[Viral infection of the lower respiratory tract in hospitalized infants: etiology, clinical features and risk factors].
Identifieur interne : 000656 ( Main/Exploration ); précédent : 000655; suivant : 000657[Viral infection of the lower respiratory tract in hospitalized infants: etiology, clinical features and risk factors].
Auteurs : M L García García ; M. Ordobás Gabin ; C. Calvo Reya ; M. González Alvarez ; J. Aguilar Ruiz ; A. Arregui Sierra ; P. Pérez Bre ASource :
- Anales espanoles de pediatria [ 0302-4342 ] ; 2001.
Descripteurs français
- KwdFr :
- MESH :
- diagnostic : Infections de l'appareil respiratoire.
- virologie : Infections de l'appareil respiratoire.
- épidémiologie : Espagne, Infections de l'appareil respiratoire.
- Facteurs de risque, Femelle, Hospitalisation, Humains, Mâle, Nourrisson.
- Wicri :
- geographic : Espagne.
English descriptors
- KwdEn :
- MESH :
- geographic , epidemiology : Spain.
- diagnosis : Respiratory Tract Infections.
- epidemiology : Respiratory Tract Infections.
- virology : Respiratory Tract Infections.
- Female, Hospitalization, Humans, Infant, Male, Risk Factors.
Abstract
OBJECTIVES
The aim of this study was to assess the clinical and virological characteristics of lower respiratory tract (LRT) infection in hospitalized infants in Spain and to identify clinical, radiological or laboratory parameters that could, on admission, be associated with a more severe clinical course.
PATIENTS AND METHODS
A prospective study of infants less than 24 months old hospitalized for LRT infection during six consecutive seasons was performed.
RESULTS
A total of 617 infants were included in the study. Diagnosis was bronchiolitis in 64 %, wheezy bronchitis in 24.6 %, laryngitis in 4.4 % and pneumonia in 6.8 %. The mean age was 269 188 days, the male/female ratio was 1:6 and the mean hospital stay was 6.6 3.5 days. At least one viral agent was identified in 55.6 % of the episodes, of which 83.6 % were due to respiratory syncytial virus (RSV). Other less frequently identified viruses were parainfluenza in 7 %, adenovirus in 4.3 % and influenza in 4 %. Coinfection was identified in 6.2 % of RSV-positive infants. These infants were younger (p < 0.005), had higher respiratory distress assessment instrument (RDAI) scores and longer hospital stay than infants in the other etiologic groups. Chest radiographs were performed in 94.3 % of the infants and 39.5 % showed infiltrate or atelectasis. This radiological alteration was significantly associated with a fever of more than 38.5 C and reactive C protein concentrations of more than 30 mg/L (p < 0.001 and p < 0.002), but not with higher RDAI score, SaO2 equal to or less than 87 %, or longer hospital stay. In the crude analysis, hospitalization for more than 5 days was associated with lower age (p < 0.01), a mean RDAI score of more than 6 (p < 0.003), SaO2 equal to or less than 87 % (p < 0.01) and RSV infection (p < 0.001). However, in the multivariate analysis only SaO2 equal to or less than 87 % and RSV infection were significantly associated with prolonged hospitalization.
CONCLUSION
The most common lower respiratory tract infections in hospitalized infants in Spain are the various types of RSV-positive bronchiolitis, which have a clinical pattern similar to that described in other countries. Hypoxia on admission and RSV infection are the most important risk factors for prolonged hospitalization.
PubMed: 11472660
Affiliations:
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Calvo Reya</name></author><author><name sortKey="Gonzalez Alvarez, M" sort="Gonzalez Alvarez, M" uniqKey="Gonzalez Alvarez M" first="M" last="González Alvarez">M. González Alvarez</name></author><author><name sortKey="Aguilar Ruiz, J" sort="Aguilar Ruiz, J" uniqKey="Aguilar Ruiz J" first="J" last="Aguilar Ruiz">J. Aguilar Ruiz</name></author><author><name sortKey="Arregui Sierra, A" sort="Arregui Sierra, A" uniqKey="Arregui Sierra A" first="A" last="Arregui Sierra">A. Arregui Sierra</name></author><author><name sortKey="Perez Bre A, P" sort="Perez Bre A, P" uniqKey="Perez Bre A P" first="P" last="Pérez Bre A">P. Pérez Bre A</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2001">2001</date><idno type="RBID">pubmed:11472660</idno><idno type="pmid">11472660</idno><idno type="wicri:Area/Main/Corpus">00659</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">00659</idno><idno type="wicri:Area/Main/Curation">000659</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000659</idno><idno type="wicri:Area/Main/Exploration">000659</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">[Viral infection of the lower respiratory tract in hospitalized infants: etiology, clinical features and risk factors].</title><author><name sortKey="Garcia Garcia, M L" sort="Garcia Garcia, M L" uniqKey="Garcia Garcia M" first="M L" last="García García">M L García García</name><affiliation><nlm:affiliation>Servicio de Pediatría. Hospital Severo Ochoa. Madrid.</nlm:affiliation><wicri:noCountry code="no comma">Servicio de Pediatría. Hospital Severo Ochoa. Madrid.</wicri:noCountry></affiliation></author><author><name sortKey="Ordobas Gabin, M" sort="Ordobas Gabin, M" uniqKey="Ordobas Gabin M" first="M" last="Ordobás Gabin">M. Ordobás Gabin</name></author><author><name sortKey="Calvo Reya, C" sort="Calvo Reya, C" uniqKey="Calvo Reya C" first="C" last="Calvo Reya">C. Calvo Reya</name></author><author><name sortKey="Gonzalez Alvarez, M" sort="Gonzalez Alvarez, M" uniqKey="Gonzalez Alvarez M" first="M" last="González Alvarez">M. González Alvarez</name></author><author><name sortKey="Aguilar Ruiz, J" sort="Aguilar Ruiz, J" uniqKey="Aguilar Ruiz J" first="J" last="Aguilar Ruiz">J. Aguilar Ruiz</name></author><author><name sortKey="Arregui Sierra, A" sort="Arregui Sierra, A" uniqKey="Arregui Sierra A" first="A" last="Arregui Sierra">A. Arregui Sierra</name></author><author><name sortKey="Perez Bre A, P" sort="Perez Bre A, P" uniqKey="Perez Bre A P" first="P" last="Pérez Bre A">P. Pérez Bre A</name></author></analytic><series><title level="j">Anales espanoles de pediatria</title><idno type="ISSN">0302-4342</idno><imprint><date when="2001" type="published">2001</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Female (MeSH)</term><term>Hospitalization (MeSH)</term><term>Humans (MeSH)</term><term>Infant (MeSH)</term><term>Male (MeSH)</term><term>Respiratory Tract Infections (diagnosis)</term><term>Respiratory Tract Infections (epidemiology)</term><term>Respiratory Tract Infections (virology)</term><term>Risk Factors (MeSH)</term><term>Spain (epidemiology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Espagne (épidémiologie)</term><term>Facteurs de risque (MeSH)</term><term>Femelle (MeSH)</term><term>Hospitalisation (MeSH)</term><term>Humains (MeSH)</term><term>Infections de l'appareil respiratoire (diagnostic)</term><term>Infections de l'appareil respiratoire (virologie)</term><term>Infections de l'appareil respiratoire (épidémiologie)</term><term>Mâle (MeSH)</term><term>Nourrisson (MeSH)</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Spain</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Respiratory Tract Infections</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Infections de l'appareil respiratoire</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Respiratory Tract Infections</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections de l'appareil respiratoire</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Respiratory Tract Infections</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Espagne</term><term>Infections de l'appareil respiratoire</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Female</term><term>Hospitalization</term><term>Humans</term><term>Infant</term><term>Male</term><term>Risk Factors</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Facteurs de risque</term><term>Femelle</term><term>Hospitalisation</term><term>Humains</term><term>Mâle</term><term>Nourrisson</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Espagne</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>OBJECTIVES</b></p><p>The aim of this study was to assess the clinical and virological characteristics of lower respiratory tract (LRT) infection in hospitalized infants in Spain and to identify clinical, radiological or laboratory parameters that could, on admission, be associated with a more severe clinical course.</p></div><div type="abstract" xml:lang="en"><p><b>PATIENTS AND METHODS</b></p><p>A prospective study of infants less than 24 months old hospitalized for LRT infection during six consecutive seasons was performed.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>A total of 617 infants were included in the study. Diagnosis was bronchiolitis in 64 %, wheezy bronchitis in 24.6 %, laryngitis in 4.4 % and pneumonia in 6.8 %. The mean age was 269 188 days, the male/female ratio was 1:6 and the mean hospital stay was 6.6 3.5 days. At least one viral agent was identified in 55.6 % of the episodes, of which 83.6 % were due to respiratory syncytial virus (RSV). Other less frequently identified viruses were parainfluenza in 7 %, adenovirus in 4.3 % and influenza in 4 %. Coinfection was identified in 6.2 % of RSV-positive infants. These infants were younger (p < 0.005), had higher respiratory distress assessment instrument (RDAI) scores and longer hospital stay than infants in the other etiologic groups. Chest radiographs were performed in 94.3 % of the infants and 39.5 % showed infiltrate or atelectasis. This radiological alteration was significantly associated with a fever of more than 38.5 C and reactive C protein concentrations of more than 30 mg/L (p < 0.001 and p < 0.002), but not with higher RDAI score, SaO2 equal to or less than 87 %, or longer hospital stay. In the crude analysis, hospitalization for more than 5 days was associated with lower age (p < 0.01), a mean RDAI score of more than 6 (p < 0.003), SaO2 equal to or less than 87 % (p < 0.01) and RSV infection (p < 0.001). However, in the multivariate analysis only SaO2 equal to or less than 87 % and RSV infection were significantly associated with prolonged hospitalization.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSION</b></p><p>The most common lower respiratory tract infections in hospitalized infants in Spain are the various types of RSV-positive bronchiolitis, which have a clinical pattern similar to that described in other countries. Hypoxia on admission and RSV infection are the most important risk factors for prolonged hospitalization.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">11472660</PMID><DateCompleted><Year>2001</Year><Month>10</Month><Day>11</Day></DateCompleted><DateRevised><Year>2006</Year><Month>11</Month><Day>15</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0302-4342</ISSN><JournalIssue CitedMedium="Print"><Volume>55</Volume><Issue>2</Issue><PubDate><Year>2001</Year><Month>Aug</Month></PubDate></JournalIssue><Title>Anales espanoles de pediatria</Title><ISOAbbreviation>An. Esp. Pediatr.</ISOAbbreviation></Journal><ArticleTitle>[Viral infection of the lower respiratory tract in hospitalized infants: etiology, clinical features and risk factors].</ArticleTitle><Pagination><MedlinePgn>101-7</MedlinePgn></Pagination><Abstract><AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">The aim of this study was to assess the clinical and virological characteristics of lower respiratory tract (LRT) infection in hospitalized infants in Spain and to identify clinical, radiological or laboratory parameters that could, on admission, be associated with a more severe clinical course.</AbstractText><AbstractText Label="PATIENTS AND METHODS" NlmCategory="METHODS">A prospective study of infants less than 24 months old hospitalized for LRT infection during six consecutive seasons was performed.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">A total of 617 infants were included in the study. Diagnosis was bronchiolitis in 64 %, wheezy bronchitis in 24.6 %, laryngitis in 4.4 % and pneumonia in 6.8 %. The mean age was 269 188 days, the male/female ratio was 1:6 and the mean hospital stay was 6.6 3.5 days. At least one viral agent was identified in 55.6 % of the episodes, of which 83.6 % were due to respiratory syncytial virus (RSV). Other less frequently identified viruses were parainfluenza in 7 %, adenovirus in 4.3 % and influenza in 4 %. Coinfection was identified in 6.2 % of RSV-positive infants. These infants were younger (p < 0.005), had higher respiratory distress assessment instrument (RDAI) scores and longer hospital stay than infants in the other etiologic groups. Chest radiographs were performed in 94.3 % of the infants and 39.5 % showed infiltrate or atelectasis. This radiological alteration was significantly associated with a fever of more than 38.5 C and reactive C protein concentrations of more than 30 mg/L (p < 0.001 and p < 0.002), but not with higher RDAI score, SaO2 equal to or less than 87 %, or longer hospital stay. In the crude analysis, hospitalization for more than 5 days was associated with lower age (p < 0.01), a mean RDAI score of more than 6 (p < 0.003), SaO2 equal to or less than 87 % (p < 0.01) and RSV infection (p < 0.001). However, in the multivariate analysis only SaO2 equal to or less than 87 % and RSV infection were significantly associated with prolonged hospitalization.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">The most common lower respiratory tract infections in hospitalized infants in Spain are the various types of RSV-positive bronchiolitis, which have a clinical pattern similar to that described in other countries. Hypoxia on admission and RSV infection are the most important risk factors for prolonged hospitalization.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>García García</LastName><ForeName>M L</ForeName><Initials>ML</Initials><AffiliationInfo><Affiliation>Servicio de Pediatría. Hospital Severo Ochoa. Madrid.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ordobás Gabin</LastName><ForeName>M</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Calvo Reya</LastName><ForeName>C</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>González Alvarez</LastName><ForeName>M</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Aguilar Ruiz</LastName><ForeName>J</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Arregui Sierra</LastName><ForeName>A</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Pérez Breña</LastName><ForeName>P</ForeName><Initials>P</Initials></Author></AuthorList><Language>spa</Language><PublicationTypeList><PublicationType UI="D004740">English Abstract</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><VernacularTitle>Infecciones virales de vías respiratorias inferiores en lactantes hospitalizados: etiología, características clínicas y factores de riesgo.</VernacularTitle></Article><MedlineJournalInfo><Country>Spain</Country><MedlineTA>An Esp Pediatr</MedlineTA><NlmUniqueID>0420463</NlmUniqueID><ISSNLinking>0302-4342</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006760" MajorTopicYN="N">Hospitalization</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007223" MajorTopicYN="N">Infant</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012141" MajorTopicYN="N">Respiratory Tract Infections</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName><QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012307" MajorTopicYN="N">Risk Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013030" MajorTopicYN="N" Type="Geographic">Spain</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2001</Year><Month>7</Month><Day>27</Day><Hour>10</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2001</Year><Month>10</Month><Day>12</Day><Hour>10</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2001</Year><Month>7</Month><Day>27</Day><Hour>10</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">11472660</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list></list><tree><noCountry><name sortKey="Aguilar Ruiz, J" sort="Aguilar Ruiz, J" uniqKey="Aguilar Ruiz J" first="J" last="Aguilar Ruiz">J. Aguilar Ruiz</name><name sortKey="Arregui Sierra, A" sort="Arregui Sierra, A" uniqKey="Arregui Sierra A" first="A" last="Arregui Sierra">A. Arregui Sierra</name><name sortKey="Calvo Reya, C" sort="Calvo Reya, C" uniqKey="Calvo Reya C" first="C" last="Calvo Reya">C. Calvo Reya</name><name sortKey="Garcia Garcia, M L" sort="Garcia Garcia, M L" uniqKey="Garcia Garcia M" first="M L" last="García García">M L García García</name><name sortKey="Gonzalez Alvarez, M" sort="Gonzalez Alvarez, M" uniqKey="Gonzalez Alvarez M" first="M" last="González Alvarez">M. González Alvarez</name><name sortKey="Ordobas Gabin, M" sort="Ordobas Gabin, M" uniqKey="Ordobas Gabin M" first="M" last="Ordobás Gabin">M. Ordobás Gabin</name><name sortKey="Perez Bre A, P" sort="Perez Bre A, P" uniqKey="Perez Bre A P" first="P" last="Pérez Bre A">P. Pérez Bre A</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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