Prognosis of 2009 A(H1N1) influenza in hospitalized pregnant women in a context of early diagnosis and antiviral therapy.
Identifieur interne : 000304 ( Main/Exploration ); précédent : 000303; suivant : 000305Prognosis of 2009 A(H1N1) influenza in hospitalized pregnant women in a context of early diagnosis and antiviral therapy.
Auteurs : José Ram N Pa O-Pardo [Espagne] ; Jesús Rodríguez-Ba O ; Nuria Martínez-Sánchez ; Diego Viasus ; M Carmen Fari As ; María Leyes ; Francisco L Pez-Medrano ; Jer Nimo Pach N ; Julián Torre-Cisneros ; José Antonio Oteo ; Tomás Pumarola ; Mercedes García-Gasalla ; Lucía Ortega ; Ferrán Segura ; Jordi CarrataláSource :
- Antiviral therapy [ 2040-2058 ] ; 2012.
Descripteurs français
- KwdFr :
- Adolescent (MeSH), Adulte (MeSH), Adulte d'âge moyen (MeSH), Antiviraux (administration et posologie), Antiviraux (usage thérapeutique), Complications infectieuses de la grossesse (diagnostic), Complications infectieuses de la grossesse (traitement médicamenteux), Complications infectieuses de la grossesse (épidémiologie), Espagne (épidémiologie), Femelle (MeSH), Grippe humaine (MeSH), Grossesse (MeSH), Humains (MeSH), Jeune adulte (MeSH), Oséltamivir (administration et posologie), Oséltamivir (usage thérapeutique), Pandémies (MeSH), Sous-type H1N1 du virus de la grippe A (MeSH).
- MESH :
- administration et posologie : Antiviraux, Oséltamivir.
- diagnostic : Complications infectieuses de la grossesse.
- traitement médicamenteux : Complications infectieuses de la grossesse.
- usage thérapeutique : Antiviraux, Oséltamivir.
- épidémiologie : Complications infectieuses de la grossesse, Espagne.
- Adolescent, Adulte, Adulte d'âge moyen, Femelle, Grippe humaine, Grossesse, Humains, Jeune adulte, Pandémies, Sous-type H1N1 du virus de la grippe A.
- Wicri :
- geographic : Espagne.
English descriptors
- KwdEn :
- Adolescent (MeSH), Adult (MeSH), Antiviral Agents (administration & dosage), Antiviral Agents (therapeutic use), Female (MeSH), Humans (MeSH), Influenza A Virus, H1N1 Subtype (MeSH), Influenza, Human (MeSH), Middle Aged (MeSH), Oseltamivir (administration & dosage), Oseltamivir (therapeutic use), Pandemics (MeSH), Pregnancy (MeSH), Pregnancy Complications, Infectious (diagnosis), Pregnancy Complications, Infectious (drug therapy), Pregnancy Complications, Infectious (epidemiology), Spain (epidemiology), Young Adult (MeSH).
- MESH :
- chemical , administration & dosage : Antiviral Agents, Oseltamivir.
- chemical , therapeutic use : Antiviral Agents, Oseltamivir.
- geographic , epidemiology : Spain.
- diagnosis : Pregnancy Complications, Infectious.
- drug therapy : Pregnancy Complications, Infectious.
- epidemiology : Pregnancy Complications, Infectious.
- Adolescent, Adult, Female, Humans, Influenza A Virus, H1N1 Subtype, Influenza, Human, Middle Aged, Pandemics, Pregnancy, Young Adult.
Abstract
BACKGROUND
Initial reports suggested that novel A(H1N1) influenza virus (2009 A[H1N1]v) infection was significantly more severe in pregnant than in non-pregnant women. In Spain, antiviral therapy was recommended for pregnant women from the beginning of the 2009 pandemic.
METHODS
The prospective cohort study included consecutive pregnant and non-pregnant women of reproductive age with a proven diagnosis of 2009 A(H1N1)v admitted to any of the 13 participating Spanish hospitals between 12 June and 10 November 2009.
RESULTS
In total, 98 pregnant and 112 non-pregnant women with proven 2009 A(H1N1)v hospitalized during the study period were included. Influenza was more severe among non-pregnant patients than pregnant patients with respect to outcomes of both intensive care unit admission (18% versus 2%; P<0.001) and death (5 versus 0; P=0.06). Pregnant women had fewer associated comorbid conditions other than pregnancy (18% versus 44%; P<0.001); they were also admitted earlier than non-pregnant women (median days since onset of symptoms: 2 versus 3; P<0.001) and a higher percentage received early antiviral therapy (41% versus 28%; P=0.03). Neither a multivariate nor a matched cohort analysis found pregnancy to be associated with greater severity than that associated with hospitalized, seriously ill non-pregnant women.
CONCLUSIONS
2009 A(H1N1)v influenza was not associated with worse outcomes in hospitalized pregnant women compared with non-pregnant ones of reproductive age in a context of early diagnosis and antiviral therapy.
DOI: 10.3851/IMP2019
PubMed: 22301005
Affiliations:
Links toward previous steps (curation, corpus...)
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Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital Universitario La Paz - IDIPAZ, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Rodriguez Ba O, Jesus" sort="Rodriguez Ba O, Jesus" uniqKey="Rodriguez Ba O J" first="Jesús" last="Rodríguez-Ba O">Jesús Rodríguez-Ba O</name></author><author><name sortKey="Martinez Sanchez, Nuria" sort="Martinez Sanchez, Nuria" uniqKey="Martinez Sanchez N" first="Nuria" last="Martínez-Sánchez">Nuria Martínez-Sánchez</name></author><author><name sortKey="Viasus, Diego" sort="Viasus, Diego" uniqKey="Viasus D" first="Diego" last="Viasus">Diego Viasus</name></author><author><name sortKey="Fari As, M Carmen" sort="Fari As, M Carmen" uniqKey="Fari As M" first="M Carmen" last="Fari As">M Carmen Fari As</name></author><author><name sortKey="Leyes, Maria" sort="Leyes, Maria" 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first="Mercedes" last="García-Gasalla">Mercedes García-Gasalla</name></author><author><name sortKey="Ortega, Lucia" sort="Ortega, Lucia" uniqKey="Ortega L" first="Lucía" last="Ortega">Lucía Ortega</name></author><author><name sortKey="Segura, Ferran" sort="Segura, Ferran" uniqKey="Segura F" first="Ferrán" last="Segura">Ferrán Segura</name></author><author><name sortKey="Carratala, Jordi" sort="Carratala, Jordi" uniqKey="Carratala J" first="Jordi" last="Carratalá">Jordi Carratalá</name></author></analytic><series><title level="j">Antiviral therapy</title><idno type="eISSN">2040-2058</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent (MeSH)</term><term>Adult (MeSH)</term><term>Antiviral Agents (administration & dosage)</term><term>Antiviral Agents (therapeutic use)</term><term>Female (MeSH)</term><term>Humans (MeSH)</term><term>Influenza A Virus, H1N1 Subtype (MeSH)</term><term>Influenza, Human (MeSH)</term><term>Middle Aged (MeSH)</term><term>Oseltamivir (administration & dosage)</term><term>Oseltamivir (therapeutic use)</term><term>Pandemics (MeSH)</term><term>Pregnancy (MeSH)</term><term>Pregnancy Complications, Infectious (diagnosis)</term><term>Pregnancy Complications, Infectious (drug therapy)</term><term>Pregnancy Complications, Infectious (epidemiology)</term><term>Spain (epidemiology)</term><term>Young Adult (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent (MeSH)</term><term>Adulte (MeSH)</term><term>Adulte d'âge moyen (MeSH)</term><term>Antiviraux (administration et posologie)</term><term>Antiviraux (usage thérapeutique)</term><term>Complications infectieuses de la grossesse (diagnostic)</term><term>Complications infectieuses de la grossesse (traitement médicamenteux)</term><term>Complications infectieuses de la grossesse (épidémiologie)</term><term>Espagne (épidémiologie)</term><term>Femelle (MeSH)</term><term>Grippe humaine (MeSH)</term><term>Grossesse (MeSH)</term><term>Humains (MeSH)</term><term>Jeune adulte (MeSH)</term><term>Oséltamivir (administration et posologie)</term><term>Oséltamivir (usage thérapeutique)</term><term>Pandémies (MeSH)</term><term>Sous-type H1N1 du virus de la grippe A (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Antiviral Agents</term><term>Oseltamivir</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiviral Agents</term><term>Oseltamivir</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Spain</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Antiviraux</term><term>Oséltamivir</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Pregnancy Complications, Infectious</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Complications infectieuses de la grossesse</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Pregnancy Complications, Infectious</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Pregnancy Complications, Infectious</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Complications infectieuses de la grossesse</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antiviraux</term><term>Oséltamivir</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Complications infectieuses de la grossesse</term><term>Espagne</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Female</term><term>Humans</term><term>Influenza A Virus, H1N1 Subtype</term><term>Influenza, Human</term><term>Middle Aged</term><term>Pandemics</term><term>Pregnancy</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Femelle</term><term>Grippe humaine</term><term>Grossesse</term><term>Humains</term><term>Jeune adulte</term><term>Pandémies</term><term>Sous-type H1N1 du virus de la grippe A</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Espagne</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b></p><p>Initial reports suggested that novel A(H1N1) influenza virus (2009 A[H1N1]v) infection was significantly more severe in pregnant than in non-pregnant women. In Spain, antiviral therapy was recommended for pregnant women from the beginning of the 2009 pandemic.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>The prospective cohort study included consecutive pregnant and non-pregnant women of reproductive age with a proven diagnosis of 2009 A(H1N1)v admitted to any of the 13 participating Spanish hospitals between 12 June and 10 November 2009.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>In total, 98 pregnant and 112 non-pregnant women with proven 2009 A(H1N1)v hospitalized during the study period were included. Influenza was more severe among non-pregnant patients than pregnant patients with respect to outcomes of both intensive care unit admission (18% versus 2%; P<0.001) and death (5 versus 0; P=0.06). Pregnant women had fewer associated comorbid conditions other than pregnancy (18% versus 44%; P<0.001); they were also admitted earlier than non-pregnant women (median days since onset of symptoms: 2 versus 3; P<0.001) and a higher percentage received early antiviral therapy (41% versus 28%; P=0.03). Neither a multivariate nor a matched cohort analysis found pregnancy to be associated with greater severity than that associated with hospitalized, seriously ill non-pregnant women.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b></p><p>2009 A(H1N1)v influenza was not associated with worse outcomes in hospitalized pregnant women compared with non-pregnant ones of reproductive age in a context of early diagnosis and antiviral therapy.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">22301005</PMID><DateCompleted><Year>2012</Year><Month>09</Month><Day>05</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">2040-2058</ISSN><JournalIssue CitedMedium="Internet"><Volume>17</Volume><Issue>4</Issue><PubDate><Year>2012</Year></PubDate></JournalIssue><Title>Antiviral therapy</Title><ISOAbbreviation>Antivir. Ther. (Lond.)</ISOAbbreviation></Journal><ArticleTitle>Prognosis of 2009 A(H1N1) influenza in hospitalized pregnant women in a context of early diagnosis and antiviral therapy.</ArticleTitle><Pagination><MedlinePgn>719-28</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.3851/IMP2019</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Initial reports suggested that novel A(H1N1) influenza virus (2009 A[H1N1]v) infection was significantly more severe in pregnant than in non-pregnant women. In Spain, antiviral therapy was recommended for pregnant women from the beginning of the 2009 pandemic.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">The prospective cohort study included consecutive pregnant and non-pregnant women of reproductive age with a proven diagnosis of 2009 A(H1N1)v admitted to any of the 13 participating Spanish hospitals between 12 June and 10 November 2009.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">In total, 98 pregnant and 112 non-pregnant women with proven 2009 A(H1N1)v hospitalized during the study period were included. Influenza was more severe among non-pregnant patients than pregnant patients with respect to outcomes of both intensive care unit admission (18% versus 2%; P<0.001) and death (5 versus 0; P=0.06). Pregnant women had fewer associated comorbid conditions other than pregnancy (18% versus 44%; P<0.001); they were also admitted earlier than non-pregnant women (median days since onset of symptoms: 2 versus 3; P<0.001) and a higher percentage received early antiviral therapy (41% versus 28%; P=0.03). Neither a multivariate nor a matched cohort analysis found pregnancy to be associated with greater severity than that associated with hospitalized, seriously ill non-pregnant women.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">2009 A(H1N1)v influenza was not associated with worse outcomes in hospitalized pregnant women compared with non-pregnant ones of reproductive age in a context of early diagnosis and antiviral therapy.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Paño-Pardo</LastName><ForeName>José Ramón</ForeName><Initials>JR</Initials><AffiliationInfo><Affiliation>Hospital Universitario La Paz - IDIPAZ, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rodríguez-Baño</LastName><ForeName>Jesús</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Martínez-Sánchez</LastName><ForeName>Nuria</ForeName><Initials>N</Initials></Author><Author ValidYN="Y"><LastName>Viasus</LastName><ForeName>Diego</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Fariñas</LastName><ForeName>M Carmen</ForeName><Initials>MC</Initials></Author><Author ValidYN="Y"><LastName>Leyes</LastName><ForeName>María</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>López-Medrano</LastName><ForeName>Francisco</ForeName><Initials>F</Initials></Author><Author ValidYN="Y"><LastName>Pachón</LastName><ForeName>Jerónimo</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Torre-Cisneros</LastName><ForeName>Julián</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Oteo</LastName><ForeName>José Antonio</ForeName><Initials>JA</Initials></Author><Author ValidYN="Y"><LastName>Pumarola</LastName><ForeName>Tomás</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>García-Gasalla</LastName><ForeName>Mercedes</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Ortega</LastName><ForeName>Lucía</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Segura</LastName><ForeName>Ferrán</ForeName><Initials>F</Initials></Author><Author ValidYN="Y"><LastName>Carratalá</LastName><ForeName>Jordi</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><CollectiveName>Novel Influenza A(H1N1) Study Group of the Spanish Network for Research in Infectious Diseases (REIPI)</CollectiveName></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2011</Year><Month>12</Month><Day>16</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Antivir Ther</MedlineTA><NlmUniqueID>9815705</NlmUniqueID><ISSNLinking>1359-6535</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000998">Antiviral Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>20O93L6F9H</RegistryNumber><NameOfSubstance UI="D053139">Oseltamivir</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000998" MajorTopicYN="N">Antiviral Agents</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D053118" MajorTopicYN="Y">Influenza A Virus, H1N1 Subtype</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007251" MajorTopicYN="N">Influenza, Human</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D053139" MajorTopicYN="N">Oseltamivir</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D058873" MajorTopicYN="N">Pandemics</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011247" MajorTopicYN="N">Pregnancy</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011251" MajorTopicYN="N">Pregnancy Complications, Infectious</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="Y">diagnosis</QualifierName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013030" MajorTopicYN="N" Type="Geographic">Spain</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName></MeshHeading></MeshHeadingList><InvestigatorList><Investigator ValidYN="Y"><LastName>Martín-Quirsós</LastName><ForeName>A</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Romero-Gómez</LastName><ForeName>M</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Ruíz-Carrascoso</LastName><ForeName>G</ForeName><Initials>G</Initials></Investigator><Investigator ValidYN="Y"><LastName>Figueira</LastName><ForeName>J C</ForeName><Initials>JC</Initials></Investigator><Investigator ValidYN="Y"><LastName>Prados</LastName><ForeName>M C</ForeName><Initials>MC</Initials></Investigator><Investigator ValidYN="Y"><LastName>Sánchez-Pastor</LastName><ForeName>Margarita</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Domínguez</LastName><ForeName>A</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Valiente</LastName><ForeName>A</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Fernándex-Cuenca</LastName><ForeName>F</ForeName><Initials>F</Initials></Investigator><Investigator ValidYN="Y"><LastName>Aenzana</LastName><ForeName>A</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Gudiol</LastName><ForeName>F</ForeName><Initials>F</Initials></Investigator><Investigator 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Pa O-Pardo</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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|texte= Prognosis of 2009 A(H1N1) influenza in hospitalized pregnant women in a context of early diagnosis and antiviral therapy.
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