Rapid spread of drug-resistant influenza A viruses in the Basque Country, northern Spain, 2000-1 to 2008-9.
Identifieur interne : 000519 ( Main/Exploration ); précédent : 000518; suivant : 000520Rapid spread of drug-resistant influenza A viruses in the Basque Country, northern Spain, 2000-1 to 2008-9.
Auteurs : D. Vicente [Espagne] ; G. Cilla ; M. Montes ; J. Mendiola ; E. Pérez-TralleroSource :
- Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin [ 1560-7917 ] ; 2009.
Descripteurs français
- KwdFr :
- Adamantane (usage thérapeutique), Espagne (épidémiologie), Grippe humaine (épidémiologie), Humains (MeSH), Mutation (effets des médicaments et des substances chimiques), Mutation (génétique), Oséltamivir (usage thérapeutique), Résistance virale aux médicaments (effets des médicaments et des substances chimiques), Résistance virale aux médicaments (génétique), Sous-type H1N1 du virus de la grippe A (effets des médicaments et des substances chimiques), Sous-type H1N1 du virus de la grippe A (génétique), Sous-type H3N2 du virus de la grippe A (effets des médicaments et des substances chimiques), Sous-type H3N2 du virus de la grippe A (génétique), Tests de sensibilité microbienne (MeSH).
- MESH :
- effets des médicaments et des substances chimiques : Mutation, Résistance virale aux médicaments, Sous-type H1N1 du virus de la grippe A, Sous-type H3N2 du virus de la grippe A.
- génétique : Mutation, Résistance virale aux médicaments, Sous-type H1N1 du virus de la grippe A, Sous-type H3N2 du virus de la grippe A.
- usage thérapeutique : Adamantane, Oséltamivir.
- épidémiologie : Espagne, Grippe humaine.
- Humains, Tests de sensibilité microbienne.
- Wicri :
- geographic : Espagne.
English descriptors
- KwdEn :
- Adamantane (therapeutic use), Drug Resistance, Viral (drug effects), Drug Resistance, Viral (genetics), Humans (MeSH), Influenza A Virus, H1N1 Subtype (drug effects), Influenza A Virus, H1N1 Subtype (genetics), Influenza A Virus, H3N2 Subtype (drug effects), Influenza A Virus, H3N2 Subtype (genetics), Influenza, Human (epidemiology), Microbial Sensitivity Tests (MeSH), Mutation (drug effects), Mutation (genetics), Oseltamivir (therapeutic use), Spain (epidemiology).
- MESH :
- chemical , therapeutic use : Adamantane, Oseltamivir.
- geographic , epidemiology : Spain.
- drug effects : Drug Resistance, Viral, Influenza A Virus, H1N1 Subtype, Influenza A Virus, H3N2 Subtype, Mutation.
- epidemiology : Influenza, Human.
- genetics : Drug Resistance, Viral, Influenza A Virus, H1N1 Subtype, Influenza A Virus, H3N2 Subtype, Mutation.
- Humans, Microbial Sensitivity Tests.
Abstract
A worldwide increase of adamantane-resistant influenza A(H3N2) and oseltamivir-resistant influenza A(H1N1) viruses has been observed in recent years. The aim of this study was to analyse the prevalence of antiviral drug-resistant influenza A in a region of northern Spain. Resistance to adamantanes was detected in 45.3% (68/150) of influenza AH3 viruses analysed for the period from 2000-1 to 2008-9. Adamantane-resistance was absent in our region during the 2000-1 to 2002-3 influenza seasons. However, after the first adamantane-resistant virus (characterised as A/Fujian/411/2002) was detected in the 2003-4 season, a rapid increase in the proportion of resistant strains was observed (4.9% [2/41], 80% [8/10] and 100% [53/53] in the 2004-5, 2006-7 and 2008-9 seasons, respectively). Four of the first five adamantane-resistant AH3 viruses detected were isolated from adult patients, but the subsequent spread was observed mainly among children. No resistance to adamantanes was detected among the 65 influenza AH1 viruses analysed throughout the study period. Among the 172 influenza A (76 AH1 and 96 AH3) viruses analysed, five strains (AH1 with mutation H274Y) showed oseltamivir resistance, and all were detected in the last season. Amantadine use was very scarce in our region, and oseltamivir was not used at all; therefore the increase of resistance was attributed to imported drug-resistant influenza viruses.
DOI: 10.2807/ese.14.20.19215-en
PubMed: 19460286
Affiliations:
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Vicente</name><affiliation wicri:level="1"><nlm:affiliation>Microbiology Service and Reference Laboratory for Influenza Infections of the Basque Country, Hospital Donostia, San Sebastián, Spain. mikrobiol@terra.es</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Microbiology Service and Reference Laboratory for Influenza Infections of the Basque Country, Hospital Donostia, San Sebastián</wicri:regionArea><wicri:noRegion>San Sebastián</wicri:noRegion></affiliation></author><author><name sortKey="Cilla, G" sort="Cilla, G" uniqKey="Cilla G" first="G" last="Cilla">G. Cilla</name></author><author><name sortKey="Montes, M" sort="Montes, M" uniqKey="Montes M" first="M" last="Montes">M. Montes</name></author><author><name sortKey="Mendiola, J" sort="Mendiola, J" uniqKey="Mendiola J" first="J" last="Mendiola">J. Mendiola</name></author><author><name sortKey="Perez Trallero, E" sort="Perez Trallero, E" uniqKey="Perez Trallero E" first="E" last="Pérez-Trallero">E. Pérez-Trallero</name></author></analytic><series><title level="j">Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin</title><idno type="eISSN">1560-7917</idno><imprint><date when="2009" type="published">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adamantane (therapeutic use)</term><term>Drug Resistance, Viral (drug effects)</term><term>Drug Resistance, Viral (genetics)</term><term>Humans (MeSH)</term><term>Influenza A Virus, H1N1 Subtype (drug effects)</term><term>Influenza A Virus, H1N1 Subtype (genetics)</term><term>Influenza A Virus, H3N2 Subtype (drug effects)</term><term>Influenza A Virus, H3N2 Subtype (genetics)</term><term>Influenza, Human (epidemiology)</term><term>Microbial Sensitivity Tests (MeSH)</term><term>Mutation (drug effects)</term><term>Mutation (genetics)</term><term>Oseltamivir (therapeutic use)</term><term>Spain (epidemiology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adamantane (usage thérapeutique)</term><term>Espagne (épidémiologie)</term><term>Grippe humaine (épidémiologie)</term><term>Humains (MeSH)</term><term>Mutation (effets des médicaments et des substances chimiques)</term><term>Mutation (génétique)</term><term>Oséltamivir (usage thérapeutique)</term><term>Résistance virale aux médicaments (effets des médicaments et des substances chimiques)</term><term>Résistance virale aux médicaments (génétique)</term><term>Sous-type H1N1 du virus de la grippe A (effets des médicaments et des substances chimiques)</term><term>Sous-type H1N1 du virus de la grippe A (génétique)</term><term>Sous-type H3N2 du virus de la grippe A (effets des médicaments et des substances chimiques)</term><term>Sous-type H3N2 du virus de la grippe A (génétique)</term><term>Tests de sensibilité microbienne (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Adamantane</term><term>Oseltamivir</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Spain</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Drug Resistance, Viral</term><term>Influenza A Virus, H1N1 Subtype</term><term>Influenza A Virus, H3N2 Subtype</term><term>Mutation</term></keywords><keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Mutation</term><term>Résistance virale aux médicaments</term><term>Sous-type H1N1 du virus de la grippe A</term><term>Sous-type H3N2 du virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Drug Resistance, Viral</term><term>Influenza A Virus, H1N1 Subtype</term><term>Influenza A Virus, H3N2 Subtype</term><term>Mutation</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Mutation</term><term>Résistance virale aux médicaments</term><term>Sous-type H1N1 du virus de la grippe A</term><term>Sous-type H3N2 du virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Adamantane</term><term>Oséltamivir</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Espagne</term><term>Grippe humaine</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term><term>Microbial Sensitivity Tests</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Humains</term><term>Tests de sensibilité microbienne</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Espagne</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A worldwide increase of adamantane-resistant influenza A(H3N2) and oseltamivir-resistant influenza A(H1N1) viruses has been observed in recent years. The aim of this study was to analyse the prevalence of antiviral drug-resistant influenza A in a region of northern Spain. Resistance to adamantanes was detected in 45.3% (68/150) of influenza AH3 viruses analysed for the period from 2000-1 to 2008-9. Adamantane-resistance was absent in our region during the 2000-1 to 2002-3 influenza seasons. However, after the first adamantane-resistant virus (characterised as A/Fujian/411/2002) was detected in the 2003-4 season, a rapid increase in the proportion of resistant strains was observed (4.9% [2/41], 80% [8/10] and 100% [53/53] in the 2004-5, 2006-7 and 2008-9 seasons, respectively). Four of the first five adamantane-resistant AH3 viruses detected were isolated from adult patients, but the subsequent spread was observed mainly among children. No resistance to adamantanes was detected among the 65 influenza AH1 viruses analysed throughout the study period. Among the 172 influenza A (76 AH1 and 96 AH3) viruses analysed, five strains (AH1 with mutation H274Y) showed oseltamivir resistance, and all were detected in the last season. Amantadine use was very scarce in our region, and oseltamivir was not used at all; therefore the increase of resistance was attributed to imported drug-resistant influenza viruses.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">19460286</PMID><DateCompleted><Year>2009</Year><Month>08</Month><Day>18</Day></DateCompleted><DateRevised><Year>2019</Year><Month>06</Month><Day>08</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1560-7917</ISSN><JournalIssue CitedMedium="Internet"><Volume>14</Volume><Issue>20</Issue><PubDate><Year>2009</Year><Month>May</Month><Day>21</Day></PubDate></JournalIssue><Title>Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin</Title><ISOAbbreviation>Euro Surveill.</ISOAbbreviation></Journal><ArticleTitle>Rapid spread of drug-resistant influenza A viruses in the Basque Country, northern Spain, 2000-1 to 2008-9.</ArticleTitle><ELocationID EIdType="pii" ValidYN="Y">19215</ELocationID><Abstract><AbstractText>A worldwide increase of adamantane-resistant influenza A(H3N2) and oseltamivir-resistant influenza A(H1N1) viruses has been observed in recent years. The aim of this study was to analyse the prevalence of antiviral drug-resistant influenza A in a region of northern Spain. Resistance to adamantanes was detected in 45.3% (68/150) of influenza AH3 viruses analysed for the period from 2000-1 to 2008-9. Adamantane-resistance was absent in our region during the 2000-1 to 2002-3 influenza seasons. However, after the first adamantane-resistant virus (characterised as A/Fujian/411/2002) was detected in the 2003-4 season, a rapid increase in the proportion of resistant strains was observed (4.9% [2/41], 80% [8/10] and 100% [53/53] in the 2004-5, 2006-7 and 2008-9 seasons, respectively). Four of the first five adamantane-resistant AH3 viruses detected were isolated from adult patients, but the subsequent spread was observed mainly among children. No resistance to adamantanes was detected among the 65 influenza AH1 viruses analysed throughout the study period. Among the 172 influenza A (76 AH1 and 96 AH3) viruses analysed, five strains (AH1 with mutation H274Y) showed oseltamivir resistance, and all were detected in the last season. Amantadine use was very scarce in our region, and oseltamivir was not used at all; therefore the increase of resistance was attributed to imported drug-resistant influenza viruses.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Vicente</LastName><ForeName>D</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Microbiology Service and Reference Laboratory for Influenza Infections of the Basque Country, Hospital Donostia, San Sebastián, Spain. mikrobiol@terra.es</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cilla</LastName><ForeName>G</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Montes</LastName><ForeName>M</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Mendiola</LastName><ForeName>J</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Pérez-Trallero</LastName><ForeName>E</ForeName><Initials>E</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2009</Year><Month>05</Month><Day>21</Day></ArticleDate></Article><MedlineJournalInfo><Country>Sweden</Country><MedlineTA>Euro Surveill</MedlineTA><NlmUniqueID>100887452</NlmUniqueID><ISSNLinking>1025-496X</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>20O93L6F9H</RegistryNumber><NameOfSubstance UI="D053139">Oseltamivir</NameOfSubstance></Chemical><Chemical><RegistryNumber>PJY633525U</RegistryNumber><NameOfSubstance UI="D000218">Adamantane</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000218" MajorTopicYN="N">Adamantane</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D024882" MajorTopicYN="N">Drug Resistance, Viral</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D053118" MajorTopicYN="N">Influenza A Virus, H1N1 Subtype</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D053122" MajorTopicYN="N">Influenza A Virus, H3N2 Subtype</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007251" MajorTopicYN="N">Influenza, Human</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008826" MajorTopicYN="N">Microbial Sensitivity Tests</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009154" MajorTopicYN="N">Mutation</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D053139" MajorTopicYN="N">Oseltamivir</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013030" MajorTopicYN="N" Type="Geographic">Spain</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2009</Year><Month>5</Month><Day>23</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2009</Year><Month>5</Month><Day>23</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2009</Year><Month>8</Month><Day>19</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">19460286</ArticleId><ArticleId IdType="doi">10.2807/ese.14.20.19215-en</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Espagne</li></country></list><tree><noCountry><name sortKey="Cilla, G" sort="Cilla, G" uniqKey="Cilla G" first="G" last="Cilla">G. Cilla</name><name sortKey="Mendiola, J" sort="Mendiola, J" uniqKey="Mendiola J" first="J" last="Mendiola">J. Mendiola</name><name sortKey="Montes, M" sort="Montes, M" uniqKey="Montes M" first="M" last="Montes">M. Montes</name><name sortKey="Perez Trallero, E" sort="Perez Trallero, E" uniqKey="Perez Trallero E" first="E" last="Pérez-Trallero">E. Pérez-Trallero</name></noCountry><country name="Espagne"><noRegion><name sortKey="Vicente, D" sort="Vicente, D" uniqKey="Vicente D" first="D" last="Vicente">D. Vicente</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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