GrippeCanadaV4, Main, Exploration, bibRecordById, pubmed:29029166

Beyond Antigenic Match: Possible Agent-Host and Immuno-epidemiological Influences on Influenza Vaccine Effectiveness During the 2015-2016 Season in Canada.

Identifieur interne : 000120 ( Main/Exploration ); précédent : 000119; suivant : 000121

Beyond Antigenic Match: Possible Agent-Host and Immuno-epidemiological Influences on Influenza Vaccine Effectiveness During the 2015-2016 Season in Canada.

Auteurs : Danuta M. Skowronski [Canada] ; Catharine Chambers [Canada] ; Suzana Sabaiduc [Canada] ; Gaston De Serres [Canada] ; Anne-Luise Winter [Canada] ; James A. Dickinson [Canada] ; Jonathan B. Gubbay [Canada] ; Steven J. Drews [Canada] ; Christine Martineau ; Hugues Charest ; Mel Krajden [Canada] ; Nathalie Bastien [Canada] ; Yan Li [Canada]

Source :

The Journal of infectious diseases [ 1537-6613 ] ; 2017.

RBID : pubmed:29029166

Descripteurs français

KwdFr :
- Adulte (MeSH), Adulte d'âge moyen (MeSH), Analyse de regroupements (MeSH), Analyse de séquence d'ADN (MeSH), Antigènes viraux (immunologie), Canada (épidémiologie), Enfant (MeSH), Enfant d'âge préscolaire (MeSH), Facteurs âges (MeSH), Femelle (MeSH), Grippe humaine (prévention et contrôle), Grippe humaine (virologie), Grippe humaine (épidémiologie), Humains (MeSH), Immunisation (méthodes), Immunogénicité des vaccins (MeSH), Jeune adulte (MeSH), Mâle (MeSH), Nourrisson (MeSH), Phylogenèse (MeSH), Résultat thérapeutique (MeSH), Similitude de séquences (MeSH), Sous-type H1N1 du virus de la grippe A (classification), Sous-type H1N1 du virus de la grippe A (génétique), Sous-type H1N1 du virus de la grippe A (immunologie), Sous-type H1N1 du virus de la grippe A (isolement et purification), Sujet âgé (MeSH), Sujet âgé de 80 ans ou plus (MeSH), Tests d'inhibition de l'hémagglutination (MeSH), Vaccins antigrippaux (administration et posologie), Vaccins antigrippaux (immunologie), Variation des antigènes (MeSH), Virus influenza B (classification), Virus influenza B (génétique), Virus influenza B (immunologie), Virus influenza B (isolement et purification).
MESH :
- administration et posologie : Vaccins antigrippaux.
- génétique : Sous-type H1N1 du virus de la grippe A, Virus influenza B.
- immunologie : Antigènes viraux, Sous-type H1N1 du virus de la grippe A, Vaccins antigrippaux, Virus influenza B.
- isolement et purification : Sous-type H1N1 du virus de la grippe A, Virus influenza B.
- méthodes : Immunisation.
- prévention et contrôle : Grippe humaine.
- virologie : Grippe humaine.
- épidémiologie : Canada, Grippe humaine.
- Adulte, Adulte d'âge moyen, Analyse de regroupements, Analyse de séquence d'ADN, Enfant, Enfant d'âge préscolaire, Facteurs âges, Femelle, Humains, Immunogénicité des vaccins, Jeune adulte, Mâle, Nourrisson, Phylogenèse, Résultat thérapeutique, Similitude de séquences, Sujet âgé, Sujet âgé de 80 ans ou plus, Tests d'inhibition de l'hémagglutination, Variation des antigènes.
Wicri :
- geographic : Canada.

English descriptors

KwdEn :
- Adult (MeSH), Age Factors (MeSH), Aged (MeSH), Aged, 80 and over (MeSH), Antigenic Variation (MeSH), Antigens, Viral (immunology), Canada (epidemiology), Child (MeSH), Child, Preschool (MeSH), Cluster Analysis (MeSH), Female (MeSH), Hemagglutination Inhibition Tests (MeSH), Humans (MeSH), Immunization (methods), Immunogenicity, Vaccine (MeSH), Infant (MeSH), Influenza A Virus, H1N1 Subtype (classification), Influenza A Virus, H1N1 Subtype (genetics), Influenza A Virus, H1N1 Subtype (immunology), Influenza A Virus, H1N1 Subtype (isolation & purification), Influenza B virus (classification), Influenza B virus (genetics), Influenza B virus (immunology), Influenza B virus (isolation & purification), Influenza Vaccines (administration & dosage), Influenza Vaccines (immunology), Influenza, Human (epidemiology), Influenza, Human (prevention & control), Influenza, Human (virology), Male (MeSH), Middle Aged (MeSH), Phylogeny (MeSH), Sequence Analysis, DNA (MeSH), Sequence Homology (MeSH), Treatment Outcome (MeSH), Young Adult (MeSH).
MESH :
- chemical , administration & dosage : Influenza Vaccines.
- chemical , immunology : Antigens, Viral, Influenza Vaccines.
- geographic , epidemiology : Canada.
- classification : Influenza A Virus, H1N1 Subtype, Influenza B virus.
- epidemiology : Influenza, Human.
- genetics : Influenza A Virus, H1N1 Subtype, Influenza B virus.
- immunology : Influenza A Virus, H1N1 Subtype, Influenza B virus.
- isolation & purification : Influenza A Virus, H1N1 Subtype, Influenza B virus.
- methods : Immunization.
- prevention & control : Influenza, Human.
- virology : Influenza, Human.
- Adult, Age Factors, Aged, Aged, 80 and over, Antigenic Variation, Child, Child, Preschool, Cluster Analysis, Female, Hemagglutination Inhibition Tests, Humans, Immunogenicity, Vaccine, Infant, Male, Middle Aged, Phylogeny, Sequence Analysis, DNA, Sequence Homology, Treatment Outcome, Young Adult.

Abstract

Background

Vaccine effectiveness (VE) estimates for 2015-2016 seasonal influenza vaccine are reported from Canada's Sentinel Practitioner Surveillance Network (SPSN). This season was characterized by a delayed 2009 pandemic influenza A(H1N1) virus (A[H1N1]pdm09) epidemic and concurrent influenza B(Victoria) virus activity. Potential influences on VE beyond antigenic match are explored, including viral genomic variation, birth cohort effects, prior vaccination, and epidemic period.

Methods

VE was estimated by a test-negative design comparing the adjusted odds ratio for influenza test positivity among vaccinated compared to unvaccinated participants. Vaccine-virus relatedness was assessed by gene sequencing and hemagglutination inhibition assay.

Results

Analyses included 596 influenza A(H1N1)pdm09 and 305 B(Victoria) cases and 926 test-negative controls. A(H1N1)pdm09 viruses were considered antigenically related to vaccine (unchanged since 2009), despite phylogenetic clustering within emerging clade 6B.1. The adjusted VE against A(H1N1)pdm09 was 43% (95% confidence interval [CI], 25%-57%). Compared to other age groups, VE against A(H1N1)pdm09 was lower for adults born during 1957-1976 (25%; 95% CI, -16%-51%). The VE against A(H1N1)pdm09 was also lower for participants consecutively vaccinated during both the current and prior seasons (41%; 95% CI, 18%-57%) than for those vaccinated during the current season only (75%; 95% CI, 45%-88%), and the VE among participants presenting in March-April 2016 (19%; 95% CI, -15%-44%) was lower than that among those presenting during January-February 2016 (62%; 95% CI, 44%-74%). The adjusted VE for B(Victoria) viruses was 54% (95% CI, 32%-68%), despite lineage-level mismatch to B(Yamagata) vaccine. The further variation in VE as observed for A(H1N1)pdm09 was not observed for B(Victoria).

Conclusions

Influenza VE findings may require consideration of other agent-host and immuno-epidemiologic influences on vaccine performance beyond antigenic match, including viral genomic variation, repeat vaccination, birth (immunological) cohort effects, and potential within-season waning of vaccine protection.

DOI: 10.1093/infdis/jix526
PubMed: 29029166
PubMed Central: PMC5853508

Affiliations:

Canada
Alberta, Colombie-Britannique, Ontario, Québec
Calgary, Edmonton, Québec (ville), Toronto, Vancouver
Université Laval

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000084
to stream Main, to step Curation: 000084

Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en">Beyond Antigenic Match: Possible Agent-Host and Immuno-epidemiological Influences on Influenza Vaccine Effectiveness During the 2015-2016 Season in Canada.</title>
<author><name sortKey="Skowronski, Danuta M" sort="Skowronski, Danuta M" uniqKey="Skowronski D" first="Danuta M" last="Skowronski">Danuta M. Skowronski</name>
<affiliation wicri:level="3"><nlm:affiliation>British Columbia Centre for Disease Control, Vancouver.</nlm:affiliation>
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<region type="state">Colombie-Britannique</region>
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<author><name sortKey="Chambers, Catharine" sort="Chambers, Catharine" uniqKey="Chambers C" first="Catharine" last="Chambers">Catharine Chambers</name>
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<wicri:noCountry code="no comma">Institut National de Santé Publique du Québec.</wicri:noCountry>
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<country>Canada</country>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
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<author><name sortKey="Dickinson, James A" sort="Dickinson, James A" uniqKey="Dickinson J" first="James A" last="Dickinson">James A. Dickinson</name>
<affiliation wicri:level="3"><nlm:affiliation>University of Calgary, Calgary.</nlm:affiliation>
<country>Canada</country>
<placeName><settlement type="city">Calgary</settlement>
<region type="state">Alberta</region>
</placeName>
<wicri:orgArea>University of Calgary</wicri:orgArea>
</affiliation>
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<author><name sortKey="Gubbay, Jonathan B" sort="Gubbay, Jonathan B" uniqKey="Gubbay J" first="Jonathan B" last="Gubbay">Jonathan B. Gubbay</name>
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<country>Canada</country>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
<wicri:orgArea>Public Health Ontario</wicri:orgArea>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>University of Toronto, Toronto.</nlm:affiliation>
<country>Canada</country>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
<wicri:orgArea>University of Toronto</wicri:orgArea>
</affiliation>
</author>
<author><name sortKey="Drews, Steven J" sort="Drews, Steven J" uniqKey="Drews S" first="Steven J" last="Drews">Steven J. Drews</name>
<affiliation wicri:level="3"><nlm:affiliation>Alberta Provincial Laboratory, Edmonton.</nlm:affiliation>
<country>Canada</country>
<placeName><settlement type="city">Edmonton</settlement>
<region type="state">Alberta</region>
</placeName>
<wicri:orgArea>Alberta Provincial Laboratory</wicri:orgArea>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>University of Alberta, Edmonton.</nlm:affiliation>
<country>Canada</country>
<placeName><settlement type="city">Edmonton</settlement>
<region type="state">Alberta</region>
</placeName>
<wicri:orgArea>University of Alberta</wicri:orgArea>
</affiliation>
</author>
<author><name sortKey="Martineau, Christine" sort="Martineau, Christine" uniqKey="Martineau C" first="Christine" last="Martineau">Christine Martineau</name>
<affiliation><nlm:affiliation>Institut National de Santé Publique du Québec.</nlm:affiliation>
<wicri:noCountry code="no comma">Institut National de Santé Publique du Québec.</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Charest, Hugues" sort="Charest, Hugues" uniqKey="Charest H" first="Hugues" last="Charest">Hugues Charest</name>
<affiliation><nlm:affiliation>Institut National de Santé Publique du Québec.</nlm:affiliation>
<wicri:noCountry code="no comma">Institut National de Santé Publique du Québec.</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Krajden, Mel" sort="Krajden, Mel" uniqKey="Krajden M" first="Mel" last="Krajden">Mel Krajden</name>
<affiliation wicri:level="3"><nlm:affiliation>British Columbia Centre for Disease Control, Vancouver.</nlm:affiliation>
<country>Canada</country>
<placeName><settlement type="city">Vancouver</settlement>
<region type="state">Colombie-Britannique</region>
</placeName>
<wicri:orgArea>British Columbia Centre for Disease Control</wicri:orgArea>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>University of British Columbia, Vancouver.</nlm:affiliation>
<country>Canada</country>
<placeName><settlement type="city">Vancouver</settlement>
<region type="state">Colombie-Britannique</region>
</placeName>
<wicri:orgArea>University of British Columbia</wicri:orgArea>
</affiliation>
</author>
<author><name sortKey="Bastien, Nathalie" sort="Bastien, Nathalie" uniqKey="Bastien N" first="Nathalie" last="Bastien">Nathalie Bastien</name>
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<country xml:lang="fr">Canada</country>
<wicri:regionArea>National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg</wicri:regionArea>
<wicri:noRegion>Winnipeg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Li, Yan" sort="Li, Yan" uniqKey="Li Y" first="Yan" last="Li">Yan Li</name>
<affiliation wicri:level="1"><nlm:affiliation>National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult (MeSH)</term>
<term>Age Factors (MeSH)</term>
<term>Aged (MeSH)</term>
<term>Aged, 80 and over (MeSH)</term>
<term>Antigenic Variation (MeSH)</term>
<term>Antigens, Viral (immunology)</term>
<term>Canada (epidemiology)</term>
<term>Child (MeSH)</term>
<term>Child, Preschool (MeSH)</term>
<term>Cluster Analysis (MeSH)</term>
<term>Female (MeSH)</term>
<term>Hemagglutination Inhibition Tests (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Immunization (methods)</term>
<term>Immunogenicity, Vaccine (MeSH)</term>
<term>Infant (MeSH)</term>
<term>Influenza A Virus, H1N1 Subtype (classification)</term>
<term>Influenza A Virus, H1N1 Subtype (genetics)</term>
<term>Influenza A Virus, H1N1 Subtype (immunology)</term>
<term>Influenza A Virus, H1N1 Subtype (isolation & purification)</term>
<term>Influenza B virus (classification)</term>
<term>Influenza B virus (genetics)</term>
<term>Influenza B virus (immunology)</term>
<term>Influenza B virus (isolation & purification)</term>
<term>Influenza Vaccines (administration & dosage)</term>
<term>Influenza Vaccines (immunology)</term>
<term>Influenza, Human (epidemiology)</term>
<term>Influenza, Human (prevention & control)</term>
<term>Influenza, Human (virology)</term>
<term>Male (MeSH)</term>
<term>Middle Aged (MeSH)</term>
<term>Phylogeny (MeSH)</term>
<term>Sequence Analysis, DNA (MeSH)</term>
<term>Sequence Homology (MeSH)</term>
<term>Treatment Outcome (MeSH)</term>
<term>Young Adult (MeSH)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte (MeSH)</term>
<term>Adulte d'âge moyen (MeSH)</term>
<term>Analyse de regroupements (MeSH)</term>
<term>Analyse de séquence d'ADN (MeSH)</term>
<term>Antigènes viraux (immunologie)</term>
<term>Canada (épidémiologie)</term>
<term>Enfant (MeSH)</term>
<term>Enfant d'âge préscolaire (MeSH)</term>
<term>Facteurs âges (MeSH)</term>
<term>Femelle (MeSH)</term>
<term>Grippe humaine (prévention et contrôle)</term>
<term>Grippe humaine (virologie)</term>
<term>Grippe humaine (épidémiologie)</term>
<term>Humains (MeSH)</term>
<term>Immunisation (méthodes)</term>
<term>Immunogénicité des vaccins (MeSH)</term>
<term>Jeune adulte (MeSH)</term>
<term>Mâle (MeSH)</term>
<term>Nourrisson (MeSH)</term>
<term>Phylogenèse (MeSH)</term>
<term>Résultat thérapeutique (MeSH)</term>
<term>Similitude de séquences (MeSH)</term>
<term>Sous-type H1N1 du virus de la grippe A (classification)</term>
<term>Sous-type H1N1 du virus de la grippe A (génétique)</term>
<term>Sous-type H1N1 du virus de la grippe A (immunologie)</term>
<term>Sous-type H1N1 du virus de la grippe A (isolement et purification)</term>
<term>Sujet âgé (MeSH)</term>
<term>Sujet âgé de 80 ans ou plus (MeSH)</term>
<term>Tests d'inhibition de l'hémagglutination (MeSH)</term>
<term>Vaccins antigrippaux (administration et posologie)</term>
<term>Vaccins antigrippaux (immunologie)</term>
<term>Variation des antigènes (MeSH)</term>
<term>Virus influenza B (classification)</term>
<term>Virus influenza B (génétique)</term>
<term>Virus influenza B (immunologie)</term>
<term>Virus influenza B (isolement et purification)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Influenza Vaccines</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antigens, Viral</term>
<term>Influenza Vaccines</term>
</keywords>
<keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Canada</term>
</keywords>
<keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Vaccins antigrippaux</term>
</keywords>
<keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term>
<term>Influenza B virus</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Influenza, Human</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term>
<term>Influenza B virus</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Sous-type H1N1 du virus de la grippe A</term>
<term>Virus influenza B</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Antigènes viraux</term>
<term>Sous-type H1N1 du virus de la grippe A</term>
<term>Vaccins antigrippaux</term>
<term>Virus influenza B</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term>
<term>Influenza B virus</term>
</keywords>
<keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term>
<term>Influenza B virus</term>
</keywords>
<keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Sous-type H1N1 du virus de la grippe A</term>
<term>Virus influenza B</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Immunization</term>
</keywords>
<keywords scheme="MESH" qualifier="méthodes" xml:lang="fr"><term>Immunisation</term>
</keywords>
<keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Influenza, Human</term>
</keywords>
<keywords scheme="MESH" qualifier="prévention et contrôle" xml:lang="fr"><term>Grippe humaine</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Grippe humaine</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Influenza, Human</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Canada</term>
<term>Grippe humaine</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Age Factors</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Antigenic Variation</term>
<term>Child</term>
<term>Child, Preschool</term>
<term>Cluster Analysis</term>
<term>Female</term>
<term>Hemagglutination Inhibition Tests</term>
<term>Humans</term>
<term>Immunogenicity, Vaccine</term>
<term>Infant</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Phylogeny</term>
<term>Sequence Analysis, DNA</term>
<term>Sequence Homology</term>
<term>Treatment Outcome</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Analyse de regroupements</term>
<term>Analyse de séquence d'ADN</term>
<term>Enfant</term>
<term>Enfant d'âge préscolaire</term>
<term>Facteurs âges</term>
<term>Femelle</term>
<term>Humains</term>
<term>Immunogénicité des vaccins</term>
<term>Jeune adulte</term>
<term>Mâle</term>
<term>Nourrisson</term>
<term>Phylogenèse</term>
<term>Résultat thérapeutique</term>
<term>Similitude de séquences</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Tests d'inhibition de l'hémagglutination</term>
<term>Variation des antigènes</term>
</keywords>
<keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Canada</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p><b>Background</b>
</p>
<p>Vaccine effectiveness (VE) estimates for 2015-2016 seasonal influenza vaccine are reported from Canada's Sentinel Practitioner Surveillance Network (SPSN). This season was characterized by a delayed 2009 pandemic influenza A(H1N1) virus (A[H1N1]pdm09) epidemic and concurrent influenza B(Victoria) virus activity. Potential influences on VE beyond antigenic match are explored, including viral genomic variation, birth cohort effects, prior vaccination, and epidemic period.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>Methods</b>
</p>
<p>VE was estimated by a test-negative design comparing the adjusted odds ratio for influenza test positivity among vaccinated compared to unvaccinated participants. Vaccine-virus relatedness was assessed by gene sequencing and hemagglutination inhibition assay.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>Results</b>
</p>
<p>Analyses included 596 influenza A(H1N1)pdm09 and 305 B(Victoria) cases and 926 test-negative controls. A(H1N1)pdm09 viruses were considered antigenically related to vaccine (unchanged since 2009), despite phylogenetic clustering within emerging clade 6B.1. The adjusted VE against A(H1N1)pdm09 was 43% (95% confidence interval [CI], 25%-57%). Compared to other age groups, VE against A(H1N1)pdm09 was lower for adults born during 1957-1976 (25%; 95% CI, -16%-51%). The VE against A(H1N1)pdm09 was also lower for participants consecutively vaccinated during both the current and prior seasons (41%; 95% CI, 18%-57%) than for those vaccinated during the current season only (75%; 95% CI, 45%-88%), and the VE among participants presenting in March-April 2016 (19%; 95% CI, -15%-44%) was lower than that among those presenting during January-February 2016 (62%; 95% CI, 44%-74%). The adjusted VE for B(Victoria) viruses was 54% (95% CI, 32%-68%), despite lineage-level mismatch to B(Yamagata) vaccine. The further variation in VE as observed for A(H1N1)pdm09 was not observed for B(Victoria).</p>
</div>
<div type="abstract" xml:lang="en"><p><b>Conclusions</b>
</p>
<p>Influenza VE findings may require consideration of other agent-host and immuno-epidemiologic influences on vaccine performance beyond antigenic match, including viral genomic variation, repeat vaccination, birth (immunological) cohort effects, and potential within-season waning of vaccine protection.</p>
</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">29029166</PMID>
<DateCompleted><Year>2019</Year>
<Month>03</Month>
<Day>25</Day>
</DateCompleted>
<DateRevised><Year>2019</Year>
<Month>03</Month>
<Day>25</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1537-6613</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>216</Volume>
<Issue>12</Issue>
<PubDate><Year>2017</Year>
<Month>12</Month>
<Day>19</Day>
</PubDate>
</JournalIssue>
<Title>The Journal of infectious diseases</Title>
<ISOAbbreviation>J. Infect. Dis.</ISOAbbreviation>
</Journal>
<ArticleTitle>Beyond Antigenic Match: Possible Agent-Host and Immuno-epidemiological Influences on Influenza Vaccine Effectiveness During the 2015-2016 Season in Canada.</ArticleTitle>
<Pagination><MedlinePgn>1487-1500</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1093/infdis/jix526</ELocationID>
<Abstract><AbstractText Label="Background">Vaccine effectiveness (VE) estimates for 2015-2016 seasonal influenza vaccine are reported from Canada's Sentinel Practitioner Surveillance Network (SPSN). This season was characterized by a delayed 2009 pandemic influenza A(H1N1) virus (A[H1N1]pdm09) epidemic and concurrent influenza B(Victoria) virus activity. Potential influences on VE beyond antigenic match are explored, including viral genomic variation, birth cohort effects, prior vaccination, and epidemic period.</AbstractText>
<AbstractText Label="Methods">VE was estimated by a test-negative design comparing the adjusted odds ratio for influenza test positivity among vaccinated compared to unvaccinated participants. Vaccine-virus relatedness was assessed by gene sequencing and hemagglutination inhibition assay.</AbstractText>
<AbstractText Label="Results">Analyses included 596 influenza A(H1N1)pdm09 and 305 B(Victoria) cases and 926 test-negative controls. A(H1N1)pdm09 viruses were considered antigenically related to vaccine (unchanged since 2009), despite phylogenetic clustering within emerging clade 6B.1. The adjusted VE against A(H1N1)pdm09 was 43% (95% confidence interval [CI], 25%-57%). Compared to other age groups, VE against A(H1N1)pdm09 was lower for adults born during 1957-1976 (25%; 95% CI, -16%-51%). The VE against A(H1N1)pdm09 was also lower for participants consecutively vaccinated during both the current and prior seasons (41%; 95% CI, 18%-57%) than for those vaccinated during the current season only (75%; 95% CI, 45%-88%), and the VE among participants presenting in March-April 2016 (19%; 95% CI, -15%-44%) was lower than that among those presenting during January-February 2016 (62%; 95% CI, 44%-74%). The adjusted VE for B(Victoria) viruses was 54% (95% CI, 32%-68%), despite lineage-level mismatch to B(Yamagata) vaccine. The further variation in VE as observed for A(H1N1)pdm09 was not observed for B(Victoria).</AbstractText>
<AbstractText Label="Conclusions">Influenza VE findings may require consideration of other agent-host and immuno-epidemiologic influences on vaccine performance beyond antigenic match, including viral genomic variation, repeat vaccination, birth (immunological) cohort effects, and potential within-season waning of vaccine protection.</AbstractText>
<CopyrightInformation>© The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Skowronski</LastName>
<ForeName>Danuta M</ForeName>
<Initials>DM</Initials>
<AffiliationInfo><Affiliation>British Columbia Centre for Disease Control, Vancouver.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>University of British Columbia, Vancouver.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chambers</LastName>
<ForeName>Catharine</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>British Columbia Centre for Disease Control, Vancouver.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Sabaiduc</LastName>
<ForeName>Suzana</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>British Columbia Centre for Disease Control, Vancouver.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>De Serres</LastName>
<ForeName>Gaston</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>Institut National de Santé Publique du Québec.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Laval University, Québec.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Centre Hospitalier Universitaire de Québec, Québec.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Winter</LastName>
<ForeName>Anne-Luise</ForeName>
<Initials>AL</Initials>
<AffiliationInfo><Affiliation>Public Health Ontario, Toronto.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Dickinson</LastName>
<ForeName>James A</ForeName>
<Initials>JA</Initials>
<AffiliationInfo><Affiliation>University of Calgary, Calgary.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Gubbay</LastName>
<ForeName>Jonathan B</ForeName>
<Initials>JB</Initials>
<AffiliationInfo><Affiliation>Public Health Ontario, Toronto.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>University of Toronto, Toronto.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Drews</LastName>
<ForeName>Steven J</ForeName>
<Initials>SJ</Initials>
<AffiliationInfo><Affiliation>Alberta Provincial Laboratory, Edmonton.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>University of Alberta, Edmonton.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Martineau</LastName>
<ForeName>Christine</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Institut National de Santé Publique du Québec.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Charest</LastName>
<ForeName>Hugues</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>Institut National de Santé Publique du Québec.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Krajden</LastName>
<ForeName>Mel</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>British Columbia Centre for Disease Control, Vancouver.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>University of British Columbia, Vancouver.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bastien</LastName>
<ForeName>Nathalie</ForeName>
<Initials>N</Initials>
<AffiliationInfo><Affiliation>National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Li</LastName>
<ForeName>Yan</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Canada.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
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</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>J Infect Dis</MedlineTA>
<NlmUniqueID>0413675</NlmUniqueID>
<ISSNLinking>0022-1899</ISSNLinking>
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<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000956">Antigens, Viral</NameOfSubstance>
</Chemical>
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<NameOfSubstance UI="D007252">Influenza Vaccines</NameOfSubstance>
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<CitationSubset>AIM</CitationSubset>
<CitationSubset>IM</CitationSubset>
<CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>J Infect Dis. 2017 Dec 19;216(12):1477-1480</RefSource>
<PMID Version="1">29029175</PMID>
</CommentsCorrections>
</CommentsCorrectionsList>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000367" MajorTopicYN="N">Age Factors</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000940" MajorTopicYN="N">Antigenic Variation</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000956" MajorTopicYN="N">Antigens, Viral</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002170" MajorTopicYN="N" Type="Geographic">Canada</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002648" MajorTopicYN="N">Child</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002675" MajorTopicYN="N">Child, Preschool</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016000" MajorTopicYN="N">Cluster Analysis</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006385" MajorTopicYN="N">Hemagglutination Inhibition Tests</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007114" MajorTopicYN="N">Immunization</DescriptorName>
<QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000071497" MajorTopicYN="N">Immunogenicity, Vaccine</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007223" MajorTopicYN="N">Infant</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D053118" MajorTopicYN="N">Influenza A Virus, H1N1 Subtype</DescriptorName>
<QualifierName UI="Q000145" MajorTopicYN="N">classification</QualifierName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
<QualifierName UI="Q000302" MajorTopicYN="Y">isolation & purification</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009981" MajorTopicYN="N">Influenza B virus</DescriptorName>
<QualifierName UI="Q000145" MajorTopicYN="N">classification</QualifierName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
<QualifierName UI="Q000302" MajorTopicYN="Y">isolation & purification</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007252" MajorTopicYN="N">Influenza Vaccines</DescriptorName>
<QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007251" MajorTopicYN="N">Influenza, Human</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName>
<QualifierName UI="Q000517" MajorTopicYN="Y">prevention & control</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010802" MajorTopicYN="N">Phylogeny</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017422" MajorTopicYN="N">Sequence Analysis, DNA</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017385" MajorTopicYN="N">Sequence Homology</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016896" MajorTopicYN="N">Treatment Outcome</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName>
</MeshHeading>
</MeshHeadingList>
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<Keyword MajorTopicYN="Y">birth cohort effects</Keyword>
<Keyword MajorTopicYN="Y">hemagglutination inhibition</Keyword>
<Keyword MajorTopicYN="Y">influenza A subtype</Keyword>
<Keyword MajorTopicYN="Y">influenza B lineage</Keyword>
<Keyword MajorTopicYN="Y">influenza vaccine</Keyword>
<Keyword MajorTopicYN="Y">original antigenic sin</Keyword>
<Keyword MajorTopicYN="Y">repeat vaccination</Keyword>
<Keyword MajorTopicYN="Y">sequencing</Keyword>
<Keyword MajorTopicYN="Y">vaccine effectiveness</Keyword>
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Beyond Antigenic Match: Possible Agent-Host and Immuno-epidemiological Influences on Influenza Vaccine Effectiveness During the 2015-2016 Season in Canada.

Beyond Antigenic Match: Possible Agent-Host and Immuno-epidemiological Influences on Influenza Vaccine Effectiveness During the 2015-2016 Season in Canada.

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