Symptoms of influenza virus infection in hospitalized patients.
Identifieur interne : 000285 ( Main/Exploration ); précédent : 000284; suivant : 000286Symptoms of influenza virus infection in hospitalized patients.
Auteurs : C. Van Den Dool [Pays-Bas] ; E. Hak ; J. Wallinga ; A M Van Loon ; J W J. Lammers ; M J M. BontenSource :
- Infection control and hospital epidemiology [ 0899-823X ] ; 2008.
Descripteurs français
- KwdFr :
- Adolescent (MeSH), Adulte (MeSH), Adulte d'âge moyen (MeSH), Enquêtes et questionnaires (MeSH), Femelle (MeSH), Fièvre (virologie), Fièvre (épidémiologie), Grippe humaine (diagnostic), Grippe humaine (épidémiologie), Humains (MeSH), Hôpitaux (MeSH), Mâle (MeSH), Orthomyxoviridae (isolement et purification), Pays-Bas (épidémiologie), Prévalence (MeSH), Réaction de polymérisation en chaîne (MeSH), Sensibilité et spécificité (MeSH), Sujet âgé (MeSH), Sujet âgé de 80 ans ou plus (MeSH), Toux (virologie), Toux (épidémiologie), Études de cohortes (MeSH), Études prospectives (MeSH).
- MESH :
- diagnostic : Grippe humaine.
- isolement et purification : Orthomyxoviridae.
- virologie : Fièvre, Toux.
- épidémiologie : Fièvre, Grippe humaine, Pays-Bas, Toux.
- Adolescent, Adulte, Adulte d'âge moyen, Enquêtes et questionnaires, Femelle, Humains, Hôpitaux, Mâle, Prévalence, Réaction de polymérisation en chaîne, Sensibilité et spécificité, Sujet âgé, Sujet âgé de 80 ans ou plus, Études de cohortes, Études prospectives.
- Wicri :
- geographic : Pays-Bas.
English descriptors
- KwdEn :
- Adolescent (MeSH), Adult (MeSH), Aged (MeSH), Aged, 80 and over (MeSH), Cohort Studies (MeSH), Cough (epidemiology), Cough (virology), Female (MeSH), Fever (epidemiology), Fever (virology), Hospitals (MeSH), Humans (MeSH), Influenza, Human (diagnosis), Influenza, Human (epidemiology), Male (MeSH), Middle Aged (MeSH), Netherlands (epidemiology), Orthomyxoviridae (isolation & purification), Polymerase Chain Reaction (MeSH), Prevalence (MeSH), Prospective Studies (MeSH), Sensitivity and Specificity (MeSH), Surveys and Questionnaires (MeSH).
- MESH :
- geographic , epidemiology : Netherlands.
- diagnosis : Influenza, Human.
- epidemiology : Cough, Fever, Influenza, Human.
- isolation & purification : Orthomyxoviridae.
- virology : Cough, Fever.
- Adolescent, Adult, Aged, Aged, 80 and over, Cohort Studies, Female, Hospitals, Humans, Male, Middle Aged, Polymerase Chain Reaction, Prevalence, Prospective Studies, Sensitivity and Specificity, Surveys and Questionnaires.
Abstract
BACKGROUND
During influenza outbreaks, fever and cough are the most accurate symptoms in predicting influenza virus infection in the community.
OBJECTIVE
To determine the usefulness of fever, cough, and other symptoms for diagnosing influenza virus infection in hospitalized patients.
DESIGN
Prospective cohort study.
SETTING
Three wards (pulmonology, internal medicine and infectious diseases, and geriatrics) of a tertiary care hospital in the Netherlands.
PATIENTS
All patients staying in the wards during peak national influenza activity in the 2005-2006 and 2006-2007 influenza seasons.
METHODS
During peak influenza activity, the presence of fever, cough, and/or other symptoms possibly associated with influenza was monitored for all patients, and nose and throat swab samples were taken twice weekly for virologic analysis.
RESULTS
Of 264 patients, 23 (9%) tested positive for influenza virus. The positive predictive value of fever and cough for the diagnosis of influenza virus infection was 23% (95% confidence interval, 0%-62%), and the sensitivity was 35% (95% confidence interval, 11%-58%). The combination of symptoms with the highest positive predictive value (40%) was that of cough, chills, and obstructed nose or coryza. The combination of cough and chills or fever had the highest sensitivity (60%). None of the combinations of symptoms had both a positive predictive value and a sensitivity higher than 40%.
CONCLUSIONS
Both the sensitivity and the positive predictive value of fever, cough, and/or other symptoms for the diagnosis of influenza virus infection in hospitalized patients are low. The use of these common symptoms for treatment decisions and infection control management will probably be insufficient to contain a nosocomial outbreak, because many influenza cases will remain unidentified.
DOI: 10.1086/529211
PubMed: 18462143
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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Hak</name></author><author><name sortKey="Wallinga, J" sort="Wallinga, J" uniqKey="Wallinga J" first="J" last="Wallinga">J. Wallinga</name></author><author><name sortKey="Van Loon, A M" sort="Van Loon, A M" uniqKey="Van Loon A" first="A M" last="Van Loon">A M Van Loon</name></author><author><name sortKey="Lammers, J W J" sort="Lammers, J W J" uniqKey="Lammers J" first="J W J" last="Lammers">J W J. Lammers</name></author><author><name sortKey="Bonten, M J M" sort="Bonten, M J M" uniqKey="Bonten M" first="M J M" last="Bonten">M J M. Bonten</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2008">2008</date><idno type="RBID">pubmed:18462143</idno><idno type="pmid">18462143</idno><idno type="doi">10.1086/529211</idno><idno type="wicri:Area/Main/Corpus">000288</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000288</idno><idno type="wicri:Area/Main/Curation">000288</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000288</idno><idno type="wicri:Area/Main/Exploration">000288</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Symptoms of influenza virus infection in hospitalized patients.</title><author><name sortKey="Van Den Dool, C" sort="Van Den Dool, C" uniqKey="Van Den Dool C" first="C" last="Van Den Dool">C. Van Den Dool</name><affiliation wicri:level="1"><nlm:affiliation>Julius Center for Health Sciences and Primary Care, Str. 6.131, University Medical Center Utrecht, P.O. Box 85 500, 3508 GA Utrecht, The Netherlands. c.vandendool@umcutrecht.nlreferences</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Julius Center for Health Sciences and Primary Care, Str. 6.131, University Medical Center Utrecht, P.O. Box 85 500, 3508 GA Utrecht</wicri:regionArea><wicri:noRegion>3508 GA Utrecht</wicri:noRegion></affiliation></author><author><name sortKey="Hak, E" sort="Hak, E" uniqKey="Hak E" first="E" last="Hak">E. Hak</name></author><author><name sortKey="Wallinga, J" sort="Wallinga, J" uniqKey="Wallinga J" first="J" last="Wallinga">J. Wallinga</name></author><author><name sortKey="Van Loon, A M" sort="Van Loon, A M" uniqKey="Van Loon A" first="A M" last="Van Loon">A M Van Loon</name></author><author><name sortKey="Lammers, J W J" sort="Lammers, J W J" uniqKey="Lammers J" first="J W J" last="Lammers">J W J. Lammers</name></author><author><name sortKey="Bonten, M J M" sort="Bonten, M J M" uniqKey="Bonten M" first="M J M" last="Bonten">M J M. Bonten</name></author></analytic><series><title level="j">Infection control and hospital epidemiology</title><idno type="ISSN">0899-823X</idno><imprint><date when="2008" type="published">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent (MeSH)</term><term>Adult (MeSH)</term><term>Aged (MeSH)</term><term>Aged, 80 and over (MeSH)</term><term>Cohort Studies (MeSH)</term><term>Cough (epidemiology)</term><term>Cough (virology)</term><term>Female (MeSH)</term><term>Fever (epidemiology)</term><term>Fever (virology)</term><term>Hospitals (MeSH)</term><term>Humans (MeSH)</term><term>Influenza, Human (diagnosis)</term><term>Influenza, Human (epidemiology)</term><term>Male (MeSH)</term><term>Middle Aged (MeSH)</term><term>Netherlands (epidemiology)</term><term>Orthomyxoviridae (isolation & purification)</term><term>Polymerase Chain Reaction (MeSH)</term><term>Prevalence (MeSH)</term><term>Prospective Studies (MeSH)</term><term>Sensitivity and Specificity (MeSH)</term><term>Surveys and Questionnaires (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent (MeSH)</term><term>Adulte (MeSH)</term><term>Adulte d'âge moyen (MeSH)</term><term>Enquêtes et questionnaires (MeSH)</term><term>Femelle (MeSH)</term><term>Fièvre (virologie)</term><term>Fièvre (épidémiologie)</term><term>Grippe humaine (diagnostic)</term><term>Grippe humaine (épidémiologie)</term><term>Humains (MeSH)</term><term>Hôpitaux (MeSH)</term><term>Mâle (MeSH)</term><term>Orthomyxoviridae (isolement et purification)</term><term>Pays-Bas (épidémiologie)</term><term>Prévalence (MeSH)</term><term>Réaction de polymérisation en chaîne (MeSH)</term><term>Sensibilité et spécificité (MeSH)</term><term>Sujet âgé (MeSH)</term><term>Sujet âgé de 80 ans ou plus (MeSH)</term><term>Toux (virologie)</term><term>Toux (épidémiologie)</term><term>Études de cohortes (MeSH)</term><term>Études prospectives (MeSH)</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Netherlands</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Grippe humaine</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Cough</term><term>Fever</term><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Orthomyxoviridae</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Orthomyxoviridae</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Fièvre</term><term>Toux</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Cough</term><term>Fever</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Fièvre</term><term>Grippe humaine</term><term>Pays-Bas</term><term>Toux</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Cohort Studies</term><term>Female</term><term>Hospitals</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Polymerase Chain Reaction</term><term>Prevalence</term><term>Prospective Studies</term><term>Sensitivity and Specificity</term><term>Surveys and Questionnaires</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Enquêtes et questionnaires</term><term>Femelle</term><term>Humains</term><term>Hôpitaux</term><term>Mâle</term><term>Prévalence</term><term>Réaction de polymérisation en chaîne</term><term>Sensibilité et spécificité</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Études de cohortes</term><term>Études prospectives</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Pays-Bas</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b></p><p>During influenza outbreaks, fever and cough are the most accurate symptoms in predicting influenza virus infection in the community.</p></div><div type="abstract" xml:lang="en"><p><b>OBJECTIVE</b></p><p>To determine the usefulness of fever, cough, and other symptoms for diagnosing influenza virus infection in hospitalized patients.</p></div><div type="abstract" xml:lang="en"><p><b>DESIGN</b></p><p>Prospective cohort study.</p></div><div type="abstract" xml:lang="en"><p><b>SETTING</b></p><p>Three wards (pulmonology, internal medicine and infectious diseases, and geriatrics) of a tertiary care hospital in the Netherlands.</p></div><div type="abstract" xml:lang="en"><p><b>PATIENTS</b></p><p>All patients staying in the wards during peak national influenza activity in the 2005-2006 and 2006-2007 influenza seasons.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>During peak influenza activity, the presence of fever, cough, and/or other symptoms possibly associated with influenza was monitored for all patients, and nose and throat swab samples were taken twice weekly for virologic analysis.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>Of 264 patients, 23 (9%) tested positive for influenza virus. The positive predictive value of fever and cough for the diagnosis of influenza virus infection was 23% (95% confidence interval, 0%-62%), and the sensitivity was 35% (95% confidence interval, 11%-58%). The combination of symptoms with the highest positive predictive value (40%) was that of cough, chills, and obstructed nose or coryza. The combination of cough and chills or fever had the highest sensitivity (60%). None of the combinations of symptoms had both a positive predictive value and a sensitivity higher than 40%.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b></p><p>Both the sensitivity and the positive predictive value of fever, cough, and/or other symptoms for the diagnosis of influenza virus infection in hospitalized patients are low. The use of these common symptoms for treatment decisions and infection control management will probably be insufficient to contain a nosocomial outbreak, because many influenza cases will remain unidentified.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">18462143</PMID><DateCompleted><Year>2008</Year><Month>11</Month><Day>13</Day></DateCompleted><DateRevised><Year>2019</Year><Month>12</Month><Day>10</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0899-823X</ISSN><JournalIssue CitedMedium="Print"><Volume>29</Volume><Issue>4</Issue><PubDate><Year>2008</Year><Month>Apr</Month></PubDate></JournalIssue><Title>Infection control and hospital epidemiology</Title><ISOAbbreviation>Infect Control Hosp Epidemiol</ISOAbbreviation></Journal><ArticleTitle>Symptoms of influenza virus infection in hospitalized patients.</ArticleTitle><Pagination><MedlinePgn>314-9</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1086/529211</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">During influenza outbreaks, fever and cough are the most accurate symptoms in predicting influenza virus infection in the community.</AbstractText><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To determine the usefulness of fever, cough, and other symptoms for diagnosing influenza virus infection in hospitalized patients.</AbstractText><AbstractText Label="DESIGN" NlmCategory="METHODS">Prospective cohort study.</AbstractText><AbstractText Label="SETTING" NlmCategory="METHODS">Three wards (pulmonology, internal medicine and infectious diseases, and geriatrics) of a tertiary care hospital in the Netherlands.</AbstractText><AbstractText Label="PATIENTS" NlmCategory="METHODS">All patients staying in the wards during peak national influenza activity in the 2005-2006 and 2006-2007 influenza seasons.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">During peak influenza activity, the presence of fever, cough, and/or other symptoms possibly associated with influenza was monitored for all patients, and nose and throat swab samples were taken twice weekly for virologic analysis.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Of 264 patients, 23 (9%) tested positive for influenza virus. The positive predictive value of fever and cough for the diagnosis of influenza virus infection was 23% (95% confidence interval, 0%-62%), and the sensitivity was 35% (95% confidence interval, 11%-58%). The combination of symptoms with the highest positive predictive value (40%) was that of cough, chills, and obstructed nose or coryza. The combination of cough and chills or fever had the highest sensitivity (60%). None of the combinations of symptoms had both a positive predictive value and a sensitivity higher than 40%.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Both the sensitivity and the positive predictive value of fever, cough, and/or other symptoms for the diagnosis of influenza virus infection in hospitalized patients are low. The use of these common symptoms for treatment decisions and infection control management will probably be insufficient to contain a nosocomial outbreak, because many influenza cases will remain unidentified.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>van den Dool</LastName><ForeName>C</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Julius Center for Health Sciences and Primary Care, Str. 6.131, University Medical Center Utrecht, P.O. Box 85 500, 3508 GA Utrecht, The Netherlands. c.vandendool@umcutrecht.nlreferences</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hak</LastName><ForeName>E</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Wallinga</LastName><ForeName>J</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>van Loon</LastName><ForeName>A M</ForeName><Initials>AM</Initials></Author><Author ValidYN="Y"><LastName>Lammers</LastName><ForeName>J W J</ForeName><Initials>JW</Initials></Author><Author ValidYN="Y"><LastName>Bonten</LastName><ForeName>M J M</ForeName><Initials>MJ</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType><PublicationType UI="D023361">Validation Study</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Infect Control Hosp Epidemiol</MedlineTA><NlmUniqueID>8804099</NlmUniqueID><ISSNLinking>0899-823X</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><CitationSubset>N</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015331" MajorTopicYN="N">Cohort Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003371" MajorTopicYN="N">Cough</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005334" MajorTopicYN="N">Fever</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006761" MajorTopicYN="N">Hospitals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007251" MajorTopicYN="N">Influenza, Human</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="Y">diagnosis</QualifierName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009426" MajorTopicYN="N" Type="Geographic">Netherlands</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009975" MajorTopicYN="N">Orthomyxoviridae</DescriptorName><QualifierName UI="Q000302" MajorTopicYN="Y">isolation & purification</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016133" MajorTopicYN="N">Polymerase Chain Reaction</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015995" MajorTopicYN="N">Prevalence</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011446" MajorTopicYN="N">Prospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012680" MajorTopicYN="N">Sensitivity and Specificity</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011795" MajorTopicYN="N">Surveys and Questionnaires</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2008</Year><Month>5</Month><Day>9</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2008</Year><Month>11</Month><Day>14</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2008</Year><Month>5</Month><Day>9</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">18462143</ArticleId><ArticleId IdType="doi">10.1086/529211</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Pays-Bas</li></country></list><tree><noCountry><name sortKey="Bonten, M J M" sort="Bonten, M J M" uniqKey="Bonten M" first="M J M" last="Bonten">M J M. Bonten</name><name sortKey="Hak, E" sort="Hak, E" uniqKey="Hak E" first="E" last="Hak">E. Hak</name><name sortKey="Lammers, J W J" sort="Lammers, J W J" uniqKey="Lammers J" first="J W J" last="Lammers">J W J. Lammers</name><name sortKey="Van Loon, A M" sort="Van Loon, A M" uniqKey="Van Loon A" first="A M" last="Van Loon">A M Van Loon</name><name sortKey="Wallinga, J" sort="Wallinga, J" uniqKey="Wallinga J" first="J" last="Wallinga">J. Wallinga</name></noCountry><country name="Pays-Bas"><noRegion><name sortKey="Van Den Dool, C" sort="Van Den Dool, C" uniqKey="Van Den Dool C" first="C" last="Van Den Dool">C. Van Den Dool</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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