Increased reactions to pediatric influenza vaccination following concomitant pneumococcal vaccination.
Identifieur interne : 000374 ( Main/Exploration ); précédent : 000373; suivant : 000375Increased reactions to pediatric influenza vaccination following concomitant pneumococcal vaccination.
Auteurs : Paul G. Van Buynder [Canada] ; Gillian Frosst ; Jan L. Van Buynder ; Francios-William Tremblay ; Alie Ross ; Claire Jardine ; Bao Gang FeiSource :
- Influenza and other respiratory viruses [ 1750-2659 ] ; 2013.
Descripteurs français
- KwdFr :
- Calendrier vaccinal (MeSH), Crises convulsives fébriles (induit chimiquement), Crises convulsives fébriles (épidémiologie), Effets secondaires indésirables des médicaments (anatomopathologie), Effets secondaires indésirables des médicaments (épidémiologie), Enfant d'âge préscolaire (MeSH), Femelle (MeSH), Humains (MeSH), Mâle (MeSH), Nourrisson (MeSH), Nouveau-Brunswick (épidémiologie), Vaccination (effets indésirables), Vaccins antigrippaux (administration et posologie), Vaccins antigrippaux (effets indésirables), Vaccins antipneumococciques (administration et posologie).
- MESH :
- administration et posologie : Vaccins antigrippaux, Vaccins antipneumococciques.
- anatomopathologie : Effets secondaires indésirables des médicaments.
- effets indésirables : Vaccination, Vaccins antigrippaux.
- induit chimiquement : Crises convulsives fébriles.
- épidémiologie : Crises convulsives fébriles, Effets secondaires indésirables des médicaments, Nouveau-Brunswick.
- Calendrier vaccinal, Enfant d'âge préscolaire, Femelle, Humains, Mâle, Nourrisson.
English descriptors
- KwdEn :
- Child, Preschool (MeSH), Drug-Related Side Effects and Adverse Reactions (epidemiology), Drug-Related Side Effects and Adverse Reactions (pathology), Female (MeSH), Humans (MeSH), Immunization Schedule (MeSH), Infant (MeSH), Influenza Vaccines (administration & dosage), Influenza Vaccines (adverse effects), Male (MeSH), New Brunswick (epidemiology), Pneumococcal Vaccines (administration & dosage), Seizures, Febrile (chemically induced), Seizures, Febrile (epidemiology), Vaccination (adverse effects).
- MESH :
- chemical , administration & dosage : Influenza Vaccines, Pneumococcal Vaccines.
- chemical , adverse effects : Influenza Vaccines.
- geographic , epidemiology : New Brunswick.
- adverse effects : Vaccination.
- chemically induced : Seizures, Febrile.
- epidemiology : Drug-Related Side Effects and Adverse Reactions, Seizures, Febrile.
- pathology : Drug-Related Side Effects and Adverse Reactions.
- Child, Preschool, Female, Humans, Immunization Schedule, Infant, Male.
Abstract
BACKGROUND
Influenza in children causes significant morbidity and hospitalizations and also some mortality particularly in children < 5 years of age. Influenza vaccination in children has been shown to be safe and effective, but in 2010 the pediatric influenza vaccination program was suspended in Western Australia after the rate of febrile convulsions observed (9/1000 doses) was 55 times the previously reported rate. In 2009, over 80% of all children in New Brunswick were vaccinated with an adjuvanted monovalent H1N1 vaccine shown to have very high effectiveness, raising the prospect of potential hyper-responsiveness because of residual protection. We conducted enhanced post-marketing surveillance to monitor local and general reactions.
METHODS
Parents of participating children seen at dedicated vaccination clinics were given influenza vaccine survey kits to record local and general symptoms up to 3 days following receipt of season influenza vaccine.
RESULTS
Febrile reactions of ≥ 38° occurred in <10% of children who received a first dose of seasonal influenza vaccine (n = 660) and severe febrile incidents with fever ≥ 39° were uncommon. Concurrent administration of other vaccine(s) including conjugated pneumococcal vaccine appeared to increase reactogenicity. No child in the study had a febrile convulsion.
CONCLUSION
Influenza vaccines in children are safe, and this study provides a baseline for rapid assessment studies at the start of a vaccine season. Parents should be aware of increased fevers with concurrent vaccine administration, and antipyretics should be considered.
DOI: 10.1111/j.1750-2659.2012.00364.x
PubMed: 22498052
PubMed Central: PMC5780760
Affiliations:
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Van Buynder</name></author><author><name sortKey="Tremblay, Francios William" sort="Tremblay, Francios William" uniqKey="Tremblay F" first="Francios-William" last="Tremblay">Francios-William Tremblay</name></author><author><name sortKey="Ross, Alie" sort="Ross, Alie" uniqKey="Ross A" first="Alie" last="Ross">Alie Ross</name></author><author><name sortKey="Jardine, Claire" sort="Jardine, Claire" uniqKey="Jardine C" first="Claire" last="Jardine">Claire Jardine</name></author><author><name sortKey="Fei, Bao Gang" sort="Fei, Bao Gang" uniqKey="Fei B" first="Bao Gang" last="Fei">Bao Gang Fei</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2013">2013</date><idno type="RBID">pubmed:22498052</idno><idno type="pmid">22498052</idno><idno type="doi">10.1111/j.1750-2659.2012.00364.x</idno><idno type="pmc">PMC5780760</idno><idno type="wicri:Area/Main/Corpus">000452</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000452</idno><idno type="wicri:Area/Main/Curation">000452</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000452</idno><idno type="wicri:Area/Main/Exploration">000452</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Increased reactions to pediatric influenza vaccination following concomitant pneumococcal vaccination.</title><author><name sortKey="Van Buynder, Paul G" sort="Van Buynder, Paul G" uniqKey="Van Buynder P" first="Paul G" last="Van Buynder">Paul G. 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Van Buynder</name></author><author><name sortKey="Tremblay, Francios William" sort="Tremblay, Francios William" uniqKey="Tremblay F" first="Francios-William" last="Tremblay">Francios-William Tremblay</name></author><author><name sortKey="Ross, Alie" sort="Ross, Alie" uniqKey="Ross A" first="Alie" last="Ross">Alie Ross</name></author><author><name sortKey="Jardine, Claire" sort="Jardine, Claire" uniqKey="Jardine C" first="Claire" last="Jardine">Claire Jardine</name></author><author><name sortKey="Fei, Bao Gang" sort="Fei, Bao Gang" uniqKey="Fei B" first="Bao Gang" last="Fei">Bao Gang Fei</name></author></analytic><series><title level="j">Influenza and other respiratory viruses</title><idno type="eISSN">1750-2659</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Child, Preschool (MeSH)</term><term>Drug-Related Side Effects and Adverse Reactions (epidemiology)</term><term>Drug-Related Side Effects and Adverse Reactions (pathology)</term><term>Female (MeSH)</term><term>Humans (MeSH)</term><term>Immunization Schedule (MeSH)</term><term>Infant (MeSH)</term><term>Influenza Vaccines (administration & dosage)</term><term>Influenza Vaccines (adverse effects)</term><term>Male (MeSH)</term><term>New Brunswick (epidemiology)</term><term>Pneumococcal Vaccines (administration & dosage)</term><term>Seizures, Febrile (chemically induced)</term><term>Seizures, Febrile (epidemiology)</term><term>Vaccination (adverse effects)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Calendrier vaccinal (MeSH)</term><term>Crises convulsives fébriles (induit chimiquement)</term><term>Crises convulsives fébriles (épidémiologie)</term><term>Effets secondaires indésirables des médicaments (anatomopathologie)</term><term>Effets secondaires indésirables des médicaments (épidémiologie)</term><term>Enfant d'âge préscolaire (MeSH)</term><term>Femelle (MeSH)</term><term>Humains (MeSH)</term><term>Mâle (MeSH)</term><term>Nourrisson (MeSH)</term><term>Nouveau-Brunswick (épidémiologie)</term><term>Vaccination (effets indésirables)</term><term>Vaccins antigrippaux (administration et posologie)</term><term>Vaccins antigrippaux (effets indésirables)</term><term>Vaccins antipneumococciques (administration et posologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Influenza Vaccines</term><term>Pneumococcal Vaccines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Influenza Vaccines</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>New Brunswick</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Vaccins antigrippaux</term><term>Vaccins antipneumococciques</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Vaccination</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Effets secondaires indésirables des médicaments</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Seizures, Febrile</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Vaccination</term><term>Vaccins antigrippaux</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Drug-Related Side Effects and Adverse Reactions</term><term>Seizures, Febrile</term></keywords><keywords scheme="MESH" qualifier="induit chimiquement" xml:lang="fr"><term>Crises convulsives fébriles</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Drug-Related Side Effects and Adverse Reactions</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Crises convulsives fébriles</term><term>Effets secondaires indésirables des médicaments</term><term>Nouveau-Brunswick</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Child, Preschool</term><term>Female</term><term>Humans</term><term>Immunization Schedule</term><term>Infant</term><term>Male</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Calendrier vaccinal</term><term>Enfant d'âge préscolaire</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Nourrisson</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b></p><p>Influenza in children causes significant morbidity and hospitalizations and also some mortality particularly in children < 5 years of age. Influenza vaccination in children has been shown to be safe and effective, but in 2010 the pediatric influenza vaccination program was suspended in Western Australia after the rate of febrile convulsions observed (9/1000 doses) was 55 times the previously reported rate. In 2009, over 80% of all children in New Brunswick were vaccinated with an adjuvanted monovalent H1N1 vaccine shown to have very high effectiveness, raising the prospect of potential hyper-responsiveness because of residual protection. We conducted enhanced post-marketing surveillance to monitor local and general reactions.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>Parents of participating children seen at dedicated vaccination clinics were given influenza vaccine survey kits to record local and general symptoms up to 3 days following receipt of season influenza vaccine.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>Febrile reactions of ≥ 38° occurred in <10% of children who received a first dose of seasonal influenza vaccine (n = 660) and severe febrile incidents with fever ≥ 39° were uncommon. Concurrent administration of other vaccine(s) including conjugated pneumococcal vaccine appeared to increase reactogenicity. No child in the study had a febrile convulsion.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSION</b></p><p> Influenza vaccines in children are safe, and this study provides a baseline for rapid assessment studies at the start of a vaccine season. Parents should be aware of increased fevers with concurrent vaccine administration, and antipyretics should be considered.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">22498052</PMID><DateCompleted><Year>2013</Year><Month>07</Month><Day>29</Day></DateCompleted><DateRevised><Year>2018</Year><Month>11</Month><Day>13</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1750-2659</ISSN><JournalIssue CitedMedium="Internet"><Volume>7</Volume><Issue>2</Issue><PubDate><Year>2013</Year><Month>Mar</Month></PubDate></JournalIssue><Title>Influenza and other respiratory viruses</Title><ISOAbbreviation>Influenza Other Respir Viruses</ISOAbbreviation></Journal><ArticleTitle>Increased reactions to pediatric influenza vaccination following concomitant pneumococcal vaccination.</ArticleTitle><Pagination><MedlinePgn>184-90</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1111/j.1750-2659.2012.00364.x</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Influenza in children causes significant morbidity and hospitalizations and also some mortality particularly in children < 5 years of age. Influenza vaccination in children has been shown to be safe and effective, but in 2010 the pediatric influenza vaccination program was suspended in Western Australia after the rate of febrile convulsions observed (9/1000 doses) was 55 times the previously reported rate. In 2009, over 80% of all children in New Brunswick were vaccinated with an adjuvanted monovalent H1N1 vaccine shown to have very high effectiveness, raising the prospect of potential hyper-responsiveness because of residual protection. We conducted enhanced post-marketing surveillance to monitor local and general reactions.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Parents of participating children seen at dedicated vaccination clinics were given influenza vaccine survey kits to record local and general symptoms up to 3 days following receipt of season influenza vaccine.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Febrile reactions of ≥ 38° occurred in <10% of children who received a first dose of seasonal influenza vaccine (n = 660) and severe febrile incidents with fever ≥ 39° were uncommon. Concurrent administration of other vaccine(s) including conjugated pneumococcal vaccine appeared to increase reactogenicity. No child in the study had a febrile convulsion.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS"> Influenza vaccines in children are safe, and this study provides a baseline for rapid assessment studies at the start of a vaccine season. Parents should be aware of increased fevers with concurrent vaccine administration, and antipyretics should be considered.</AbstractText><CopyrightInformation>© 2012 Blackwell Publishing Ltd and Her Majesty the Queen in Right of Canada 2012. Reproduced with the permission of the Minister Health.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Van Buynder</LastName><ForeName>Paul G</ForeName><Initials>PG</Initials><AffiliationInfo><Affiliation>Fraser Health Authority, Surrey, British Columbia, Canada. pjvb@iinet.net.au</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Frosst</LastName><ForeName>Gillian</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Van Buynder</LastName><ForeName>Jan L</ForeName><Initials>JL</Initials></Author><Author ValidYN="Y"><LastName>Tremblay</LastName><ForeName>Francios-William</ForeName><Initials>FW</Initials></Author><Author ValidYN="Y"><LastName>Ross</LastName><ForeName>Alie</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Jardine</LastName><ForeName>Claire</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Fei</LastName><ForeName>Bao 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Effects and Adverse Reactions</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007115" MajorTopicYN="Y">Immunization Schedule</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007223" MajorTopicYN="N">Infant</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007252" MajorTopicYN="N">Influenza Vaccines</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName><QualifierName UI="Q000009" MajorTopicYN="Y">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName 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sortKey="Van Buynder, Jan L" sort="Van Buynder, Jan L" uniqKey="Van Buynder J" first="Jan L" last="Van Buynder">Jan L. Van Buynder</name></noCountry><country name="Canada"><noRegion><name sortKey="Van Buynder, Paul G" sort="Van Buynder, Paul G" uniqKey="Van Buynder P" first="Paul G" last="Van Buynder">Paul G. Van Buynder</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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