Antigenic relationship between H1 and H2 of influenza A virus.
Identifieur interne : 000195 ( 1957/Analysis ); précédent : 000194; suivant : 000196Antigenic relationship between H1 and H2 of influenza A virus.
Auteurs : G Q Liu ; X C Gong ; J M Zhu ; G F Ren ; R L Fan ; W Q RuanSource :
- Scientia Sinica [ 0250-7870 ] ; 1980.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- MESH :
- chemical , immunology : Antigens, Viral, Immune Sera.
- classification : Influenza A virus.
- immunology : Influenza A virus.
- Animals, Cricetinae, Hemagglutination Inhibition Tests, Hemagglutination, Viral, Neutralization Tests, Recombination, Genetic.
Abstract
Using cloned viruses of proven purity, and by the methods of hemagglutination inhibition, single radial hemolysis, strain-specific complement fixation and neutralization tests we have demonstrated the serological cross reaction between late H1N1 variant (Dutch/56) and H2N2 of influenza A virus with fowl and hamster antisera. Such a cross reaction is not detected with earlier H1N1 variants. Serological crossing covers variants of H2N2 virus isolated from 1957-1966 but in decreasing titers, and disappears with the last variant of H2N2 isolated late in 1967. Analysis with mono-specific antisera or antigens prepared with recombinants reveal that the hemagglutinins of late H1N1 and H2N2 are related, while their neuraminidases are distinct. We have discussed the bearing of such antigenic relationships to previous epidemiological observations on the partial protection of patients convalescent from late H1N1 disease against H2N2 and to the recombination theory for the origin of H2N2 virus.
PubMed: 7444427
Affiliations:
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pubmed:7444427Le document en format XML
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influenza A virus.</title><author><name sortKey="Liu, G Q" sort="Liu, G Q" uniqKey="Liu G" first="G Q" last="Liu">G Q Liu</name></author><author><name sortKey="Gong, X C" sort="Gong, X C" uniqKey="Gong X" first="X C" last="Gong">X C Gong</name></author><author><name sortKey="Zhu, J M" sort="Zhu, J M" uniqKey="Zhu J" first="J M" last="Zhu">J M Zhu</name></author><author><name sortKey="Ren, G F" sort="Ren, G F" uniqKey="Ren G" first="G F" last="Ren">G F Ren</name></author><author><name sortKey="Fan, R L" sort="Fan, R L" uniqKey="Fan R" first="R L" last="Fan">R L Fan</name></author><author><name sortKey="Ruan, W Q" sort="Ruan, W Q" uniqKey="Ruan W" first="W Q" last="Ruan">W Q Ruan</name></author></analytic><series><title level="j">Scientia Sinica</title><idno type="ISSN">0250-7870</idno><imprint><date when="1980" type="published">1980</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antigens, Viral (immunology)</term><term>Cricetinae</term><term>Hemagglutination Inhibition Tests</term><term>Hemagglutination, Viral</term><term>Immune Sera (immunology)</term><term>Influenza A virus (classification)</term><term>Influenza A virus (immunology)</term><term>Neutralization Tests</term><term>Recombination, Genetic</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Antigènes viraux (immunologie)</term><term>Cricetinae</term><term>Hémagglutination virale</term><term>Recombinaison génétique</term><term>Sérums immuns (immunologie)</term><term>Tests d'inhibition de l'hémagglutination</term><term>Tests de neutralisation</term><term>Virus de la grippe A ()</term><term>Virus de la grippe A (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antigens, Viral</term><term>Immune Sera</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Influenza A virus</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Antigènes viraux</term><term>Sérums immuns</term><term>Virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Influenza A virus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cricetinae</term><term>Hemagglutination Inhibition Tests</term><term>Hemagglutination, Viral</term><term>Neutralization Tests</term><term>Recombination, Genetic</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Cricetinae</term><term>Hémagglutination virale</term><term>Recombinaison génétique</term><term>Tests d'inhibition de l'hémagglutination</term><term>Tests de neutralisation</term><term>Virus de la grippe A</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Using cloned viruses of proven purity, and by the methods of hemagglutination inhibition, single radial hemolysis, strain-specific complement fixation and neutralization tests we have demonstrated the serological cross reaction between late H1N1 variant (Dutch/56) and H2N2 of influenza A virus with fowl and hamster antisera. Such a cross reaction is not detected with earlier H1N1 variants. Serological crossing covers variants of H2N2 virus isolated from 1957-1966 but in decreasing titers, and disappears with the last variant of H2N2 isolated late in 1967. Analysis with mono-specific antisera or antigens prepared with recombinants reveal that the hemagglutinins of late H1N1 and H2N2 are related, while their neuraminidases are distinct. We have discussed the bearing of such antigenic relationships to previous epidemiological observations on the partial protection of patients convalescent from late H1N1 disease against H2N2 and to the recombination theory for the origin of H2N2 virus.</div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Fan, R L" sort="Fan, R L" uniqKey="Fan R" first="R L" last="Fan">R L Fan</name><name sortKey="Gong, X C" sort="Gong, X C" uniqKey="Gong X" first="X C" last="Gong">X C Gong</name><name sortKey="Liu, G Q" sort="Liu, G Q" uniqKey="Liu G" first="G Q" last="Liu">G Q Liu</name><name sortKey="Ren, G F" sort="Ren, G F" uniqKey="Ren G" first="G F" last="Ren">G F Ren</name><name sortKey="Ruan, W Q" sort="Ruan, W Q" uniqKey="Ruan W" first="W Q" last="Ruan">W Q Ruan</name><name sortKey="Zhu, J M" sort="Zhu, J M" uniqKey="Zhu J" first="J M" last="Zhu">J M Zhu</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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