Association of Parkinson's disease with infections and occupational exposure to possible vectors.
Identifieur interne : 000478 ( Main/Exploration ); précédent : 000477; suivant : 000479Association of Parkinson's disease with infections and occupational exposure to possible vectors.
Auteurs : M Anne Harris [Canada] ; Joseph K. Tsui ; Stephen A. Marion ; Hui Shen ; Kay TeschkeSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2012.
Descripteurs français
- KwdFr :
- Adulte d'âge moyen (MeSH), Animaux (MeSH), Animaux de compagnie (MeSH), Bases de données factuelles (MeSH), Bovins (MeSH), Chats (MeSH), Colombie-Britannique (épidémiologie), Exposition professionnelle (effets indésirables), Facteurs de risque (MeSH), Femelle (MeSH), Fumer (effets indésirables), Fumer (épidémiologie), Humains (MeSH), Maladie de Parkinson (étiologie), Maladies virales (complications), Maladies virales (épidémiologie), Modèles logistiques (MeSH), Mâle (MeSH), Odds ratio (MeSH), Sujet âgé (MeSH), Vaccins antigrippaux (MeSH), Vecteurs de maladies (MeSH), Zoonoses (MeSH), Études cas-témoins (MeSH).
- MESH :
- effets indésirables : Exposition professionnelle, Fumer, Maladies virales.
- épidémiologie : Colombie-Britannique, Fumer, Maladies virales.
- étiologie : Maladie de Parkinson.
- Adulte d'âge moyen, Animaux, Animaux de compagnie, Bases de données factuelles, Bovins, Chats, Facteurs de risque, Femelle, Humains, Modèles logistiques, Mâle, Odds ratio, Sujet âgé, Vaccins antigrippaux, Vecteurs de maladies, Zoonoses, Études cas-témoins.
English descriptors
- KwdEn :
- Aged (MeSH), Animals (MeSH), British Columbia (epidemiology), Case-Control Studies (MeSH), Cats (MeSH), Cattle (MeSH), Databases, Factual (MeSH), Disease Vectors (MeSH), Female (MeSH), Humans (MeSH), Infections (complications), Influenza Vaccines (MeSH), Logistic Models (MeSH), Male (MeSH), Middle Aged (MeSH), Occupational Exposure (adverse effects), Odds Ratio (MeSH), Parkinson Disease (etiology), Pets (MeSH), Risk Factors (MeSH), Smoking (adverse effects), Smoking (epidemiology), Virus Diseases (complications), Virus Diseases (epidemiology), Zoonoses (MeSH).
- MESH :
- chemical : Influenza Vaccines.
- geographic , epidemiology : British Columbia.
- adverse effects : Occupational Exposure, Smoking.
- complications : Infections, Virus Diseases.
- epidemiology : Smoking, Virus Diseases.
- etiology : Parkinson Disease.
- Aged, Animals, Case-Control Studies, Cats, Cattle, Databases, Factual, Disease Vectors, Female, Humans, Logistic Models, Male, Middle Aged, Odds Ratio, Pets, Risk Factors, Zoonoses.
Abstract
The ultimate causes of idiopathic Parkinson's disease (PD) are not fully known, but environmental and occupational causes are suspected. Postencephalitic parkinsonism has been linked to influenza, and other viral infections have also been suspected to relate to PD. We estimated the relationship between PD and both infections and possible vectors of infection (i.e., animal and human) in a population-based, case-control study in British Columbia, Canada. We recruited 403 cases detected by their use of antiparkinsonian medications and 405 controls from the registrants of the provincial universal health insurance plan. Severe influenza was associated with PD (odds ratio [OR]: 2.01; 95% confidence interval [CI]: 1.16-3.48), although this effect was attenuated when reports were restricted to those occurring 10 or more years before diagnosis. Childhood illnesses were inversely associated with PD, particularly red measles (OR: 0.65; 95% CI: 0.48-0.90). Several animal exposures were associated with PD, with statistically significant effects for cats (OR: 2.06; 95% CI: 1.09-3.92) and cattle (OR: 2.23; 95% CI: 1.22-4.09). Influenza infection may be associated with PD. The inverse relationships with childhood infections may suggest an increased risk with subclinical or asymptomatic childhood infections. Occupational exposure to animals may increase risk through transmission of infections or may indicate exposure to another agent of interest (e.g., bacterial endotoxin).
DOI: 10.1002/mds.25077
PubMed: 22753266
Affiliations:
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Le document en format XML
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Tsui</name></author><author><name sortKey="Marion, Stephen A" sort="Marion, Stephen A" uniqKey="Marion S" first="Stephen A" last="Marion">Stephen A. Marion</name></author><author><name sortKey="Shen, Hui" sort="Shen, Hui" uniqKey="Shen H" first="Hui" last="Shen">Hui Shen</name></author><author><name sortKey="Teschke, Kay" sort="Teschke, Kay" uniqKey="Teschke K" first="Kay" last="Teschke">Kay Teschke</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2012">2012</date><idno type="RBID">pubmed:22753266</idno><idno type="pmid">22753266</idno><idno type="doi">10.1002/mds.25077</idno><idno type="wicri:Area/Main/Corpus">000436</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000436</idno><idno type="wicri:Area/Main/Curation">000436</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000436</idno><idno type="wicri:Area/Main/Exploration">000436</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Association of Parkinson's disease with infections and occupational exposure to possible vectors.</title><author><name sortKey="Harris, M Anne" sort="Harris, M Anne" uniqKey="Harris M" first="M Anne" last="Harris">M Anne Harris</name><affiliation wicri:level="1"><nlm:affiliation>University of British Columbia, School of Population and Public Health, Vancouver, British Columbia, Canada. m.anne.harris@alumni.ubc.ca</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>University of British Columbia, School of Population and Public Health, Vancouver, British Columbia</wicri:regionArea><wicri:noRegion>British Columbia</wicri:noRegion></affiliation></author><author><name sortKey="Tsui, Joseph K" sort="Tsui, Joseph K" uniqKey="Tsui J" first="Joseph K" last="Tsui">Joseph K. 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Marion</name></author><author><name sortKey="Shen, Hui" sort="Shen, Hui" uniqKey="Shen H" first="Hui" last="Shen">Hui Shen</name></author><author><name sortKey="Teschke, Kay" sort="Teschke, Kay" uniqKey="Teschke K" first="Kay" last="Teschke">Kay Teschke</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged (MeSH)</term><term>Animals (MeSH)</term><term>British Columbia (epidemiology)</term><term>Case-Control Studies (MeSH)</term><term>Cats (MeSH)</term><term>Cattle (MeSH)</term><term>Databases, Factual (MeSH)</term><term>Disease Vectors (MeSH)</term><term>Female (MeSH)</term><term>Humans (MeSH)</term><term>Infections (complications)</term><term>Influenza Vaccines (MeSH)</term><term>Logistic Models (MeSH)</term><term>Male (MeSH)</term><term>Middle Aged (MeSH)</term><term>Occupational Exposure (adverse effects)</term><term>Odds Ratio (MeSH)</term><term>Parkinson Disease (etiology)</term><term>Pets (MeSH)</term><term>Risk Factors (MeSH)</term><term>Smoking (adverse effects)</term><term>Smoking (epidemiology)</term><term>Virus Diseases (complications)</term><term>Virus Diseases (epidemiology)</term><term>Zoonoses (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen (MeSH)</term><term>Animaux (MeSH)</term><term>Animaux de compagnie (MeSH)</term><term>Bases de données factuelles (MeSH)</term><term>Bovins (MeSH)</term><term>Chats (MeSH)</term><term>Colombie-Britannique (épidémiologie)</term><term>Exposition professionnelle (effets indésirables)</term><term>Facteurs de risque (MeSH)</term><term>Femelle (MeSH)</term><term>Fumer (effets indésirables)</term><term>Fumer (épidémiologie)</term><term>Humains (MeSH)</term><term>Maladie de Parkinson (étiologie)</term><term>Maladies virales (complications)</term><term>Maladies virales (épidémiologie)</term><term>Modèles logistiques (MeSH)</term><term>Mâle (MeSH)</term><term>Odds ratio (MeSH)</term><term>Sujet âgé (MeSH)</term><term>Vaccins antigrippaux (MeSH)</term><term>Vecteurs de maladies (MeSH)</term><term>Zoonoses (MeSH)</term><term>Études cas-témoins (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Influenza Vaccines</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>British Columbia</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Occupational Exposure</term><term>Smoking</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Infections</term><term>Virus Diseases</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Exposition professionnelle</term><term>Fumer</term><term>Maladies virales</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Smoking</term><term>Virus Diseases</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Colombie-Britannique</term><term>Fumer</term><term>Maladies virales</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Maladie de Parkinson</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Animals</term><term>Case-Control Studies</term><term>Cats</term><term>Cattle</term><term>Databases, Factual</term><term>Disease Vectors</term><term>Female</term><term>Humans</term><term>Logistic Models</term><term>Male</term><term>Middle Aged</term><term>Odds Ratio</term><term>Pets</term><term>Risk Factors</term><term>Zoonoses</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Animaux</term><term>Animaux de compagnie</term><term>Bases de données factuelles</term><term>Bovins</term><term>Chats</term><term>Facteurs de risque</term><term>Femelle</term><term>Humains</term><term>Modèles logistiques</term><term>Mâle</term><term>Odds ratio</term><term>Sujet âgé</term><term>Vaccins antigrippaux</term><term>Vecteurs de maladies</term><term>Zoonoses</term><term>Études cas-témoins</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The ultimate causes of idiopathic Parkinson's disease (PD) are not fully known, but environmental and occupational causes are suspected. Postencephalitic parkinsonism has been linked to influenza, and other viral infections have also been suspected to relate to PD. We estimated the relationship between PD and both infections and possible vectors of infection (i.e., animal and human) in a population-based, case-control study in British Columbia, Canada. We recruited 403 cases detected by their use of antiparkinsonian medications and 405 controls from the registrants of the provincial universal health insurance plan. Severe influenza was associated with PD (odds ratio [OR]: 2.01; 95% confidence interval [CI]: 1.16-3.48), although this effect was attenuated when reports were restricted to those occurring 10 or more years before diagnosis. Childhood illnesses were inversely associated with PD, particularly red measles (OR: 0.65; 95% CI: 0.48-0.90). Several animal exposures were associated with PD, with statistically significant effects for cats (OR: 2.06; 95% CI: 1.09-3.92) and cattle (OR: 2.23; 95% CI: 1.22-4.09). Influenza infection may be associated with PD. The inverse relationships with childhood infections may suggest an increased risk with subclinical or asymptomatic childhood infections. Occupational exposure to animals may increase risk through transmission of infections or may indicate exposure to another agent of interest (e.g., bacterial endotoxin).</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">22753266</PMID><DateCompleted><Year>2012</Year><Month>12</Month><Day>17</Day></DateCompleted><DateRevised><Year>2019</Year><Month>12</Month><Day>10</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN><JournalIssue CitedMedium="Internet"><Volume>27</Volume><Issue>9</Issue><PubDate><Year>2012</Year><Month>Aug</Month></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Association of Parkinson's disease with infections and occupational exposure to possible vectors.</ArticleTitle><Pagination><MedlinePgn>1111-7</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/mds.25077</ELocationID><Abstract><AbstractText>The ultimate causes of idiopathic Parkinson's disease (PD) are not fully known, but environmental and occupational causes are suspected. Postencephalitic parkinsonism has been linked to influenza, and other viral infections have also been suspected to relate to PD. We estimated the relationship between PD and both infections and possible vectors of infection (i.e., animal and human) in a population-based, case-control study in British Columbia, Canada. We recruited 403 cases detected by their use of antiparkinsonian medications and 405 controls from the registrants of the provincial universal health insurance plan. Severe influenza was associated with PD (odds ratio [OR]: 2.01; 95% confidence interval [CI]: 1.16-3.48), although this effect was attenuated when reports were restricted to those occurring 10 or more years before diagnosis. Childhood illnesses were inversely associated with PD, particularly red measles (OR: 0.65; 95% CI: 0.48-0.90). Several animal exposures were associated with PD, with statistically significant effects for cats (OR: 2.06; 95% CI: 1.09-3.92) and cattle (OR: 2.23; 95% CI: 1.22-4.09). Influenza infection may be associated with PD. The inverse relationships with childhood infections may suggest an increased risk with subclinical or asymptomatic childhood infections. Occupational exposure to animals may increase risk through transmission of infections or may indicate exposure to another agent of interest (e.g., bacterial endotoxin).</AbstractText><CopyrightInformation>Copyright © 2012 Movement Disorder Society.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Harris</LastName><ForeName>M Anne</ForeName><Initials>MA</Initials><AffiliationInfo><Affiliation>University of British Columbia, School of Population and Public Health, Vancouver, British Columbia, Canada. m.anne.harris@alumni.ubc.ca</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tsui</LastName><ForeName>Joseph K</ForeName><Initials>JK</Initials></Author><Author ValidYN="Y"><LastName>Marion</LastName><ForeName>Stephen A</ForeName><Initials>SA</Initials></Author><Author ValidYN="Y"><LastName>Shen</LastName><ForeName>Hui</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Teschke</LastName><ForeName>Kay</ForeName><Initials>K</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><Agency>Canadian Institutes of Health Research</Agency><Country>Canada</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2012</Year><Month>07</Month><Day>02</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007252">Influenza Vaccines</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001955" MajorTopicYN="N" Type="Geographic">British Columbia</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016022" MajorTopicYN="N">Case-Control Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002415" MajorTopicYN="N">Cats</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002417" MajorTopicYN="N">Cattle</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016208" MajorTopicYN="N">Databases, Factual</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004199" MajorTopicYN="N">Disease Vectors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007239" MajorTopicYN="N">Infections</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007252" MajorTopicYN="N">Influenza Vaccines</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016015" MajorTopicYN="N">Logistic Models</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016273" MajorTopicYN="N">Occupational Exposure</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="Y">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016017" MajorTopicYN="N">Odds Ratio</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName><QualifierName UI="Q000209" MajorTopicYN="Y">etiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D057805" MajorTopicYN="N">Pets</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012307" MajorTopicYN="N">Risk Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012907" MajorTopicYN="N">Smoking</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014777" MajorTopicYN="N">Virus Diseases</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015047" MajorTopicYN="N">Zoonoses</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2011</Year><Month>10</Month><Day>21</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2012</Year><Month>04</Month><Day>27</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2012</Year><Month>05</Month><Day>09</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2012</Year><Month>7</Month><Day>4</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2012</Year><Month>7</Month><Day>4</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2012</Year><Month>12</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">22753266</ArticleId><ArticleId IdType="doi">10.1002/mds.25077</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Canada</li></country></list><tree><noCountry><name sortKey="Marion, Stephen A" sort="Marion, Stephen A" uniqKey="Marion S" first="Stephen A" last="Marion">Stephen A. Marion</name><name sortKey="Shen, Hui" sort="Shen, Hui" uniqKey="Shen H" first="Hui" last="Shen">Hui Shen</name><name sortKey="Teschke, Kay" sort="Teschke, Kay" uniqKey="Teschke K" first="Kay" last="Teschke">Kay Teschke</name><name sortKey="Tsui, Joseph K" sort="Tsui, Joseph K" uniqKey="Tsui J" first="Joseph K" last="Tsui">Joseph K. Tsui</name></noCountry><country name="Canada"><noRegion><name sortKey="Harris, M Anne" sort="Harris, M Anne" uniqKey="Harris M" first="M Anne" last="Harris">M Anne Harris</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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