<orgName type="acronym">INRA</orgName>
<date type="start">1946-05-18</date>
<date type="end">2019-12-31</date>
<desc>
<address>
<country key="FR"></country>
</address>
<ref type="url">http://www.inra.fr</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR_A1260" active="#struct-198056" type="direct">
<org type="institution" xml:id="struct-198056" status="VALID">
<idno type="IdRef">15863621X</idno>
<idno type="ISNI">0000 0001 2176 4817</idno>
<orgName>Aix Marseille Université</orgName>
<orgName type="acronym">AMU</orgName>
<date type="start">2012-01-01</date>
<desc>
<address>
<addrLine>Aix-Marseille UniversitéJardins du Pharo58 Boulevard Charles Livon13284 Marseille cedex 7</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-amu.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="U1062" active="#struct-303623" type="direct">
<org type="institution" xml:id="struct-303623" status="VALID">
<idno type="IdRef">026388278</idno>
<orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
<orgName type="acronym">INSERM</orgName>
<desc>
<address>
<addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.inserm.fr</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName>
<settlement type="city">Marseille</settlement>
<region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
</placeName>
<orgName type="university">Université d'Aix-Marseille</orgName>
</affiliation>
</author>
<author>
<name sortKey="Fotso, Aurelien Fotso" sort="Fotso, Aurelien Fotso" uniqKey="Fotso A" first="Aurelien Fotso" last="Fotso">Aurelien Fotso Fotso</name>
<affiliation wicri:level="1">
<hal:affiliation type="laboratory" xml:id="struct-180118" status="OLD">
<idno type="RNSR">197417835D</idno>
<idno type="IdRef">123019265</idno>
<orgName>Nutrition, obésité et risque thrombotique</orgName>
<orgName type="acronym">NORT</orgName>
<date type="start">1974</date>
<date type="end">2017-12-31</date>
<desc>
<address>
<addrLine>Faculté de Médecine Timone - 27 Bd Jean Moulin 13385 Marseille Cedex 5</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://nort.univ-amu.fr/</ref>
</desc>
<listRelation>
<relation name="UMR_A1260" active="#struct-92114" type="direct"></relation>
<relation name="UMR_A1260" active="#struct-198056" type="direct"></relation>
<relation name="U1062" active="#struct-303623" type="direct"></relation>
</listRelation>
<tutelles>
<tutelle name="UMR_A1260" active="#struct-92114" type="direct">
<org type="institution" xml:id="struct-92114" status="OLD">
<orgName>Institut National de la Recherche Agronomique</orgName>
<orgName type="acronym">INRA</orgName>
<date type="start">1946-05-18</date>
<date type="end">2019-12-31</date>
<desc>
<address>
<country key="FR"></country>
</address>
<ref type="url">http://www.inra.fr</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR_A1260" active="#struct-198056" type="direct">
<org type="institution" xml:id="struct-198056" status="VALID">
<idno type="IdRef">15863621X</idno>
<idno type="ISNI">0000 0001 2176 4817</idno>
<orgName>Aix Marseille Université</orgName>
<orgName type="acronym">AMU</orgName>
<date type="start">2012-01-01</date>
<desc>
<address>
<addrLine>Aix-Marseille UniversitéJardins du Pharo58 Boulevard Charles Livon13284 Marseille cedex 7</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-amu.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="U1062" active="#struct-303623" type="direct">
<org type="institution" xml:id="struct-303623" status="VALID">
<idno type="IdRef">026388278</idno>
<orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
<orgName type="acronym">INSERM</orgName>
<desc>
<address>
<addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.inserm.fr</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName>
<settlement type="city">Marseille</settlement>
<region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
</placeName>
<orgName type="university">Université d'Aix-Marseille</orgName>
</affiliation>
</author>
<author>
<name sortKey="Alessi, Marie Christine" sort="Alessi, Marie Christine" uniqKey="Alessi M" first="Marie-Christine" last="Alessi">Marie-Christine Alessi</name>
<affiliation wicri:level="1">
<hal:affiliation type="laboratory" xml:id="struct-180118" status="OLD">
<idno type="RNSR">197417835D</idno>
<idno type="IdRef">123019265</idno>
<orgName>Nutrition, obésité et risque thrombotique</orgName>
<orgName type="acronym">NORT</orgName>
<date type="start">1974</date>
<date type="end">2017-12-31</date>
<desc>
<address>
<addrLine>Faculté de Médecine Timone - 27 Bd Jean Moulin 13385 Marseille Cedex 5</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://nort.univ-amu.fr/</ref>
</desc>
<listRelation>
<relation name="UMR_A1260" active="#struct-92114" type="direct"></relation>
<relation name="UMR_A1260" active="#struct-198056" type="direct"></relation>
<relation name="U1062" active="#struct-303623" type="direct"></relation>
</listRelation>
<tutelles>
<tutelle name="UMR_A1260" active="#struct-92114" type="direct">
<org type="institution" xml:id="struct-92114" status="OLD">
<orgName>Institut National de la Recherche Agronomique</orgName>
<orgName type="acronym">INRA</orgName>
<date type="start">1946-05-18</date>
<date type="end">2019-12-31</date>
<desc>
<address>
<country key="FR"></country>
</address>
<ref type="url">http://www.inra.fr</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR_A1260" active="#struct-198056" type="direct">
<org type="institution" xml:id="struct-198056" status="VALID">
<idno type="IdRef">15863621X</idno>
<idno type="ISNI">0000 0001 2176 4817</idno>
<orgName>Aix Marseille Université</orgName>
<orgName type="acronym">AMU</orgName>
<date type="start">2012-01-01</date>
<desc>
<address>
<addrLine>Aix-Marseille UniversitéJardins du Pharo58 Boulevard Charles Livon13284 Marseille cedex 7</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-amu.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="U1062" active="#struct-303623" type="direct">
<org type="institution" xml:id="struct-303623" status="VALID">
<idno type="IdRef">026388278</idno>
<orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
<orgName type="acronym">INSERM</orgName>
<desc>
<address>
<addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.inserm.fr</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName>
<settlement type="city">Marseille</settlement>
<region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
</placeName>
<orgName type="university">Université d'Aix-Marseille</orgName>
</affiliation>
</author>
<author>
<name sortKey="Riteau, Beatrice" sort="Riteau, Beatrice" uniqKey="Riteau B" first="Beatrice" last="Riteau">Beatrice Riteau</name>
<affiliation wicri:level="1">
<hal:affiliation type="laboratory" xml:id="struct-180118" status="OLD">
<idno type="RNSR">197417835D</idno>
<idno type="IdRef">123019265</idno>
<orgName>Nutrition, obésité et risque thrombotique</orgName>
<orgName type="acronym">NORT</orgName>
<date type="start">1974</date>
<date type="end">2017-12-31</date>
<desc>
<address>
<addrLine>Faculté de Médecine Timone - 27 Bd Jean Moulin 13385 Marseille Cedex 5</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://nort.univ-amu.fr/</ref>
</desc>
<listRelation>
<relation name="UMR_A1260" active="#struct-92114" type="direct"></relation>
<relation name="UMR_A1260" active="#struct-198056" type="direct"></relation>
<relation name="U1062" active="#struct-303623" type="direct"></relation>
</listRelation>
<tutelles>
<tutelle name="UMR_A1260" active="#struct-92114" type="direct">
<org type="institution" xml:id="struct-92114" status="OLD">
<orgName>Institut National de la Recherche Agronomique</orgName>
<orgName type="acronym">INRA</orgName>
<date type="start">1946-05-18</date>
<date type="end">2019-12-31</date>
<desc>
<address>
<country key="FR"></country>
</address>
<ref type="url">http://www.inra.fr</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR_A1260" active="#struct-198056" type="direct">
<org type="institution" xml:id="struct-198056" status="VALID">
<idno type="IdRef">15863621X</idno>
<idno type="ISNI">0000 0001 2176 4817</idno>
<orgName>Aix Marseille Université</orgName>
<orgName type="acronym">AMU</orgName>
<date type="start">2012-01-01</date>
<desc>
<address>
<addrLine>Aix-Marseille UniversitéJardins du Pharo58 Boulevard Charles Livon13284 Marseille cedex 7</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-amu.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="U1062" active="#struct-303623" type="direct">
<org type="institution" xml:id="struct-303623" status="VALID">
<idno type="IdRef">026388278</idno>
<orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
<orgName type="acronym">INSERM</orgName>
<desc>
<address>
<addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.inserm.fr</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName>
<settlement type="city">Marseille</settlement>
<region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
</placeName>
<orgName type="university">Université d'Aix-Marseille</orgName>
</affiliation>
</author>
</analytic>
<idno type="DOI">10.3390/ijms19051400</idno>
<series>
<title level="j">International Journal of Molecular Sciences</title>
<idno type="ISSN">1422-0067</idno>
<imprint>
<date type="datePub">2018</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc>
<textClass>
<keywords scheme="mix" xml:lang="en">
<term>Annexin A1</term>
<term>FPR2</term>
<term>influenza</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front>
<div type="abstract" xml:lang="en">
<p>The Formyl Peptide Receptor 2 (FPR2) is a novel promising target for the treatment of influenza. During viral infection, FPR2 is activated by annexinA1, which is present in the envelope of influenza viruses; this activation promotes virus replication. Here, we investigated whether blockage of FPR2 would affect the genome trafficking of influenza virus. We found that, upon infection and cell treatment with the specific FPR2 antagonist WRW4 or the anti-FPR2 monoclonal antibody, FN-1D6-AI, influenza viruses were blocked into endosomes. This effect was independent on the strain and was observed for H1N1 and H3N2 viruses. In addition, blocking FPR2signaling in alveolar lung A549 epithelial cells with the monoclonal anti-FPR2 antibody significantly inhibited virus replication. Altogether, these results show that FPR2signaling interferes with the endosomal trafficking of influenza viruses and provides, for the first time, the proof of concept that monoclonal antibodies directed against FPR2 inhibit virus replication. Antibodies-based therapeutics have emerged as attractive reagents in infectious diseases. Thus, this study suggests that the use of anti-FPR2 antibodies against influenza hold great promise for the future.</p>
</div>
</front>
</TEI>
<hal api="V3">
<titleStmt>
<title xml:lang="en">The Annexin A1 Receptor FPR2 Regulates the Endosomal Export of Influenza Virus</title>
<author role="aut">
<persName>
<forename type="first">Fryad</forename>
<surname>Rahman</surname>
</persName>
<idno type="halauthorid">1500010</idno>
<affiliation ref="#struct-180118"></affiliation>
<affiliation ref="#struct-527021"></affiliation>
</author>
<author role="aut">
<persName>
<forename type="first">Mohammad</forename>
<surname>Chebbo</surname>
</persName>
<idno type="halauthorid">11454505</idno>
<affiliation ref="#struct-527021"></affiliation>
</author>
<author role="aut">
<persName>
<forename type="first">Noemie</forename>
<surname>Courtin</surname>
</persName>
<idno type="halauthorid">1637512</idno>
<affiliation ref="#struct-180118"></affiliation>
<affiliation ref="#struct-527021"></affiliation>
</author>
<author role="aut">
<persName>
<forename type="first">Aurelien Fotso</forename>
<surname>Fotso</surname>
</persName>
<idno type="halauthorid">1481781</idno>
<affiliation ref="#struct-180118"></affiliation>
<affiliation ref="#struct-527021"></affiliation>
</author>
<author role="aut">
<persName>
<forename type="first">Marie-Christine</forename>
<surname>Alessi</surname>
</persName>
<email type="md5">279f3d58b01a03fd7bf7cd6b2684b605</email>
<email type="domain">univ-amu.fr</email>
<idno type="idhal" notation="string">marie-christine-alessi</idno>
<idno type="idhal" notation="numeric">12718</idno>
<idno type="halauthorid">1432571</idno>
<idno type="ORCID">https://orcid.org/0000-0003-3927-5792</idno>
<affiliation ref="#struct-180118"></affiliation>
<affiliation ref="#struct-527021"></affiliation>
</author>
<author role="aut">
<persName>
<forename type="first">Beatrice</forename>
<surname>Riteau</surname>
</persName>
<idno type="halauthorid">616549</idno>
<affiliation ref="#struct-180118"></affiliation>
<affiliation ref="#struct-527021"></affiliation>
</author>
<editor role="depositor">
<persName>
<forename>Annick</forename>
<surname>Prémilleux</surname>
</persName>
<email type="md5">9afe080a6ab9b3e06cea052736594026</email>
<email type="domain">inserm.fr</email>
</editor>
<funder>AgenceNationale de la Recherche (ANR HemoFlu to BR), Fondation de France (to BR), Association Vaincre la Mucoviscidose and Gregory LeMarchal (to BR), SATT Sud-Est (to BR) and the Fonds de Recherche en Santé Respiratoire et de la Fondation du Souffle–Formation pour la Recherche 2017</funder>
</titleStmt>
<editionStmt>
<edition n="v1" type="current">
<date type="whenSubmitted">2020-01-21 15:27:20</date>
<date type="whenModified">2020-03-17 03:09:33</date>
<date type="whenReleased">2020-01-21 15:30:32</date>
<date type="whenProduced">2018</date>
<date type="whenEndEmbargoed">2020-01-21</date>
<ref type="file" target="https://hal-amu.archives-ouvertes.fr/hal-02091328/document">
<date notBefore="2020-01-21"></date>
</ref>
<ref type="file" subtype="author" n="1" target="https://hal-amu.archives-ouvertes.fr/hal-02091328/file/ijms-19-01400.pdf">
<date notBefore="2020-01-21"></date>
</ref>
<ref type="externalLink" target="https://www.mdpi.com/1422-0067/19/5/1400/pdf"></ref>
</edition>
<respStmt>
<resp>contributor</resp>
<name key="74017">
<persName>
<forename>Annick</forename>
<surname>Prémilleux</surname>
</persName>
<email type="md5">9afe080a6ab9b3e06cea052736594026</email>
<email type="domain">inserm.fr</email>
</name>
</respStmt>
</editionStmt>
<publicationStmt>
<distributor>CCSD</distributor>
<idno type="halId">hal-02091328</idno>
<idno type="halUri">https://hal-amu.archives-ouvertes.fr/hal-02091328</idno>
<idno type="halBibtex">rahman:hal-02091328</idno>
<idno type="halRefHtml">International Journal of Molecular Sciences, MDPI, 2018, 19 (5), ⟨10.3390/ijms19051400⟩</idno>
<idno type="halRef">International Journal of Molecular Sciences, MDPI, 2018, 19 (5), ⟨10.3390/ijms19051400⟩</idno>
<availability status="restricted">
<licence target="http://creativecommons.org/licenses/by/">Attribution</licence>
</availability>
</publicationStmt>
<seriesStmt>
<idno type="stamp" n="UNIV-AMU">Aix Marseille Université</idno>
<idno type="stamp" n="TEST-AMU">Espace de test AMU</idno>
<idno type="stamp" n="INRA">INRA - Institut national de la recherche agronomique</idno>
<idno type="stamp" n="AGREENIUM">Archive ouverte en agrobiosciences</idno>
<idno type="stamp" n="INRAE">Institut National de Recherche en Agriculture, Alimentation et Environnement</idno>
</seriesStmt>
<notesStmt>
<note type="audience" n="2">International</note>
<note type="popular" n="0">No</note>
<note type="peer" n="1">Yes</note>
</notesStmt>
<sourceDesc>
<biblStruct>
<analytic>
<title xml:lang="en">The Annexin A1 Receptor FPR2 Regulates the Endosomal Export of Influenza Virus</title>
<author role="aut">
<persName>
<forename type="first">Fryad</forename>
<surname>Rahman</surname>
</persName>
<idno type="halauthorid">1500010</idno>
<affiliation ref="#struct-180118"></affiliation>
<affiliation ref="#struct-527021"></affiliation>
</author>
<author role="aut">
<persName>
<forename type="first">Mohammad</forename>
<surname>Chebbo</surname>
</persName>
<idno type="halauthorid">11454505</idno>
<affiliation ref="#struct-527021"></affiliation>
</author>
<author role="aut">
<persName>
<forename type="first">Noemie</forename>
<surname>Courtin</surname>
</persName>
<idno type="halauthorid">1637512</idno>
<affiliation ref="#struct-180118"></affiliation>
<affiliation ref="#struct-527021"></affiliation>
</author>
<author role="aut">
<persName>
<forename type="first">Aurelien Fotso</forename>
<surname>Fotso</surname>
</persName>
<idno type="halauthorid">1481781</idno>
<affiliation ref="#struct-180118"></affiliation>
<affiliation ref="#struct-527021"></affiliation>
</author>
<author role="aut">
<persName>
<forename type="first">Marie-Christine</forename>
<surname>Alessi</surname>
</persName>
<email type="md5">279f3d58b01a03fd7bf7cd6b2684b605</email>
<email type="domain">univ-amu.fr</email>
<idno type="idhal" notation="string">marie-christine-alessi</idno>
<idno type="idhal" notation="numeric">12718</idno>
<idno type="halauthorid">1432571</idno>
<idno type="ORCID">https://orcid.org/0000-0003-3927-5792</idno>
<affiliation ref="#struct-180118"></affiliation>
<affiliation ref="#struct-527021"></affiliation>
</author>
<author role="aut">
<persName>
<forename type="first">Beatrice</forename>
<surname>Riteau</surname>
</persName>
<idno type="halauthorid">616549</idno>
<affiliation ref="#struct-180118"></affiliation>
<affiliation ref="#struct-527021"></affiliation>
</author>
</analytic>
<monogr>
<idno type="halJournalId" status="VALID">103547</idno>
<idno type="issn">1422-0067</idno>
<title level="j">International Journal of Molecular Sciences</title>
<imprint>
<publisher>MDPI</publisher>
<biblScope unit="volume">19</biblScope>
<biblScope unit="issue">5</biblScope>
<date type="datePub">2018</date>
</imprint>
</monogr>
<idno type="doi">10.3390/ijms19051400</idno>
</biblStruct>
</sourceDesc>
<profileDesc>
<langUsage>
<language ident="en">English</language>
</langUsage>
<textClass>
<keywords scheme="author">
<term xml:lang="en">influenza</term>
<term xml:lang="en">FPR2</term>
<term xml:lang="en">Annexin A1</term>
</keywords>
<classCode scheme="halDomain" n="sdv">Life Sciences [q-bio]</classCode>
<classCode scheme="halTypology" n="ART">Journal articles</classCode>
</textClass>
<abstract xml:lang="en">
<p>The Formyl Peptide Receptor 2 (FPR2) is a novel promising target for the treatment of influenza. During viral infection, FPR2 is activated by annexinA1, which is present in the envelope of influenza viruses; this activation promotes virus replication. Here, we investigated whether blockage of FPR2 would affect the genome trafficking of influenza virus. We found that, upon infection and cell treatment with the specific FPR2 antagonist WRW4 or the anti-FPR2 monoclonal antibody, FN-1D6-AI, influenza viruses were blocked into endosomes. This effect was independent on the strain and was observed for H1N1 and H3N2 viruses. In addition, blocking FPR2signaling in alveolar lung A549 epithelial cells with the monoclonal anti-FPR2 antibody significantly inhibited virus replication. Altogether, these results show that FPR2signaling interferes with the endosomal trafficking of influenza viruses and provides, for the first time, the proof of concept that monoclonal antibodies directed against FPR2 inhibit virus replication. Antibodies-based therapeutics have emerged as attractive reagents in infectious diseases. Thus, this study suggests that the use of anti-FPR2 antibodies against influenza hold great promise for the future.</p>
</abstract>
</profileDesc>
</hal>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/Hal/Checkpoint

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000036 | SxmlIndent | more

Ou

HfdSelect -h $EXPLOR_AREA/Data/Hal/Checkpoint/biblio.hfd -nk 000036 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    H2N2V1
   |flux=    Hal
   |étape=   Checkpoint
   |type=    RBID
   |clé=     Hal:hal-02091328
   |texte=   The Annexin A1 Receptor FPR2 Regulates the Endosomal Export of Influenza Virus
}}
Wicri

This area was generated with Dilib version V0.6.33.
Data generation: Tue Apr 14 19:59:40 2020. Site generation: Thu Mar 25 15:38:26 2021