GrippeEspagneV1, Main, Exploration, bibRecord, 000016

The role of respiratory viruses in children with humoral immunodeficiency on immunoglobulin replacement therapy.

Identifieur interne : 000016 ( Main/Exploration ); précédent : 000015; suivant : 000017

The role of respiratory viruses in children with humoral immunodeficiency on immunoglobulin replacement therapy.

Auteurs : Marta Benavides-Nieto [Espagne] ; Ana Méndez-Echevarría [Espagne] ; Teresa Del Rosal [Espagne] ; María Luz García-García [Espagne] ; Inmaculada Casas [Espagne] ; Francisco Pozo [Espagne] ; Olga De La Serna [Espagne] ; Eduardo Lopez-Granados [Espagne] ; Rebeca Rodriguez-Pena [Espagne] ; Cristina Calvo [Espagne, Italie]

Source :

Pediatric pulmonology [ 1099-0496 ] ; 2019.

RBID : pubmed:30575324

Descripteurs français

KwdFr :
- Adolescent (MeSH), Déficits immunitaires (physiopathologie), Déficits immunitaires (traitement médicamenteux), Déficits immunitaires (épidémiologie), Enfant (MeSH), Enfant d'âge préscolaire (MeSH), Espagne (épidémiologie), Femelle (MeSH), Humains (MeSH), Immunoglobulines (usage thérapeutique), Infections de l'appareil respiratoire (physiopathologie), Infections de l'appareil respiratoire (traitement médicamenteux), Infections de l'appareil respiratoire (épidémiologie), Maladies virales (physiopathologie), Maladies virales (traitement médicamenteux), Maladies virales (épidémiologie), Mâle (MeSH), Tests de la fonction respiratoire (MeSH), Études cas-témoins (MeSH).
MESH :
- physiopathologie : Déficits immunitaires, Infections de l'appareil respiratoire, Maladies virales.
- traitement médicamenteux : Déficits immunitaires, Infections de l'appareil respiratoire, Maladies virales.
- usage thérapeutique : Immunoglobulines.
- épidémiologie : Déficits immunitaires, Espagne, Infections de l'appareil respiratoire, Maladies virales.
- Adolescent, Enfant, Enfant d'âge préscolaire, Femelle, Humains, Mâle, Tests de la fonction respiratoire, Études cas-témoins.
Wicri :
- geographic : Espagne.

English descriptors

KwdEn :
- Adolescent (MeSH), Case-Control Studies (MeSH), Child (MeSH), Child, Preschool (MeSH), Female (MeSH), Humans (MeSH), Immunoglobulins (therapeutic use), Immunologic Deficiency Syndromes (drug therapy), Immunologic Deficiency Syndromes (epidemiology), Immunologic Deficiency Syndromes (physiopathology), Male (MeSH), Respiratory Function Tests (MeSH), Respiratory Tract Infections (drug therapy), Respiratory Tract Infections (epidemiology), Respiratory Tract Infections (physiopathology), Spain (epidemiology), Virus Diseases (drug therapy), Virus Diseases (epidemiology), Virus Diseases (physiopathology).
MESH :
- chemical , therapeutic use : Immunoglobulins.
- geographic , epidemiology : Spain.
- drug therapy : Immunologic Deficiency Syndromes, Respiratory Tract Infections, Virus Diseases.
- epidemiology : Immunologic Deficiency Syndromes, Respiratory Tract Infections, Virus Diseases.
- physiopathology : Immunologic Deficiency Syndromes, Respiratory Tract Infections, Virus Diseases.
- Adolescent, Case-Control Studies, Child, Child, Preschool, Female, Humans, Male, Respiratory Function Tests.

Abstract

BACKGROUND

The role of viruses in children with respiratory tract infections and humoral immunodeficiencies has hardly been studied. We have evaluated these infections in children with humoral immunodeficiencies who required immunoglobulin replacement therapy, considering their relationship with symptoms, lung function, bacterial co-infection, and outcomes.

METHODS

We conducted a prospective case-control study during a 1-year period, including children with humoral immunodeficiencies receiving immunoglobulin replacement therapy. For each patient, at least one healthy family member was included. Respiratory samples for viral detection were taken every 1-3 months, and in case of respiratory tract infections. Symptoms questionnaires were filled biweekly. Spirometry and sputum culture were performed in every episode.

RESULTS

Sixty-six episodes were analyzed in 14 patients (median age 12 years; IQR 7-17), identifying 18 respiratory viruses (27.3%), being rhinovirus the most frequently isolated one (12/18; 66%). Positive viral episodes were associated with clinical symptoms (89% vs 43%), more frequent antibiotic treatment (44% vs 15%) or hospital admission (22% vs 0%) than negative ones. Patients with positive viral detection showed impaired lung function, with lower FEV1 and FVC values.

CONCLUSIONS

In our experience, viral respiratory tract infections can cause significant respiratory symptoms and impaired lung function, in children with HID, despite immunoglobulin replacement therapy. These patients could benefit from the monitoring of viral infections, as these may be a gateway for ongoing lung damage.

DOI: 10.1002/ppul.24214
PubMed: 30575324
PubMed Central: PMC7167964

Affiliations:

Links toward previous steps (curation, corpus...)

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Le document en format XML

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<author><name sortKey="Mendez Echevarria, Ana" sort="Mendez Echevarria, Ana" uniqKey="Mendez Echevarria A" first="Ana" last="Méndez-Echevarría">Ana Méndez-Echevarría</name>
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<author><name sortKey="Del Rosal, Teresa" sort="Del Rosal, Teresa" uniqKey="Del Rosal T" first="Teresa" last="Del Rosal">Teresa Del Rosal</name>
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<author><name sortKey="Garcia Garcia, Maria Luz" sort="Garcia Garcia, Maria Luz" uniqKey="Garcia Garcia M" first="María Luz" last="García-García">María Luz García-García</name>
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<author><name sortKey="Casas, Inmaculada" sort="Casas, Inmaculada" uniqKey="Casas I" first="Inmaculada" last="Casas">Inmaculada Casas</name>
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<author><name sortKey="Pozo, Francisco" sort="Pozo, Francisco" uniqKey="Pozo F" first="Francisco" last="Pozo">Francisco Pozo</name>
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<author><name sortKey="De La Serna, Olga" sort="De La Serna, Olga" uniqKey="De La Serna O" first="Olga" last="De La Serna">Olga De La Serna</name>
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<author><name sortKey="Lopez Granados, Eduardo" sort="Lopez Granados, Eduardo" uniqKey="Lopez Granados E" first="Eduardo" last="Lopez-Granados">Eduardo Lopez-Granados</name>
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<author><name sortKey="Rodriguez Pena, Rebeca" sort="Rodriguez Pena, Rebeca" uniqKey="Rodriguez Pena R" first="Rebeca" last="Rodriguez-Pena">Rebeca Rodriguez-Pena</name>
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<author><name sortKey="Calvo, Cristina" sort="Calvo, Cristina" uniqKey="Calvo C" first="Cristina" last="Calvo">Cristina Calvo</name>
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<wicri:regionArea>Pediatric Infectious Diseases Department, Hospital Universitario La Paz, Madrid, Fundación IdiPaz, Madrid</wicri:regionArea>
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<country xml:lang="fr">Espagne</country>
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<placeName><settlement type="city">Madrid</settlement>
<region nuts="2" type="region">Communauté de Madrid</region>
</placeName>
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<affiliation wicri:level="1"><nlm:affiliation>TEDDY Network (European Network of Excellence for Pediatric Clinical Research), Pavia, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>TEDDY Network (European Network of Excellence for Pediatric Clinical Research), Pavia</wicri:regionArea>
<wicri:noRegion>Pavia</wicri:noRegion>
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<series><title level="j">Pediatric pulmonology</title>
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<imprint><date when="2019" type="published">2019</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent (MeSH)</term>
<term>Case-Control Studies (MeSH)</term>
<term>Child (MeSH)</term>
<term>Child, Preschool (MeSH)</term>
<term>Female (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Immunoglobulins (therapeutic use)</term>
<term>Immunologic Deficiency Syndromes (drug therapy)</term>
<term>Immunologic Deficiency Syndromes (epidemiology)</term>
<term>Immunologic Deficiency Syndromes (physiopathology)</term>
<term>Male (MeSH)</term>
<term>Respiratory Function Tests (MeSH)</term>
<term>Respiratory Tract Infections (drug therapy)</term>
<term>Respiratory Tract Infections (epidemiology)</term>
<term>Respiratory Tract Infections (physiopathology)</term>
<term>Spain (epidemiology)</term>
<term>Virus Diseases (drug therapy)</term>
<term>Virus Diseases (epidemiology)</term>
<term>Virus Diseases (physiopathology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent (MeSH)</term>
<term>Déficits immunitaires (physiopathologie)</term>
<term>Déficits immunitaires (traitement médicamenteux)</term>
<term>Déficits immunitaires (épidémiologie)</term>
<term>Enfant (MeSH)</term>
<term>Enfant d'âge préscolaire (MeSH)</term>
<term>Espagne (épidémiologie)</term>
<term>Femelle (MeSH)</term>
<term>Humains (MeSH)</term>
<term>Immunoglobulines (usage thérapeutique)</term>
<term>Infections de l'appareil respiratoire (physiopathologie)</term>
<term>Infections de l'appareil respiratoire (traitement médicamenteux)</term>
<term>Infections de l'appareil respiratoire (épidémiologie)</term>
<term>Maladies virales (physiopathologie)</term>
<term>Maladies virales (traitement médicamenteux)</term>
<term>Maladies virales (épidémiologie)</term>
<term>Mâle (MeSH)</term>
<term>Tests de la fonction respiratoire (MeSH)</term>
<term>Études cas-témoins (MeSH)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Immunoglobulins</term>
</keywords>
<keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Spain</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Immunologic Deficiency Syndromes</term>
<term>Respiratory Tract Infections</term>
<term>Virus Diseases</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Immunologic Deficiency Syndromes</term>
<term>Respiratory Tract Infections</term>
<term>Virus Diseases</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Déficits immunitaires</term>
<term>Infections de l'appareil respiratoire</term>
<term>Maladies virales</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Immunologic Deficiency Syndromes</term>
<term>Respiratory Tract Infections</term>
<term>Virus Diseases</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Déficits immunitaires</term>
<term>Infections de l'appareil respiratoire</term>
<term>Maladies virales</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Immunoglobulines</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Déficits immunitaires</term>
<term>Espagne</term>
<term>Infections de l'appareil respiratoire</term>
<term>Maladies virales</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adolescent</term>
<term>Case-Control Studies</term>
<term>Child</term>
<term>Child, Preschool</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Respiratory Function Tests</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term>
<term>Enfant</term>
<term>Enfant d'âge préscolaire</term>
<term>Femelle</term>
<term>Humains</term>
<term>Mâle</term>
<term>Tests de la fonction respiratoire</term>
<term>Études cas-témoins</term>
</keywords>
<keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Espagne</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b>
</p>
<p>The role of viruses in children with respiratory tract infections and humoral immunodeficiencies has hardly been studied. We have evaluated these infections in children with humoral immunodeficiencies who required immunoglobulin replacement therapy, considering their relationship with symptoms, lung function, bacterial co-infection, and outcomes.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>METHODS</b>
</p>
<p>We conducted a prospective case-control study during a 1-year period, including children with humoral immunodeficiencies receiving immunoglobulin replacement therapy. For each patient, at least one healthy family member was included. Respiratory samples for viral detection were taken every 1-3 months, and in case of respiratory tract infections. Symptoms questionnaires were filled biweekly. Spirometry and sputum culture were performed in every episode.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>RESULTS</b>
</p>
<p>Sixty-six episodes were analyzed in 14 patients (median age 12 years; IQR 7-17), identifying 18 respiratory viruses (27.3%), being rhinovirus the most frequently isolated one (12/18; 66%). Positive viral episodes were associated with clinical symptoms (89% vs 43%), more frequent antibiotic treatment (44% vs 15%) or hospital admission (22% vs 0%) than negative ones. Patients with positive viral detection showed impaired lung function, with lower FEV1 and FVC values.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b>
</p>
<p>In our experience, viral respiratory tract infections can cause significant respiratory symptoms and impaired lung function, in children with HID, despite immunoglobulin replacement therapy. These patients could benefit from the monitoring of viral infections, as these may be a gateway for ongoing lung damage.</p>
</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" IndexingMethod="Curated" Owner="NLM"><PMID Version="1">30575324</PMID>
<DateCompleted><Year>2020</Year>
<Month>01</Month>
<Day>28</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>04</Month>
<Day>22</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1099-0496</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>54</Volume>
<Issue>2</Issue>
<PubDate><Year>2019</Year>
<Month>02</Month>
</PubDate>
</JournalIssue>
<Title>Pediatric pulmonology</Title>
<ISOAbbreviation>Pediatr. Pulmonol.</ISOAbbreviation>
</Journal>
<ArticleTitle>The role of respiratory viruses in children with humoral immunodeficiency on immunoglobulin replacement therapy.</ArticleTitle>
<Pagination><MedlinePgn>194-199</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1002/ppul.24214</ELocationID>
<Abstract><AbstractText Label="BACKGROUND">The role of viruses in children with respiratory tract infections and humoral immunodeficiencies has hardly been studied. We have evaluated these infections in children with humoral immunodeficiencies who required immunoglobulin replacement therapy, considering their relationship with symptoms, lung function, bacterial co-infection, and outcomes.</AbstractText>
<AbstractText Label="METHODS">We conducted a prospective case-control study during a 1-year period, including children with humoral immunodeficiencies receiving immunoglobulin replacement therapy. For each patient, at least one healthy family member was included. Respiratory samples for viral detection were taken every 1-3 months, and in case of respiratory tract infections. Symptoms questionnaires were filled biweekly. Spirometry and sputum culture were performed in every episode.</AbstractText>
<AbstractText Label="RESULTS">Sixty-six episodes were analyzed in 14 patients (median age 12 years; IQR 7-17), identifying 18 respiratory viruses (27.3%), being rhinovirus the most frequently isolated one (12/18; 66%). Positive viral episodes were associated with clinical symptoms (89% vs 43%), more frequent antibiotic treatment (44% vs 15%) or hospital admission (22% vs 0%) than negative ones. Patients with positive viral detection showed impaired lung function, with lower FEV1 and FVC values.</AbstractText>
<AbstractText Label="CONCLUSIONS">In our experience, viral respiratory tract infections can cause significant respiratory symptoms and impaired lung function, in children with HID, despite immunoglobulin replacement therapy. These patients could benefit from the monitoring of viral infections, as these may be a gateway for ongoing lung damage.</AbstractText>
<CopyrightInformation>© 2018 Wiley Periodicals, Inc.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Benavides-Nieto</LastName>
<ForeName>Marta</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Pediatric Infectious Diseases Department, Hospital Universitario La Paz, Madrid, Fundación IdiPaz, Madrid, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Méndez-Echevarría</LastName>
<ForeName>Ana</ForeName>
<Initials>A</Initials>
<Identifier Source="ORCID">0000-0002-7455-9080</Identifier>
<AffiliationInfo><Affiliation>Pediatric Infectious Diseases Department, Hospital Universitario La Paz, Madrid, Fundación IdiPaz, Madrid, Spain.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Translational Research Network in Pediatric Infectious Diseases (RITIP), Madrid, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Del Rosal</LastName>
<ForeName>Teresa</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Pediatric Infectious Diseases Department, Hospital Universitario La Paz, Madrid, Fundación IdiPaz, Madrid, Spain.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Translational Research Network in Pediatric Infectious Diseases (RITIP), Madrid, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>García-García</LastName>
<ForeName>María Luz</ForeName>
<Initials>ML</Initials>
<Identifier Source="ORCID">0000-0003-4906-4227</Identifier>
<AffiliationInfo><Affiliation>Translational Research Network in Pediatric Infectious Diseases (RITIP), Madrid, Spain.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Pediatrics and Pneumology Department, Severo Ochoa Hospital, Leganés, Madrid, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Casas</LastName>
<ForeName>Inmaculada</ForeName>
<Initials>I</Initials>
<AffiliationInfo><Affiliation>Translational Research Network in Pediatric Infectious Diseases (RITIP), Madrid, Spain.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Respiratory Virus and Influenza Unit, CNM, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Pozo</LastName>
<ForeName>Francisco</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>Translational Research Network in Pediatric Infectious Diseases (RITIP), Madrid, Spain.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Respiratory Virus and Influenza Unit, CNM, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>de la Serna</LastName>
<ForeName>Olga</ForeName>
<Initials>O</Initials>
<AffiliationInfo><Affiliation>Paediatric Pneumology Department, Hospital La Paz, Madrid, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lopez-Granados</LastName>
<ForeName>Eduardo</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>Immunology Department, Hospital Universitario La Paz, Fundación IdiPaz, Madrid, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Rodriguez-Pena</LastName>
<ForeName>Rebeca</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Immunology Department, Hospital Universitario La Paz, Fundación IdiPaz, Madrid, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Calvo</LastName>
<ForeName>Cristina</ForeName>
<Initials>C</Initials>
<Identifier Source="ORCID">0000-0002-6503-3423</Identifier>
<AffiliationInfo><Affiliation>Pediatric Infectious Diseases Department, Hospital Universitario La Paz, Madrid, Fundación IdiPaz, Madrid, Spain.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Translational Research Network in Pediatric Infectious Diseases (RITIP), Madrid, Spain.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>TEDDY Network (European Network of Excellence for Pediatric Clinical Research), Pavia, Italy.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2018</Year>
<Month>12</Month>
<Day>21</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Pediatr Pulmonol</MedlineTA>
<NlmUniqueID>8510590</NlmUniqueID>
<ISSNLinking>1099-0496</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D007136">Immunoglobulins</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016022" MajorTopicYN="N">Case-Control Studies</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002648" MajorTopicYN="N">Child</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002675" MajorTopicYN="N">Child, Preschool</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007136" MajorTopicYN="N">Immunoglobulins</DescriptorName>
<QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007153" MajorTopicYN="Y">Immunologic Deficiency Syndromes</DescriptorName>
<QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
<QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012129" MajorTopicYN="N">Respiratory Function Tests</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012141" MajorTopicYN="Y">Respiratory Tract Infections</DescriptorName>
<QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
<QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013030" MajorTopicYN="N" Type="Geographic">Spain</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014777" MajorTopicYN="Y">Virus Diseases</DescriptorName>
<QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
<QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">humoral immunodeficiency</Keyword>
<Keyword MajorTopicYN="Y">immunoglobulin replacement therapy</Keyword>
<Keyword MajorTopicYN="Y">lung function</Keyword>
<Keyword MajorTopicYN="Y">respiratory tract infection</Keyword>
<Keyword MajorTopicYN="Y">virus</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2018</Year>
<Month>07</Month>
<Day>02</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2018</Year>
<Month>11</Month>
<Day>14</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2018</Year>
<Month>12</Month>
<Day>24</Day>
<Hour>6</Hour>
<Minute>0</Minute>
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<PubMedPubDate PubStatus="medline"><Year>2020</Year>
<Month>1</Month>
<Day>29</Day>
<Hour>6</Hour>
<Minute>0</Minute>
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<PubMedPubDate PubStatus="entrez"><Year>2018</Year>
<Month>12</Month>
<Day>22</Day>
<Hour>6</Hour>
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<affiliations><list><country><li>Espagne</li>
<li>Italie</li>
</country>
<region><li>Communauté de Madrid</li>
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<settlement><li>Madrid</li>
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<tree><country name="Espagne"><region name="Communauté de Madrid"><name sortKey="Benavides Nieto, Marta" sort="Benavides Nieto, Marta" uniqKey="Benavides Nieto M" first="Marta" last="Benavides-Nieto">Marta Benavides-Nieto</name>
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<name sortKey="Calvo, Cristina" sort="Calvo, Cristina" uniqKey="Calvo C" first="Cristina" last="Calvo">Cristina Calvo</name>
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<name sortKey="Casas, Inmaculada" sort="Casas, Inmaculada" uniqKey="Casas I" first="Inmaculada" last="Casas">Inmaculada Casas</name>
<name sortKey="Casas, Inmaculada" sort="Casas, Inmaculada" uniqKey="Casas I" first="Inmaculada" last="Casas">Inmaculada Casas</name>
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<name sortKey="Del Rosal, Teresa" sort="Del Rosal, Teresa" uniqKey="Del Rosal T" first="Teresa" last="Del Rosal">Teresa Del Rosal</name>
<name sortKey="Garcia Garcia, Maria Luz" sort="Garcia Garcia, Maria Luz" uniqKey="Garcia Garcia M" first="María Luz" last="García-García">María Luz García-García</name>
<name sortKey="Garcia Garcia, Maria Luz" sort="Garcia Garcia, Maria Luz" uniqKey="Garcia Garcia M" first="María Luz" last="García-García">María Luz García-García</name>
<name sortKey="Lopez Granados, Eduardo" sort="Lopez Granados, Eduardo" uniqKey="Lopez Granados E" first="Eduardo" last="Lopez-Granados">Eduardo Lopez-Granados</name>
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<name sortKey="Mendez Echevarria, Ana" sort="Mendez Echevarria, Ana" uniqKey="Mendez Echevarria A" first="Ana" last="Méndez-Echevarría">Ana Méndez-Echevarría</name>
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<name sortKey="Pozo, Francisco" sort="Pozo, Francisco" uniqKey="Pozo F" first="Francisco" last="Pozo">Francisco Pozo</name>
<name sortKey="Rodriguez Pena, Rebeca" sort="Rodriguez Pena, Rebeca" uniqKey="Rodriguez Pena R" first="Rebeca" last="Rodriguez-Pena">Rebeca Rodriguez-Pena</name>
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<country name="Italie"><noRegion><name sortKey="Calvo, Cristina" sort="Calvo, Cristina" uniqKey="Calvo C" first="Cristina" last="Calvo">Cristina Calvo</name>
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</record>

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EXPLOR_STEP=$WICRI_ROOT/Sante/explor/GrippeEspagneV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000016 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000016 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    GrippeEspagneV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     pubmed:30575324
   |texte=   The role of respiratory viruses in children with humoral immunodeficiency on immunoglobulin replacement therapy.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:30575324" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a GrippeEspagneV1

This area was generated with Dilib version V0.6.37.
Data generation: Fri Sep 25 11:01:38 2020. Site generation: Sat Feb 13 17:38:04 2021

	Serveur d'exploration sur la grippe en Espagne
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur la grippe en Espagne

The role of respiratory viruses in children with humoral immunodeficiency on immunoglobulin replacement therapy.

The role of respiratory viruses in children with humoral immunodeficiency on immunoglobulin replacement therapy.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki