[Splenomegaly in an Eritrean refugee: the hyper-reactive malaria splenomegaly syndrome.]
Identifieur interne : 000061 ( Main/Exploration ); précédent : 000060; suivant : 000062[Splenomegaly in an Eritrean refugee: the hyper-reactive malaria splenomegaly syndrome.]
Auteurs : M M Cruijsen [Pays-Bas] ; I J Reuling ; M. Keuter ; R W Sauerwein ; A J Van Der Ven ; Q. De MastSource :
- Nederlands tijdschrift voor geneeskunde [ 1876-8784 ]
Descripteurs français
- KwdFr :
- Adulte (MeSH), Humains (MeSH), Hépatomégalie (MeSH), Mâle (MeSH), Paludisme (diagnostic), Paludisme (parasitologie), Paludisme (traitement médicamenteux), Pays-Bas (MeSH), Réfugiés (MeSH), Splénomégalie (diagnostic), Splénomégalie (parasitologie), Splénomégalie (traitement médicamenteux), Syndrome (MeSH), Érythrée (MeSH).
- MESH :
- diagnostic : Paludisme, Splénomégalie.
- parasitologie : Paludisme, Splénomégalie.
- traitement médicamenteux : Paludisme, Splénomégalie.
- Adulte, Humains, Hépatomégalie, Mâle, Pays-Bas, Réfugiés, Syndrome, Érythrée.
English descriptors
- KwdEn :
- MESH :
- diagnosis : Malaria, Splenomegaly.
- drug therapy : Malaria, Splenomegaly.
- parasitology : Malaria, Splenomegaly.
- Adult, Eritrea, Hepatomegaly, Humans, Male, Netherlands, Refugees, Syndrome.
Abstract
BACKGROUND
Hyper-reactive malaria splenomegaly (HMS) is a rare and potentially severe complication of malaria. It is likely that the incidence of patients with HMS will rise in the Netherlands due to the recent increase in asylum-seekers from Sub-Saharan Africa. It can be difficult to diagnose this disease, as this case shows.
CASE DESCRIPTION
A 31-year-old male from Eritrea was admitted with fever and dyspnea, caused by an influenza A-infection. The patient also presented with cachexia, pronounced hepatosplenomegaly and pancytopenia. Microscopic diagnostic analysis for malaria was negative. HMS was eventually diagnosed through high-sensitivity qPCR for malaria, which showed the presence of a very low level of Plasmodium falciparum parasitemia; furthermore, IgM levels were high and malaria serology was strongly positive.
CONCLUSION
HMS should be considered in patients from malaria-endemic areas presenting with splenomegaly and pancytopenia. Because standard diagnostics for malaria are often negative in this population, malaria serology and sensitive qPCR play an important diagnostic role.
PubMed: 27848905
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">[Splenomegaly in an Eritrean refugee: the hyper-reactive malaria splenomegaly syndrome.]</title>
<author><name sortKey="Cruijsen, M M" sort="Cruijsen, M M" uniqKey="Cruijsen M" first="M M" last="Cruijsen">M M Cruijsen</name>
<affiliation wicri:level="3"><nlm:affiliation>Radboudumc, Nijmegen.</nlm:affiliation>
<country>Pays-Bas</country>
<placeName><settlement type="city">Nimègue</settlement>
<region type="province" nuts="2">Gueldre</region>
</placeName>
<wicri:orgArea>Radboudumc</wicri:orgArea>
</affiliation>
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<author><name sortKey="Reuling, I J" sort="Reuling, I J" uniqKey="Reuling I" first="I J" last="Reuling">I J Reuling</name>
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<author><name sortKey="Keuter, M" sort="Keuter, M" uniqKey="Keuter M" first="M" last="Keuter">M. Keuter</name>
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<author><name sortKey="Sauerwein, R W" sort="Sauerwein, R W" uniqKey="Sauerwein R" first="R W" last="Sauerwein">R W Sauerwein</name>
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<author><name sortKey="Van Der Ven, A J" sort="Van Der Ven, A J" uniqKey="Van Der Ven A" first="A J" last="Van Der Ven">A J Van Der Ven</name>
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<author><name sortKey="De Mast, Q" sort="De Mast, Q" uniqKey="De Mast Q" first="Q" last="De Mast">Q. De Mast</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">[Splenomegaly in an Eritrean refugee: the hyper-reactive malaria splenomegaly syndrome.]</title>
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<affiliation wicri:level="3"><nlm:affiliation>Radboudumc, Nijmegen.</nlm:affiliation>
<country>Pays-Bas</country>
<placeName><settlement type="city">Nimègue</settlement>
<region type="province" nuts="2">Gueldre</region>
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<author><name sortKey="Reuling, I J" sort="Reuling, I J" uniqKey="Reuling I" first="I J" last="Reuling">I J Reuling</name>
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<author><name sortKey="Keuter, M" sort="Keuter, M" uniqKey="Keuter M" first="M" last="Keuter">M. Keuter</name>
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<author><name sortKey="Sauerwein, R W" sort="Sauerwein, R W" uniqKey="Sauerwein R" first="R W" last="Sauerwein">R W Sauerwein</name>
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<author><name sortKey="Van Der Ven, A J" sort="Van Der Ven, A J" uniqKey="Van Der Ven A" first="A J" last="Van Der Ven">A J Van Der Ven</name>
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<series><title level="j">Nederlands tijdschrift voor geneeskunde</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult (MeSH)</term>
<term>Eritrea (MeSH)</term>
<term>Hepatomegaly (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Malaria (diagnosis)</term>
<term>Malaria (drug therapy)</term>
<term>Malaria (parasitology)</term>
<term>Male (MeSH)</term>
<term>Netherlands (MeSH)</term>
<term>Refugees (MeSH)</term>
<term>Splenomegaly (diagnosis)</term>
<term>Splenomegaly (drug therapy)</term>
<term>Splenomegaly (parasitology)</term>
<term>Syndrome (MeSH)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte (MeSH)</term>
<term>Humains (MeSH)</term>
<term>Hépatomégalie (MeSH)</term>
<term>Mâle (MeSH)</term>
<term>Paludisme (diagnostic)</term>
<term>Paludisme (parasitologie)</term>
<term>Paludisme (traitement médicamenteux)</term>
<term>Pays-Bas (MeSH)</term>
<term>Réfugiés (MeSH)</term>
<term>Splénomégalie (diagnostic)</term>
<term>Splénomégalie (parasitologie)</term>
<term>Splénomégalie (traitement médicamenteux)</term>
<term>Syndrome (MeSH)</term>
<term>Érythrée (MeSH)</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Malaria</term>
<term>Splenomegaly</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Paludisme</term>
<term>Splénomégalie</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Malaria</term>
<term>Splenomegaly</term>
</keywords>
<keywords scheme="MESH" qualifier="parasitologie" xml:lang="fr"><term>Paludisme</term>
<term>Splénomégalie</term>
</keywords>
<keywords scheme="MESH" qualifier="parasitology" xml:lang="en"><term>Malaria</term>
<term>Splenomegaly</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Paludisme</term>
<term>Splénomégalie</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Eritrea</term>
<term>Hepatomegaly</term>
<term>Humans</term>
<term>Male</term>
<term>Netherlands</term>
<term>Refugees</term>
<term>Syndrome</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte</term>
<term>Humains</term>
<term>Hépatomégalie</term>
<term>Mâle</term>
<term>Pays-Bas</term>
<term>Réfugiés</term>
<term>Syndrome</term>
<term>Érythrée</term>
</keywords>
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<front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b>
</p>
<p>Hyper-reactive malaria splenomegaly (HMS) is a rare and potentially severe complication of malaria. It is likely that the incidence of patients with HMS will rise in the Netherlands due to the recent increase in asylum-seekers from Sub-Saharan Africa. It can be difficult to diagnose this disease, as this case shows.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>CASE DESCRIPTION</b>
</p>
<p>A 31-year-old male from Eritrea was admitted with fever and dyspnea, caused by an influenza A-infection. The patient also presented with cachexia, pronounced hepatosplenomegaly and pancytopenia. Microscopic diagnostic analysis for malaria was negative. HMS was eventually diagnosed through high-sensitivity qPCR for malaria, which showed the presence of a very low level of Plasmodium falciparum parasitemia; furthermore, IgM levels were high and malaria serology was strongly positive.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>CONCLUSION</b>
</p>
<p>HMS should be considered in patients from malaria-endemic areas presenting with splenomegaly and pancytopenia. Because standard diagnostics for malaria are often negative in this population, malaria serology and sensitive qPCR play an important diagnostic role.</p>
</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27848905</PMID>
<DateCompleted><Year>2018</Year>
<Month>02</Month>
<Day>22</Day>
</DateCompleted>
<DateRevised><Year>2018</Year>
<Month>08</Month>
<Day>07</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1876-8784</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>160</Volume>
<PubDate><MedlineDate>2016</MedlineDate>
</PubDate>
</JournalIssue>
<Title>Nederlands tijdschrift voor geneeskunde</Title>
<ISOAbbreviation>Ned Tijdschr Geneeskd</ISOAbbreviation>
</Journal>
<ArticleTitle>[Splenomegaly in an Eritrean refugee: the hyper-reactive malaria splenomegaly syndrome.]</ArticleTitle>
<Pagination><MedlinePgn>D444</MedlinePgn>
</Pagination>
<Abstract><AbstractText Label="BACKGROUND">Hyper-reactive malaria splenomegaly (HMS) is a rare and potentially severe complication of malaria. It is likely that the incidence of patients with HMS will rise in the Netherlands due to the recent increase in asylum-seekers from Sub-Saharan Africa. It can be difficult to diagnose this disease, as this case shows.</AbstractText>
<AbstractText Label="CASE DESCRIPTION">A 31-year-old male from Eritrea was admitted with fever and dyspnea, caused by an influenza A-infection. The patient also presented with cachexia, pronounced hepatosplenomegaly and pancytopenia. Microscopic diagnostic analysis for malaria was negative. HMS was eventually diagnosed through high-sensitivity qPCR for malaria, which showed the presence of a very low level of Plasmodium falciparum parasitemia; furthermore, IgM levels were high and malaria serology was strongly positive.</AbstractText>
<AbstractText Label="CONCLUSION">HMS should be considered in patients from malaria-endemic areas presenting with splenomegaly and pancytopenia. Because standard diagnostics for malaria are often negative in this population, malaria serology and sensitive qPCR play an important diagnostic role.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Cruijsen</LastName>
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<Author ValidYN="Y"><LastName>Reuling</LastName>
<ForeName>I J</ForeName>
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<Author ValidYN="Y"><LastName>Keuter</LastName>
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<Initials>M</Initials>
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<ForeName>A J</ForeName>
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<VernacularTitle>Splenomegalie bij een Eritrese vluchteling.</VernacularTitle>
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<MedlineJournalInfo><Country>Netherlands</Country>
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<NlmUniqueID>0400770</NlmUniqueID>
<ISSNLinking>0028-2162</ISSNLinking>
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<MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
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<MeshHeading><DescriptorName UI="D006529" MajorTopicYN="N">Hepatomegaly</DescriptorName>
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<MeshHeading><DescriptorName UI="D012036" MajorTopicYN="Y">Refugees</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013163" MajorTopicYN="N">Splenomegaly</DescriptorName>
<QualifierName UI="Q000175" MajorTopicYN="Y">diagnosis</QualifierName>
<QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName>
<QualifierName UI="Q000469" MajorTopicYN="N">parasitology</QualifierName>
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<MeshHeading><DescriptorName UI="D013577" MajorTopicYN="N">Syndrome</DescriptorName>
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<Month>11</Month>
<Day>17</Day>
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<affiliations><list><country><li>Pays-Bas</li>
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<settlement><li>Nimègue</li>
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<tree><noCountry><name sortKey="De Mast, Q" sort="De Mast, Q" uniqKey="De Mast Q" first="Q" last="De Mast">Q. De Mast</name>
<name sortKey="Keuter, M" sort="Keuter, M" uniqKey="Keuter M" first="M" last="Keuter">M. Keuter</name>
<name sortKey="Reuling, I J" sort="Reuling, I J" uniqKey="Reuling I" first="I J" last="Reuling">I J Reuling</name>
<name sortKey="Sauerwein, R W" sort="Sauerwein, R W" uniqKey="Sauerwein R" first="R W" last="Sauerwein">R W Sauerwein</name>
<name sortKey="Van Der Ven, A J" sort="Van Der Ven, A J" uniqKey="Van Der Ven A" first="A J" last="Van Der Ven">A J Van Der Ven</name>
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<country name="Pays-Bas"><region name="Gueldre"><name sortKey="Cruijsen, M M" sort="Cruijsen, M M" uniqKey="Cruijsen M" first="M M" last="Cruijsen">M M Cruijsen</name>
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