Influenza A H1N1/2009 infection in pediatric solid organ transplant recipients.
Identifieur interne : 000278 ( Main/Corpus ); précédent : 000277; suivant : 000279Influenza A H1N1/2009 infection in pediatric solid organ transplant recipients.
Auteurs : J. Gavaldà ; E. Cabral ; E. Alonso ; P. Perez-Romero ; A. Pérez ; J. Quintero ; M. Campins ; R. Vilalta ; A. Alonso ; O. Len ; M. Navarro ; J. Nieto ; P. Jara ; R. Charco ; A. Pahissa ; E. CorderoSource :
- Transplant infectious disease : an official journal of the Transplantation Society [ 1399-3062 ] ; 2012.
English descriptors
- KwdEn :
- Adolescent (MeSH), Antiviral Agents (therapeutic use), Child (MeSH), Female (MeSH), Humans (MeSH), Immunocompromised Host (MeSH), Influenza A Virus, H1N1 Subtype (MeSH), Influenza, Human (epidemiology), Influenza, Human (prevention & control), Influenza, Human (virology), Kidney Transplantation (adverse effects), Liver Transplantation (adverse effects), Male (MeSH), Pandemics (MeSH), Pneumonia (etiology), Retrospective Studies (MeSH), Spain (epidemiology).
- MESH :
- chemical , therapeutic use : Antiviral Agents.
- geographic , epidemiology : Spain.
- adverse effects : Kidney Transplantation, Liver Transplantation.
- epidemiology : Influenza, Human.
- etiology : Pneumonia.
- prevention & control : Influenza, Human.
- virology : Influenza, Human.
- Adolescent, Child, Female, Humans, Immunocompromised Host, Influenza A Virus, H1N1 Subtype, Male, Pandemics, Retrospective Studies.
Abstract
AIM AND METHOD
The aim of this study was to describe the clinical characteristics and outcome of pandemic influenza A H1N1/2009 (pH1N1) infection, in a retrospective cohort of pediatric patients with kidney and/or liver transplant and confirmed pH1N1 infection from June to December 2009, diagnosed in 2 Spanish teaching hospitals.
RESULTS
Forty-nine patients were included. Pneumonia was diagnosed in 4 patients (8.2%), and 3 of them required respiratory support. There were no related deaths.
CONCLUSION
Antiviral treatment within 48 h was associated with a lower likelihood of pneumonia (0/38, 0%) than treatment started after 48 h (4/11, 36.3%) (P < 0.01).
DOI: 10.1111/tid.12005
PubMed: 22998763
Links to Exploration step
pubmed:22998763Le document en format XML
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<author><name sortKey="Gavalda, J" sort="Gavalda, J" uniqKey="Gavalda J" first="J" last="Gavaldà">J. Gavaldà</name>
<affiliation><nlm:affiliation>Department of Infectious Diseases, Hospital Universitari Vall d'Hebron, Barcelona, Spain; Spanish Network for Research in Infectious Diseases (REIPI), Spain. joan.gavalda@vhir.org</nlm:affiliation>
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<author><name sortKey="Cabral, E" sort="Cabral, E" uniqKey="Cabral E" first="E" last="Cabral">E. Cabral</name>
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<author><name sortKey="Alonso, E" sort="Alonso, E" uniqKey="Alonso E" first="E" last="Alonso">E. Alonso</name>
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<author><name sortKey="Perez Romero, P" sort="Perez Romero, P" uniqKey="Perez Romero P" first="P" last="Perez-Romero">P. Perez-Romero</name>
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<author><name sortKey="Perez, A" sort="Perez, A" uniqKey="Perez A" first="A" last="Pérez">A. Pérez</name>
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<author><name sortKey="Quintero, J" sort="Quintero, J" uniqKey="Quintero J" first="J" last="Quintero">J. Quintero</name>
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<author><name sortKey="Campins, M" sort="Campins, M" uniqKey="Campins M" first="M" last="Campins">M. Campins</name>
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<author><name sortKey="Vilalta, R" sort="Vilalta, R" uniqKey="Vilalta R" first="R" last="Vilalta">R. Vilalta</name>
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<author><name sortKey="Alonso, A" sort="Alonso, A" uniqKey="Alonso A" first="A" last="Alonso">A. Alonso</name>
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<author><name sortKey="Len, O" sort="Len, O" uniqKey="Len O" first="O" last="Len">O. Len</name>
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<author><name sortKey="Navarro, M" sort="Navarro, M" uniqKey="Navarro M" first="M" last="Navarro">M. Navarro</name>
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<author><name sortKey="Nieto, J" sort="Nieto, J" uniqKey="Nieto J" first="J" last="Nieto">J. Nieto</name>
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<author><name sortKey="Charco, R" sort="Charco, R" uniqKey="Charco R" first="R" last="Charco">R. Charco</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Influenza A H1N1/2009 infection in pediatric solid organ transplant recipients.</title>
<author><name sortKey="Gavalda, J" sort="Gavalda, J" uniqKey="Gavalda J" first="J" last="Gavaldà">J. Gavaldà</name>
<affiliation><nlm:affiliation>Department of Infectious Diseases, Hospital Universitari Vall d'Hebron, Barcelona, Spain; Spanish Network for Research in Infectious Diseases (REIPI), Spain. joan.gavalda@vhir.org</nlm:affiliation>
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<author><name sortKey="Cabral, E" sort="Cabral, E" uniqKey="Cabral E" first="E" last="Cabral">E. Cabral</name>
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<author><name sortKey="Alonso, E" sort="Alonso, E" uniqKey="Alonso E" first="E" last="Alonso">E. Alonso</name>
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<author><name sortKey="Perez Romero, P" sort="Perez Romero, P" uniqKey="Perez Romero P" first="P" last="Perez-Romero">P. Perez-Romero</name>
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<author><name sortKey="Perez, A" sort="Perez, A" uniqKey="Perez A" first="A" last="Pérez">A. Pérez</name>
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<author><name sortKey="Vilalta, R" sort="Vilalta, R" uniqKey="Vilalta R" first="R" last="Vilalta">R. Vilalta</name>
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<author><name sortKey="Len, O" sort="Len, O" uniqKey="Len O" first="O" last="Len">O. Len</name>
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<author><name sortKey="Navarro, M" sort="Navarro, M" uniqKey="Navarro M" first="M" last="Navarro">M. Navarro</name>
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<author><name sortKey="Nieto, J" sort="Nieto, J" uniqKey="Nieto J" first="J" last="Nieto">J. Nieto</name>
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<series><title level="j">Transplant infectious disease : an official journal of the Transplantation Society</title>
<idno type="eISSN">1399-3062</idno>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent (MeSH)</term>
<term>Antiviral Agents (therapeutic use)</term>
<term>Child (MeSH)</term>
<term>Female (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Immunocompromised Host (MeSH)</term>
<term>Influenza A Virus, H1N1 Subtype (MeSH)</term>
<term>Influenza, Human (epidemiology)</term>
<term>Influenza, Human (prevention & control)</term>
<term>Influenza, Human (virology)</term>
<term>Kidney Transplantation (adverse effects)</term>
<term>Liver Transplantation (adverse effects)</term>
<term>Male (MeSH)</term>
<term>Pandemics (MeSH)</term>
<term>Pneumonia (etiology)</term>
<term>Retrospective Studies (MeSH)</term>
<term>Spain (epidemiology)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiviral Agents</term>
</keywords>
<keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Spain</term>
</keywords>
<keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Kidney Transplantation</term>
<term>Liver Transplantation</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Influenza, Human</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Pneumonia</term>
</keywords>
<keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Influenza, Human</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Influenza, Human</term>
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<keywords scheme="MESH" xml:lang="en"><term>Adolescent</term>
<term>Child</term>
<term>Female</term>
<term>Humans</term>
<term>Immunocompromised Host</term>
<term>Influenza A Virus, H1N1 Subtype</term>
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<front><div type="abstract" xml:lang="en"><p><b>AIM AND METHOD</b>
</p>
<p>The aim of this study was to describe the clinical characteristics and outcome of pandemic influenza A H1N1/2009 (pH1N1) infection, in a retrospective cohort of pediatric patients with kidney and/or liver transplant and confirmed pH1N1 infection from June to December 2009, diagnosed in 2 Spanish teaching hospitals.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>RESULTS</b>
</p>
<p>Forty-nine patients were included. Pneumonia was diagnosed in 4 patients (8.2%), and 3 of them required respiratory support. There were no related deaths.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>CONCLUSION</b>
</p>
<p>Antiviral treatment within 48 h was associated with a lower likelihood of pneumonia (0/38, 0%) than treatment started after 48 h (4/11, 36.3%) (P < 0.01).</p>
</div>
</front>
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<Title>Transplant infectious disease : an official journal of the Transplantation Society</Title>
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<ArticleTitle>Influenza A H1N1/2009 infection in pediatric solid organ transplant recipients.</ArticleTitle>
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<AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Antiviral treatment within 48 h was associated with a lower likelihood of pneumonia (0/38, 0%) than treatment started after 48 h (4/11, 36.3%) (P < 0.01).</AbstractText>
<CopyrightInformation>© 2012 John Wiley & Sons A/S.</CopyrightInformation>
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