GrippeEspagneV1, Main, Exploration, bibRecord, 000037

Clinical Effectiveness of Influenza Vaccination After Allogeneic Hematopoietic Stem Cell Transplantation: A Cross-sectional, Prospective, Observational Study.

Identifieur interne : 000037 ( Main/Exploration ); précédent : 000036; suivant : 000038

Clinical Effectiveness of Influenza Vaccination After Allogeneic Hematopoietic Stem Cell Transplantation: A Cross-sectional, Prospective, Observational Study.

Auteurs : José Luis Pi Ana [Espagne] ; Ariadna Pérez [Espagne] ; Juan Montoro [Espagne] ; Estela Giménez [Espagne] ; María Dolores G Mez [Espagne] ; Ignacio Lorenzo [Espagne] ; Silvia Madrid [Espagne] ; Eva María González [Espagne] ; Víctor Vinuesa [Espagne] ; Juan Carlos Hernández-Boluda [Espagne] ; Miguel Salavert [Espagne] ; Guillermo Sanz [Espagne] ; Carlos Solano [Espagne] ; Jaime Sanz [Espagne] ; David Navarro [Espagne]

Source :

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [ 1537-6591 ] ; 2019.

RBID : pubmed:30239624

Descripteurs français

KwdFr :
- Adolescent (MeSH), Adulte (MeSH), Adulte d'âge moyen (MeSH), Espagne (MeSH), Facteurs de risque (MeSH), Femelle (MeSH), Grippe humaine (prévention et contrôle), Hospitalisation (MeSH), Humains (MeSH), Jeune adulte (MeSH), Mâle (MeSH), Odds ratio (MeSH), Résultat thérapeutique (MeSH), Sujet immunodéprimé (MeSH), Sujet âgé (MeSH), Transplantation de cellules souches hématopoïétiques (MeSH), Transplantation homologue (MeSH), Vaccination (statistiques et données numériques), Vaccins antigrippaux (administration et posologie), Vaccins antigrippaux (immunologie), Études prospectives (MeSH), Études rétrospectives (MeSH), Études transversales (MeSH).
MESH :
- administration et posologie : Vaccins antigrippaux.
- immunologie : Vaccins antigrippaux.
- prévention et contrôle : Grippe humaine.
- statistiques et données numériques : Vaccination.
- Adolescent, Adulte, Adulte d'âge moyen, Espagne, Facteurs de risque, Femelle, Hospitalisation, Humains, Jeune adulte, Mâle, Odds ratio, Résultat thérapeutique, Sujet immunodéprimé, Sujet âgé, Transplantation de cellules souches hématopoïétiques, Transplantation homologue, Études prospectives, Études rétrospectives, Études transversales.
Wicri :
- geographic : Espagne.

English descriptors

KwdEn :
- Adolescent (MeSH), Adult (MeSH), Aged (MeSH), Cross-Sectional Studies (MeSH), Female (MeSH), Hematopoietic Stem Cell Transplantation (MeSH), Hospitalization (MeSH), Humans (MeSH), Immunocompromised Host (MeSH), Influenza Vaccines (administration & dosage), Influenza Vaccines (immunology), Influenza, Human (prevention & control), Male (MeSH), Middle Aged (MeSH), Odds Ratio (MeSH), Prospective Studies (MeSH), Retrospective Studies (MeSH), Risk Factors (MeSH), Spain (MeSH), Transplantation, Homologous (MeSH), Treatment Outcome (MeSH), Vaccination (statistics & numerical data), Young Adult (MeSH).
MESH :
- chemical , administration & dosage : Influenza Vaccines.
- chemical , immunology : Influenza Vaccines.
- geographic : Spain.
- prevention & control : Influenza, Human.
- statistics & numerical data : Vaccination.
- Adolescent, Adult, Aged, Cross-Sectional Studies, Female, Hematopoietic Stem Cell Transplantation, Hospitalization, Humans, Immunocompromised Host, Male, Middle Aged, Odds Ratio, Prospective Studies, Retrospective Studies, Risk Factors, Transplantation, Homologous, Treatment Outcome, Young Adult.

Abstract

BACKGROUND

Vaccination is the primary method for preventing influenza respiratory virus infection (RVI). Although the influenza vaccine is able to achieve serological responses in some allogeneic hematopoietic stem cell transplantation (allo-HSCT) recipients, its clinical benefits are still uncertain.

METHODS

In this prospective, cross-sectional study, we retrospectively analyzed the effect of inactivated trivalent influenza vaccination on the prevalence of influenza RVI in a consecutive cohort of 136 allo-HSCT adult recipients who developed 161 RVI over 5 flu seasons (from 2013 to 2018). Respiratory viruses in upper- and/or lower-respiratory tract specimens were tested using multiplex polymerase chain reaction panel assays.

RESULTS

Overall, we diagnosed 74 episodes (46%) of influenza RVI in 70 allo-HSCT recipients. Influenza RVI occurred in 51% of the non-vaccinated compared to 36% of the vaccinated recipients (P = .036). A multivariate analysis showed that influenza vaccination was associated with a lower prevalence of influenza RVI (odds ratio [OR] 0.39, P = .01). A multivariate risk factor analysis of lower-respiratory tract disease (LRTD) identified 2 conditions associated with the probability of influenza RVI progression: influenza vaccination (OR 0.12, 95% confidence interval [CI] 0.014-1, P = .05) and a high-risk immunodeficiency score (OR 36, 95% CI 2.26-575, P = .011). Influenza vaccination was also associated with a lower likelihood of an influenza-related hospital admission (14% vs 2%, P = .04).

CONCLUSIONS

This study shows that influenza vaccination may have a clinical benefit in allo-HSCT recipients with virologically-confirmed RVI, in terms of a lower influenza RVI prevalence, slower LRTD progression, and lower likelihood of hospital admission.

DOI: 10.1093/cid/ciy792
PubMed: 30239624
PubMed Central: PMC7108095

Affiliations:

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Le document en format XML

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<author><name sortKey="Navarro, David" sort="Navarro, David" uniqKey="Navarro D" first="David" last="Navarro">David Navarro</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Clinical Effectiveness of Influenza Vaccination After Allogeneic Hematopoietic Stem Cell Transplantation: A Cross-sectional, Prospective, Observational Study.</title>
<author><name sortKey="Pi Ana, Jose Luis" sort="Pi Ana, Jose Luis" uniqKey="Pi Ana J" first="José Luis" last="Pi Ana">José Luis Pi Ana</name>
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<country xml:lang="fr">Espagne</country>
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<wicri:noRegion>Institute for Research INCLIVA</wicri:noRegion>
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<author><name sortKey="Montoro, Juan" sort="Montoro, Juan" uniqKey="Montoro J" first="Juan" last="Montoro">Juan Montoro</name>
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<affiliation wicri:level="3"><nlm:affiliation>CIBERONC, Instituto Carlos III, Madrid, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
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<author><name sortKey="Gimenez, Estela" sort="Gimenez, Estela" uniqKey="Gimenez E" first="Estela" last="Giménez">Estela Giménez</name>
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<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Microbiology Department, Hospital Clínico Universitario, Institute for Research INCLIVA</wicri:regionArea>
<wicri:noRegion>Institute for Research INCLIVA</wicri:noRegion>
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<author><name sortKey="G Mez, Maria Dolores" sort="G Mez, Maria Dolores" uniqKey="G Mez M" first="María Dolores" last="G Mez">María Dolores G Mez</name>
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<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Microbiology Department, Hospital Universitari i Politècnic La Fe</wicri:regionArea>
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<author><name sortKey="Lorenzo, Ignacio" sort="Lorenzo, Ignacio" uniqKey="Lorenzo I" first="Ignacio" last="Lorenzo">Ignacio Lorenzo</name>
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<author><name sortKey="Madrid, Silvia" sort="Madrid, Silvia" uniqKey="Madrid S" first="Silvia" last="Madrid">Silvia Madrid</name>
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<wicri:noRegion>Institute for Research INCLIVA</wicri:noRegion>
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<author><name sortKey="Gonzalez, Eva Maria" sort="Gonzalez, Eva Maria" uniqKey="Gonzalez E" first="Eva María" last="González">Eva María González</name>
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<wicri:noRegion>Hospital Universitari i Politècnic La Fe</wicri:noRegion>
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<author><name sortKey="Vinuesa, Victor" sort="Vinuesa, Victor" uniqKey="Vinuesa V" first="Víctor" last="Vinuesa">Víctor Vinuesa</name>
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<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Microbiology Department, Hospital Clínico Universitario, Institute for Research INCLIVA</wicri:regionArea>
<wicri:noRegion>Institute for Research INCLIVA</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hernandez Boluda, Juan Carlos" sort="Hernandez Boluda, Juan Carlos" uniqKey="Hernandez Boluda J" first="Juan Carlos" last="Hernández-Boluda">Juan Carlos Hernández-Boluda</name>
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<wicri:noRegion>Hospital Universitari i Politècnic La Fe</wicri:noRegion>
</affiliation>
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<author><name sortKey="Salavert, Miguel" sort="Salavert, Miguel" uniqKey="Salavert M" first="Miguel" last="Salavert">Miguel Salavert</name>
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<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Infectious Diseases, Hospital Universitari i Politècnic La Fe</wicri:regionArea>
<wicri:noRegion>Hospital Universitari i Politècnic La Fe</wicri:noRegion>
</affiliation>
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<author><name sortKey="Sanz, Guillermo" sort="Sanz, Guillermo" uniqKey="Sanz G" first="Guillermo" last="Sanz">Guillermo Sanz</name>
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<wicri:noRegion>Valencia</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>CIBERONC, Instituto Carlos III, Madrid, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>CIBERONC, Instituto Carlos III, Madrid</wicri:regionArea>
<placeName><settlement type="city">Madrid</settlement>
<region nuts="2" type="region">Communauté de Madrid</region>
</placeName>
</affiliation>
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<author><name sortKey="Solano, Carlos" sort="Solano, Carlos" uniqKey="Solano C" first="Carlos" last="Solano">Carlos Solano</name>
<affiliation wicri:level="1"><nlm:affiliation>Microbiology Department, Hospital Universitari i Politècnic La Fe, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Microbiology Department, Hospital Universitari i Politècnic La Fe</wicri:regionArea>
<wicri:noRegion>Hospital Universitari i Politècnic La Fe</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, School of Medicine, University of Valencia, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Medicine, School of Medicine, University of Valencia</wicri:regionArea>
<wicri:noRegion>University of Valencia</wicri:noRegion>
</affiliation>
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<author><name sortKey="Sanz, Jaime" sort="Sanz, Jaime" uniqKey="Sanz J" first="Jaime" last="Sanz">Jaime Sanz</name>
<affiliation wicri:level="1"><nlm:affiliation>Hematology Department, Hospital Universitari i Politècnic La Fe, Valencia, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Hematology Department, Hospital Universitari i Politècnic La Fe, Valencia</wicri:regionArea>
<wicri:noRegion>Valencia</wicri:noRegion>
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<affiliation wicri:level="3"><nlm:affiliation>CIBERONC, Instituto Carlos III, Madrid, Spain.</nlm:affiliation>
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<region nuts="2" type="region">Communauté de Madrid</region>
</placeName>
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<author><name sortKey="Navarro, David" sort="Navarro, David" uniqKey="Navarro D" first="David" last="Navarro">David Navarro</name>
<affiliation wicri:level="1"><nlm:affiliation>Microbiology Department, Hospital Clínico Universitario, Institute for Research INCLIVA, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Microbiology Department, Hospital Clínico Universitario, Institute for Research INCLIVA</wicri:regionArea>
<wicri:noRegion>Institute for Research INCLIVA</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology, School of Medicine, University of Valencia, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Microbiology, School of Medicine, University of Valencia</wicri:regionArea>
<wicri:noRegion>University of Valencia</wicri:noRegion>
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<series><title level="j">Clinical infectious diseases : an official publication of the Infectious Diseases Society of America</title>
<idno type="eISSN">1537-6591</idno>
<imprint><date when="2019" type="published">2019</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent (MeSH)</term>
<term>Adult (MeSH)</term>
<term>Aged (MeSH)</term>
<term>Cross-Sectional Studies (MeSH)</term>
<term>Female (MeSH)</term>
<term>Hematopoietic Stem Cell Transplantation (MeSH)</term>
<term>Hospitalization (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Immunocompromised Host (MeSH)</term>
<term>Influenza Vaccines (administration & dosage)</term>
<term>Influenza Vaccines (immunology)</term>
<term>Influenza, Human (prevention & control)</term>
<term>Male (MeSH)</term>
<term>Middle Aged (MeSH)</term>
<term>Odds Ratio (MeSH)</term>
<term>Prospective Studies (MeSH)</term>
<term>Retrospective Studies (MeSH)</term>
<term>Risk Factors (MeSH)</term>
<term>Spain (MeSH)</term>
<term>Transplantation, Homologous (MeSH)</term>
<term>Treatment Outcome (MeSH)</term>
<term>Vaccination (statistics & numerical data)</term>
<term>Young Adult (MeSH)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent (MeSH)</term>
<term>Adulte (MeSH)</term>
<term>Adulte d'âge moyen (MeSH)</term>
<term>Espagne (MeSH)</term>
<term>Facteurs de risque (MeSH)</term>
<term>Femelle (MeSH)</term>
<term>Grippe humaine (prévention et contrôle)</term>
<term>Hospitalisation (MeSH)</term>
<term>Humains (MeSH)</term>
<term>Jeune adulte (MeSH)</term>
<term>Mâle (MeSH)</term>
<term>Odds ratio (MeSH)</term>
<term>Résultat thérapeutique (MeSH)</term>
<term>Sujet immunodéprimé (MeSH)</term>
<term>Sujet âgé (MeSH)</term>
<term>Transplantation de cellules souches hématopoïétiques (MeSH)</term>
<term>Transplantation homologue (MeSH)</term>
<term>Vaccination (statistiques et données numériques)</term>
<term>Vaccins antigrippaux (administration et posologie)</term>
<term>Vaccins antigrippaux (immunologie)</term>
<term>Études prospectives (MeSH)</term>
<term>Études rétrospectives (MeSH)</term>
<term>Études transversales (MeSH)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Influenza Vaccines</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Influenza Vaccines</term>
</keywords>
<keywords scheme="MESH" type="geographic" xml:lang="en"><term>Spain</term>
</keywords>
<keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Vaccins antigrippaux</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Vaccins antigrippaux</term>
</keywords>
<keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Influenza, Human</term>
</keywords>
<keywords scheme="MESH" qualifier="prévention et contrôle" xml:lang="fr"><term>Grippe humaine</term>
</keywords>
<keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Vaccination</term>
</keywords>
<keywords scheme="MESH" qualifier="statistiques et données numériques" xml:lang="fr"><term>Vaccination</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>Aged</term>
<term>Cross-Sectional Studies</term>
<term>Female</term>
<term>Hematopoietic Stem Cell Transplantation</term>
<term>Hospitalization</term>
<term>Humans</term>
<term>Immunocompromised Host</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Odds Ratio</term>
<term>Prospective Studies</term>
<term>Retrospective Studies</term>
<term>Risk Factors</term>
<term>Transplantation, Homologous</term>
<term>Treatment Outcome</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term>
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Espagne</term>
<term>Facteurs de risque</term>
<term>Femelle</term>
<term>Hospitalisation</term>
<term>Humains</term>
<term>Jeune adulte</term>
<term>Mâle</term>
<term>Odds ratio</term>
<term>Résultat thérapeutique</term>
<term>Sujet immunodéprimé</term>
<term>Sujet âgé</term>
<term>Transplantation de cellules souches hématopoïétiques</term>
<term>Transplantation homologue</term>
<term>Études prospectives</term>
<term>Études rétrospectives</term>
<term>Études transversales</term>
</keywords>
<keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Espagne</term>
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<front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b>
</p>
<p>Vaccination is the primary method for preventing influenza respiratory virus infection (RVI). Although the influenza vaccine is able to achieve serological responses in some allogeneic hematopoietic stem cell transplantation (allo-HSCT) recipients, its clinical benefits are still uncertain.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>METHODS</b>
</p>
<p>In this prospective, cross-sectional study, we retrospectively analyzed the effect of inactivated trivalent influenza vaccination on the prevalence of influenza RVI in a consecutive cohort of 136 allo-HSCT adult recipients who developed 161 RVI over 5 flu seasons (from 2013 to 2018). Respiratory viruses in upper- and/or lower-respiratory tract specimens were tested using multiplex polymerase chain reaction panel assays.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>RESULTS</b>
</p>
<p>Overall, we diagnosed 74 episodes (46%) of influenza RVI in 70 allo-HSCT recipients. Influenza RVI occurred in 51% of the non-vaccinated compared to 36% of the vaccinated recipients (P = .036). A multivariate analysis showed that influenza vaccination was associated with a lower prevalence of influenza RVI (odds ratio [OR] 0.39, P = .01). A multivariate risk factor analysis of lower-respiratory tract disease (LRTD) identified 2 conditions associated with the probability of influenza RVI progression: influenza vaccination (OR 0.12, 95% confidence interval [CI] 0.014-1, P = .05) and a high-risk immunodeficiency score (OR 36, 95% CI 2.26-575, P = .011). Influenza vaccination was also associated with a lower likelihood of an influenza-related hospital admission (14% vs 2%, P = .04).</p>
</div>
<div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b>
</p>
<p>This study shows that influenza vaccination may have a clinical benefit in allo-HSCT recipients with virologically-confirmed RVI, in terms of a lower influenza RVI prevalence, slower LRTD progression, and lower likelihood of hospital admission.</p>
</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">30239624</PMID>
<DateCompleted><Year>2020</Year>
<Month>08</Month>
<Day>04</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>08</Month>
<Day>04</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1537-6591</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>68</Volume>
<Issue>11</Issue>
<PubDate><Year>2019</Year>
<Month>05</Month>
<Day>17</Day>
</PubDate>
</JournalIssue>
<Title>Clinical infectious diseases : an official publication of the Infectious Diseases Society of America</Title>
<ISOAbbreviation>Clin. Infect. Dis.</ISOAbbreviation>
</Journal>
<ArticleTitle>Clinical Effectiveness of Influenza Vaccination After Allogeneic Hematopoietic Stem Cell Transplantation: A Cross-sectional, Prospective, Observational Study.</ArticleTitle>
<Pagination><MedlinePgn>1894-1903</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1093/cid/ciy792</ELocationID>
<Abstract><AbstractText Label="BACKGROUND">Vaccination is the primary method for preventing influenza respiratory virus infection (RVI). Although the influenza vaccine is able to achieve serological responses in some allogeneic hematopoietic stem cell transplantation (allo-HSCT) recipients, its clinical benefits are still uncertain.</AbstractText>
<AbstractText Label="METHODS">In this prospective, cross-sectional study, we retrospectively analyzed the effect of inactivated trivalent influenza vaccination on the prevalence of influenza RVI in a consecutive cohort of 136 allo-HSCT adult recipients who developed 161 RVI over 5 flu seasons (from 2013 to 2018). Respiratory viruses in upper- and/or lower-respiratory tract specimens were tested using multiplex polymerase chain reaction panel assays.</AbstractText>
<AbstractText Label="RESULTS">Overall, we diagnosed 74 episodes (46%) of influenza RVI in 70 allo-HSCT recipients. Influenza RVI occurred in 51% of the non-vaccinated compared to 36% of the vaccinated recipients (P = .036). A multivariate analysis showed that influenza vaccination was associated with a lower prevalence of influenza RVI (odds ratio [OR] 0.39, P = .01). A multivariate risk factor analysis of lower-respiratory tract disease (LRTD) identified 2 conditions associated with the probability of influenza RVI progression: influenza vaccination (OR 0.12, 95% confidence interval [CI] 0.014-1, P = .05) and a high-risk immunodeficiency score (OR 36, 95% CI 2.26-575, P = .011). Influenza vaccination was also associated with a lower likelihood of an influenza-related hospital admission (14% vs 2%, P = .04).</AbstractText>
<AbstractText Label="CONCLUSIONS">This study shows that influenza vaccination may have a clinical benefit in allo-HSCT recipients with virologically-confirmed RVI, in terms of a lower influenza RVI prevalence, slower LRTD progression, and lower likelihood of hospital admission.</AbstractText>
<CopyrightInformation>© The Author(s) 2018. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Piñana</LastName>
<ForeName>José Luis</ForeName>
<Initials>JL</Initials>
<AffiliationInfo><Affiliation>Hematology Department, Hospital Universitari i Politècnic La Fe, Valencia, Spain.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>CIBERONC, Instituto Carlos III, Madrid, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Pérez</LastName>
<ForeName>Ariadna</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Hematology Department, Institute for Research INCLIVA, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Montoro</LastName>
<ForeName>Juan</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Hematology Department, Hospital Universitari i Politècnic La Fe, Valencia, Spain.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>CIBERONC, Instituto Carlos III, Madrid, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Giménez</LastName>
<ForeName>Estela</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>Microbiology Department, Hospital Clínico Universitario, Institute for Research INCLIVA, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Gómez</LastName>
<ForeName>María Dolores</ForeName>
<Initials>MD</Initials>
<AffiliationInfo><Affiliation>Microbiology Department, Hospital Universitari i Politècnic La Fe, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lorenzo</LastName>
<ForeName>Ignacio</ForeName>
<Initials>I</Initials>
<AffiliationInfo><Affiliation>Hematology Department, Hospital Universitari i Politècnic La Fe, Valencia, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Madrid</LastName>
<ForeName>Silvia</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Microbiology Department, Hospital Clínico Universitario, Institute for Research INCLIVA, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>González</LastName>
<ForeName>Eva María</ForeName>
<Initials>EM</Initials>
<AffiliationInfo><Affiliation>Microbiology Department, Hospital Universitari i Politècnic La Fe, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Vinuesa</LastName>
<ForeName>Víctor</ForeName>
<Initials>V</Initials>
<AffiliationInfo><Affiliation>Microbiology Department, Hospital Clínico Universitario, Institute for Research INCLIVA, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hernández-Boluda</LastName>
<ForeName>Juan Carlos</ForeName>
<Initials>JC</Initials>
<AffiliationInfo><Affiliation>Microbiology Department, Hospital Universitari i Politècnic La Fe, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Salavert</LastName>
<ForeName>Miguel</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Department of Infectious Diseases, Hospital Universitari i Politècnic La Fe, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Sanz</LastName>
<ForeName>Guillermo</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>Hematology Department, Hospital Universitari i Politècnic La Fe, Valencia, Spain.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>CIBERONC, Instituto Carlos III, Madrid, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Solano</LastName>
<ForeName>Carlos</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Microbiology Department, Hospital Universitari i Politècnic La Fe, Spain.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Medicine, School of Medicine, University of Valencia, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Sanz</LastName>
<ForeName>Jaime</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Hematology Department, Hospital Universitari i Politècnic La Fe, Valencia, Spain.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>CIBERONC, Instituto Carlos III, Madrid, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Navarro</LastName>
<ForeName>David</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>Microbiology Department, Hospital Clínico Universitario, Institute for Research INCLIVA, Spain.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Microbiology, School of Medicine, University of Valencia, Spain.</Affiliation>
</AffiliationInfo>
</Author>
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<Keyword MajorTopicYN="Y">community-acquired respiratory virus</Keyword>
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<Keyword MajorTopicYN="Y">influenza virus</Keyword>
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<ReferenceList><Reference><Citation>Transpl Infect Dis. 2013 Jun;15(3):219-32</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23363310</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Am J Med. 1997 Mar 17;102(3A):27-30; discussion 42-3</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10868139</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Bone Marrow Transplant. 2005 Nov;36(10):897-900</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16170332</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Clin Infect Dis. 2000 Feb;30(2):342-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10671339</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Clin Infect Dis. 2014 Feb;58(3):e44-100</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24311479</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Acta Haematol. 1994;91(3):115-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8091931</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Transpl Infect Dis. 2013 Dec;15(6):634-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23890163</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Haematologica. 2011 Feb;96(2):307-14</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20971824</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Am J Med. 1997 Mar 17;102(3A):44-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10868142</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Transplantation. 2008 Jul 27;86(2):257-63</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18645488</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Transpl Infect Dis. 2015 Jun;17(3):371-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25817044</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Transpl Infect Dis. 2014 Dec;16(6):878-86</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25405922</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Haematologica. 2011 Aug;96(8):1231-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21546495</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Diagn Microbiol Infect Dis. 2015 May;82(1):40-3</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25724853</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Bone Marrow Transplant. 2001 Sep;28(5):479-84</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11593321</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Transpl Infect Dis. 2009 Apr;11(2):100-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19175540</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biol Blood Marrow Transplant. 2001;7 Suppl:8S-10S</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11777103</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Clin Infect Dis. 2014 May;58(10):1357-68</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24599766</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Clin Infect Dis. 2013 Jan;56(2):258-66</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23024295</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biol Blood Marrow Transplant. 2018 Mar;24(3):563-570</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29155041</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Bone Marrow Transplant. 2009 Oct;44(8):521-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19861986</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Blood. 2011 May 12;117(19):5050-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21372154</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Bone Marrow Transplant. 2008 Apr;41(8):743-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18176614</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Transplantation. 1974 Oct;18(4):295-304</Citation>
<ArticleIdList><ArticleId IdType="pubmed">4153799</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Clin Infect Dis. 2018 May 17;66(11):1698-1704</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29253089</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Blood. 2014 May 22;123(21):3263-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24700783</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biol Blood Marrow Transplant. 2016 Mar;22(3):542-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26638804</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Vaccine. 2011 Apr 5;29(16):2825-33</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21345379</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Open Forum Infect Dis. 2018 Apr 12;5(5):ofy077</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29780847</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Bone Marrow Transplant. 1993 Jan;11(1):1-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8431706</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
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<affiliations><list><country><li>Espagne</li>
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<name sortKey="Lorenzo, Ignacio" sort="Lorenzo, Ignacio" uniqKey="Lorenzo I" first="Ignacio" last="Lorenzo">Ignacio Lorenzo</name>
<name sortKey="Madrid, Silvia" sort="Madrid, Silvia" uniqKey="Madrid S" first="Silvia" last="Madrid">Silvia Madrid</name>
<name sortKey="Montoro, Juan" sort="Montoro, Juan" uniqKey="Montoro J" first="Juan" last="Montoro">Juan Montoro</name>
<name sortKey="Montoro, Juan" sort="Montoro, Juan" uniqKey="Montoro J" first="Juan" last="Montoro">Juan Montoro</name>
<name sortKey="Navarro, David" sort="Navarro, David" uniqKey="Navarro D" first="David" last="Navarro">David Navarro</name>
<name sortKey="Navarro, David" sort="Navarro, David" uniqKey="Navarro D" first="David" last="Navarro">David Navarro</name>
<name sortKey="Perez, Ariadna" sort="Perez, Ariadna" uniqKey="Perez A" first="Ariadna" last="Pérez">Ariadna Pérez</name>
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<name sortKey="Salavert, Miguel" sort="Salavert, Miguel" uniqKey="Salavert M" first="Miguel" last="Salavert">Miguel Salavert</name>
<name sortKey="Sanz, Guillermo" sort="Sanz, Guillermo" uniqKey="Sanz G" first="Guillermo" last="Sanz">Guillermo Sanz</name>
<name sortKey="Sanz, Guillermo" sort="Sanz, Guillermo" uniqKey="Sanz G" first="Guillermo" last="Sanz">Guillermo Sanz</name>
<name sortKey="Sanz, Jaime" sort="Sanz, Jaime" uniqKey="Sanz J" first="Jaime" last="Sanz">Jaime Sanz</name>
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<name sortKey="Solano, Carlos" sort="Solano, Carlos" uniqKey="Solano C" first="Carlos" last="Solano">Carlos Solano</name>
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<name sortKey="Vinuesa, Victor" sort="Vinuesa, Victor" uniqKey="Vinuesa V" first="Víctor" last="Vinuesa">Víctor Vinuesa</name>
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   |texte=   Clinical Effectiveness of Influenza Vaccination After Allogeneic Hematopoietic Stem Cell Transplantation: A Cross-sectional, Prospective, Observational Study.
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Clinical Effectiveness of Influenza Vaccination After Allogeneic Hematopoietic Stem Cell Transplantation: A Cross-sectional, Prospective, Observational Study.

Clinical Effectiveness of Influenza Vaccination After Allogeneic Hematopoietic Stem Cell Transplantation: A Cross-sectional, Prospective, Observational Study.

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