Smoking may increase the risk of influenza hospitalization and reduce influenza vaccine effectiveness in the elderly.
Identifieur interne : 000051 ( Main/Exploration ); précédent : 000050; suivant : 000052Smoking may increase the risk of influenza hospitalization and reduce influenza vaccine effectiveness in the elderly.
Auteurs : Pere Godoy [Espagne] ; Jesús Castilla [Espagne] ; Núria Soldevila [Espagne] ; José María Mayoral [Espagne] ; Diana Toledo [Espagne] ; Vicente Martín [Espagne] ; Jenaro Astray [Espagne] ; Mikel Egurrola [Espagne] ; Maria Morales-Suarez-Varela [Espagne] ; Angela Domínguez [Espagne]Source :
- European journal of public health [ 1464-360X ] ; 2018.
Descripteurs français
- KwdFr :
- Comorbidité (MeSH), Espagne (épidémiologie), Facteurs de risque (MeSH), Femelle (MeSH), Fumer (épidémiologie), Grippe humaine (prévention et contrôle), Grippe humaine (épidémiologie), Hospitalisation (statistiques et données numériques), Humains (MeSH), Mâle (MeSH), Résultat thérapeutique (MeSH), Sujet âgé (MeSH), Sujet âgé de 80 ans ou plus (MeSH), Vaccins antigrippaux (usage thérapeutique), Études cas-témoins (MeSH), Évaluation gériatrique (statistiques et données numériques).
- MESH :
- prévention et contrôle : Grippe humaine.
- statistiques et données numériques : Hospitalisation, Évaluation gériatrique.
- usage thérapeutique : Vaccins antigrippaux.
- épidémiologie : Espagne, Fumer, Grippe humaine.
- Comorbidité, Facteurs de risque, Femelle, Humains, Mâle, Résultat thérapeutique, Sujet âgé, Sujet âgé de 80 ans ou plus, Études cas-témoins.
- Wicri :
- geographic : Espagne.
English descriptors
- KwdEn :
- Aged (MeSH), Aged, 80 and over (MeSH), Case-Control Studies (MeSH), Comorbidity (MeSH), Female (MeSH), Geriatric Assessment (statistics & numerical data), Hospitalization (statistics & numerical data), Humans (MeSH), Influenza Vaccines (therapeutic use), Influenza, Human (epidemiology), Influenza, Human (prevention & control), Male (MeSH), Risk Factors (MeSH), Smoking (epidemiology), Spain (epidemiology), Treatment Outcome (MeSH).
- MESH :
- chemical , therapeutic use : Influenza Vaccines.
- geographic , epidemiology : Spain.
- epidemiology : Influenza, Human, Smoking.
- prevention & control : Influenza, Human.
- statistics & numerical data : Geriatric Assessment, Hospitalization.
- Aged, Aged, 80 and over, Case-Control Studies, Comorbidity, Female, Humans, Male, Risk Factors, Treatment Outcome.
Abstract
Background
Through its effects on the immune system, smoking may facilitate influenza virus infection, its severity and its most frequent complications. The objective was to investigate the smoking history as a risk factor for influenza hospitalization and influenza vaccine effectiveness in elderly smokers/ex-smokers and non-smokers.
Methods
We carried out a multicenter case-control study in the 2013-2014 and 2014-2015 influenza seasons. Cases aged ≥65 years and age-, sex-matched controls were selected from 20 Spanish hospitals. We collected epidemiological variables, comorbidities, vaccination history and the smoking history. The risk of hospitalization due to smoking (current smokers and ex-smokers) was determined using the adjusted odds ratio (aOR) with conditional logistic regression models. Vaccine effectiveness (VE) was calculated using the formula: VE = (1 - aOR) × 100.
Results
We studied 728 cases and 1826 controls. Cases had a higher frequency of smoking (47.4% vs 42.1%). Smoking was associated with an increased risk of influenza hospitalization (aOR = 1.32, 95% CI: 1.04-1.68). Influenza vaccine effectiveness in preventing hospitalization was 21% (95% CI: -2 to 39) in current/ex-smokers and 39% in non-smokers (95% CI: 22-52).
Conclusions
A history of smoking may increase the risk of hospitalization in smokers and ex-smokers. Preventing smoking could reduce hospitalizations due to influenza. Smokers and ex-smokers should be informed of the risk of hospitalization due to influenza infection, and encouraged to stop smoking. Smokers should be considered an at-risk group to be aggressively targeted for routine influenza vaccination.
DOI: 10.1093/eurpub/ckx130
PubMed: 29020390
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>IRBLleida, University of Lleida, Lleida, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>IRBLleida, University of Lleida, Lleida</wicri:regionArea><wicri:noRegion>Lleida</wicri:noRegion></affiliation></author><author><name sortKey="Castilla, Jesus" sort="Castilla, Jesus" uniqKey="Castilla J" first="Jesús" last="Castilla">Jesús Castilla</name><affiliation wicri:level="3"><nlm:affiliation>CIBER Epidemiology and Public Health, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>CIBER Epidemiology and Public Health, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Public Health Institute of Navarra, IdiSNA, Pamplona, 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type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Mayoral, Jose Maria" sort="Mayoral, Jose Maria" uniqKey="Mayoral J" first="José María" last="Mayoral">José María Mayoral</name><affiliation wicri:level="1"><nlm:affiliation>Surveillance Service, Andalusian Government, Seville, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Surveillance Service, Andalusian Government, Seville</wicri:regionArea><wicri:noRegion>Seville</wicri:noRegion></affiliation></author><author><name sortKey="Toledo, Diana" sort="Toledo, Diana" uniqKey="Toledo D" first="Diana" last="Toledo">Diana Toledo</name><affiliation wicri:level="3"><nlm:affiliation>CIBER Epidemiology and Public Health, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>CIBER Epidemiology and Public Health, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>University of Barcelona, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>University of Barcelona, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Martin, Vicente" sort="Martin, Vicente" uniqKey="Martin V" first="Vicente" last="Martín">Vicente Martín</name><affiliation wicri:level="3"><nlm:affiliation>CIBER Epidemiology and Public Health, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>CIBER Epidemiology and Public Health, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>University of Leon, Leon, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>University of Leon, Leon</wicri:regionArea><wicri:noRegion>Leon</wicri:noRegion></affiliation></author><author><name sortKey="Astray, Jenaro" sort="Astray, Jenaro" uniqKey="Astray J" first="Jenaro" last="Astray">Jenaro Astray</name><affiliation wicri:level="3"><nlm:affiliation>CIBER Epidemiology and Public Health, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>CIBER Epidemiology and Public Health, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Area of Epidemiology, Community of Madrid, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Area of Epidemiology, Community of Madrid, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Egurrola, Mikel" sort="Egurrola, Mikel" uniqKey="Egurrola M" first="Mikel" last="Egurrola">Mikel Egurrola</name><affiliation wicri:level="1"><nlm:affiliation>Hospital de Galdakao, Unansolo, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital de Galdakao, Unansolo</wicri:regionArea><wicri:noRegion>Unansolo</wicri:noRegion></affiliation></author><author><name sortKey="Morales Suarez Varela, Maria" sort="Morales Suarez Varela, Maria" uniqKey="Morales Suarez Varela M" first="Maria" last="Morales-Suarez-Varela">Maria Morales-Suarez-Varela</name><affiliation wicri:level="3"><nlm:affiliation>CIBER Epidemiology and Public Health, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>CIBER Epidemiology and Public Health, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>University of Valencia, Valencia, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>University of Valencia, Valencia</wicri:regionArea><wicri:noRegion>Valencia</wicri:noRegion></affiliation></author><author><name sortKey="Dominguez, Angela" sort="Dominguez, Angela" uniqKey="Dominguez A" first="Angela" last="Domínguez">Angela Domínguez</name><affiliation wicri:level="3"><nlm:affiliation>CIBER Epidemiology and Public Health, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>CIBER Epidemiology and Public Health, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>University of Barcelona, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>University of Barcelona, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2018">2018</date><idno type="RBID">pubmed:29020390</idno><idno type="pmid">29020390</idno><idno type="doi">10.1093/eurpub/ckx130</idno><idno type="wicri:Area/Main/Corpus">00082</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">00082</idno><idno type="wicri:Area/Main/Curation">000082</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000082</idno><idno type="wicri:Area/Main/Exploration">000082</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Smoking may increase the risk of influenza hospitalization and reduce influenza vaccine effectiveness in the elderly.</title><author><name sortKey="Godoy, Pere" sort="Godoy, Pere" uniqKey="Godoy P" first="Pere" last="Godoy">Pere Godoy</name><affiliation wicri:level="3"><nlm:affiliation>Department of Health, Generalitat of Catalonia, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Health, Generalitat of Catalonia, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>CIBER Epidemiology and Public Health, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>CIBER Epidemiology and Public Health, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>IRBLleida, University of Lleida, Lleida, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>IRBLleida, University of Lleida, Lleida</wicri:regionArea><wicri:noRegion>Lleida</wicri:noRegion></affiliation></author><author><name sortKey="Castilla, Jesus" sort="Castilla, Jesus" uniqKey="Castilla J" first="Jesús" last="Castilla">Jesús Castilla</name><affiliation wicri:level="3"><nlm:affiliation>CIBER Epidemiology and Public Health, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>CIBER Epidemiology and Public Health, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Public Health Institute of Navarra, IdiSNA, Pamplona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Public Health Institute of Navarra, IdiSNA, Pamplona</wicri:regionArea><wicri:noRegion>Pamplona</wicri:noRegion></affiliation></author><author><name sortKey="Soldevila, Nuria" sort="Soldevila, Nuria" uniqKey="Soldevila N" first="Núria" last="Soldevila">Núria Soldevila</name><affiliation wicri:level="3"><nlm:affiliation>CIBER Epidemiology and Public Health, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>CIBER Epidemiology and Public Health, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>University of Barcelona, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>University of Barcelona, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Mayoral, Jose Maria" sort="Mayoral, Jose Maria" uniqKey="Mayoral J" first="José María" last="Mayoral">José María Mayoral</name><affiliation wicri:level="1"><nlm:affiliation>Surveillance Service, Andalusian Government, Seville, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Surveillance Service, Andalusian Government, Seville</wicri:regionArea><wicri:noRegion>Seville</wicri:noRegion></affiliation></author><author><name sortKey="Toledo, Diana" sort="Toledo, Diana" uniqKey="Toledo D" first="Diana" last="Toledo">Diana Toledo</name><affiliation wicri:level="3"><nlm:affiliation>CIBER Epidemiology and Public Health, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>CIBER Epidemiology and Public Health, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>University of Barcelona, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>University of Barcelona, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Martin, Vicente" sort="Martin, Vicente" uniqKey="Martin V" first="Vicente" last="Martín">Vicente Martín</name><affiliation wicri:level="3"><nlm:affiliation>CIBER Epidemiology and Public Health, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>CIBER Epidemiology and Public Health, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>University of Leon, Leon, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>University of Leon, Leon</wicri:regionArea><wicri:noRegion>Leon</wicri:noRegion></affiliation></author><author><name sortKey="Astray, Jenaro" sort="Astray, Jenaro" uniqKey="Astray J" first="Jenaro" last="Astray">Jenaro Astray</name><affiliation wicri:level="3"><nlm:affiliation>CIBER Epidemiology and Public Health, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>CIBER Epidemiology and Public Health, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Area of Epidemiology, Community of Madrid, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Area of Epidemiology, Community of Madrid, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Egurrola, Mikel" sort="Egurrola, Mikel" uniqKey="Egurrola M" first="Mikel" last="Egurrola">Mikel Egurrola</name><affiliation wicri:level="1"><nlm:affiliation>Hospital de Galdakao, Unansolo, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital de Galdakao, Unansolo</wicri:regionArea><wicri:noRegion>Unansolo</wicri:noRegion></affiliation></author><author><name sortKey="Morales Suarez Varela, Maria" sort="Morales Suarez Varela, Maria" uniqKey="Morales Suarez Varela M" first="Maria" last="Morales-Suarez-Varela">Maria Morales-Suarez-Varela</name><affiliation wicri:level="3"><nlm:affiliation>CIBER Epidemiology and Public Health, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>CIBER Epidemiology and Public Health, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>University of Valencia, Valencia, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>University of Valencia, Valencia</wicri:regionArea><wicri:noRegion>Valencia</wicri:noRegion></affiliation></author><author><name sortKey="Dominguez, Angela" sort="Dominguez, Angela" uniqKey="Dominguez A" first="Angela" last="Domínguez">Angela Domínguez</name><affiliation wicri:level="3"><nlm:affiliation>CIBER Epidemiology and Public Health, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>CIBER Epidemiology and Public Health, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>University of Barcelona, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>University of Barcelona, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author></analytic><series><title level="j">European journal of public health</title><idno type="eISSN">1464-360X</idno><imprint><date when="2018" type="published">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged (MeSH)</term><term>Aged, 80 and over (MeSH)</term><term>Case-Control Studies (MeSH)</term><term>Comorbidity (MeSH)</term><term>Female (MeSH)</term><term>Geriatric Assessment (statistics & numerical data)</term><term>Hospitalization (statistics & numerical data)</term><term>Humans (MeSH)</term><term>Influenza Vaccines (therapeutic use)</term><term>Influenza, Human (epidemiology)</term><term>Influenza, Human (prevention & control)</term><term>Male (MeSH)</term><term>Risk Factors (MeSH)</term><term>Smoking (epidemiology)</term><term>Spain (epidemiology)</term><term>Treatment Outcome (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Comorbidité (MeSH)</term><term>Espagne (épidémiologie)</term><term>Facteurs de risque (MeSH)</term><term>Femelle (MeSH)</term><term>Fumer (épidémiologie)</term><term>Grippe humaine (prévention et contrôle)</term><term>Grippe humaine (épidémiologie)</term><term>Hospitalisation (statistiques et données numériques)</term><term>Humains (MeSH)</term><term>Mâle (MeSH)</term><term>Résultat thérapeutique (MeSH)</term><term>Sujet âgé (MeSH)</term><term>Sujet âgé de 80 ans ou plus (MeSH)</term><term>Vaccins antigrippaux (usage thérapeutique)</term><term>Études cas-témoins (MeSH)</term><term>Évaluation gériatrique (statistiques et données numériques)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Influenza Vaccines</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Spain</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Influenza, Human</term><term>Smoking</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="prévention et contrôle" xml:lang="fr"><term>Grippe humaine</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Geriatric Assessment</term><term>Hospitalization</term></keywords><keywords scheme="MESH" qualifier="statistiques et données numériques" xml:lang="fr"><term>Hospitalisation</term><term>Évaluation gériatrique</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Vaccins antigrippaux</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Espagne</term><term>Fumer</term><term>Grippe humaine</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Case-Control Studies</term><term>Comorbidity</term><term>Female</term><term>Humans</term><term>Male</term><term>Risk Factors</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Comorbidité</term><term>Facteurs de risque</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Résultat thérapeutique</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Études cas-témoins</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Espagne</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>Background</b></p><p>Through its effects on the immune system, smoking may facilitate influenza virus infection, its severity and its most frequent complications. The objective was to investigate the smoking history as a risk factor for influenza hospitalization and influenza vaccine effectiveness in elderly smokers/ex-smokers and non-smokers.</p></div><div type="abstract" xml:lang="en"><p><b>Methods</b></p><p>We carried out a multicenter case-control study in the 2013-2014 and 2014-2015 influenza seasons. Cases aged ≥65 years and age-, sex-matched controls were selected from 20 Spanish hospitals. We collected epidemiological variables, comorbidities, vaccination history and the smoking history. The risk of hospitalization due to smoking (current smokers and ex-smokers) was determined using the adjusted odds ratio (aOR) with conditional logistic regression models. Vaccine effectiveness (VE) was calculated using the formula: VE = (1 - aOR) × 100.</p></div><div type="abstract" xml:lang="en"><p><b>Results</b></p><p>We studied 728 cases and 1826 controls. Cases had a higher frequency of smoking (47.4% vs 42.1%). Smoking was associated with an increased risk of influenza hospitalization (aOR = 1.32, 95% CI: 1.04-1.68). Influenza vaccine effectiveness in preventing hospitalization was 21% (95% CI: -2 to 39) in current/ex-smokers and 39% in non-smokers (95% CI: 22-52).</p></div><div type="abstract" xml:lang="en"><p><b>Conclusions</b></p><p>A history of smoking may increase the risk of hospitalization in smokers and ex-smokers. Preventing smoking could reduce hospitalizations due to influenza. Smokers and ex-smokers should be informed of the risk of hospitalization due to influenza infection, and encouraged to stop smoking. Smokers should be considered an at-risk group to be aggressively targeted for routine influenza vaccination.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">29020390</PMID><DateCompleted><Year>2019</Year><Month>01</Month><Day>25</Day></DateCompleted><DateRevised><Year>2019</Year><Month>01</Month><Day>25</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1464-360X</ISSN><JournalIssue CitedMedium="Internet"><Volume>28</Volume><Issue>1</Issue><PubDate><Year>2018</Year><Month>02</Month><Day>01</Day></PubDate></JournalIssue><Title>European journal of public health</Title><ISOAbbreviation>Eur J Public Health</ISOAbbreviation></Journal><ArticleTitle>Smoking may increase the risk of influenza hospitalization and reduce influenza vaccine effectiveness in the elderly.</ArticleTitle><Pagination><MedlinePgn>150-155</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1093/eurpub/ckx130</ELocationID><Abstract><AbstractText Label="Background">Through its effects on the immune system, smoking may facilitate influenza virus infection, its severity and its most frequent complications. The objective was to investigate the smoking history as a risk factor for influenza hospitalization and influenza vaccine effectiveness in elderly smokers/ex-smokers and non-smokers.</AbstractText><AbstractText Label="Methods">We carried out a multicenter case-control study in the 2013-2014 and 2014-2015 influenza seasons. Cases aged ≥65 years and age-, sex-matched controls were selected from 20 Spanish hospitals. We collected epidemiological variables, comorbidities, vaccination history and the smoking history. The risk of hospitalization due to smoking (current smokers and ex-smokers) was determined using the adjusted odds ratio (aOR) with conditional logistic regression models. Vaccine effectiveness (VE) was calculated using the formula: VE = (1 - aOR) × 100.</AbstractText><AbstractText Label="Results">We studied 728 cases and 1826 controls. Cases had a higher frequency of smoking (47.4% vs 42.1%). Smoking was associated with an increased risk of influenza hospitalization (aOR = 1.32, 95% CI: 1.04-1.68). Influenza vaccine effectiveness in preventing hospitalization was 21% (95% CI: -2 to 39) in current/ex-smokers and 39% in non-smokers (95% CI: 22-52).</AbstractText><AbstractText Label="Conclusions">A history of smoking may increase the risk of hospitalization in smokers and ex-smokers. Preventing smoking could reduce hospitalizations due to influenza. Smokers and ex-smokers should be informed of the risk of hospitalization due to influenza infection, and encouraged to stop smoking. Smokers should be considered an at-risk group to be aggressively targeted for routine influenza vaccination.</AbstractText><CopyrightInformation>© The Author 2017. Published by Oxford University Press on behalf of the European Public Health Association. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Godoy</LastName><ForeName>Pere</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Health, Generalitat of Catalonia, Barcelona, Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>CIBER Epidemiology and Public Health, Madrid, Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>IRBLleida, University of Lleida, Lleida, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Castilla</LastName><ForeName>Jesús</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>CIBER Epidemiology and Public Health, Madrid, Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Public Health Institute of Navarra, IdiSNA, Pamplona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Soldevila</LastName><ForeName>Núria</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>CIBER Epidemiology and Public Health, Madrid, Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>University of Barcelona, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mayoral</LastName><ForeName>José María</ForeName><Initials>JM</Initials><AffiliationInfo><Affiliation>Surveillance Service, Andalusian Government, Seville, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Toledo</LastName><ForeName>Diana</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>CIBER Epidemiology and Public Health, Madrid, Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>University of Barcelona, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Martín</LastName><ForeName>Vicente</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>CIBER Epidemiology and Public Health, Madrid, Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>University of Leon, Leon, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Astray</LastName><ForeName>Jenaro</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>CIBER Epidemiology and Public Health, Madrid, Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Area of Epidemiology, Community of Madrid, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Egurrola</LastName><ForeName>Mikel</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Hospital de Galdakao, Unansolo, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Morales-Suarez-Varela</LastName><ForeName>Maria</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>CIBER Epidemiology and Public Health, Madrid, Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>University of Valencia, Valencia, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Domínguez</LastName><ForeName>Angela</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>CIBER Epidemiology and Public Health, Madrid, Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>University of Barcelona, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>CIBERESP Cases and Controls in Pandemic Influenza Working Group, Spain*</CollectiveName></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016448">Multicenter Study</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Eur J Public Health</MedlineTA><NlmUniqueID>9204966</NlmUniqueID><ISSNLinking>1101-1262</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007252">Influenza Vaccines</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016022" MajorTopicYN="N">Case-Control Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015897" MajorTopicYN="N">Comorbidity</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015577" MajorTopicYN="N">Geriatric Assessment</DescriptorName><QualifierName UI="Q000706" MajorTopicYN="Y">statistics & numerical data</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006760" MajorTopicYN="N">Hospitalization</DescriptorName><QualifierName UI="Q000706" MajorTopicYN="Y">statistics & numerical data</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007252" MajorTopicYN="N">Influenza Vaccines</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007251" MajorTopicYN="N">Influenza, Human</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName><QualifierName UI="Q000517" MajorTopicYN="Y">prevention & control</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012307" MajorTopicYN="N">Risk Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012907" MajorTopicYN="N">Smoking</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013030" MajorTopicYN="N" Type="Geographic">Spain</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016896" MajorTopicYN="N">Treatment Outcome</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>10</Month><Day>12</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2019</Year><Month>1</Month><Day>27</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>10</Month><Day>12</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">29020390</ArticleId><ArticleId IdType="pii">4108100</ArticleId><ArticleId IdType="doi">10.1093/eurpub/ckx130</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Espagne</li></country><region><li>Catalogne</li><li>Communauté de Madrid</li></region><settlement><li>Barcelone</li><li>Madrid</li></settlement></list><tree><country name="Espagne"><region name="Catalogne"><name sortKey="Godoy, Pere" sort="Godoy, Pere" uniqKey="Godoy P" first="Pere" last="Godoy">Pere Godoy</name></region><name sortKey="Astray, Jenaro" sort="Astray, Jenaro" uniqKey="Astray J" first="Jenaro" last="Astray">Jenaro Astray</name><name sortKey="Astray, Jenaro" sort="Astray, Jenaro" uniqKey="Astray J" first="Jenaro" last="Astray">Jenaro Astray</name><name sortKey="Castilla, Jesus" sort="Castilla, Jesus" uniqKey="Castilla J" first="Jesús" last="Castilla">Jesús Castilla</name><name sortKey="Castilla, Jesus" sort="Castilla, Jesus" uniqKey="Castilla J" first="Jesús" last="Castilla">Jesús Castilla</name><name sortKey="Dominguez, Angela" sort="Dominguez, Angela" uniqKey="Dominguez A" first="Angela" last="Domínguez">Angela Domínguez</name><name sortKey="Dominguez, Angela" sort="Dominguez, Angela" uniqKey="Dominguez A" first="Angela" last="Domínguez">Angela Domínguez</name><name sortKey="Egurrola, Mikel" sort="Egurrola, Mikel" uniqKey="Egurrola M" first="Mikel" last="Egurrola">Mikel Egurrola</name><name sortKey="Godoy, Pere" sort="Godoy, Pere" uniqKey="Godoy P" first="Pere" last="Godoy">Pere Godoy</name><name sortKey="Godoy, Pere" sort="Godoy, Pere" uniqKey="Godoy P" first="Pere" last="Godoy">Pere Godoy</name><name sortKey="Martin, Vicente" sort="Martin, Vicente" uniqKey="Martin V" first="Vicente" last="Martín">Vicente Martín</name><name sortKey="Martin, Vicente" sort="Martin, Vicente" uniqKey="Martin V" first="Vicente" last="Martín">Vicente Martín</name><name sortKey="Mayoral, Jose Maria" sort="Mayoral, Jose Maria" uniqKey="Mayoral J" first="José María" last="Mayoral">José María Mayoral</name><name sortKey="Morales Suarez Varela, Maria" sort="Morales Suarez Varela, Maria" uniqKey="Morales Suarez Varela M" first="Maria" last="Morales-Suarez-Varela">Maria Morales-Suarez-Varela</name><name sortKey="Morales Suarez Varela, Maria" sort="Morales Suarez Varela, Maria" uniqKey="Morales Suarez Varela M" first="Maria" last="Morales-Suarez-Varela">Maria Morales-Suarez-Varela</name><name sortKey="Soldevila, Nuria" sort="Soldevila, Nuria" uniqKey="Soldevila N" first="Núria" last="Soldevila">Núria Soldevila</name><name sortKey="Soldevila, Nuria" sort="Soldevila, Nuria" uniqKey="Soldevila N" first="Núria" last="Soldevila">Núria Soldevila</name><name sortKey="Toledo, Diana" sort="Toledo, Diana" uniqKey="Toledo D" first="Diana" last="Toledo">Diana Toledo</name><name sortKey="Toledo, Diana" sort="Toledo, Diana" uniqKey="Toledo D" first="Diana" last="Toledo">Diana Toledo</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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