Adjuvanted vaccines in pregnancy: no evidence for effect of the adjuvanted H1N1/09 vaccination on occurrence of preeclampsia or intra-uterine growth restriction.
Identifieur interne : 000096 ( Main/Curation ); précédent : 000095; suivant : 000097Adjuvanted vaccines in pregnancy: no evidence for effect of the adjuvanted H1N1/09 vaccination on occurrence of preeclampsia or intra-uterine growth restriction.
Auteurs : Alies Coenders [Pays-Bas] ; Nienke K. Koopmans [Pays-Bas] ; Kim Broekhuijsen [Pays-Bas] ; Henk Groen [Pays-Bas] ; Janna M A. Karstenberg-Kramer [Pays-Bas] ; Kim Van Goor [Pays-Bas] ; Mariette Groenewout [Pays-Bas] ; Aren J. Van Loon [Pays-Bas] ; Marijke M. Faas [Pays-Bas] ; Maria G. Van Pampus [Pays-Bas]Source :
- European journal of obstetrics, gynecology, and reproductive biology [ 1872-7654 ] ; 2015.
Descripteurs français
- KwdFr :
- Adulte (MeSH), Analyse de variance (MeSH), Femelle (MeSH), Grippe humaine (prévention et contrôle), Grossesse (MeSH), Humains (MeSH), Issue de la grossesse (MeSH), Nouveau-né (MeSH), Pays-Bas (MeSH), Pré-éclampsie (épidémiologie), Pré-éclampsie (étiologie), Retard de croissance intra-utérin (épidémiologie), Retard de croissance intra-utérin (étiologie), Sous-type H1N1 du virus de la grippe A (immunologie), Vaccins antigrippaux (effets indésirables), Études cas-témoins (MeSH).
- MESH :
- effets indésirables : Vaccins antigrippaux.
- immunologie : Sous-type H1N1 du virus de la grippe A.
- prévention et contrôle : Grippe humaine.
- épidémiologie : Pré-éclampsie, Retard de croissance intra-utérin.
- étiologie : Pré-éclampsie, Retard de croissance intra-utérin.
- Adulte, Analyse de variance, Femelle, Grossesse, Humains, Issue de la grossesse, Nouveau-né, Pays-Bas, Études cas-témoins.
- Wicri :
- geographic : Pays-Bas.
English descriptors
- KwdEn :
- Adult (MeSH), Analysis of Variance (MeSH), Case-Control Studies (MeSH), Female (MeSH), Fetal Growth Retardation (epidemiology), Fetal Growth Retardation (etiology), Humans (MeSH), Infant, Newborn (MeSH), Influenza A Virus, H1N1 Subtype (immunology), Influenza Vaccines (adverse effects), Influenza, Human (prevention & control), Netherlands (MeSH), Pre-Eclampsia (epidemiology), Pre-Eclampsia (etiology), Pregnancy (MeSH), Pregnancy Outcome (MeSH).
- MESH :
- chemical , adverse effects : Influenza Vaccines.
- geographic : Netherlands.
- epidemiology : Fetal Growth Retardation, Pre-Eclampsia.
- etiology : Fetal Growth Retardation, Pre-Eclampsia.
- immunology : Influenza A Virus, H1N1 Subtype.
- prevention & control : Influenza, Human.
- Adult, Analysis of Variance, Case-Control Studies, Female, Humans, Infant, Newborn, Pregnancy, Pregnancy Outcome.
Abstract
OBJECTIVE
During the H1N1/09 pandemic, pregnant women in the Netherlands were vaccinated with an adjuvanted vaccine. During pregnancy, the maternal immune system changes to enable placental development and growth and acceptance of the semi-allogeneic fetus. As an adjuvant is a pro-inflammatory substance, it may interfere with these immunological changes, resulting in poor placentation or placental growth, which may result in preeclampsia (PE) and fetal intra-uterine growth restriction (IUGR). This study investigated a possible association between adjuvanted H1N1/09 vaccination and the development of PE and/or IUGR.
STUDY DESIGN
Case-control study. Cases were Dutch women with PE and/or IUGR occurring during H1N1/09 vaccination program. Controls had uncomplicated pregnancies during the same period. Maternal characteristics, pregnancy and neonatal outcomes were collected from medical files. Participants were contacted by telephone to enquire about vaccination. Data were analyzed using t-tests, Chi-square tests or Fisher's exact tests. Multivariate analysis was conducted to control for confounders.
RESULTS
We included 254 cases and 247 controls. Of the cases, 90 (35.4%) were vaccinated, compared to 87 (35.2%) of the controls (OR:1.009, 95% CI:0.70-1.46, p:0.961). The majority (73.5%) had been vaccinated in second and third trimester. In multivariate analysis, there were no confounders influencing these results. Exploratory subgroup analysis did not show an association between vaccination status in subgroups of women with either PE or IUGR.
CONCLUSION
Our study showed no association between adjuvanted H1N1/09 vaccination and PE and/or IUGR.
DOI: 10.1016/j.ejogrb.2015.01.011
PubMed: 25681994
Links toward previous steps (curation, corpus...)
- to stream Main, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000096
Links to Exploration step
pubmed:25681994Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Adjuvanted vaccines in pregnancy: no evidence for effect of the adjuvanted H1N1/09 vaccination on occurrence of preeclampsia or intra-uterine growth restriction.</title><author><name sortKey="Coenders, Alies" sort="Coenders, Alies" uniqKey="Coenders A" first="Alies" last="Coenders">Alies Coenders</name><affiliation wicri:level="1"><nlm:affiliation>University of Groningen, University Medical Center Groningen, Department of Obstetrics and Gynecology, Groningen, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>University of Groningen, University Medical Center Groningen, Department of Obstetrics and Gynecology, Groningen</wicri:regionArea></affiliation></author><author><name sortKey="Koopmans, Nienke K" sort="Koopmans, Nienke K" uniqKey="Koopmans N" first="Nienke K" last="Koopmans">Nienke K. Koopmans</name><affiliation wicri:level="1"><nlm:affiliation>University of Groningen, University Medical Center Groningen, Department of Obstetrics and Gynecology, Groningen, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>University of Groningen, University Medical Center Groningen, Department of Obstetrics and Gynecology, Groningen</wicri:regionArea></affiliation></author><author><name sortKey="Broekhuijsen, Kim" sort="Broekhuijsen, Kim" uniqKey="Broekhuijsen K" first="Kim" last="Broekhuijsen">Kim Broekhuijsen</name><affiliation wicri:level="1"><nlm:affiliation>Martini Hospital Groningen, Department of Obstetrics and Gynecology, Groningen, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Martini Hospital Groningen, Department of Obstetrics and Gynecology, Groningen</wicri:regionArea></affiliation></author><author><name sortKey="Groen, Henk" sort="Groen, Henk" uniqKey="Groen H" first="Henk" last="Groen">Henk Groen</name><affiliation wicri:level="1"><nlm:affiliation>University of Groningen, University Medical Center Groningen, Department of Epidemiology, Groningen, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>University of Groningen, University Medical Center Groningen, Department of Epidemiology, Groningen</wicri:regionArea></affiliation></author><author><name sortKey="Karstenberg Kramer, Janna M A" sort="Karstenberg Kramer, Janna M A" uniqKey="Karstenberg Kramer J" first="Janna M A" last="Karstenberg-Kramer">Janna M A. Karstenberg-Kramer</name><affiliation wicri:level="1"><nlm:affiliation>University of Groningen, University Medical Center Groningen, Department of Pathology and Medical biology, Section Medical biology, Groningen, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>University of Groningen, University Medical Center Groningen, Department of Pathology and Medical biology, Section Medical biology, Groningen</wicri:regionArea></affiliation></author><author><name sortKey="Van Goor, Kim" sort="Van Goor, Kim" uniqKey="Van Goor K" first="Kim" last="Van Goor">Kim Van Goor</name><affiliation wicri:level="1"><nlm:affiliation>University of Groningen, University Medical Center Groningen, Department of Pathology and Medical biology, Section Medical biology, Groningen, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>University of Groningen, University Medical Center Groningen, Department of Pathology and Medical biology, Section Medical biology, Groningen</wicri:regionArea></affiliation></author><author><name sortKey="Groenewout, Mariette" sort="Groenewout, Mariette" uniqKey="Groenewout M" first="Mariette" last="Groenewout">Mariette Groenewout</name><affiliation wicri:level="1"><nlm:affiliation>University of Groningen, University Medical Center Groningen, Department of Obstetrics and Gynecology, Groningen, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>University of Groningen, University Medical Center Groningen, Department of Obstetrics and Gynecology, Groningen</wicri:regionArea></affiliation></author><author><name sortKey="Van Loon, Aren J" sort="Van Loon, Aren J" uniqKey="Van Loon A" first="Aren J" last="Van Loon">Aren J. Van Loon</name><affiliation wicri:level="1"><nlm:affiliation>Martini Hospital Groningen, Department of Obstetrics and Gynecology, Groningen, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Martini Hospital Groningen, Department of Obstetrics and Gynecology, Groningen</wicri:regionArea></affiliation></author><author><name sortKey="Faas, Marijke M" sort="Faas, Marijke M" uniqKey="Faas M" first="Marijke M" last="Faas">Marijke M. Faas</name><affiliation wicri:level="1"><nlm:affiliation>University of Groningen, University Medical Center Groningen, Department of Pathology and Medical biology, Section Medical biology, Groningen, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>University of Groningen, University Medical Center Groningen, Department of Pathology and Medical biology, Section Medical biology, Groningen</wicri:regionArea></affiliation></author><author><name sortKey="Van Pampus, Maria G" sort="Van Pampus, Maria G" uniqKey="Van Pampus M" first="Maria G" last="Van Pampus">Maria G. Van Pampus</name><affiliation wicri:level="1"><nlm:affiliation>Onze Lieve Vrouwe Gasthuis, Department of Obstetrics and Gynecology, PO Box 95500, 1090 HM Amsterdam, The Netherlands. Electronic address: m.g.vanpampus@olvg.nl.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Onze Lieve Vrouwe Gasthuis, Department of Obstetrics and Gynecology, PO Box 95500, 1090 HM Amsterdam</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25681994</idno><idno type="pmid">25681994</idno><idno type="doi">10.1016/j.ejogrb.2015.01.011</idno><idno type="wicri:Area/Main/Corpus">000096</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000096</idno><idno type="wicri:Area/Main/Curation">000096</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000096</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Adjuvanted vaccines in pregnancy: no evidence for effect of the adjuvanted H1N1/09 vaccination on occurrence of preeclampsia or intra-uterine growth restriction.</title><author><name sortKey="Coenders, Alies" sort="Coenders, Alies" uniqKey="Coenders A" first="Alies" last="Coenders">Alies Coenders</name><affiliation wicri:level="1"><nlm:affiliation>University of Groningen, University Medical Center Groningen, Department of Obstetrics and Gynecology, Groningen, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>University of Groningen, University Medical Center Groningen, Department of Obstetrics and Gynecology, Groningen</wicri:regionArea></affiliation></author><author><name sortKey="Koopmans, Nienke K" sort="Koopmans, Nienke K" uniqKey="Koopmans N" first="Nienke K" last="Koopmans">Nienke K. Koopmans</name><affiliation wicri:level="1"><nlm:affiliation>University of Groningen, University Medical Center Groningen, Department of Obstetrics and Gynecology, Groningen, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>University of Groningen, University Medical Center Groningen, Department of Obstetrics and Gynecology, Groningen</wicri:regionArea></affiliation></author><author><name sortKey="Broekhuijsen, Kim" sort="Broekhuijsen, Kim" uniqKey="Broekhuijsen K" first="Kim" last="Broekhuijsen">Kim Broekhuijsen</name><affiliation wicri:level="1"><nlm:affiliation>Martini Hospital Groningen, Department of Obstetrics and Gynecology, Groningen, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Martini Hospital Groningen, Department of Obstetrics and Gynecology, Groningen</wicri:regionArea></affiliation></author><author><name sortKey="Groen, Henk" sort="Groen, Henk" uniqKey="Groen H" first="Henk" last="Groen">Henk Groen</name><affiliation wicri:level="1"><nlm:affiliation>University of Groningen, University Medical Center Groningen, Department of Epidemiology, Groningen, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>University of Groningen, University Medical Center Groningen, Department of Epidemiology, Groningen</wicri:regionArea></affiliation></author><author><name sortKey="Karstenberg Kramer, Janna M A" sort="Karstenberg Kramer, Janna M A" uniqKey="Karstenberg Kramer J" first="Janna M A" last="Karstenberg-Kramer">Janna M A. Karstenberg-Kramer</name><affiliation wicri:level="1"><nlm:affiliation>University of Groningen, University Medical Center Groningen, Department of Pathology and Medical biology, Section Medical biology, Groningen, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>University of Groningen, University Medical Center Groningen, Department of Pathology and Medical biology, Section Medical biology, Groningen</wicri:regionArea></affiliation></author><author><name sortKey="Van Goor, Kim" sort="Van Goor, Kim" uniqKey="Van Goor K" first="Kim" last="Van Goor">Kim Van Goor</name><affiliation wicri:level="1"><nlm:affiliation>University of Groningen, University Medical Center Groningen, Department of Pathology and Medical biology, Section Medical biology, Groningen, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>University of Groningen, University Medical Center Groningen, Department of Pathology and Medical biology, Section Medical biology, Groningen</wicri:regionArea></affiliation></author><author><name sortKey="Groenewout, Mariette" sort="Groenewout, Mariette" uniqKey="Groenewout M" first="Mariette" last="Groenewout">Mariette Groenewout</name><affiliation wicri:level="1"><nlm:affiliation>University of Groningen, University Medical Center Groningen, Department of Obstetrics and Gynecology, Groningen, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>University of Groningen, University Medical Center Groningen, Department of Obstetrics and Gynecology, Groningen</wicri:regionArea></affiliation></author><author><name sortKey="Van Loon, Aren J" sort="Van Loon, Aren J" uniqKey="Van Loon A" first="Aren J" last="Van Loon">Aren J. Van Loon</name><affiliation wicri:level="1"><nlm:affiliation>Martini Hospital Groningen, Department of Obstetrics and Gynecology, Groningen, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Martini Hospital Groningen, Department of Obstetrics and Gynecology, Groningen</wicri:regionArea></affiliation></author><author><name sortKey="Faas, Marijke M" sort="Faas, Marijke M" uniqKey="Faas M" first="Marijke M" last="Faas">Marijke M. Faas</name><affiliation wicri:level="1"><nlm:affiliation>University of Groningen, University Medical Center Groningen, Department of Pathology and Medical biology, Section Medical biology, Groningen, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>University of Groningen, University Medical Center Groningen, Department of Pathology and Medical biology, Section Medical biology, Groningen</wicri:regionArea></affiliation></author><author><name sortKey="Van Pampus, Maria G" sort="Van Pampus, Maria G" uniqKey="Van Pampus M" first="Maria G" last="Van Pampus">Maria G. Van Pampus</name><affiliation wicri:level="1"><nlm:affiliation>Onze Lieve Vrouwe Gasthuis, Department of Obstetrics and Gynecology, PO Box 95500, 1090 HM Amsterdam, The Netherlands. Electronic address: m.g.vanpampus@olvg.nl.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Onze Lieve Vrouwe Gasthuis, Department of Obstetrics and Gynecology, PO Box 95500, 1090 HM Amsterdam</wicri:regionArea></affiliation></author></analytic><series><title level="j">European journal of obstetrics, gynecology, and reproductive biology</title><idno type="eISSN">1872-7654</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult (MeSH)</term><term>Analysis of Variance (MeSH)</term><term>Case-Control Studies (MeSH)</term><term>Female (MeSH)</term><term>Fetal Growth Retardation (epidemiology)</term><term>Fetal Growth Retardation (etiology)</term><term>Humans (MeSH)</term><term>Infant, Newborn (MeSH)</term><term>Influenza A Virus, H1N1 Subtype (immunology)</term><term>Influenza Vaccines (adverse effects)</term><term>Influenza, Human (prevention & control)</term><term>Netherlands (MeSH)</term><term>Pre-Eclampsia (epidemiology)</term><term>Pre-Eclampsia (etiology)</term><term>Pregnancy (MeSH)</term><term>Pregnancy Outcome (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte (MeSH)</term><term>Analyse de variance (MeSH)</term><term>Femelle (MeSH)</term><term>Grippe humaine (prévention et contrôle)</term><term>Grossesse (MeSH)</term><term>Humains (MeSH)</term><term>Issue de la grossesse (MeSH)</term><term>Nouveau-né (MeSH)</term><term>Pays-Bas (MeSH)</term><term>Pré-éclampsie (épidémiologie)</term><term>Pré-éclampsie (étiologie)</term><term>Retard de croissance intra-utérin (épidémiologie)</term><term>Retard de croissance intra-utérin (étiologie)</term><term>Sous-type H1N1 du virus de la grippe A (immunologie)</term><term>Vaccins antigrippaux (effets indésirables)</term><term>Études cas-témoins (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Influenza Vaccines</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Netherlands</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Vaccins antigrippaux</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Fetal Growth Retardation</term><term>Pre-Eclampsia</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Fetal Growth Retardation</term><term>Pre-Eclampsia</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Sous-type H1N1 du virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="prévention et contrôle" xml:lang="fr"><term>Grippe humaine</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Pré-éclampsie</term><term>Retard de croissance intra-utérin</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Pré-éclampsie</term><term>Retard de croissance intra-utérin</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Analysis of Variance</term><term>Case-Control Studies</term><term>Female</term><term>Humans</term><term>Infant, Newborn</term><term>Pregnancy</term><term>Pregnancy Outcome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Analyse de variance</term><term>Femelle</term><term>Grossesse</term><term>Humains</term><term>Issue de la grossesse</term><term>Nouveau-né</term><term>Pays-Bas</term><term>Études cas-témoins</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Pays-Bas</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>OBJECTIVE</b></p><p>During the H1N1/09 pandemic, pregnant women in the Netherlands were vaccinated with an adjuvanted vaccine. During pregnancy, the maternal immune system changes to enable placental development and growth and acceptance of the semi-allogeneic fetus. As an adjuvant is a pro-inflammatory substance, it may interfere with these immunological changes, resulting in poor placentation or placental growth, which may result in preeclampsia (PE) and fetal intra-uterine growth restriction (IUGR). This study investigated a possible association between adjuvanted H1N1/09 vaccination and the development of PE and/or IUGR.</p></div><div type="abstract" xml:lang="en"><p><b>STUDY DESIGN</b></p><p>Case-control study. Cases were Dutch women with PE and/or IUGR occurring during H1N1/09 vaccination program. Controls had uncomplicated pregnancies during the same period. Maternal characteristics, pregnancy and neonatal outcomes were collected from medical files. Participants were contacted by telephone to enquire about vaccination. Data were analyzed using t-tests, Chi-square tests or Fisher's exact tests. Multivariate analysis was conducted to control for confounders.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>We included 254 cases and 247 controls. Of the cases, 90 (35.4%) were vaccinated, compared to 87 (35.2%) of the controls (OR:1.009, 95% CI:0.70-1.46, p:0.961). The majority (73.5%) had been vaccinated in second and third trimester. In multivariate analysis, there were no confounders influencing these results. Exploratory subgroup analysis did not show an association between vaccination status in subgroups of women with either PE or IUGR.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSION</b></p><p>Our study showed no association between adjuvanted H1N1/09 vaccination and PE and/or IUGR.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25681994</PMID><DateCompleted><Year>2015</Year><Month>12</Month><Day>14</Day></DateCompleted><DateRevised><Year>2015</Year><Month>03</Month><Day>27</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1872-7654</ISSN><JournalIssue CitedMedium="Internet"><Volume>187</Volume><PubDate><Year>2015</Year><Month>Apr</Month></PubDate></JournalIssue><Title>European journal of obstetrics, gynecology, and reproductive biology</Title><ISOAbbreviation>Eur. J. Obstet. Gynecol. Reprod. Biol.</ISOAbbreviation></Journal><ArticleTitle>Adjuvanted vaccines in pregnancy: no evidence for effect of the adjuvanted H1N1/09 vaccination on occurrence of preeclampsia or intra-uterine growth restriction.</ArticleTitle><Pagination><MedlinePgn>14-9</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.ejogrb.2015.01.011</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S0301-2115(15)00020-2</ELocationID><Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">During the H1N1/09 pandemic, pregnant women in the Netherlands were vaccinated with an adjuvanted vaccine. During pregnancy, the maternal immune system changes to enable placental development and growth and acceptance of the semi-allogeneic fetus. As an adjuvant is a pro-inflammatory substance, it may interfere with these immunological changes, resulting in poor placentation or placental growth, which may result in preeclampsia (PE) and fetal intra-uterine growth restriction (IUGR). This study investigated a possible association between adjuvanted H1N1/09 vaccination and the development of PE and/or IUGR.</AbstractText><AbstractText Label="STUDY DESIGN" NlmCategory="METHODS">Case-control study. Cases were Dutch women with PE and/or IUGR occurring during H1N1/09 vaccination program. Controls had uncomplicated pregnancies during the same period. Maternal characteristics, pregnancy and neonatal outcomes were collected from medical files. Participants were contacted by telephone to enquire about vaccination. Data were analyzed using t-tests, Chi-square tests or Fisher's exact tests. Multivariate analysis was conducted to control for confounders.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">We included 254 cases and 247 controls. Of the cases, 90 (35.4%) were vaccinated, compared to 87 (35.2%) of the controls (OR:1.009, 95% CI:0.70-1.46, p:0.961). The majority (73.5%) had been vaccinated in second and third trimester. In multivariate analysis, there were no confounders influencing these results. Exploratory subgroup analysis did not show an association between vaccination status in subgroups of women with either PE or IUGR.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Our study showed no association between adjuvanted H1N1/09 vaccination and PE and/or IUGR.</AbstractText><CopyrightInformation>Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Coenders</LastName><ForeName>Alies</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>University of Groningen, University Medical Center Groningen, Department of Obstetrics and Gynecology, Groningen, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Koopmans</LastName><ForeName>Nienke K</ForeName><Initials>NK</Initials><AffiliationInfo><Affiliation>University of Groningen, University Medical Center Groningen, Department of Obstetrics and Gynecology, Groningen, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Broekhuijsen</LastName><ForeName>Kim</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Martini Hospital Groningen, Department of Obstetrics and Gynecology, Groningen, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Groen</LastName><ForeName>Henk</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>University of Groningen, University Medical Center Groningen, Department of Epidemiology, Groningen, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Karstenberg-Kramer</LastName><ForeName>Janna M A</ForeName><Initials>JM</Initials><AffiliationInfo><Affiliation>University of Groningen, University Medical Center Groningen, Department of Pathology and Medical biology, Section Medical biology, Groningen, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>van Goor</LastName><ForeName>Kim</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>University of Groningen, University Medical Center Groningen, Department of Pathology and Medical biology, Section Medical biology, Groningen, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Groenewout</LastName><ForeName>Mariette</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>University of Groningen, University Medical Center Groningen, Department of Obstetrics and Gynecology, Groningen, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>van Loon</LastName><ForeName>Aren J</ForeName><Initials>AJ</Initials><AffiliationInfo><Affiliation>Martini Hospital Groningen, Department of Obstetrics and Gynecology, Groningen, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Faas</LastName><ForeName>Marijke M</ForeName><Initials>MM</Initials><AffiliationInfo><Affiliation>University of Groningen, University Medical Center Groningen, Department of Pathology and Medical biology, Section Medical biology, Groningen, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>van Pampus</LastName><ForeName>Maria G</ForeName><Initials>MG</Initials><AffiliationInfo><Affiliation>Onze Lieve Vrouwe Gasthuis, Department of Obstetrics and Gynecology, PO Box 95500, 1090 HM Amsterdam, The Netherlands. Electronic address: m.g.vanpampus@olvg.nl.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>01</Month><Day>23</Day></ArticleDate></Article><MedlineJournalInfo><Country>Ireland</Country><MedlineTA>Eur J Obstet Gynecol Reprod Biol</MedlineTA><NlmUniqueID>0375672</NlmUniqueID><ISSNLinking>0301-2115</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007252">Influenza Vaccines</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000704" MajorTopicYN="N">Analysis of Variance</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016022" MajorTopicYN="N">Case-Control Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005317" MajorTopicYN="N">Fetal Growth Retardation</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000209" MajorTopicYN="Y">etiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007231" MajorTopicYN="N">Infant, Newborn</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D053118" MajorTopicYN="N">Influenza A Virus, H1N1 Subtype</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007252" MajorTopicYN="N">Influenza Vaccines</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="Y">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007251" MajorTopicYN="N">Influenza, Human</DescriptorName><QualifierName UI="Q000517" MajorTopicYN="N">prevention & control</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009426" MajorTopicYN="N" Type="Geographic">Netherlands</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011225" MajorTopicYN="N">Pre-Eclampsia</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000209" MajorTopicYN="Y">etiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011247" MajorTopicYN="N">Pregnancy</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011256" MajorTopicYN="N">Pregnancy Outcome</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Adjuvant</Keyword><Keyword MajorTopicYN="N">H1N1/09</Keyword><Keyword MajorTopicYN="N">Intra-uterine growth restriction.</Keyword><Keyword MajorTopicYN="N">Preeclampsia</Keyword><Keyword MajorTopicYN="N">Vaccination</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2014</Year><Month>10</Month><Day>16</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2015</Year><Month>01</Month><Day>13</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>2</Month><Day>16</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>2</Month><Day>16</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>12</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">25681994</ArticleId><ArticleId IdType="pii">S0301-2115(15)00020-2</ArticleId><ArticleId IdType="doi">10.1016/j.ejogrb.2015.01.011</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/GrippePaysBasV1/Data/Main/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000096 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Curation/biblio.hfd -nk 000096 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= GrippePaysBasV1
|flux= Main
|étape= Curation
|type= RBID
|clé= pubmed:25681994
|texte= Adjuvanted vaccines in pregnancy: no evidence for effect of the adjuvanted H1N1/09 vaccination on occurrence of preeclampsia or intra-uterine growth restriction.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Curation/RBID.i -Sk "pubmed:25681994" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Curation/biblio.hfd \
| NlmPubMed2Wicri -a GrippePaysBasV1
| This area was generated with Dilib version V0.6.35. |  |