GrippeFranceV1, Main, Exploration, bibRecord, 000006

Mortality of critically ill patients with severe influenza starting four years after the 2009 pandemic.

Identifieur interne : 000006 ( Main/Exploration ); précédent : 000005; suivant : 000007

Mortality of critically ill patients with severe influenza starting four years after the 2009 pandemic.

Auteurs : David Vandroux [France] ; Jérôme Allyn [France] ; Cyril Ferdynus [France] ; Bernard-Alex Gaüzere [France] ; Hugo Kerambrun [France] ; Thomas Galas [France] ; Nicolas Allou [France] ; Romain Persichini [France] ; Olivier Martinet [France] ; Julien Jabot [France]

Source :

Infectious diseases (London, England) [ 2374-4243 ]

RBID : pubmed:31538824

Descripteurs français

KwdFr :
- Adulte d'âge moyen (MeSH), Facteurs de risque (MeSH), Femelle (MeSH), France (MeSH), Grippe humaine (mortalité), Humains (MeSH), Iles (MeSH), Indice de gravité de la maladie (MeSH), Infections communautaires (microbiologie), Infections communautaires (mortalité), Infections communautaires (virologie), Maladie grave (MeSH), Mâle (MeSH), Pandémies (statistiques et données numériques), Pneumopathie infectieuse (mortalité), Sujet âgé (MeSH), Unités de soins intensifs (statistiques et données numériques), Études rétrospectives (MeSH).
MESH :
- microbiologie : Infections communautaires.
- mortalité : Grippe humaine, Infections communautaires, Pneumopathie infectieuse.
- statistiques et données numériques : Pandémies, Unités de soins intensifs.
- virologie : Infections communautaires.
- Adulte d'âge moyen, Facteurs de risque, Femelle, France, Humains, Iles, Indice de gravité de la maladie, Maladie grave, Mâle, Sujet âgé, Études rétrospectives.
Wicri :
- geographic : France.

English descriptors

KwdEn :
- Aged (MeSH), Community-Acquired Infections (microbiology), Community-Acquired Infections (mortality), Community-Acquired Infections (virology), Critical Illness (MeSH), Female (MeSH), France (MeSH), Humans (MeSH), Influenza, Human (mortality), Intensive Care Units (statistics & numerical data), Islands (MeSH), Male (MeSH), Middle Aged (MeSH), Pandemics (statistics & numerical data), Pneumonia (mortality), Retrospective Studies (MeSH), Risk Factors (MeSH), Severity of Illness Index (MeSH).
MESH :
- geographic : France.
- microbiology : Community-Acquired Infections.
- mortality : Community-Acquired Infections, Influenza, Human, Pneumonia.
- statistics & numerical data : Intensive Care Units, Pandemics.
- virology : Community-Acquired Infections.
- Aged, Critical Illness, Female, Humans, Islands, Male, Middle Aged, Retrospective Studies, Risk Factors, Severity of Illness Index.

Abstract

Background: In Reunion Island, influenza is not considered a serious illness despite significant mortality in intensive care unit (ICU). We assess the post-pandemic mortality of influenza by comparing it to other community-acquired pneumonia in our ICU. Methods: Retrospective, descriptive, and single-centre cohort study. The main aim was to determine the standardized mortality ratio (SMR) for influenza based on the quartiles of the SAPSII score in the reference population of 954 patients hospitalized for community-acquired pneumonia. Another aim was to analyze the risk factors for mortality in influenza patients. Results: 127 consecutive patients were hospitalized in our ICU with a positive influenza PCR, from January 2013 to December 2017. The mortality rate of these patients was 31% (CI 95%: 23-39%). In patients hospitalized for community-acquired pneumonia, the SMR of patients with influenza was 1.24 (CI 95%: 0.89-1.70). At admission, thirty-nine patients (31%) had superinfections, in 17 caused by methicillin-susceptible Staphylococcus aureus. Need for renal replacement therapy (RR 2.53 [1.29-4.93]) or ECMO (RR 2.35 [1.16-4.74]) were associated with mortality. Twenty-four patients underwent ECMO, 17 with VV-ECMO. Conclusions: Mortality in patients with influenza pneumonia was higher than the expected mortality in community-acquired pneumonia. Although generally considered benign, influenza is a deadly infection in ICU patients in Reunion Island.

DOI: 10.1080/23744235.2019.1668957
PubMed: 31538824

Affiliations:

France

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Le document en format XML

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<author><name sortKey="Vandroux, David" sort="Vandroux, David" uniqKey="Vandroux D" first="David" last="Vandroux">David Vandroux</name>
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<affiliation wicri:level="1"><nlm:affiliation>René Labusquière Centre of Tropical Medicine, University of Bordeaux , Bordeaux Cedex , France.</nlm:affiliation>
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<affiliation wicri:level="1"><nlm:affiliation>UMR 1094 Neuroépidémiologie Tropicale, University of Limoges , Limoges , France.</nlm:affiliation>
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<author><name sortKey="Allyn, Jerome" sort="Allyn, Jerome" uniqKey="Allyn J" first="Jérôme" last="Allyn">Jérôme Allyn</name>
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<author><name sortKey="Gauzere, Bernard Alex" sort="Gauzere, Bernard Alex" uniqKey="Gauzere B" first="Bernard-Alex" last="Gaüzere">Bernard-Alex Gaüzere</name>
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<author><name sortKey="Allou, Nicolas" sort="Allou, Nicolas" uniqKey="Allou N" first="Nicolas" last="Allou">Nicolas Allou</name>
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<country xml:lang="fr">France</country>
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<author><name sortKey="Jabot, Julien" sort="Jabot, Julien" uniqKey="Jabot J" first="Julien" last="Jabot">Julien Jabot</name>
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<affiliation wicri:level="1"><nlm:affiliation>René Labusquière Centre of Tropical Medicine, University of Bordeaux , Bordeaux Cedex , France.</nlm:affiliation>
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<author><name sortKey="Allyn, Jerome" sort="Allyn, Jerome" uniqKey="Allyn J" first="Jérôme" last="Allyn">Jérôme Allyn</name>
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<country xml:lang="fr">France</country>
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<author><name sortKey="Ferdynus, Cyril" sort="Ferdynus, Cyril" uniqKey="Ferdynus C" first="Cyril" last="Ferdynus">Cyril Ferdynus</name>
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<author><name sortKey="Gauzere, Bernard Alex" sort="Gauzere, Bernard Alex" uniqKey="Gauzere B" first="Bernard-Alex" last="Gaüzere">Bernard-Alex Gaüzere</name>
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<author><name sortKey="Kerambrun, Hugo" sort="Kerambrun, Hugo" uniqKey="Kerambrun H" first="Hugo" last="Kerambrun">Hugo Kerambrun</name>
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<country xml:lang="fr">France</country>
<wicri:regionArea>Intensive Care Unit, Félix Guyon Hospital, University Teaching Hospital of La Réunion , Saint Denis </wicri:regionArea>
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<wicri:noRegion>Saint Denis </wicri:noRegion>
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<author><name sortKey="Galas, Thomas" sort="Galas, Thomas" uniqKey="Galas T" first="Thomas" last="Galas">Thomas Galas</name>
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<country xml:lang="fr">France</country>
<wicri:regionArea>Intensive Care Unit, Félix Guyon Hospital, University Teaching Hospital of La Réunion , Saint Denis </wicri:regionArea>
<wicri:noRegion>Saint Denis </wicri:noRegion>
<wicri:noRegion>Saint Denis </wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Allou, Nicolas" sort="Allou, Nicolas" uniqKey="Allou N" first="Nicolas" last="Allou">Nicolas Allou</name>
<affiliation wicri:level="1"><nlm:affiliation>Intensive Care Unit, Félix Guyon Hospital, University Teaching Hospital of La Réunion , Saint Denis , France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Intensive Care Unit, Félix Guyon Hospital, University Teaching Hospital of La Réunion , Saint Denis </wicri:regionArea>
<wicri:noRegion>Saint Denis </wicri:noRegion>
<wicri:noRegion>Saint Denis </wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Persichini, Romain" sort="Persichini, Romain" uniqKey="Persichini R" first="Romain" last="Persichini">Romain Persichini</name>
<affiliation wicri:level="1"><nlm:affiliation>Intensive Care Unit, Félix Guyon Hospital, University Teaching Hospital of La Réunion , Saint Denis , France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Intensive Care Unit, Félix Guyon Hospital, University Teaching Hospital of La Réunion , Saint Denis </wicri:regionArea>
<wicri:noRegion>Saint Denis </wicri:noRegion>
<wicri:noRegion>Saint Denis </wicri:noRegion>
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<author><name sortKey="Martinet, Olivier" sort="Martinet, Olivier" uniqKey="Martinet O" first="Olivier" last="Martinet">Olivier Martinet</name>
<affiliation wicri:level="1"><nlm:affiliation>Intensive Care Unit, Félix Guyon Hospital, University Teaching Hospital of La Réunion , Saint Denis , France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Intensive Care Unit, Félix Guyon Hospital, University Teaching Hospital of La Réunion , Saint Denis </wicri:regionArea>
<wicri:noRegion>Saint Denis </wicri:noRegion>
<wicri:noRegion>Saint Denis </wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Jabot, Julien" sort="Jabot, Julien" uniqKey="Jabot J" first="Julien" last="Jabot">Julien Jabot</name>
<affiliation wicri:level="1"><nlm:affiliation>Intensive Care Unit, Félix Guyon Hospital, University Teaching Hospital of La Réunion , Saint Denis , France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Intensive Care Unit, Félix Guyon Hospital, University Teaching Hospital of La Réunion , Saint Denis </wicri:regionArea>
<wicri:noRegion>Saint Denis </wicri:noRegion>
<wicri:noRegion>Saint Denis </wicri:noRegion>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged (MeSH)</term>
<term>Community-Acquired Infections (microbiology)</term>
<term>Community-Acquired Infections (mortality)</term>
<term>Community-Acquired Infections (virology)</term>
<term>Critical Illness (MeSH)</term>
<term>Female (MeSH)</term>
<term>France (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Influenza, Human (mortality)</term>
<term>Intensive Care Units (statistics & numerical data)</term>
<term>Islands (MeSH)</term>
<term>Male (MeSH)</term>
<term>Middle Aged (MeSH)</term>
<term>Pandemics (statistics & numerical data)</term>
<term>Pneumonia (mortality)</term>
<term>Retrospective Studies (MeSH)</term>
<term>Risk Factors (MeSH)</term>
<term>Severity of Illness Index (MeSH)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen (MeSH)</term>
<term>Facteurs de risque (MeSH)</term>
<term>Femelle (MeSH)</term>
<term>France (MeSH)</term>
<term>Grippe humaine (mortalité)</term>
<term>Humains (MeSH)</term>
<term>Iles (MeSH)</term>
<term>Indice de gravité de la maladie (MeSH)</term>
<term>Infections communautaires (microbiologie)</term>
<term>Infections communautaires (mortalité)</term>
<term>Infections communautaires (virologie)</term>
<term>Maladie grave (MeSH)</term>
<term>Mâle (MeSH)</term>
<term>Pandémies (statistiques et données numériques)</term>
<term>Pneumopathie infectieuse (mortalité)</term>
<term>Sujet âgé (MeSH)</term>
<term>Unités de soins intensifs (statistiques et données numériques)</term>
<term>Études rétrospectives (MeSH)</term>
</keywords>
<keywords scheme="MESH" type="geographic" xml:lang="en"><term>France</term>
</keywords>
<keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Infections communautaires</term>
</keywords>
<keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Community-Acquired Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Community-Acquired Infections</term>
<term>Influenza, Human</term>
<term>Pneumonia</term>
</keywords>
<keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Grippe humaine</term>
<term>Infections communautaires</term>
<term>Pneumopathie infectieuse</term>
</keywords>
<keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Intensive Care Units</term>
<term>Pandemics</term>
</keywords>
<keywords scheme="MESH" qualifier="statistiques et données numériques" xml:lang="fr"><term>Pandémies</term>
<term>Unités de soins intensifs</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections communautaires</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Community-Acquired Infections</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Critical Illness</term>
<term>Female</term>
<term>Humans</term>
<term>Islands</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Retrospective Studies</term>
<term>Risk Factors</term>
<term>Severity of Illness Index</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term>
<term>Facteurs de risque</term>
<term>Femelle</term>
<term>France</term>
<term>Humains</term>
<term>Iles</term>
<term>Indice de gravité de la maladie</term>
<term>Maladie grave</term>
<term>Mâle</term>
<term>Sujet âgé</term>
<term>Études rétrospectives</term>
</keywords>
<keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>France</term>
</keywords>
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<front><div type="abstract" xml:lang="en"><b>Background</b>
: In Reunion Island, influenza is not considered a serious illness despite significant mortality in intensive care unit (ICU). We assess the post-pandemic mortality of influenza by comparing it to other community-acquired pneumonia in our ICU. <b>Methods</b>
: Retrospective, descriptive, and single-centre cohort study. The main aim was to determine the standardized mortality ratio (SMR) for influenza based on the quartiles of the SAPSII score in the reference population of 954 patients hospitalized for community-acquired pneumonia. Another aim was to analyze the risk factors for mortality in influenza patients. <b>Results</b>
: 127 consecutive patients were hospitalized in our ICU with a positive influenza PCR, from January 2013 to December 2017. The mortality rate of these patients was 31% (CI 95%: 23-39%). In patients hospitalized for community-acquired pneumonia, the SMR of patients with influenza was 1.24 (CI 95%: 0.89-1.70). At admission, thirty-nine patients (31%) had superinfections, in 17 caused by methicillin-susceptible <i>Staphylococcus aureus</i>
. Need for renal replacement therapy (RR 2.53 [1.29-4.93]) or ECMO (RR 2.35 [1.16-4.74]) were associated with mortality. Twenty-four patients underwent ECMO, 17 with VV-ECMO. <b>Conclusions</b>
: Mortality in patients with influenza pneumonia was higher than the expected mortality in community-acquired pneumonia. Although generally considered benign, influenza is a deadly infection in ICU patients in Reunion Island.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">31538824</PMID>
<DateCompleted><Year>2020</Year>
<Month>04</Month>
<Day>14</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>04</Month>
<Day>14</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">2374-4243</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>51</Volume>
<Issue>11-12</Issue>
<PubDate><MedlineDate>2019 Nov - Dec</MedlineDate>
</PubDate>
</JournalIssue>
<Title>Infectious diseases (London, England)</Title>
<ISOAbbreviation>Infect Dis (Lond)</ISOAbbreviation>
</Journal>
<ArticleTitle>Mortality of critically ill patients with severe influenza starting four years after the 2009 pandemic.</ArticleTitle>
<Pagination><MedlinePgn>831-837</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1080/23744235.2019.1668957</ELocationID>
<Abstract><AbstractText><b>Background</b>
: In Reunion Island, influenza is not considered a serious illness despite significant mortality in intensive care unit (ICU). We assess the post-pandemic mortality of influenza by comparing it to other community-acquired pneumonia in our ICU. <b>Methods</b>
: Retrospective, descriptive, and single-centre cohort study. The main aim was to determine the standardized mortality ratio (SMR) for influenza based on the quartiles of the SAPSII score in the reference population of 954 patients hospitalized for community-acquired pneumonia. Another aim was to analyze the risk factors for mortality in influenza patients. <b>Results</b>
: 127 consecutive patients were hospitalized in our ICU with a positive influenza PCR, from January 2013 to December 2017. The mortality rate of these patients was 31% (CI 95%: 23-39%). In patients hospitalized for community-acquired pneumonia, the SMR of patients with influenza was 1.24 (CI 95%: 0.89-1.70). At admission, thirty-nine patients (31%) had superinfections, in 17 caused by methicillin-susceptible <i>Staphylococcus aureus</i>
. Need for renal replacement therapy (RR 2.53 [1.29-4.93]) or ECMO (RR 2.35 [1.16-4.74]) were associated with mortality. Twenty-four patients underwent ECMO, 17 with VV-ECMO. <b>Conclusions</b>
: Mortality in patients with influenza pneumonia was higher than the expected mortality in community-acquired pneumonia. Although generally considered benign, influenza is a deadly infection in ICU patients in Reunion Island.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Vandroux</LastName>
<ForeName>David</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>Intensive Care Unit, Félix Guyon Hospital, University Teaching Hospital of La Réunion , Saint Denis , France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>René Labusquière Centre of Tropical Medicine, University of Bordeaux , Bordeaux Cedex , France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>UMR 1094 Neuroépidémiologie Tropicale, University of Limoges , Limoges , France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Allyn</LastName>
<ForeName>Jérôme</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Intensive Care Unit, Félix Guyon Hospital, University Teaching Hospital of La Réunion , Saint Denis , France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ferdynus</LastName>
<ForeName>Cyril</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Unité de Soutien Méthodologique , Saint Denis , France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Gaüzere</LastName>
<ForeName>Bernard-Alex</ForeName>
<Initials>BA</Initials>
<AffiliationInfo><Affiliation>Intensive Care Unit, Félix Guyon Hospital, University Teaching Hospital of La Réunion , Saint Denis , France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>René Labusquière Centre of Tropical Medicine, University of Bordeaux , Bordeaux Cedex , France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kerambrun</LastName>
<ForeName>Hugo</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>Intensive Care Unit, Félix Guyon Hospital, University Teaching Hospital of La Réunion , Saint Denis , France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Galas</LastName>
<ForeName>Thomas</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Intensive Care Unit, Félix Guyon Hospital, University Teaching Hospital of La Réunion , Saint Denis , France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Allou</LastName>
<ForeName>Nicolas</ForeName>
<Initials>N</Initials>
<AffiliationInfo><Affiliation>Intensive Care Unit, Félix Guyon Hospital, University Teaching Hospital of La Réunion , Saint Denis , France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Persichini</LastName>
<ForeName>Romain</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Intensive Care Unit, Félix Guyon Hospital, University Teaching Hospital of La Réunion , Saint Denis , France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Martinet</LastName>
<ForeName>Olivier</ForeName>
<Initials>O</Initials>
<AffiliationInfo><Affiliation>Intensive Care Unit, Félix Guyon Hospital, University Teaching Hospital of La Réunion , Saint Denis , France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Jabot</LastName>
<ForeName>Julien</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Intensive Care Unit, Félix Guyon Hospital, University Teaching Hospital of La Réunion , Saint Denis , France.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType>
<PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2019</Year>
<Month>09</Month>
<Day>20</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>Infect Dis (Lond)</MedlineTA>
<NlmUniqueID>101650235</NlmUniqueID>
<ISSNLinking>2374-4243</ISSNLinking>
</MedlineJournalInfo>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017714" MajorTopicYN="N">Community-Acquired Infections</DescriptorName>
<QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName>
<QualifierName UI="Q000401" MajorTopicYN="Y">mortality</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016638" MajorTopicYN="N">Critical Illness</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005602" MajorTopicYN="N" Type="Geographic">France</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007251" MajorTopicYN="N">Influenza, Human</DescriptorName>
<QualifierName UI="Q000401" MajorTopicYN="Y">mortality</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007362" MajorTopicYN="N">Intensive Care Units</DescriptorName>
<QualifierName UI="Q000706" MajorTopicYN="Y">statistics & numerical data</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D062312" MajorTopicYN="N">Islands</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D058873" MajorTopicYN="N">Pandemics</DescriptorName>
<QualifierName UI="Q000706" MajorTopicYN="Y">statistics & numerical data</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011014" MajorTopicYN="N">Pneumonia</DescriptorName>
<QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012189" MajorTopicYN="N">Retrospective Studies</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012307" MajorTopicYN="N">Risk Factors</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012720" MajorTopicYN="N">Severity of Illness Index</DescriptorName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">ICU</Keyword>
<Keyword MajorTopicYN="Y">Influenza</Keyword>
<Keyword MajorTopicYN="Y">Reunion Island</Keyword>
<Keyword MajorTopicYN="Y">pneumonia</Keyword>
<Keyword MajorTopicYN="Y">post-pandemic</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2019</Year>
<Month>9</Month>
<Day>21</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2020</Year>
<Month>4</Month>
<Day>15</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2019</Year>
<Month>9</Month>
<Day>21</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">31538824</ArticleId>
<ArticleId IdType="doi">10.1080/23744235.2019.1668957</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>France</li>
</country>
</list>
<tree><country name="France"><noRegion><name sortKey="Vandroux, David" sort="Vandroux, David" uniqKey="Vandroux D" first="David" last="Vandroux">David Vandroux</name>
</noRegion>
<name sortKey="Allou, Nicolas" sort="Allou, Nicolas" uniqKey="Allou N" first="Nicolas" last="Allou">Nicolas Allou</name>
<name sortKey="Allyn, Jerome" sort="Allyn, Jerome" uniqKey="Allyn J" first="Jérôme" last="Allyn">Jérôme Allyn</name>
<name sortKey="Ferdynus, Cyril" sort="Ferdynus, Cyril" uniqKey="Ferdynus C" first="Cyril" last="Ferdynus">Cyril Ferdynus</name>
<name sortKey="Galas, Thomas" sort="Galas, Thomas" uniqKey="Galas T" first="Thomas" last="Galas">Thomas Galas</name>
<name sortKey="Gauzere, Bernard Alex" sort="Gauzere, Bernard Alex" uniqKey="Gauzere B" first="Bernard-Alex" last="Gaüzere">Bernard-Alex Gaüzere</name>
<name sortKey="Gauzere, Bernard Alex" sort="Gauzere, Bernard Alex" uniqKey="Gauzere B" first="Bernard-Alex" last="Gaüzere">Bernard-Alex Gaüzere</name>
<name sortKey="Jabot, Julien" sort="Jabot, Julien" uniqKey="Jabot J" first="Julien" last="Jabot">Julien Jabot</name>
<name sortKey="Kerambrun, Hugo" sort="Kerambrun, Hugo" uniqKey="Kerambrun H" first="Hugo" last="Kerambrun">Hugo Kerambrun</name>
<name sortKey="Martinet, Olivier" sort="Martinet, Olivier" uniqKey="Martinet O" first="Olivier" last="Martinet">Olivier Martinet</name>
<name sortKey="Persichini, Romain" sort="Persichini, Romain" uniqKey="Persichini R" first="Romain" last="Persichini">Romain Persichini</name>
<name sortKey="Vandroux, David" sort="Vandroux, David" uniqKey="Vandroux D" first="David" last="Vandroux">David Vandroux</name>
<name sortKey="Vandroux, David" sort="Vandroux, David" uniqKey="Vandroux D" first="David" last="Vandroux">David Vandroux</name>
</country>
</tree>
</affiliations>
</record>

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Mortality of critically ill patients with severe influenza starting four years after the 2009 pandemic.

Mortality of critically ill patients with severe influenza starting four years after the 2009 pandemic.

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