H2N2V1, 1957, Analysis, bibRecordById, ISTEX:83F87137D739FC45281956817CE39B77B286E47E

Nucleotide and deduced amino acid sequence of hemagglutinin-neuraminidase genes of human type 3 parainfluenza viruses isolated from 1957 to 1983

Identifieur interne : 000178 ( 1957/Analysis ); précédent : 000177; suivant : 000179

Nucleotide and deduced amino acid sequence of hemagglutinin-neuraminidase genes of human type 3 parainfluenza viruses isolated from 1957 to 1983

Auteurs : Kathleen L. Van Wyke Coelingh [États-Unis] ; Christine C. Winter [États-Unis] ; Brian R. Murphy [États-Unis]

Source :

Virology [ 0042-6822 ] ; 1988.

RBID : ISTEX:83F87137D739FC45281956817CE39B77B286E47E

English descriptors

Teeft :
- Academic press, Acid sequence, Amino, Amino acid homology, Amino acid sequences, Antigenic, Antigenic variants, Australian virus, Chanock, Clinical strains, Coding, Coding region, Coelingh, Control elements, Gene, Genetic heterogeneity, Helical structure, High degree, Homology, Human parainfluenza type, Human parainfluenza virus type, Human type, Influenza, Influenza virus, Molecular basis, Monoclonal antibodies, Noncoding, Noncoding region, Noncoding regions, Noncoding sequences, Nucleic acid, Nucleotide, Nucleotide differences, Nucleotide sequence, Nucleotide sequences, Parainfluenza, Parainfluenza viruses, Piv3, Piv3 infection, Piv3 population, Piv3 strains, Prototype, Prototype strain, Reactivity patterns, Secondary structure, Sequence analysis, Structural constraints, Terminal deoxynucleotidyl transferase, Transcriptional, Uneven distribution, Virology, Washington strain, Wyke coelingh.

Abstract

Abstract: We have sequenced the coding and noncoding regions of the hemagglutinin-neuraminidase (HN) genes of six clinical strains of human type 3 parainfluenza virus (PIV3) isolated between 1973 and 1983, and compared them to the prototype 1957 strain. Sequence variability does not result from the accumulation of mutations over time, but represents genetic heterogeneity in HN genes within the PIV3 population. Most of the nucleotide diversity occurs in the 5′ noncoding sequences, exclusive of regions supplying transcriptional and translational control elements. Although the overall amino acid homology among HN proteins is very high, most variability is concentrated in domains at the carboxyl and amino terminus. This uneven distribution of amino acid diversity may reflect both functional and structural constraints on different HN domains and the epidemiologic features of PIV3 infection.

Url:

https://api.istex.fr/ark:/67375/6H6-248GV18Z-P/fulltext.pdf

DOI: 10.1016/0042-6822(88)90402-3

Affiliations:

États-Unis

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ISTEX:83F87137D739FC45281956817CE39B77B286E47E

Le document en format XML

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<front><div type="abstract" xml:lang="en">Abstract: We have sequenced the coding and noncoding regions of the hemagglutinin-neuraminidase (HN) genes of six clinical strains of human type 3 parainfluenza virus (PIV3) isolated between 1973 and 1983, and compared them to the prototype 1957 strain. Sequence variability does not result from the accumulation of mutations over time, but represents genetic heterogeneity in HN genes within the PIV3 population. Most of the nucleotide diversity occurs in the 5′ noncoding sequences, exclusive of regions supplying transcriptional and translational control elements. Although the overall amino acid homology among HN proteins is very high, most variability is concentrated in domains at the carboxyl and amino terminus. This uneven distribution of amino acid diversity may reflect both functional and structural constraints on different HN domains and the epidemiologic features of PIV3 infection.</div>
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Nucleotide and deduced amino acid sequence of hemagglutinin-neuraminidase genes of human type 3 parainfluenza viruses isolated from 1957 to 1983

Nucleotide and deduced amino acid sequence of hemagglutinin-neuraminidase genes of human type 3 parainfluenza viruses isolated from 1957 to 1983

Source :

English descriptors

Abstract

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Links to Exploration step

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