GrippeCanadaV4, Main, Exploration, bibRecordById, pubmed:24313991

Genetic characterization of seasonal influenza A (H3N2) viruses in Ontario during 2010-2011 influenza season: high prevalence of mutations at antigenic sites.

Identifieur interne : 000300 ( Main/Exploration ); précédent : 000299; suivant : 000301

Genetic characterization of seasonal influenza A (H3N2) viruses in Ontario during 2010-2011 influenza season: high prevalence of mutations at antigenic sites.

Auteurs : Alireza Eshaghi [Canada] ; Venkata R. Duvvuri ; Aimin Li ; Samir N. Patel ; Nathalie Bastien ; Yan Li ; Donald E. Low ; Jonathan B. Gubbay

Source :

Influenza and other respiratory viruses [ 1750-2659 ] ; 2014.

RBID : pubmed:24313991

Descripteurs français

English descriptors

KwdEn :
- Antigens, Viral (genetics), Antigens, Viral (immunology), Genotype (MeSH), Hemagglutination Inhibition Tests (MeSH), Hemagglutinin Glycoproteins, Influenza Virus (genetics), Hemagglutinin Glycoproteins, Influenza Virus (immunology), Humans (MeSH), Influenza A Virus, H3N2 Subtype (genetics), Influenza A Virus, H3N2 Subtype (immunology), Influenza A Virus, H3N2 Subtype (isolation & purification), Influenza, Human (virology), Mutation Rate (MeSH), Mutation, Missense (MeSH), Nasopharynx (virology), Neuraminidase (genetics), Neuraminidase (immunology), Ontario (MeSH), Phylogeny (MeSH), RNA, Viral (genetics), Sequence Analysis, DNA (MeSH), Serotyping (MeSH), Viral Proteins (genetics), Viral Proteins (immunology).
MESH :
- chemical , genetics : Antigens, Viral, Hemagglutinin Glycoproteins, Influenza Virus, Neuraminidase, RNA, Viral, Viral Proteins.
- chemical , immunology : Antigens, Viral, Hemagglutinin Glycoproteins, Influenza Virus, Neuraminidase, Viral Proteins.
- geographic : Ontario.
- genetics : Influenza A Virus, H3N2 Subtype.
- immunology : Influenza A Virus, H3N2 Subtype.
- isolation & purification : Influenza A Virus, H3N2 Subtype.
- virology : Influenza, Human, Nasopharynx.
- Genotype, Hemagglutination Inhibition Tests, Humans, Mutation Rate, Mutation, Missense, Phylogeny, Sequence Analysis, DNA, Serotyping.

Abstract

BACKGROUND

The direct effect of antigenic site mutations in influenza viruses on antigenic drift and vaccine effectiveness is poorly understood.

OBJECTIVE

To investigate the genetic and antigenic characteristics of human influenza A (H3N2) viruses circulating in Ontario during the early 2010-2011 winter season.

STUDY DESIGN

We sequenced the hemagglutinin (HA) and neuraminidase (NA) genes from 41 A(H3N2) viruses detected in nasopharyngeal specimens. Strain typing was performed by hemagglutination inhibition (HI) assay. Molecular and phylogenetic tree analyses were conducted.

RESULTS

HA and NA genes showed high similarity to the 2010-2011 vaccine strain, A/Perth/16/2009 (H3N2)-like virus (97·7-98·5% and 98·7-99·5% amino acid (AA) identity, respectively). Compared to A/Perth/16/2009 strain, HA gene mutations were documented at 28 different AA positions across all five H3 antigenic sites, with a range of 5-11 mutations in individual viruses. Thirty-six (88%) viruses had 8 AA substitutions in common; none of these had reduced HI titer. Among Ontario isolates, 11 antigenic site AAs were positively selected with an increase in glycosylation sites.

CONCLUSION

The presence of antigenic site mutations with high frequency among 2010-2011 influenza H3N2 isolates confirms ongoing adaptive H3N2 evolution. These may represent early phylogenetic changes that could cause antigenic drift with further mutations. Clinical relevance of antigenic site mutations not causing drift in HI assays is unknown and requires further investigation. In addition, viral sequencing information will assist with vaccine strain planning and may facilitate early detection of vaccine escape.

DOI: 10.1111/irv.12219
PubMed: 24313991
PubMed Central: PMC4186474

Affiliations:

Canada

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000317
to stream Main, to step Curation: 000317

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Genetic characterization of seasonal influenza A (H3N2) viruses in Ontario during 2010-2011 influenza season: high prevalence of mutations at antigenic sites.</title>
<author><name sortKey="Eshaghi, Alireza" sort="Eshaghi, Alireza" uniqKey="Eshaghi A" first="Alireza" last="Eshaghi">Alireza Eshaghi</name>
<affiliation wicri:level="1"><nlm:affiliation>Ontario Agency for Health Protection and Promotion, Toronto, ON, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Ontario Agency for Health Protection and Promotion, Toronto, ON</wicri:regionArea>
<wicri:noRegion>ON</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Duvvuri, Venkata R" sort="Duvvuri, Venkata R" uniqKey="Duvvuri V" first="Venkata R" last="Duvvuri">Venkata R. Duvvuri</name>
</author>
<author><name sortKey="Li, Aimin" sort="Li, Aimin" uniqKey="Li A" first="Aimin" last="Li">Aimin Li</name>
</author>
<author><name sortKey="Patel, Samir N" sort="Patel, Samir N" uniqKey="Patel S" first="Samir N" last="Patel">Samir N. Patel</name>
</author>
<author><name sortKey="Bastien, Nathalie" sort="Bastien, Nathalie" uniqKey="Bastien N" first="Nathalie" last="Bastien">Nathalie Bastien</name>
</author>
<author><name sortKey="Li, Yan" sort="Li, Yan" uniqKey="Li Y" first="Yan" last="Li">Yan Li</name>
</author>
<author><name sortKey="Low, Donald E" sort="Low, Donald E" uniqKey="Low D" first="Donald E" last="Low">Donald E. Low</name>
</author>
<author><name sortKey="Gubbay, Jonathan B" sort="Gubbay, Jonathan B" uniqKey="Gubbay J" first="Jonathan B" last="Gubbay">Jonathan B. Gubbay</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2014">2014</date>
<idno type="RBID">pubmed:24313991</idno>
<idno type="pmid">24313991</idno>
<idno type="doi">10.1111/irv.12219</idno>
<idno type="pmc">PMC4186474</idno>
<idno type="wicri:Area/Main/Corpus">000317</idno>
<idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000317</idno>
<idno type="wicri:Area/Main/Curation">000317</idno>
<idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000317</idno>
<idno type="wicri:Area/Main/Exploration">000317</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Genetic characterization of seasonal influenza A (H3N2) viruses in Ontario during 2010-2011 influenza season: high prevalence of mutations at antigenic sites.</title>
<author><name sortKey="Eshaghi, Alireza" sort="Eshaghi, Alireza" uniqKey="Eshaghi A" first="Alireza" last="Eshaghi">Alireza Eshaghi</name>
<affiliation wicri:level="1"><nlm:affiliation>Ontario Agency for Health Protection and Promotion, Toronto, ON, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Ontario Agency for Health Protection and Promotion, Toronto, ON</wicri:regionArea>
<wicri:noRegion>ON</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Duvvuri, Venkata R" sort="Duvvuri, Venkata R" uniqKey="Duvvuri V" first="Venkata R" last="Duvvuri">Venkata R. Duvvuri</name>
</author>
<author><name sortKey="Li, Aimin" sort="Li, Aimin" uniqKey="Li A" first="Aimin" last="Li">Aimin Li</name>
</author>
<author><name sortKey="Patel, Samir N" sort="Patel, Samir N" uniqKey="Patel S" first="Samir N" last="Patel">Samir N. Patel</name>
</author>
<author><name sortKey="Bastien, Nathalie" sort="Bastien, Nathalie" uniqKey="Bastien N" first="Nathalie" last="Bastien">Nathalie Bastien</name>
</author>
<author><name sortKey="Li, Yan" sort="Li, Yan" uniqKey="Li Y" first="Yan" last="Li">Yan Li</name>
</author>
<author><name sortKey="Low, Donald E" sort="Low, Donald E" uniqKey="Low D" first="Donald E" last="Low">Donald E. Low</name>
</author>
<author><name sortKey="Gubbay, Jonathan B" sort="Gubbay, Jonathan B" uniqKey="Gubbay J" first="Jonathan B" last="Gubbay">Jonathan B. Gubbay</name>
</author>
</analytic>
<series><title level="j">Influenza and other respiratory viruses</title>
<idno type="eISSN">1750-2659</idno>
<imprint><date when="2014" type="published">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antigens, Viral (genetics)</term>
<term>Antigens, Viral (immunology)</term>
<term>Genotype (MeSH)</term>
<term>Hemagglutination Inhibition Tests (MeSH)</term>
<term>Hemagglutinin Glycoproteins, Influenza Virus (genetics)</term>
<term>Hemagglutinin Glycoproteins, Influenza Virus (immunology)</term>
<term>Humans (MeSH)</term>
<term>Influenza A Virus, H3N2 Subtype (genetics)</term>
<term>Influenza A Virus, H3N2 Subtype (immunology)</term>
<term>Influenza A Virus, H3N2 Subtype (isolation & purification)</term>
<term>Influenza, Human (virology)</term>
<term>Mutation Rate (MeSH)</term>
<term>Mutation, Missense (MeSH)</term>
<term>Nasopharynx (virology)</term>
<term>Neuraminidase (genetics)</term>
<term>Neuraminidase (immunology)</term>
<term>Ontario (MeSH)</term>
<term>Phylogeny (MeSH)</term>
<term>RNA, Viral (genetics)</term>
<term>Sequence Analysis, DNA (MeSH)</term>
<term>Serotyping (MeSH)</term>
<term>Viral Proteins (genetics)</term>
<term>Viral Proteins (immunology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>ARN viral (génétique)</term>
<term>Analyse de séquence d'ADN (MeSH)</term>
<term>Antigènes viraux (génétique)</term>
<term>Antigènes viraux (immunologie)</term>
<term>Glycoprotéine hémagglutinine du virus influenza (génétique)</term>
<term>Glycoprotéine hémagglutinine du virus influenza (immunologie)</term>
<term>Grippe humaine (virologie)</term>
<term>Génotype (MeSH)</term>
<term>Humains (MeSH)</term>
<term>Mutation faux-sens (MeSH)</term>
<term>Ontario (MeSH)</term>
<term>Partie nasale du pharynx (virologie)</term>
<term>Phylogenèse (MeSH)</term>
<term>Protéines virales (génétique)</term>
<term>Protéines virales (immunologie)</term>
<term>Sialidase (génétique)</term>
<term>Sialidase (immunologie)</term>
<term>Sous-type H3N2 du virus de la grippe A (génétique)</term>
<term>Sous-type H3N2 du virus de la grippe A (immunologie)</term>
<term>Sous-type H3N2 du virus de la grippe A (isolement et purification)</term>
<term>Sérotypie (MeSH)</term>
<term>Taux de mutation (MeSH)</term>
<term>Tests d'inhibition de l'hémagglutination (MeSH)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Antigens, Viral</term>
<term>Hemagglutinin Glycoproteins, Influenza Virus</term>
<term>Neuraminidase</term>
<term>RNA, Viral</term>
<term>Viral Proteins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antigens, Viral</term>
<term>Hemagglutinin Glycoproteins, Influenza Virus</term>
<term>Neuraminidase</term>
<term>Viral Proteins</term>
</keywords>
<keywords scheme="MESH" type="geographic" xml:lang="en"><term>Ontario</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Influenza A Virus, H3N2 Subtype</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>ARN viral</term>
<term>Antigènes viraux</term>
<term>Glycoprotéine hémagglutinine du virus influenza</term>
<term>Protéines virales</term>
<term>Sialidase</term>
<term>Sous-type H3N2 du virus de la grippe A</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Antigènes viraux</term>
<term>Glycoprotéine hémagglutinine du virus influenza</term>
<term>Protéines virales</term>
<term>Sialidase</term>
<term>Sous-type H3N2 du virus de la grippe A</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Influenza A Virus, H3N2 Subtype</term>
</keywords>
<keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Influenza A Virus, H3N2 Subtype</term>
</keywords>
<keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Sous-type H3N2 du virus de la grippe A</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Grippe humaine</term>
<term>Partie nasale du pharynx</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Influenza, Human</term>
<term>Nasopharynx</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Genotype</term>
<term>Hemagglutination Inhibition Tests</term>
<term>Humans</term>
<term>Mutation Rate</term>
<term>Mutation, Missense</term>
<term>Phylogeny</term>
<term>Sequence Analysis, DNA</term>
<term>Serotyping</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Analyse de séquence d'ADN</term>
<term>Génotype</term>
<term>Humains</term>
<term>Mutation faux-sens</term>
<term>Ontario</term>
<term>Phylogenèse</term>
<term>Sérotypie</term>
<term>Taux de mutation</term>
<term>Tests d'inhibition de l'hémagglutination</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b>
</p>
<p>The direct effect of antigenic site mutations in influenza viruses on antigenic drift and vaccine effectiveness is poorly understood.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>OBJECTIVE</b>
</p>
<p>To investigate the genetic and antigenic characteristics of human influenza A (H3N2) viruses circulating in Ontario during the early 2010-2011 winter season.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>STUDY DESIGN</b>
</p>
<p>We sequenced the hemagglutinin (HA) and neuraminidase (NA) genes from 41 A(H3N2) viruses detected in nasopharyngeal specimens. Strain typing was performed by hemagglutination inhibition (HI) assay. Molecular and phylogenetic tree analyses were conducted.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>RESULTS</b>
</p>
<p>HA and NA genes showed high similarity to the 2010-2011 vaccine strain, A/Perth/16/2009 (H3N2)-like virus (97·7-98·5% and 98·7-99·5% amino acid (AA) identity, respectively). Compared to A/Perth/16/2009 strain, HA gene mutations were documented at 28 different AA positions across all five H3 antigenic sites, with a range of 5-11 mutations in individual viruses. Thirty-six (88%) viruses had 8 AA substitutions in common; none of these had reduced HI titer. Among Ontario isolates, 11 antigenic site AAs were positively selected with an increase in glycosylation sites.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>CONCLUSION</b>
</p>
<p>The presence of antigenic site mutations with high frequency among 2010-2011 influenza H3N2 isolates confirms ongoing adaptive H3N2 evolution. These may represent early phylogenetic changes that could cause antigenic drift with further mutations. Clinical relevance of antigenic site mutations not causing drift in HI assays is unknown and requires further investigation. In addition, viral sequencing information will assist with vaccine strain planning and may facilitate early detection of vaccine escape.</p>
</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">24313991</PMID>
<DateCompleted><Year>2014</Year>
<Month>10</Month>
<Day>22</Day>
</DateCompleted>
<DateRevised><Year>2018</Year>
<Month>11</Month>
<Day>13</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1750-2659</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>8</Volume>
<Issue>2</Issue>
<PubDate><Year>2014</Year>
<Month>Mar</Month>
</PubDate>
</JournalIssue>
<Title>Influenza and other respiratory viruses</Title>
<ISOAbbreviation>Influenza Other Respir Viruses</ISOAbbreviation>
</Journal>
<ArticleTitle>Genetic characterization of seasonal influenza A (H3N2) viruses in Ontario during 2010-2011 influenza season: high prevalence of mutations at antigenic sites.</ArticleTitle>
<Pagination><MedlinePgn>250-7</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1111/irv.12219</ELocationID>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">The direct effect of antigenic site mutations in influenza viruses on antigenic drift and vaccine effectiveness is poorly understood.</AbstractText>
<AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To investigate the genetic and antigenic characteristics of human influenza A (H3N2) viruses circulating in Ontario during the early 2010-2011 winter season.</AbstractText>
<AbstractText Label="STUDY DESIGN" NlmCategory="METHODS">We sequenced the hemagglutinin (HA) and neuraminidase (NA) genes from 41 A(H3N2) viruses detected in nasopharyngeal specimens. Strain typing was performed by hemagglutination inhibition (HI) assay. Molecular and phylogenetic tree analyses were conducted.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">HA and NA genes showed high similarity to the 2010-2011 vaccine strain, A/Perth/16/2009 (H3N2)-like virus (97·7-98·5% and 98·7-99·5% amino acid (AA) identity, respectively). Compared to A/Perth/16/2009 strain, HA gene mutations were documented at 28 different AA positions across all five H3 antigenic sites, with a range of 5-11 mutations in individual viruses. Thirty-six (88%) viruses had 8 AA substitutions in common; none of these had reduced HI titer. Among Ontario isolates, 11 antigenic site AAs were positively selected with an increase in glycosylation sites.</AbstractText>
<AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">The presence of antigenic site mutations with high frequency among 2010-2011 influenza H3N2 isolates confirms ongoing adaptive H3N2 evolution. These may represent early phylogenetic changes that could cause antigenic drift with further mutations. Clinical relevance of antigenic site mutations not causing drift in HI assays is unknown and requires further investigation. In addition, viral sequencing information will assist with vaccine strain planning and may facilitate early detection of vaccine escape.</AbstractText>
<CopyrightInformation>© 2013 The Authors. Influenza and Other Respiratory Viruses Published by John Wiley & Sons Ltd.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Eshaghi</LastName>
<ForeName>Alireza</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Ontario Agency for Health Protection and Promotion, Toronto, ON, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Duvvuri</LastName>
<ForeName>Venkata R</ForeName>
<Initials>VR</Initials>
</Author>
<Author ValidYN="Y"><LastName>Li</LastName>
<ForeName>Aimin</ForeName>
<Initials>A</Initials>
</Author>
<Author ValidYN="Y"><LastName>Patel</LastName>
<ForeName>Samir N</ForeName>
<Initials>SN</Initials>
</Author>
<Author ValidYN="Y"><LastName>Bastien</LastName>
<ForeName>Nathalie</ForeName>
<Initials>N</Initials>
</Author>
<Author ValidYN="Y"><LastName>Li</LastName>
<ForeName>Yan</ForeName>
<Initials>Y</Initials>
</Author>
<Author ValidYN="Y"><LastName>Low</LastName>
<ForeName>Donald E</ForeName>
<Initials>DE</Initials>
</Author>
<Author ValidYN="Y"><LastName>Gubbay</LastName>
<ForeName>Jonathan B</ForeName>
<Initials>JB</Initials>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2013</Year>
<Month>12</Month>
<Day>06</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>Influenza Other Respir Viruses</MedlineTA>
<NlmUniqueID>101304007</NlmUniqueID>
<ISSNLinking>1750-2640</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000956">Antigens, Viral</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D019267">Hemagglutinin Glycoproteins, Influenza Virus</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D012367">RNA, Viral</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D014764">Viral Proteins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 3.2.1.18</RegistryNumber>
<NameOfSubstance UI="C487630">NA protein, influenza A virus</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 3.2.1.18</RegistryNumber>
<NameOfSubstance UI="D009439">Neuraminidase</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000956" MajorTopicYN="N">Antigens, Viral</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005838" MajorTopicYN="N">Genotype</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006385" MajorTopicYN="N">Hemagglutination Inhibition Tests</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D019267" MajorTopicYN="N">Hemagglutinin Glycoproteins, Influenza Virus</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D053122" MajorTopicYN="N">Influenza A Virus, H3N2 Subtype</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
<QualifierName UI="Q000302" MajorTopicYN="Y">isolation & purification</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007251" MajorTopicYN="N">Influenza, Human</DescriptorName>
<QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D059645" MajorTopicYN="N">Mutation Rate</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D020125" MajorTopicYN="Y">Mutation, Missense</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009305" MajorTopicYN="N">Nasopharynx</DescriptorName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009439" MajorTopicYN="N">Neuraminidase</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009864" MajorTopicYN="N" Type="Geographic">Ontario</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010802" MajorTopicYN="N">Phylogeny</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012367" MajorTopicYN="N">RNA, Viral</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017422" MajorTopicYN="N">Sequence Analysis, DNA</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012703" MajorTopicYN="N">Serotyping</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014764" MajorTopicYN="N">Viral Proteins</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Antigenic site mutations</Keyword>
<Keyword MajorTopicYN="N">genetic and antigenic characterization</Keyword>
<Keyword MajorTopicYN="N">phylogenetic analysis</Keyword>
<Keyword MajorTopicYN="N">positive selection analysis</Keyword>
<Keyword MajorTopicYN="N">seasonal influenza A (H3N2) virus</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="accepted"><Year>2013</Year>
<Month>10</Month>
<Day>26</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2013</Year>
<Month>12</Month>
<Day>10</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2013</Year>
<Month>12</Month>
<Day>10</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2014</Year>
<Month>10</Month>
<Day>23</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">24313991</ArticleId>
<ArticleId IdType="doi">10.1111/irv.12219</ArticleId>
<ArticleId IdType="pmc">PMC4186474</ArticleId>
</ArticleIdList>
<ReferenceList><Reference><Citation>Annu Rev Med. 2000;51:407-21</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10774473</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Clin Infect Dis. 2012 Aug;55(3):332-42</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22539661</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 2003 Mar 27;422(6930):428-33</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12660783</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Science. 2004 Jul 16;305(5682):371-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15218094</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 1981 Jan 29;289(5796):373-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">6162101</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 1983 May 5-11;303(5912):41-4</Citation>
<ArticleIdList><ArticleId IdType="pubmed">6188957</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Am J Public Health. 1987 Jun;77(6):712-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">3578619</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Annu Rev Immunol. 1990;8:737-71</Citation>
<ArticleIdList><ArticleId IdType="pubmed">2188678</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 1991 May 15;88(10):4270-4</Citation>
<ArticleIdList><ArticleId IdType="pubmed">1840695</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Microbiol Rev. 1992 Mar;56(1):152-79</Citation>
<ArticleIdList><ArticleId IdType="pubmed">1579108</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 1993 Jun;67(6):2972-80</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8497041</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2005 May;79(10):6472-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15858030</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Virology. 2005 May 25;336(1):113-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15866076</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 2005 Oct 20;437(7062):1162-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16208317</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2007 Apr 10;104(15):6283-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17395716</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Biol Evol. 2007 Aug;24(8):1586-91</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17483113</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Biol Evol. 2007 Aug;24(8):1596-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17488738</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Science. 2007 Aug 10;317(5839):825-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17690300</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>BMC Bioinformatics. 2007;8:460</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18034891</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Virol J. 2008;5:40</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18325125</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS Pathog. 2008 May;4(5):e1000058</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18451985</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS Pathog. 2009 Dec;5(12):e1000709</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20041223</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Clin Virol. 2012 Jan;53(1):88-92</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22036039</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Virology. 2000 Aug 15;274(1):220-31</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10936103</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>Canada</li>
</country>
</list>
<tree><noCountry><name sortKey="Bastien, Nathalie" sort="Bastien, Nathalie" uniqKey="Bastien N" first="Nathalie" last="Bastien">Nathalie Bastien</name>
<name sortKey="Duvvuri, Venkata R" sort="Duvvuri, Venkata R" uniqKey="Duvvuri V" first="Venkata R" last="Duvvuri">Venkata R. Duvvuri</name>
<name sortKey="Gubbay, Jonathan B" sort="Gubbay, Jonathan B" uniqKey="Gubbay J" first="Jonathan B" last="Gubbay">Jonathan B. Gubbay</name>
<name sortKey="Li, Aimin" sort="Li, Aimin" uniqKey="Li A" first="Aimin" last="Li">Aimin Li</name>
<name sortKey="Li, Yan" sort="Li, Yan" uniqKey="Li Y" first="Yan" last="Li">Yan Li</name>
<name sortKey="Low, Donald E" sort="Low, Donald E" uniqKey="Low D" first="Donald E" last="Low">Donald E. Low</name>
<name sortKey="Patel, Samir N" sort="Patel, Samir N" uniqKey="Patel S" first="Samir N" last="Patel">Samir N. Patel</name>
</noCountry>
<country name="Canada"><noRegion><name sortKey="Eshaghi, Alireza" sort="Eshaghi, Alireza" uniqKey="Eshaghi A" first="Alireza" last="Eshaghi">Alireza Eshaghi</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/GrippeCanadaV4/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000300 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000300 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    GrippeCanadaV4
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     pubmed:24313991
   |texte=   Genetic characterization of seasonal influenza A (H3N2) viruses in Ontario during 2010-2011 influenza season: high prevalence of mutations at antigenic sites.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:24313991" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a GrippeCanadaV4

This area was generated with Dilib version V0.6.35.
Data generation: Sat Aug 8 18:52:12 2020. Site generation: Sat Feb 13 16:40:04 2021

	Serveur d'exploration sur la grippe au Canada
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur la grippe au Canada

Genetic characterization of seasonal influenza A (H3N2) viruses in Ontario during 2010-2011 influenza season: high prevalence of mutations at antigenic sites.

Genetic characterization of seasonal influenza A (H3N2) viruses in Ontario during 2010-2011 influenza season: high prevalence of mutations at antigenic sites.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki