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Burden of four vaccine preventable diseases in older adults.

Identifieur interne : 000076 ( Main/Curation ); précédent : 000075; suivant : 000077

Burden of four vaccine preventable diseases in older adults.

Auteurs : Maartje Kristensen [Pays-Bas] ; Alies Van Lier [Pays-Bas] ; Renske Eilers [Pays-Bas] ; Scott A. Mcdonald [Pays-Bas] ; Wim Opstelten [Pays-Bas] ; Nicoline Van Der Maas [Pays-Bas] ; Wim Van Der Hoek [Pays-Bas] ; Mirjam E. Kretzschmar [Pays-Bas] ; Mark M. Nielen [Pays-Bas] ; Hester E. De Melker [Pays-Bas]

Source :

RBID : pubmed:26752065

Descripteurs français

English descriptors

Abstract

BACKGROUND

Implementation of additional targeted vaccinations to prevent infectious diseases in the older adults is under discussion in different countries. When considering the added value of such preventive measures, insight into the current disease burden will assist in prioritization. The aim of this study was derive the first estimates of the disease burden in adults aged 50 years or over in the Netherlands for influenza, pertussis, pneumococcal disease and herpes zoster.

METHODS

The average annual disease burden for these four diseases in the Netherlands was calculated for the period 2010-2013 using the disability-adjusted life years (DALY) measure. Disease models and parameters were obtained from previous research. Where possible we adapted these models specifically for older adults and applied age-specific parameters derived from literature. The disease burden based on these adapted models and parameters was compared with the disease burden based on the general population models.

RESULTS

The estimated average annual disease burden was from high to low: pneumococcal disease (37,223 DALYs/year), influenza (7941 DALYs/year), herpes zoster (942 DALYs/year), and pertussis (812 DALYs/year). The adaptation of models and parameters specifically for the elderly resulted in a higher disease burden compared to the use of general population models.

CONCLUSIONS

Among older adults, the disease burden in the period 2010-2013 was highest for pneumococcal disease, mostly because of high mortality, followed by influenza. Disease burden of herpes zoster and pertussis was relatively low and consisted mostly of years lived with disability. Better information on the course of infectious diseases and long-term consequences would enable more accurate estimation of disease burden in older adults.


DOI: 10.1016/j.vaccine.2015.12.052
PubMed: 26752065

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<term>Aged (MeSH)</term>
<term>Aged, 80 and over (MeSH)</term>
<term>Cost of Illness (MeSH)</term>
<term>Herpes Zoster (epidemiology)</term>
<term>Humans (MeSH)</term>
<term>Influenza, Human (epidemiology)</term>
<term>Middle Aged (MeSH)</term>
<term>Models, Statistical (MeSH)</term>
<term>Netherlands (epidemiology)</term>
<term>Pneumococcal Infections (epidemiology)</term>
<term>Quality-Adjusted Life Years (MeSH)</term>
<term>Vaccination (MeSH)</term>
<term>Whooping Cough (epidemiology)</term>
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<term>Adulte d'âge moyen (MeSH)</term>
<term>Années de vie ajustées sur la qualité (MeSH)</term>
<term>Coqueluche (épidémiologie)</term>
<term>Coûts indirects de la maladie (MeSH)</term>
<term>Grippe humaine (épidémiologie)</term>
<term>Humains (MeSH)</term>
<term>Infections à pneumocoques (épidémiologie)</term>
<term>Modèles statistiques (MeSH)</term>
<term>Pays-Bas (épidémiologie)</term>
<term>Sujet âgé (MeSH)</term>
<term>Sujet âgé de 80 ans ou plus (MeSH)</term>
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<term>Whooping Cough</term>
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<term>Grippe humaine</term>
<term>Infections à pneumocoques</term>
<term>Pays-Bas</term>
<term>Zona</term>
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<keywords scheme="MESH" xml:lang="en">
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Cost of Illness</term>
<term>Humans</term>
<term>Middle Aged</term>
<term>Models, Statistical</term>
<term>Quality-Adjusted Life Years</term>
<term>Vaccination</term>
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<term>Adulte d'âge moyen</term>
<term>Années de vie ajustées sur la qualité</term>
<term>Coûts indirects de la maladie</term>
<term>Humains</term>
<term>Modèles statistiques</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Vaccination</term>
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<p>
<b>BACKGROUND</b>
</p>
<p>Implementation of additional targeted vaccinations to prevent infectious diseases in the older adults is under discussion in different countries. When considering the added value of such preventive measures, insight into the current disease burden will assist in prioritization. The aim of this study was derive the first estimates of the disease burden in adults aged 50 years or over in the Netherlands for influenza, pertussis, pneumococcal disease and herpes zoster.</p>
</div>
<div type="abstract" xml:lang="en">
<p>
<b>METHODS</b>
</p>
<p>The average annual disease burden for these four diseases in the Netherlands was calculated for the period 2010-2013 using the disability-adjusted life years (DALY) measure. Disease models and parameters were obtained from previous research. Where possible we adapted these models specifically for older adults and applied age-specific parameters derived from literature. The disease burden based on these adapted models and parameters was compared with the disease burden based on the general population models.</p>
</div>
<div type="abstract" xml:lang="en">
<p>
<b>RESULTS</b>
</p>
<p>The estimated average annual disease burden was from high to low: pneumococcal disease (37,223 DALYs/year), influenza (7941 DALYs/year), herpes zoster (942 DALYs/year), and pertussis (812 DALYs/year). The adaptation of models and parameters specifically for the elderly resulted in a higher disease burden compared to the use of general population models.</p>
</div>
<div type="abstract" xml:lang="en">
<p>
<b>CONCLUSIONS</b>
</p>
<p>Among older adults, the disease burden in the period 2010-2013 was highest for pneumococcal disease, mostly because of high mortality, followed by influenza. Disease burden of herpes zoster and pertussis was relatively low and consisted mostly of years lived with disability. Better information on the course of infectious diseases and long-term consequences would enable more accurate estimation of disease burden in older adults.</p>
</div>
</front>
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<DateCompleted>
<Year>2016</Year>
<Month>09</Month>
<Day>26</Day>
</DateCompleted>
<DateRevised>
<Year>2016</Year>
<Month>01</Month>
<Day>27</Day>
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<ISSN IssnType="Electronic">1873-2518</ISSN>
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<Volume>34</Volume>
<Issue>7</Issue>
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<Year>2016</Year>
<Month>Feb</Month>
<Day>10</Day>
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<Title>Vaccine</Title>
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<ArticleTitle>Burden of four vaccine preventable diseases in older adults.</ArticleTitle>
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<ELocationID EIdType="pii" ValidYN="Y">S0264-410X(15)01863-0</ELocationID>
<Abstract>
<AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Implementation of additional targeted vaccinations to prevent infectious diseases in the older adults is under discussion in different countries. When considering the added value of such preventive measures, insight into the current disease burden will assist in prioritization. The aim of this study was derive the first estimates of the disease burden in adults aged 50 years or over in the Netherlands for influenza, pertussis, pneumococcal disease and herpes zoster.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">The average annual disease burden for these four diseases in the Netherlands was calculated for the period 2010-2013 using the disability-adjusted life years (DALY) measure. Disease models and parameters were obtained from previous research. Where possible we adapted these models specifically for older adults and applied age-specific parameters derived from literature. The disease burden based on these adapted models and parameters was compared with the disease burden based on the general population models.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">The estimated average annual disease burden was from high to low: pneumococcal disease (37,223 DALYs/year), influenza (7941 DALYs/year), herpes zoster (942 DALYs/year), and pertussis (812 DALYs/year). The adaptation of models and parameters specifically for the elderly resulted in a higher disease burden compared to the use of general population models.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Among older adults, the disease burden in the period 2010-2013 was highest for pneumococcal disease, mostly because of high mortality, followed by influenza. Disease burden of herpes zoster and pertussis was relatively low and consisted mostly of years lived with disability. Better information on the course of infectious diseases and long-term consequences would enable more accurate estimation of disease burden in older adults.</AbstractText>
<CopyrightInformation>Copyright © 2016 Elsevier Ltd. All rights reserved.</CopyrightInformation>
</Abstract>
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<LastName>Kristensen</LastName>
<ForeName>Maartje</ForeName>
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<Affiliation>Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), PO Box 1, 3720 BA Bilthoven, The Netherlands. Electronic address: maartjekristensen@gmail.com.</Affiliation>
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<LastName>van Lier</LastName>
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<Initials>A</Initials>
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<Affiliation>Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), PO Box 1, 3720 BA Bilthoven, The Netherlands. Electronic address: alies.van.lier@rivm.nl.</Affiliation>
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<Initials>R</Initials>
<AffiliationInfo>
<Affiliation>Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), PO Box 1, 3720 BA Bilthoven, The Netherlands; University of Groningen, University Medical Center Groningen, Department of Epidemiology, PO Box 30.001, 9700 RB Groningen, The Netherlands. Electronic address: renske.eilers@rivm.nl.</Affiliation>
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</Author>
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<LastName>McDonald</LastName>
<ForeName>Scott A</ForeName>
<Initials>SA</Initials>
<AffiliationInfo>
<Affiliation>Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), PO Box 1, 3720 BA Bilthoven, The Netherlands. Electronic address: scott.mcdonald@rivm.nl.</Affiliation>
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<LastName>Opstelten</LastName>
<ForeName>Wim</ForeName>
<Initials>W</Initials>
<AffiliationInfo>
<Affiliation>Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, PO Box 85500, 3508 GA Utrecht, The Netherlands. Electronic address: wopstel2@umcutrecht.nl.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>van der Maas</LastName>
<ForeName>Nicoline</ForeName>
<Initials>N</Initials>
<AffiliationInfo>
<Affiliation>Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), PO Box 1, 3720 BA Bilthoven, The Netherlands. Electronic address: nicoline.van.der.maas@rivm.nl.</Affiliation>
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</Author>
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<ForeName>Wim</ForeName>
<Initials>W</Initials>
<AffiliationInfo>
<Affiliation>Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), PO Box 1, 3720 BA Bilthoven, The Netherlands. Electronic address: wim.van.der.hoek@rivm.nl.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Kretzschmar</LastName>
<ForeName>Mirjam E</ForeName>
<Initials>ME</Initials>
<AffiliationInfo>
<Affiliation>Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), PO Box 1, 3720 BA Bilthoven, The Netherlands; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, PO Box 85500, 3508 GA Utrecht, The Netherlands. Electronic address: mirjam.kretzschmar@rivm.nl.</Affiliation>
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</Author>
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<LastName>Nielen</LastName>
<ForeName>Mark M</ForeName>
<Initials>MM</Initials>
<AffiliationInfo>
<Affiliation>NIVEL, Netherlands Institute for Health Services Research, PO Box 1568, 3500 BN Utrecht, The Netherlands. Electronic address: m.nielen@nivel.nl.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>de Melker</LastName>
<ForeName>Hester E</ForeName>
<Initials>HE</Initials>
<AffiliationInfo>
<Affiliation>Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), PO Box 1, 3720 BA Bilthoven, The Netherlands. Electronic address: hester.de.melker@rivm.nl.</Affiliation>
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<PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic">
<Year>2016</Year>
<Month>01</Month>
<Day>03</Day>
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<Country>Netherlands</Country>
<MedlineTA>Vaccine</MedlineTA>
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<ISSNLinking>0264-410X</ISSNLinking>
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<MeshHeading>
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<MeshHeading>
<DescriptorName UI="D017281" MajorTopicYN="N">Cost of Illness</DescriptorName>
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<QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName>
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<MeshHeading>
<DescriptorName UI="D007251" MajorTopicYN="N">Influenza, Human</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName>
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<MeshHeading>
<DescriptorName UI="D015233" MajorTopicYN="N">Models, Statistical</DescriptorName>
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<MeshHeading>
<DescriptorName UI="D009426" MajorTopicYN="N" Type="Geographic">Netherlands</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
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<MeshHeading>
<DescriptorName UI="D011008" MajorTopicYN="N">Pneumococcal Infections</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D019057" MajorTopicYN="N">Quality-Adjusted Life Years</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D014611" MajorTopicYN="N">Vaccination</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D014917" MajorTopicYN="N">Whooping Cough</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName>
</MeshHeading>
</MeshHeadingList>
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<Keyword MajorTopicYN="N">Disability-adjusted life years (DALY)</Keyword>
<Keyword MajorTopicYN="N">Disease burden</Keyword>
<Keyword MajorTopicYN="N">Herpes zoster</Keyword>
<Keyword MajorTopicYN="N">Influenza</Keyword>
<Keyword MajorTopicYN="N">Older adults</Keyword>
<Keyword MajorTopicYN="N">Pertussis</Keyword>
<Keyword MajorTopicYN="N">Pneumococcal disease</Keyword>
</KeywordList>
</MedlineCitation>
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<PubMedPubDate PubStatus="received">
<Year>2015</Year>
<Month>09</Month>
<Day>23</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised">
<Year>2015</Year>
<Month>12</Month>
<Day>14</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted">
<Year>2015</Year>
<Month>12</Month>
<Day>23</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez">
<Year>2016</Year>
<Month>1</Month>
<Day>12</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed">
<Year>2016</Year>
<Month>1</Month>
<Day>12</Day>
<Hour>6</Hour>
<Minute>0</Minute>
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<PubMedPubDate PubStatus="medline">
<Year>2016</Year>
<Month>9</Month>
<Day>27</Day>
<Hour>6</Hour>
<Minute>0</Minute>
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</History>
<PublicationStatus>ppublish</PublicationStatus>
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<ArticleId IdType="pubmed">26752065</ArticleId>
<ArticleId IdType="pii">S0264-410X(15)01863-0</ArticleId>
<ArticleId IdType="doi">10.1016/j.vaccine.2015.12.052</ArticleId>
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