Tissue tropism and pathology of natural influenza virus infection in black-headed gulls (Chroicocephalus ridibundus).
Identifieur interne : 000151 ( Main/Corpus ); précédent : 000150; suivant : 000152Tissue tropism and pathology of natural influenza virus infection in black-headed gulls (Chroicocephalus ridibundus).
Auteurs : Ursula Höfle ; Marco W G. Van De Bildt ; Lonneke M. Leijten ; Geert Van Amerongen ; Josanne H. Verhagen ; Ron A M. Fouchier ; Albert D M E. Osterhaus ; Thijs KuikenSource :
- Avian pathology : journal of the W.V.P.A [ 1465-3338 ] ; 2012.
English descriptors
- KwdEn :
- Animals (MeSH), Antigens, Viral (immunology), Charadriiformes (MeSH), Chick Embryo (MeSH), Cloaca (virology), Disease Reservoirs (MeSH), Epithelial Cells (virology), Epithelium (virology), Female (MeSH), Genome, Viral (genetics), Humans (MeSH), Immunohistochemistry (veterinary), Influenza A virus (classification), Influenza A virus (immunology), Influenza A virus (pathogenicity), Influenza A virus (physiology), Influenza in Birds (epidemiology), Influenza in Birds (mortality), Influenza in Birds (transmission), Influenza in Birds (virology), Intestines (virology), Male (MeSH), Netherlands (epidemiology), Oropharynx (virology), Reverse Transcriptase Polymerase Chain Reaction (MeSH), Specific Pathogen-Free Organisms (MeSH), Virus Replication (MeSH).
- MESH :
- chemical , immunology : Antigens, Viral.
- geographic , epidemiology : Netherlands.
- classification : Influenza A virus.
- epidemiology : Influenza in Birds.
- genetics : Genome, Viral.
- immunology : Influenza A virus.
- mortality : Influenza in Birds.
- pathogenicity : Influenza A virus.
- physiology : Influenza A virus.
- transmission : Influenza in Birds.
- veterinary : Immunohistochemistry.
- virology : Cloaca, Epithelial Cells, Epithelium, Influenza in Birds, Intestines, Oropharynx.
- Animals, Charadriiformes, Chick Embryo, Disease Reservoirs, Female, Humans, Male, Reverse Transcriptase Polymerase Chain Reaction, Specific Pathogen-Free Organisms, Virus Replication.
Abstract
Black-headed gulls (Chroicocephalus ridibundus) are a suitable host species to study the epidemiology of low-pathogenic avian influenza virus (LPAIV) infection in wild waterbirds because they are a common colony-breeding species in which LPAIV infection is detected frequently, limited mainly to the H13 and H16 subtypes. However, the sites of virus replication and associated lesions are poorly understood. We therefore performed virological and pathological analyses on tissues of black-headed gulls naturally infected with LPAIV. We found that 24 of 111 black-headed gulls collected from breeding colonies were infected with LPAIV (10 birds with H16N3, one bird with H13N8, 13 birds undetermined), based on virus and viral genome detection in pharyngeal and cloacal swabs. Of these 24 gulls, 15 expressed virus antigen in their tissues. Virus antigen expression was limited to epithelial cells of intestine and cloacal bursa. No histological lesions were detected in association with virus antigen expression. Our findings show that LPAIV replication in the intestinal tract of black-headed gulls is mainly a superficial infection in absence of detectable lesions, as determined recently for natural LPAIV infection in free-living mallards (Anas platyrhynchos). These findings imply that LPAIV in black-headed gulls has adapted to minimal pathogenicity to its host and that potentially the primary transmission route is faecal-oral.
DOI: 10.1080/03079457.2012.744447
PubMed: 23237367
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pubmed:23237367Le document en format XML
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Leijten</name></author><author><name sortKey="Van Amerongen, Geert" sort="Van Amerongen, Geert" uniqKey="Van Amerongen G" first="Geert" last="Van Amerongen">Geert Van Amerongen</name></author><author><name sortKey="Verhagen, Josanne H" sort="Verhagen, Josanne H" uniqKey="Verhagen J" first="Josanne H" last="Verhagen">Josanne H. Verhagen</name></author><author><name sortKey="Fouchier, Ron A M" sort="Fouchier, Ron A M" uniqKey="Fouchier R" first="Ron A M" last="Fouchier">Ron A M. Fouchier</name></author><author><name sortKey="Osterhaus, Albert D M E" sort="Osterhaus, Albert D M E" uniqKey="Osterhaus A" first="Albert D M E" last="Osterhaus">Albert D M E. Osterhaus</name></author><author><name sortKey="Kuiken, Thijs" sort="Kuiken, Thijs" uniqKey="Kuiken T" first="Thijs" last="Kuiken">Thijs Kuiken</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2012">2012</date><idno type="RBID">pubmed:23237367</idno><idno type="pmid">23237367</idno><idno type="doi">10.1080/03079457.2012.744447</idno><idno type="wicri:Area/Main/Corpus">000151</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000151</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Tissue tropism and pathology of natural influenza virus infection in black-headed gulls (Chroicocephalus ridibundus).</title><author><name sortKey="Hofle, Ursula" sort="Hofle, Ursula" uniqKey="Hofle U" first="Ursula" last="Höfle">Ursula Höfle</name><affiliation><nlm:affiliation>Instituto de Investigación en Recursos Cinegéticos IREC (CSIC-UCLM-JCCM), Ciudad Real, 13005, Ciudad Real, Spain. Ursula.hofle@uclm.es</nlm:affiliation></affiliation></author><author><name sortKey="Van De Bildt, Marco W G" sort="Van De Bildt, Marco W G" uniqKey="Van De Bildt M" first="Marco W G" last="Van De Bildt">Marco W G. Van De Bildt</name></author><author><name sortKey="Leijten, Lonneke M" sort="Leijten, Lonneke M" uniqKey="Leijten L" first="Lonneke M" last="Leijten">Lonneke M. Leijten</name></author><author><name sortKey="Van Amerongen, Geert" sort="Van Amerongen, Geert" uniqKey="Van Amerongen G" first="Geert" last="Van Amerongen">Geert Van Amerongen</name></author><author><name sortKey="Verhagen, Josanne H" sort="Verhagen, Josanne H" uniqKey="Verhagen J" first="Josanne H" last="Verhagen">Josanne H. Verhagen</name></author><author><name sortKey="Fouchier, Ron A M" sort="Fouchier, Ron A M" uniqKey="Fouchier R" first="Ron A M" last="Fouchier">Ron A M. Fouchier</name></author><author><name sortKey="Osterhaus, Albert D M E" sort="Osterhaus, Albert D M E" uniqKey="Osterhaus A" first="Albert D M E" last="Osterhaus">Albert D M E. Osterhaus</name></author><author><name sortKey="Kuiken, Thijs" sort="Kuiken, Thijs" uniqKey="Kuiken T" first="Thijs" last="Kuiken">Thijs Kuiken</name></author></analytic><series><title level="j">Avian pathology : journal of the W.V.P.A</title><idno type="eISSN">1465-3338</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term><term>Antigens, Viral (immunology)</term><term>Charadriiformes (MeSH)</term><term>Chick Embryo (MeSH)</term><term>Cloaca (virology)</term><term>Disease Reservoirs (MeSH)</term><term>Epithelial Cells (virology)</term><term>Epithelium (virology)</term><term>Female (MeSH)</term><term>Genome, Viral (genetics)</term><term>Humans (MeSH)</term><term>Immunohistochemistry (veterinary)</term><term>Influenza A virus (classification)</term><term>Influenza A virus (immunology)</term><term>Influenza A virus (pathogenicity)</term><term>Influenza A virus (physiology)</term><term>Influenza in Birds (epidemiology)</term><term>Influenza in Birds (mortality)</term><term>Influenza in Birds (transmission)</term><term>Influenza in Birds (virology)</term><term>Intestines (virology)</term><term>Male (MeSH)</term><term>Netherlands (epidemiology)</term><term>Oropharynx (virology)</term><term>Reverse Transcriptase Polymerase Chain Reaction (MeSH)</term><term>Specific Pathogen-Free Organisms (MeSH)</term><term>Virus Replication (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antigens, Viral</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Netherlands</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Influenza A virus</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Influenza in Birds</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Genome, Viral</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Influenza A virus</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Influenza in Birds</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Influenza A virus</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Influenza A virus</term></keywords><keywords scheme="MESH" qualifier="transmission" xml:lang="en"><term>Influenza in Birds</term></keywords><keywords scheme="MESH" qualifier="veterinary" xml:lang="en"><term>Immunohistochemistry</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Cloaca</term><term>Epithelial Cells</term><term>Epithelium</term><term>Influenza in Birds</term><term>Intestines</term><term>Oropharynx</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Charadriiformes</term><term>Chick Embryo</term><term>Disease Reservoirs</term><term>Female</term><term>Humans</term><term>Male</term><term>Reverse Transcriptase Polymerase Chain Reaction</term><term>Specific Pathogen-Free Organisms</term><term>Virus Replication</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Black-headed gulls (Chroicocephalus ridibundus) are a suitable host species to study the epidemiology of low-pathogenic avian influenza virus (LPAIV) infection in wild waterbirds because they are a common colony-breeding species in which LPAIV infection is detected frequently, limited mainly to the H13 and H16 subtypes. However, the sites of virus replication and associated lesions are poorly understood. We therefore performed virological and pathological analyses on tissues of black-headed gulls naturally infected with LPAIV. We found that 24 of 111 black-headed gulls collected from breeding colonies were infected with LPAIV (10 birds with H16N3, one bird with H13N8, 13 birds undetermined), based on virus and viral genome detection in pharyngeal and cloacal swabs. Of these 24 gulls, 15 expressed virus antigen in their tissues. Virus antigen expression was limited to epithelial cells of intestine and cloacal bursa. No histological lesions were detected in association with virus antigen expression. Our findings show that LPAIV replication in the intestinal tract of black-headed gulls is mainly a superficial infection in absence of detectable lesions, as determined recently for natural LPAIV infection in free-living mallards (Anas platyrhynchos). These findings imply that LPAIV in black-headed gulls has adapted to minimal pathogenicity to its host and that potentially the primary transmission route is faecal-oral.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">23237367</PMID><DateCompleted><Year>2014</Year><Month>11</Month><Day>14</Day></DateCompleted><DateRevised><Year>2012</Year><Month>12</Month><Day>14</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1465-3338</ISSN><JournalIssue CitedMedium="Internet"><Volume>41</Volume><Issue>6</Issue><PubDate><Year>2012</Year><Month>Dec</Month></PubDate></JournalIssue><Title>Avian pathology : journal of the W.V.P.A</Title><ISOAbbreviation>Avian Pathol.</ISOAbbreviation></Journal><ArticleTitle>Tissue tropism and pathology of natural influenza virus infection in black-headed gulls (Chroicocephalus ridibundus).</ArticleTitle><Pagination><MedlinePgn>547-53</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1080/03079457.2012.744447</ELocationID><Abstract><AbstractText>Black-headed gulls (Chroicocephalus ridibundus) are a suitable host species to study the epidemiology of low-pathogenic avian influenza virus (LPAIV) infection in wild waterbirds because they are a common colony-breeding species in which LPAIV infection is detected frequently, limited mainly to the H13 and H16 subtypes. However, the sites of virus replication and associated lesions are poorly understood. We therefore performed virological and pathological analyses on tissues of black-headed gulls naturally infected with LPAIV. We found that 24 of 111 black-headed gulls collected from breeding colonies were infected with LPAIV (10 birds with H16N3, one bird with H13N8, 13 birds undetermined), based on virus and viral genome detection in pharyngeal and cloacal swabs. Of these 24 gulls, 15 expressed virus antigen in their tissues. Virus antigen expression was limited to epithelial cells of intestine and cloacal bursa. No histological lesions were detected in association with virus antigen expression. Our findings show that LPAIV replication in the intestinal tract of black-headed gulls is mainly a superficial infection in absence of detectable lesions, as determined recently for natural LPAIV infection in free-living mallards (Anas platyrhynchos). These findings imply that LPAIV in black-headed gulls has adapted to minimal pathogenicity to its host and that potentially the primary transmission route is faecal-oral.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Höfle</LastName><ForeName>Ursula</ForeName><Initials>U</Initials><AffiliationInfo><Affiliation>Instituto de Investigación en Recursos Cinegéticos IREC (CSIC-UCLM-JCCM), Ciudad Real, 13005, Ciudad Real, Spain. Ursula.hofle@uclm.es</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Van de Bildt</LastName><ForeName>Marco W G</ForeName><Initials>MW</Initials></Author><Author ValidYN="Y"><LastName>Leijten</LastName><ForeName>Lonneke M</ForeName><Initials>LM</Initials></Author><Author ValidYN="Y"><LastName>Van Amerongen</LastName><ForeName>Geert</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Verhagen</LastName><ForeName>Josanne H</ForeName><Initials>JH</Initials></Author><Author ValidYN="Y"><LastName>Fouchier</LastName><ForeName>Ron A M</ForeName><Initials>RA</Initials></Author><Author ValidYN="Y"><LastName>Osterhaus</LastName><ForeName>Albert D M E</ForeName><Initials>AD</Initials></Author><Author ValidYN="Y"><LastName>Kuiken</LastName><ForeName>Thijs</ForeName><Initials>T</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>HHSN266 200700010C</GrantID><Agency>PHS HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Avian Pathol</MedlineTA><NlmUniqueID>8210638</NlmUniqueID><ISSNLinking>0307-9457</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000956">Antigens, Viral</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000956" MajorTopicYN="N">Antigens, Viral</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D046091" MajorTopicYN="Y">Charadriiformes</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002642" MajorTopicYN="N">Chick Embryo</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002988" MajorTopicYN="N">Cloaca</DescriptorName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004197" MajorTopicYN="N">Disease Reservoirs</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004847" MajorTopicYN="N">Epithelial Cells</DescriptorName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004848" MajorTopicYN="N">Epithelium</DescriptorName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016679" MajorTopicYN="N">Genome, Viral</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007150" MajorTopicYN="N">Immunohistochemistry</DescriptorName><QualifierName UI="Q000662" MajorTopicYN="N">veterinary</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009980" MajorTopicYN="N">Influenza A virus</DescriptorName><QualifierName UI="Q000145" MajorTopicYN="N">classification</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName><QualifierName UI="Q000472" MajorTopicYN="N">pathogenicity</QualifierName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005585" MajorTopicYN="N">Influenza in Birds</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName><QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName><QualifierName UI="Q000635" MajorTopicYN="N">transmission</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007422" MajorTopicYN="N">Intestines</DescriptorName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009426" MajorTopicYN="N" Type="Geographic">Netherlands</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009960" MajorTopicYN="N">Oropharynx</DescriptorName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D020133" MajorTopicYN="N">Reverse Transcriptase Polymerase Chain Reaction</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013047" MajorTopicYN="N">Specific Pathogen-Free Organisms</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014779" MajorTopicYN="N">Virus Replication</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2012</Year><Month>12</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2012</Year><Month>12</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2014</Year><Month>11</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">23237367</ArticleId><ArticleId IdType="doi">10.1080/03079457.2012.744447</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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