Respiratory syncytial virus burden among adults during flu season: an underestimated pathology.
Identifieur interne : 000054 ( Main/Exploration ); précédent : 000053; suivant : 000055Respiratory syncytial virus burden among adults during flu season: an underestimated pathology.
Auteurs : M. Kestler [Espagne] ; P. Mu Oz [Espagne] ; M. Mateos [Espagne] ; D. Adrados [Espagne] ; E. Bouza [Espagne]Source :
- The Journal of hospital infection [ 1532-2939 ] ; 2018.
Descripteurs français
- KwdFr :
- Adulte (MeSH), Adulte d'âge moyen (MeSH), Espagne (épidémiologie), Femelle (MeSH), Humains (MeSH), Hôpitaux (MeSH), Infection croisée (anatomopathologie), Infection croisée (virologie), Infection croisée (épidémiologie), Infections communautaires (anatomopathologie), Infections communautaires (virologie), Infections communautaires (épidémiologie), Infections de l'appareil respiratoire (anatomopathologie), Infections de l'appareil respiratoire (virologie), Infections de l'appareil respiratoire (épidémiologie), Infections à virus respiratoire syncytial (anatomopathologie), Infections à virus respiratoire syncytial (épidémiologie), Jeune adulte (MeSH), Mâle (MeSH), Saisons (MeSH), Sujet âgé (MeSH), Sujet âgé de 80 ans ou plus (MeSH), Techniques de diagnostic moléculaire (MeSH), Virus respiratoire syncytial humain (isolement et purification), Études prospectives (MeSH).
- MESH :
- anatomopathologie : Infection croisée, Infections communautaires, Infections de l'appareil respiratoire, Infections à virus respiratoire syncytial.
- isolement et purification : Virus respiratoire syncytial humain.
- virologie : Infection croisée, Infections communautaires, Infections de l'appareil respiratoire.
- épidémiologie : Espagne, Infection croisée, Infections communautaires, Infections de l'appareil respiratoire, Infections à virus respiratoire syncytial.
- Adulte, Adulte d'âge moyen, Femelle, Humains, Hôpitaux, Jeune adulte, Mâle, Saisons, Sujet âgé, Sujet âgé de 80 ans ou plus, Techniques de diagnostic moléculaire, Études prospectives.
- Wicri :
- geographic : Espagne.
English descriptors
- KwdEn :
- Adult (MeSH), Aged (MeSH), Aged, 80 and over (MeSH), Community-Acquired Infections (epidemiology), Community-Acquired Infections (pathology), Community-Acquired Infections (virology), Cross Infection (epidemiology), Cross Infection (pathology), Cross Infection (virology), Female (MeSH), Hospitals (MeSH), Humans (MeSH), Male (MeSH), Middle Aged (MeSH), Molecular Diagnostic Techniques (MeSH), Prospective Studies (MeSH), Respiratory Syncytial Virus Infections (epidemiology), Respiratory Syncytial Virus Infections (pathology), Respiratory Syncytial Virus, Human (isolation & purification), Respiratory Tract Infections (epidemiology), Respiratory Tract Infections (pathology), Respiratory Tract Infections (virology), Seasons (MeSH), Spain (epidemiology), Young Adult (MeSH).
- MESH :
- geographic , epidemiology : Spain.
- epidemiology : Community-Acquired Infections, Cross Infection, Respiratory Syncytial Virus Infections, Respiratory Tract Infections.
- isolation & purification : Respiratory Syncytial Virus, Human.
- pathology : Community-Acquired Infections, Cross Infection, Respiratory Syncytial Virus Infections, Respiratory Tract Infections.
- virology : Community-Acquired Infections, Cross Infection, Respiratory Tract Infections.
- Adult, Aged, Aged, 80 and over, Female, Hospitals, Humans, Male, Middle Aged, Molecular Diagnostic Techniques, Prospective Studies, Seasons, Young Adult.
Abstract
BACKGROUND
Information on the role of respiratory syncytial virus (RSV) in adult patients with influenza-like syndrome is scarce.
AIM
To assess the clinical characteristics of RSV in adult patients with respiratory manifestations during a regular influenza season.
METHODS
Prospective study in a tertiary Spanish hospital from December 2015 to February 2016. The study population included only adult patients with either community-acquired or hospital/healthcare-associated influenza-like illness, according to the European Centre for Disease Prevention and Control criteria. Samples were analysed using a rapid molecular assay (Xpert
FINDINGS
Twelve hundred patients with influenza-like respiratory infection were included. Overall, 114 of the samples (9%) were positive for influenza and 95 (8%) were positive for RSV. When RSV-positive and influenza-positive patients were compared, RSV-positive patients were older (57.7 vs 48.9 years; P = 0.03), and their disease was more frequently healthcare-related (26/95, 27.3% vs 5/114, 1.7%; P < 0.001). They also had significantly more antibiotics prescribed (77/95, 81.0% vs 70/114, 61.4%; P < 0.001) and more frequently needed hospital admission (93/95, 97.8% vs 69/114, 60.5%; P < 0.001). Mortality was also significantly higher in RSV-positive patients (14/95, 14.7% vs 7/114, 6.1%; P = 0.04).
CONCLUSION
RSV is a major cause of moderate-to-severe respiratory infection during the influenza season; acquisition is frequently nosocomial or healthcare-related; and mortality is significantly higher than with influenza virus infection. The use of a rapid molecular test as a first-step diagnostic technique is necessary to ensure that isolation measures are implemented and that spread is prevented.
DOI: 10.1016/j.jhin.2018.03.034
PubMed: 29614245
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Respiratory syncytial virus burden among adults during flu season: an underestimated pathology.</title><author><name sortKey="Kestler, M" sort="Kestler, M" uniqKey="Kestler M" first="M" last="Kestler">M. Kestler</name><affiliation wicri:level="3"><nlm:affiliation>Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañón, Madrid, Spain. Electronic address: kestler.martha@gmail.com.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañón, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Mu Oz, P" sort="Mu Oz, P" uniqKey="Mu Oz P" first="P" last="Mu Oz">P. Mu Oz</name><affiliation wicri:level="3"><nlm:affiliation>Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañón, Madrid, Spain; Instituto de Investigación Sanitaria, Hospital Gregorio Marañón, Madrid, Spain; CIBER Enfermedades Respiratorias - CIBERES (CB06/06/0058), Madrid, Spain; Medicine Department, School of Medicine, Universidad Complutense de Madrid, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañón, Madrid, Spain; Instituto de Investigación Sanitaria, Hospital Gregorio Marañón, Madrid, Spain; CIBER Enfermedades Respiratorias - CIBERES (CB06/06/0058), Madrid, Spain; Medicine Department, School of Medicine, Universidad Complutense de Madrid, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Mateos, M" sort="Mateos, M" uniqKey="Mateos M" first="M" last="Mateos">M. Mateos</name><affiliation wicri:level="3"><nlm:affiliation>Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañón, Madrid, Spain; Instituto de Investigación Sanitaria, Hospital Gregorio Marañón, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañón, Madrid, Spain; Instituto de Investigación Sanitaria, Hospital Gregorio Marañón, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Adrados, D" sort="Adrados, D" uniqKey="Adrados D" first="D" last="Adrados">D. Adrados</name><affiliation wicri:level="3"><nlm:affiliation>Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañón, Madrid, Spain; Instituto de Investigación Sanitaria, Hospital Gregorio Marañón, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañón, Madrid, Spain; Instituto de Investigación Sanitaria, Hospital Gregorio Marañón, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Bouza, E" sort="Bouza, E" uniqKey="Bouza E" first="E" last="Bouza">E. Bouza</name><affiliation wicri:level="3"><nlm:affiliation>Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañón, Madrid, Spain; Instituto de Investigación Sanitaria, Hospital Gregorio Marañón, Madrid, Spain; CIBER Enfermedades Respiratorias - CIBERES (CB06/06/0058), Madrid, Spain; Medicine Department, School of Medicine, Universidad Complutense de Madrid, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañón, Madrid, Spain; Instituto de Investigación Sanitaria, Hospital Gregorio Marañón, Madrid, Spain; CIBER Enfermedades Respiratorias - CIBERES (CB06/06/0058), Madrid, Spain; Medicine Department, School of Medicine, Universidad Complutense de Madrid, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2018">2018</date><idno type="RBID">pubmed:29614245</idno><idno type="pmid">29614245</idno><idno type="doi">10.1016/j.jhin.2018.03.034</idno><idno type="wicri:Area/Main/Corpus">00062</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">00062</idno><idno type="wicri:Area/Main/Curation">000062</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000062</idno><idno type="wicri:Area/Main/Exploration">000062</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Respiratory syncytial virus burden among adults during flu season: an underestimated pathology.</title><author><name sortKey="Kestler, M" sort="Kestler, M" uniqKey="Kestler M" first="M" last="Kestler">M. Kestler</name><affiliation wicri:level="3"><nlm:affiliation>Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañón, Madrid, Spain. Electronic address: kestler.martha@gmail.com.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañón, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Mu Oz, P" sort="Mu Oz, P" uniqKey="Mu Oz P" first="P" last="Mu Oz">P. Mu Oz</name><affiliation wicri:level="3"><nlm:affiliation>Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañón, Madrid, Spain; Instituto de Investigación Sanitaria, Hospital Gregorio Marañón, Madrid, Spain; CIBER Enfermedades Respiratorias - CIBERES (CB06/06/0058), Madrid, Spain; Medicine Department, School of Medicine, Universidad Complutense de Madrid, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañón, Madrid, Spain; Instituto de Investigación Sanitaria, Hospital Gregorio Marañón, Madrid, Spain; CIBER Enfermedades Respiratorias - CIBERES (CB06/06/0058), Madrid, Spain; Medicine Department, School of Medicine, Universidad Complutense de Madrid, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Mateos, M" sort="Mateos, M" uniqKey="Mateos M" first="M" last="Mateos">M. Mateos</name><affiliation wicri:level="3"><nlm:affiliation>Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañón, Madrid, Spain; Instituto de Investigación Sanitaria, Hospital Gregorio Marañón, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañón, Madrid, Spain; Instituto de Investigación Sanitaria, Hospital Gregorio Marañón, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Adrados, D" sort="Adrados, D" uniqKey="Adrados D" first="D" last="Adrados">D. Adrados</name><affiliation wicri:level="3"><nlm:affiliation>Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañón, Madrid, Spain; Instituto de Investigación Sanitaria, Hospital Gregorio Marañón, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañón, Madrid, Spain; Instituto de Investigación Sanitaria, Hospital Gregorio Marañón, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Bouza, E" sort="Bouza, E" uniqKey="Bouza E" first="E" last="Bouza">E. Bouza</name><affiliation wicri:level="3"><nlm:affiliation>Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañón, Madrid, Spain; Instituto de Investigación Sanitaria, Hospital Gregorio Marañón, Madrid, Spain; CIBER Enfermedades Respiratorias - CIBERES (CB06/06/0058), Madrid, Spain; Medicine Department, School of Medicine, Universidad Complutense de Madrid, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañón, Madrid, Spain; Instituto de Investigación Sanitaria, Hospital Gregorio Marañón, Madrid, Spain; CIBER Enfermedades Respiratorias - CIBERES (CB06/06/0058), Madrid, Spain; Medicine Department, School of Medicine, Universidad Complutense de Madrid, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author></analytic><series><title level="j">The Journal of hospital infection</title><idno type="eISSN">1532-2939</idno><imprint><date when="2018" type="published">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult (MeSH)</term><term>Aged (MeSH)</term><term>Aged, 80 and over (MeSH)</term><term>Community-Acquired Infections (epidemiology)</term><term>Community-Acquired Infections (pathology)</term><term>Community-Acquired Infections (virology)</term><term>Cross Infection (epidemiology)</term><term>Cross Infection (pathology)</term><term>Cross Infection (virology)</term><term>Female (MeSH)</term><term>Hospitals (MeSH)</term><term>Humans (MeSH)</term><term>Male (MeSH)</term><term>Middle Aged (MeSH)</term><term>Molecular Diagnostic Techniques (MeSH)</term><term>Prospective Studies (MeSH)</term><term>Respiratory Syncytial Virus Infections (epidemiology)</term><term>Respiratory Syncytial Virus Infections (pathology)</term><term>Respiratory Syncytial Virus, Human (isolation & purification)</term><term>Respiratory Tract Infections (epidemiology)</term><term>Respiratory Tract Infections (pathology)</term><term>Respiratory Tract Infections (virology)</term><term>Seasons (MeSH)</term><term>Spain (epidemiology)</term><term>Young Adult (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte (MeSH)</term><term>Adulte d'âge moyen (MeSH)</term><term>Espagne (épidémiologie)</term><term>Femelle (MeSH)</term><term>Humains (MeSH)</term><term>Hôpitaux (MeSH)</term><term>Infection croisée (anatomopathologie)</term><term>Infection croisée (virologie)</term><term>Infection croisée (épidémiologie)</term><term>Infections communautaires (anatomopathologie)</term><term>Infections communautaires (virologie)</term><term>Infections communautaires (épidémiologie)</term><term>Infections de l'appareil respiratoire (anatomopathologie)</term><term>Infections de l'appareil respiratoire (virologie)</term><term>Infections de l'appareil respiratoire (épidémiologie)</term><term>Infections à virus respiratoire syncytial (anatomopathologie)</term><term>Infections à virus respiratoire syncytial (épidémiologie)</term><term>Jeune adulte (MeSH)</term><term>Mâle (MeSH)</term><term>Saisons (MeSH)</term><term>Sujet âgé (MeSH)</term><term>Sujet âgé de 80 ans ou plus (MeSH)</term><term>Techniques de diagnostic moléculaire (MeSH)</term><term>Virus respiratoire syncytial humain (isolement et purification)</term><term>Études prospectives (MeSH)</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Spain</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Infection croisée</term><term>Infections communautaires</term><term>Infections de l'appareil respiratoire</term><term>Infections à virus respiratoire syncytial</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Community-Acquired Infections</term><term>Cross Infection</term><term>Respiratory Syncytial Virus Infections</term><term>Respiratory Tract Infections</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Respiratory Syncytial Virus, Human</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Virus respiratoire syncytial humain</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Community-Acquired Infections</term><term>Cross Infection</term><term>Respiratory Syncytial Virus Infections</term><term>Respiratory Tract Infections</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infection croisée</term><term>Infections communautaires</term><term>Infections de l'appareil respiratoire</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Community-Acquired Infections</term><term>Cross Infection</term><term>Respiratory Tract Infections</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Espagne</term><term>Infection croisée</term><term>Infections communautaires</term><term>Infections de l'appareil respiratoire</term><term>Infections à virus respiratoire syncytial</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Female</term><term>Hospitals</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Molecular Diagnostic Techniques</term><term>Prospective Studies</term><term>Seasons</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Femelle</term><term>Humains</term><term>Hôpitaux</term><term>Jeune adulte</term><term>Mâle</term><term>Saisons</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Techniques de diagnostic moléculaire</term><term>Études prospectives</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Espagne</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b></p><p>Information on the role of respiratory syncytial virus (RSV) in adult patients with influenza-like syndrome is scarce.</p></div><div type="abstract" xml:lang="en"><p><b>AIM</b></p><p>To assess the clinical characteristics of RSV in adult patients with respiratory manifestations during a regular influenza season.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>Prospective study in a tertiary Spanish hospital from December 2015 to February 2016. The study population included only adult patients with either community-acquired or hospital/healthcare-associated influenza-like illness, according to the European Centre for Disease Prevention and Control criteria. Samples were analysed using a rapid molecular assay (Xpert</p></div><div type="abstract" xml:lang="en"><p><b>FINDINGS</b></p><p>Twelve hundred patients with influenza-like respiratory infection were included. Overall, 114 of the samples (9%) were positive for influenza and 95 (8%) were positive for RSV. When RSV-positive and influenza-positive patients were compared, RSV-positive patients were older (57.7 vs 48.9 years; P = 0.03), and their disease was more frequently healthcare-related (26/95, 27.3% vs 5/114, 1.7%; P < 0.001). They also had significantly more antibiotics prescribed (77/95, 81.0% vs 70/114, 61.4%; P < 0.001) and more frequently needed hospital admission (93/95, 97.8% vs 69/114, 60.5%; P < 0.001). Mortality was also significantly higher in RSV-positive patients (14/95, 14.7% vs 7/114, 6.1%; P = 0.04).</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSION</b></p><p>RSV is a major cause of moderate-to-severe respiratory infection during the influenza season; acquisition is frequently nosocomial or healthcare-related; and mortality is significantly higher than with influenza virus infection. The use of a rapid molecular test as a first-step diagnostic technique is necessary to ensure that isolation measures are implemented and that spread is prevented.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">29614245</PMID><DateCompleted><Year>2019</Year><Month>01</Month><Day>14</Day></DateCompleted><DateRevised><Year>2019</Year><Month>01</Month><Day>14</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1532-2939</ISSN><JournalIssue CitedMedium="Internet"><Volume>100</Volume><Issue>4</Issue><PubDate><Year>2018</Year><Month>Dec</Month></PubDate></JournalIssue><Title>The Journal of hospital infection</Title><ISOAbbreviation>J. Hosp. Infect.</ISOAbbreviation></Journal><ArticleTitle>Respiratory syncytial virus burden among adults during flu season: an underestimated pathology.</ArticleTitle><Pagination><MedlinePgn>463-468</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0195-6701(18)30185-3</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.jhin.2018.03.034</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Information on the role of respiratory syncytial virus (RSV) in adult patients with influenza-like syndrome is scarce.</AbstractText><AbstractText Label="AIM" NlmCategory="OBJECTIVE">To assess the clinical characteristics of RSV in adult patients with respiratory manifestations during a regular influenza season.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Prospective study in a tertiary Spanish hospital from December 2015 to February 2016. The study population included only adult patients with either community-acquired or hospital/healthcare-associated influenza-like illness, according to the European Centre for Disease Prevention and Control criteria. Samples were analysed using a rapid molecular assay (Xpert<sup>®</sup> Flu/RSV). RSV-positive patients were compared with a randomly negative control group and with an influenza-positive control group.</AbstractText><AbstractText Label="FINDINGS" NlmCategory="RESULTS">Twelve hundred patients with influenza-like respiratory infection were included. Overall, 114 of the samples (9%) were positive for influenza and 95 (8%) were positive for RSV. When RSV-positive and influenza-positive patients were compared, RSV-positive patients were older (57.7 vs 48.9 years; P = 0.03), and their disease was more frequently healthcare-related (26/95, 27.3% vs 5/114, 1.7%; P < 0.001). They also had significantly more antibiotics prescribed (77/95, 81.0% vs 70/114, 61.4%; P < 0.001) and more frequently needed hospital admission (93/95, 97.8% vs 69/114, 60.5%; P < 0.001). Mortality was also significantly higher in RSV-positive patients (14/95, 14.7% vs 7/114, 6.1%; P = 0.04).</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">RSV is a major cause of moderate-to-severe respiratory infection during the influenza season; acquisition is frequently nosocomial or healthcare-related; and mortality is significantly higher than with influenza virus infection. The use of a rapid molecular test as a first-step diagnostic technique is necessary to ensure that isolation measures are implemented and that spread is prevented.</AbstractText><CopyrightInformation>Copyright © 2018 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Kestler</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañón, Madrid, Spain. Electronic address: kestler.martha@gmail.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Muñoz</LastName><ForeName>P</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañón, Madrid, Spain; Instituto de Investigación Sanitaria, Hospital Gregorio Marañón, Madrid, Spain; CIBER Enfermedades Respiratorias - CIBERES (CB06/06/0058), Madrid, Spain; Medicine Department, School of Medicine, Universidad Complutense de Madrid, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mateos</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañón, Madrid, Spain; Instituto de Investigación Sanitaria, Hospital Gregorio Marañón, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Adrados</LastName><ForeName>D</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañón, Madrid, Spain; Instituto de Investigación Sanitaria, Hospital Gregorio Marañón, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bouza</LastName><ForeName>E</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañón, Madrid, Spain; Instituto de Investigación Sanitaria, Hospital Gregorio Marañón, Madrid, Spain; CIBER Enfermedades Respiratorias - CIBERES (CB06/06/0058), Madrid, Spain; Medicine Department, School of Medicine, Universidad Complutense de Madrid, Madrid, Spain.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2018</Year><Month>03</Month><Day>31</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>J Hosp Infect</MedlineTA><NlmUniqueID>8007166</NlmUniqueID><ISSNLinking>0195-6701</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017714" MajorTopicYN="N">Community-Acquired Infections</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003428" MajorTopicYN="N">Cross Infection</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006761" MajorTopicYN="N">Hospitals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D025202" MajorTopicYN="N">Molecular Diagnostic Techniques</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011446" MajorTopicYN="N">Prospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018357" MajorTopicYN="N">Respiratory Syncytial Virus Infections</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018113" MajorTopicYN="N">Respiratory Syncytial Virus, Human</DescriptorName><QualifierName UI="Q000302" MajorTopicYN="Y">isolation & purification</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012141" MajorTopicYN="N">Respiratory Tract Infections</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012621" MajorTopicYN="N">Seasons</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013030" MajorTopicYN="N" Type="Geographic">Spain</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Adults</Keyword><Keyword MajorTopicYN="N">Influenza</Keyword><Keyword MajorTopicYN="N">Respiratory syncytial virus</Keyword><Keyword MajorTopicYN="N">Viral pneumonia</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2018</Year><Month>01</Month><Day>29</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2018</Year><Month>03</Month><Day>27</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2018</Year><Month>4</Month><Day>4</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2019</Year><Month>1</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2018</Year><Month>4</Month><Day>4</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">29614245</ArticleId><ArticleId IdType="pii">S0195-6701(18)30185-3</ArticleId><ArticleId IdType="doi">10.1016/j.jhin.2018.03.034</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Espagne</li></country><region><li>Communauté de Madrid</li></region><settlement><li>Madrid</li></settlement></list><tree><country name="Espagne"><region name="Communauté de Madrid"><name sortKey="Kestler, M" sort="Kestler, M" uniqKey="Kestler M" first="M" last="Kestler">M. Kestler</name></region><name sortKey="Adrados, D" sort="Adrados, D" uniqKey="Adrados D" first="D" last="Adrados">D. Adrados</name><name sortKey="Bouza, E" sort="Bouza, E" uniqKey="Bouza E" first="E" last="Bouza">E. Bouza</name><name sortKey="Mateos, M" sort="Mateos, M" uniqKey="Mateos M" first="M" last="Mateos">M. Mateos</name><name sortKey="Mu Oz, P" sort="Mu Oz, P" uniqKey="Mu Oz P" first="P" last="Mu Oz">P. Mu Oz</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/GrippeEspagneV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000054 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000054 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= GrippeEspagneV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:29614245
|texte= Respiratory syncytial virus burden among adults during flu season: an underestimated pathology.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:29614245" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a GrippeEspagneV1
| This area was generated with Dilib version V0.6.37. |  |