Severe 2009 A/H1N1v influenza in pregnant women in Spain.
Identifieur interne : 000380 ( Main/Exploration ); précédent : 000379; suivant : 000381Severe 2009 A/H1N1v influenza in pregnant women in Spain.
Auteurs : Enrique Maraví-Poma [Espagne] ; Ignacio Martin-Loeches ; Eva Regidor ; Clara Laplaza ; Koldo Cambra ; Sara Aldunate ; Jose Eugenio Guerrero ; Ana Loza-Vazquez ; Elena Arnau ; Jordi Almirall ; Leonardo Lorente ; Angel Arenzana ; Monica Magret ; Roberto Reig Valero ; Enrique Marquez ; Nagore Gonzalez ; Jesús Francisco Bermejo-Martin ; Jordi RelloSource :
- Critical care medicine [ 1530-0293 ] ; 2011.
Descripteurs français
- KwdFr :
- Adolescent (MeSH), Adulte (MeSH), Antiviraux (usage thérapeutique), Appréciation des risques (MeSH), Complications infectieuses de la grossesse (virologie), Complications infectieuses de la grossesse (épidémiologie), Contrôle des maladies transmissibles (MeSH), Enregistrements (MeSH), Espagne (épidémiologie), Femelle (MeSH), Grippe humaine (diagnostic), Grippe humaine (traitement médicamenteux), Grippe humaine (épidémiologie), Grossesse (MeSH), Hospitalisation (statistiques et données numériques), Humains (MeSH), Incidence (MeSH), Indice de gravité de la maladie (MeSH), Intervalles de confiance (MeSH), Jeune adulte (MeSH), Modèles linéaires (MeSH), Oséltamivir (usage thérapeutique), Répartition par âge (MeSH), Soins de réanimation (méthodes), Sous-type H1N1 du virus de la grippe A (isolement et purification), Statistique non paramétrique (MeSH), Taux de survie (MeSH), Unités de soins intensifs (MeSH), Études rétrospectives (MeSH).
- MESH :
- diagnostic : Grippe humaine.
- isolement et purification : Sous-type H1N1 du virus de la grippe A.
- méthodes : Soins de réanimation.
- statistiques et données numériques : Hospitalisation.
- traitement médicamenteux : Grippe humaine.
- usage thérapeutique : Antiviraux, Oséltamivir.
- virologie : Complications infectieuses de la grossesse.
- épidémiologie : Complications infectieuses de la grossesse, Espagne, Grippe humaine.
- Adolescent, Adulte, Appréciation des risques, Contrôle des maladies transmissibles, Enregistrements, Femelle, Grossesse, Humains, Incidence, Indice de gravité de la maladie, Intervalles de confiance, Jeune adulte, Modèles linéaires, Répartition par âge, Statistique non paramétrique, Taux de survie, Unités de soins intensifs, Études rétrospectives.
- Wicri :
- geographic : Espagne.
English descriptors
- KwdEn :
- Adolescent (MeSH), Adult (MeSH), Age Distribution (MeSH), Antiviral Agents (therapeutic use), Communicable Disease Control (MeSH), Confidence Intervals (MeSH), Critical Care (methods), Female (MeSH), Hospitalization (statistics & numerical data), Humans (MeSH), Incidence (MeSH), Influenza A Virus, H1N1 Subtype (isolation & purification), Influenza, Human (diagnosis), Influenza, Human (drug therapy), Influenza, Human (epidemiology), Intensive Care Units (MeSH), Linear Models (MeSH), Oseltamivir (therapeutic use), Pregnancy (MeSH), Pregnancy Complications, Infectious (epidemiology), Pregnancy Complications, Infectious (virology), Registries (MeSH), Retrospective Studies (MeSH), Risk Assessment (MeSH), Severity of Illness Index (MeSH), Spain (epidemiology), Statistics, Nonparametric (MeSH), Survival Rate (MeSH), Young Adult (MeSH).
- MESH :
- chemical , therapeutic use : Antiviral Agents, Oseltamivir.
- geographic , epidemiology : Spain.
- diagnosis : Influenza, Human.
- drug therapy : Influenza, Human.
- epidemiology : Influenza, Human, Pregnancy Complications, Infectious.
- isolation & purification : Influenza A Virus, H1N1 Subtype.
- methods : Critical Care.
- statistics & numerical data : Hospitalization.
- virology : Pregnancy Complications, Infectious.
- Adolescent, Adult, Age Distribution, Communicable Disease Control, Confidence Intervals, Female, Humans, Incidence, Intensive Care Units, Linear Models, Pregnancy, Registries, Retrospective Studies, Risk Assessment, Severity of Illness Index, Statistics, Nonparametric, Survival Rate, Young Adult.
Abstract
OBJECTIVES
To describe the severity of the 2009 influenza A/H1N1v illness among pregnant women admitted to Spanish intensive care units.
DESIGN AND PATIENTS
Prospective, observational, multicenter study conducted in 148 Spanish intensive care units. We reviewed demographic and clinical data from the Spanish Society of Intensive Care Medicine database reported from April 23, 2009, to February 15, 2010. We included women of reproductive age (15-44 yrs) with confirmed A/H1N1v infection admitted to intensive care units.
MAIN RESULTS
Two hundred thirty-four women of reproductive age were admitted to intensive care units, 50 (21.4%) of them pregnant. Seven deaths were recorded in pregnant and 22 in nonpregnant women. Among intensive care unit admissions, there were no statistically significant differences between pregnant women and nonpregnant in Acute Physiology and Chronic Health Evaluation II, Sequential Organ Failure Assessment scores, chest x-rays, inotrope requirement, or need for mechanical ventilation or steroid therapy. Mortality risk was significantly associated with Acute Physiology and Chronic Health Evaluation II, Sequential Organ Failure Assessment, and obesity. Viral pneumonia was more frequent in pregnant women than in nonpregnant women, with an odds ratio (adjusted for asthma, time from onset influenza symptoms to hospital admission and obesity) of 4.9 (95% confidence interval: 1.4-17.2). The development of primary viral pneumonia in women of reproductive age appeared to be related to the time of commencement of antiviral treatment, the lowest rates being reported with initiation of antiviral therapy within 48 hrs of symptom onset (63.6% vs. 82.6%, p = .03). However, antiviral therapy was started within this time span in only 14% of pregnant women.
CONCLUSIONS
More than 20% of women of reproductive age admitted to intensive care unit for pH1N1 infection were pregnant. Pregnancy was significantly associated with primary viral pneumonia. Pregnant women should receive prompt treatment with oseltamivir within 48 hrs of the onset of influenza symptoms.
DOI: 10.1097/CCM.0b013e318208ee12
PubMed: 21263317
Affiliations:
Links toward previous steps (curation, corpus...)
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uniqKey="Maravi Poma E" first="Enrique" last="Maraví-Poma">Enrique Maraví-Poma</name><affiliation wicri:level="1"><nlm:affiliation>Intensive Care Unit, Hospital Virgen del Camino, Pamplona, Spain. enrique.maravi.poma@navarra.es</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Intensive Care Unit, Hospital Virgen del Camino, Pamplona</wicri:regionArea><wicri:noRegion>Pamplona</wicri:noRegion></affiliation></author><author><name sortKey="Martin Loeches, Ignacio" sort="Martin Loeches, Ignacio" uniqKey="Martin Loeches I" first="Ignacio" last="Martin-Loeches">Ignacio Martin-Loeches</name></author><author><name sortKey="Regidor, Eva" sort="Regidor, Eva" uniqKey="Regidor E" first="Eva" last="Regidor">Eva Regidor</name></author><author><name sortKey="Laplaza, Clara" sort="Laplaza, Clara" uniqKey="Laplaza C" first="Clara" last="Laplaza">Clara Laplaza</name></author><author><name sortKey="Cambra, Koldo" sort="Cambra, Koldo" uniqKey="Cambra K" first="Koldo" last="Cambra">Koldo Cambra</name></author><author><name sortKey="Aldunate, Sara" sort="Aldunate, Sara" uniqKey="Aldunate S" first="Sara" last="Aldunate">Sara Aldunate</name></author><author><name sortKey="Guerrero, Jose Eugenio" sort="Guerrero, Jose Eugenio" uniqKey="Guerrero J" first="Jose Eugenio" last="Guerrero">Jose Eugenio Guerrero</name></author><author><name sortKey="Loza Vazquez, Ana" sort="Loza Vazquez, Ana" uniqKey="Loza Vazquez A" first="Ana" last="Loza-Vazquez">Ana Loza-Vazquez</name></author><author><name sortKey="Arnau, Elena" sort="Arnau, Elena" uniqKey="Arnau E" first="Elena" last="Arnau">Elena Arnau</name></author><author><name sortKey="Almirall, Jordi" sort="Almirall, Jordi" uniqKey="Almirall J" first="Jordi" last="Almirall">Jordi Almirall</name></author><author><name sortKey="Lorente, Leonardo" sort="Lorente, Leonardo" uniqKey="Lorente L" first="Leonardo" last="Lorente">Leonardo Lorente</name></author><author><name sortKey="Arenzana, Angel" sort="Arenzana, Angel" 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last="Rello">Jordi Rello</name></author></analytic><series><title level="j">Critical care medicine</title><idno type="eISSN">1530-0293</idno><imprint><date when="2011" type="published">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent (MeSH)</term><term>Adult (MeSH)</term><term>Age Distribution (MeSH)</term><term>Antiviral Agents (therapeutic use)</term><term>Communicable Disease Control (MeSH)</term><term>Confidence Intervals (MeSH)</term><term>Critical Care (methods)</term><term>Female (MeSH)</term><term>Hospitalization (statistics & numerical data)</term><term>Humans (MeSH)</term><term>Incidence (MeSH)</term><term>Influenza A Virus, H1N1 Subtype (isolation & purification)</term><term>Influenza, Human (diagnosis)</term><term>Influenza, Human (drug therapy)</term><term>Influenza, Human (epidemiology)</term><term>Intensive Care Units (MeSH)</term><term>Linear Models (MeSH)</term><term>Oseltamivir (therapeutic use)</term><term>Pregnancy (MeSH)</term><term>Pregnancy Complications, Infectious (epidemiology)</term><term>Pregnancy Complications, Infectious (virology)</term><term>Registries (MeSH)</term><term>Retrospective Studies (MeSH)</term><term>Risk Assessment (MeSH)</term><term>Severity of Illness Index (MeSH)</term><term>Spain (epidemiology)</term><term>Statistics, Nonparametric (MeSH)</term><term>Survival Rate (MeSH)</term><term>Young Adult (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent (MeSH)</term><term>Adulte (MeSH)</term><term>Antiviraux (usage thérapeutique)</term><term>Appréciation des risques (MeSH)</term><term>Complications infectieuses de la grossesse (virologie)</term><term>Complications infectieuses de la grossesse (épidémiologie)</term><term>Contrôle des maladies transmissibles (MeSH)</term><term>Enregistrements (MeSH)</term><term>Espagne (épidémiologie)</term><term>Femelle (MeSH)</term><term>Grippe humaine (diagnostic)</term><term>Grippe humaine (traitement médicamenteux)</term><term>Grippe humaine (épidémiologie)</term><term>Grossesse (MeSH)</term><term>Hospitalisation (statistiques et données numériques)</term><term>Humains (MeSH)</term><term>Incidence (MeSH)</term><term>Indice de gravité de la maladie (MeSH)</term><term>Intervalles de confiance (MeSH)</term><term>Jeune adulte (MeSH)</term><term>Modèles linéaires (MeSH)</term><term>Oséltamivir (usage thérapeutique)</term><term>Répartition par âge (MeSH)</term><term>Soins de réanimation (méthodes)</term><term>Sous-type H1N1 du virus de la grippe A (isolement et purification)</term><term>Statistique non paramétrique (MeSH)</term><term>Taux de survie (MeSH)</term><term>Unités de soins intensifs (MeSH)</term><term>Études rétrospectives (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiviral Agents</term><term>Oseltamivir</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Spain</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Grippe humaine</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Influenza, Human</term><term>Pregnancy Complications, Infectious</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Sous-type H1N1 du virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Critical Care</term></keywords><keywords scheme="MESH" qualifier="méthodes" xml:lang="fr"><term>Soins de réanimation</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Hospitalization</term></keywords><keywords scheme="MESH" qualifier="statistiques et données numériques" xml:lang="fr"><term>Hospitalisation</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Grippe humaine</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antiviraux</term><term>Oséltamivir</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Complications infectieuses de la grossesse</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Pregnancy Complications, Infectious</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Complications infectieuses de la grossesse</term><term>Espagne</term><term>Grippe humaine</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Age Distribution</term><term>Communicable Disease Control</term><term>Confidence Intervals</term><term>Female</term><term>Humans</term><term>Incidence</term><term>Intensive Care Units</term><term>Linear Models</term><term>Pregnancy</term><term>Registries</term><term>Retrospective Studies</term><term>Risk Assessment</term><term>Severity of Illness Index</term><term>Statistics, Nonparametric</term><term>Survival Rate</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Appréciation des risques</term><term>Contrôle des maladies transmissibles</term><term>Enregistrements</term><term>Femelle</term><term>Grossesse</term><term>Humains</term><term>Incidence</term><term>Indice de gravité de la maladie</term><term>Intervalles de confiance</term><term>Jeune adulte</term><term>Modèles linéaires</term><term>Répartition par âge</term><term>Statistique non paramétrique</term><term>Taux de survie</term><term>Unités de soins intensifs</term><term>Études rétrospectives</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Espagne</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>OBJECTIVES</b></p><p>To describe the severity of the 2009 influenza A/H1N1v illness among pregnant women admitted to Spanish intensive care units.</p></div><div type="abstract" xml:lang="en"><p><b>DESIGN AND PATIENTS</b></p><p>Prospective, observational, multicenter study conducted in 148 Spanish intensive care units. We reviewed demographic and clinical data from the Spanish Society of Intensive Care Medicine database reported from April 23, 2009, to February 15, 2010. We included women of reproductive age (15-44 yrs) with confirmed A/H1N1v infection admitted to intensive care units.</p></div><div type="abstract" xml:lang="en"><p><b>MAIN RESULTS</b></p><p>Two hundred thirty-four women of reproductive age were admitted to intensive care units, 50 (21.4%) of them pregnant. Seven deaths were recorded in pregnant and 22 in nonpregnant women. Among intensive care unit admissions, there were no statistically significant differences between pregnant women and nonpregnant in Acute Physiology and Chronic Health Evaluation II, Sequential Organ Failure Assessment scores, chest x-rays, inotrope requirement, or need for mechanical ventilation or steroid therapy. Mortality risk was significantly associated with Acute Physiology and Chronic Health Evaluation II, Sequential Organ Failure Assessment, and obesity. Viral pneumonia was more frequent in pregnant women than in nonpregnant women, with an odds ratio (adjusted for asthma, time from onset influenza symptoms to hospital admission and obesity) of 4.9 (95% confidence interval: 1.4-17.2). The development of primary viral pneumonia in women of reproductive age appeared to be related to the time of commencement of antiviral treatment, the lowest rates being reported with initiation of antiviral therapy within 48 hrs of symptom onset (63.6% vs. 82.6%, p = .03). However, antiviral therapy was started within this time span in only 14% of pregnant women.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b></p><p>More than 20% of women of reproductive age admitted to intensive care unit for pH1N1 infection were pregnant. Pregnancy was significantly associated with primary viral pneumonia. Pregnant women should receive prompt treatment with oseltamivir within 48 hrs of the onset of influenza symptoms.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">21263317</PMID><DateCompleted><Year>2011</Year><Month>08</Month><Day>18</Day></DateCompleted><DateRevised><Year>2015</Year><Month>11</Month><Day>19</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1530-0293</ISSN><JournalIssue CitedMedium="Internet"><Volume>39</Volume><Issue>5</Issue><PubDate><Year>2011</Year><Month>May</Month></PubDate></JournalIssue><Title>Critical care medicine</Title><ISOAbbreviation>Crit. Care Med.</ISOAbbreviation></Journal><ArticleTitle>Severe 2009 A/H1N1v influenza in pregnant women in Spain.</ArticleTitle><Pagination><MedlinePgn>945-51</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1097/CCM.0b013e318208ee12</ELocationID><Abstract><AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">To describe the severity of the 2009 influenza A/H1N1v illness among pregnant women admitted to Spanish intensive care units.</AbstractText><AbstractText Label="DESIGN AND PATIENTS" NlmCategory="METHODS">Prospective, observational, multicenter study conducted in 148 Spanish intensive care units. We reviewed demographic and clinical data from the Spanish Society of Intensive Care Medicine database reported from April 23, 2009, to February 15, 2010. We included women of reproductive age (15-44 yrs) with confirmed A/H1N1v infection admitted to intensive care units.</AbstractText><AbstractText Label="MAIN RESULTS" NlmCategory="RESULTS">Two hundred thirty-four women of reproductive age were admitted to intensive care units, 50 (21.4%) of them pregnant. Seven deaths were recorded in pregnant and 22 in nonpregnant women. Among intensive care unit admissions, there were no statistically significant differences between pregnant women and nonpregnant in Acute Physiology and Chronic Health Evaluation II, Sequential Organ Failure Assessment scores, chest x-rays, inotrope requirement, or need for mechanical ventilation or steroid therapy. Mortality risk was significantly associated with Acute Physiology and Chronic Health Evaluation II, Sequential Organ Failure Assessment, and obesity. Viral pneumonia was more frequent in pregnant women than in nonpregnant women, with an odds ratio (adjusted for asthma, time from onset influenza symptoms to hospital admission and obesity) of 4.9 (95% confidence interval: 1.4-17.2). The development of primary viral pneumonia in women of reproductive age appeared to be related to the time of commencement of antiviral treatment, the lowest rates being reported with initiation of antiviral therapy within 48 hrs of symptom onset (63.6% vs. 82.6%, p = .03). However, antiviral therapy was started within this time span in only 14% of pregnant women.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">More than 20% of women of reproductive age admitted to intensive care unit for pH1N1 infection were pregnant. Pregnancy was significantly associated with primary viral pneumonia. Pregnant women should receive prompt treatment with oseltamivir within 48 hrs of the onset of influenza symptoms.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Maraví-Poma</LastName><ForeName>Enrique</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Intensive Care Unit, Hospital Virgen del Camino, Pamplona, Spain. enrique.maravi.poma@navarra.es</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Martin-Loeches</LastName><ForeName>Ignacio</ForeName><Initials>I</Initials></Author><Author ValidYN="Y"><LastName>Regidor</LastName><ForeName>Eva</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Laplaza</LastName><ForeName>Clara</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Cambra</LastName><ForeName>Koldo</ForeName><Initials>K</Initials></Author><Author ValidYN="Y"><LastName>Aldunate</LastName><ForeName>Sara</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Guerrero</LastName><ForeName>Jose Eugenio</ForeName><Initials>JE</Initials></Author><Author ValidYN="Y"><LastName>Loza-Vazquez</LastName><ForeName>Ana</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Arnau</LastName><ForeName>Elena</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Almirall</LastName><ForeName>Jordi</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Lorente</LastName><ForeName>Leonardo</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Arenzana</LastName><ForeName>Angel</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Magret</LastName><ForeName>Monica</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Reig Valero</LastName><ForeName>Roberto</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Marquez</LastName><ForeName>Enrique</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Gonzalez</LastName><ForeName>Nagore</ForeName><Initials>N</Initials></Author><Author ValidYN="Y"><LastName>Bermejo-Martin</LastName><ForeName>Jesús Francisco</ForeName><Initials>JF</Initials></Author><Author ValidYN="Y"><LastName>Rello</LastName><ForeName>Jordi</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><CollectiveName>Grupo Español de Trabajo de Gripe Grave A (SEMICYUC)</CollectiveName></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Crit Care Med</MedlineTA><NlmUniqueID>0355501</NlmUniqueID><ISSNLinking>0090-3493</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000998">Antiviral Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>20O93L6F9H</RegistryNumber><NameOfSubstance UI="D053139">Oseltamivir</NameOfSubstance></Chemical></ChemicalList><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>Crit Care Med. 2011 May;39(5):1199-200</RefSource><PMID Version="1">21610574</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017677" MajorTopicYN="N">Age Distribution</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000998" MajorTopicYN="N">Antiviral Agents</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003140" 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last="Lorente">Leonardo Lorente</name><name sortKey="Loza Vazquez, Ana" sort="Loza Vazquez, Ana" uniqKey="Loza Vazquez A" first="Ana" last="Loza-Vazquez">Ana Loza-Vazquez</name><name sortKey="Magret, Monica" sort="Magret, Monica" uniqKey="Magret M" first="Monica" last="Magret">Monica Magret</name><name sortKey="Marquez, Enrique" sort="Marquez, Enrique" uniqKey="Marquez E" first="Enrique" last="Marquez">Enrique Marquez</name><name sortKey="Martin Loeches, Ignacio" sort="Martin Loeches, Ignacio" uniqKey="Martin Loeches I" first="Ignacio" last="Martin-Loeches">Ignacio Martin-Loeches</name><name sortKey="Regidor, Eva" sort="Regidor, Eva" uniqKey="Regidor E" first="Eva" last="Regidor">Eva Regidor</name><name sortKey="Reig Valero, Roberto" sort="Reig Valero, Roberto" uniqKey="Reig Valero R" first="Roberto" last="Reig Valero">Roberto Reig Valero</name><name sortKey="Rello, Jordi" sort="Rello, Jordi" uniqKey="Rello J" first="Jordi" last="Rello">Jordi Rello</name></noCountry><country name="Espagne"><noRegion><name sortKey="Maravi Poma, Enrique" sort="Maravi Poma, Enrique" uniqKey="Maravi Poma E" first="Enrique" last="Maraví-Poma">Enrique Maraví-Poma</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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