Effectiveness of pandemic H1N1 vaccine against influenza-related hospitalization in children.
Identifieur interne : 000561 ( Main/Exploration ); précédent : 000560; suivant : 000562Effectiveness of pandemic H1N1 vaccine against influenza-related hospitalization in children.
Auteurs : Rodica Gilca [Canada] ; Geneviève Deceuninck ; Gaston De Serres ; Nicole Boulianne ; Chantal Sauvageau ; Caroline Quach ; François D. Boucher ; Danuta M. SkowronskiSource :
- Pediatrics [ 1098-4275 ] ; 2011.
Descripteurs français
- KwdFr :
- Analyse de variance (MeSH), Analyse multifactorielle (MeSH), Enfant (MeSH), Enfant d'âge préscolaire (MeSH), Femelle (MeSH), Grippe humaine (immunologie), Grippe humaine (prévention et contrôle), Grippe humaine (virologie), Hospitalisation (statistiques et données numériques), Humains (MeSH), Incidence (MeSH), Intervalles de confiance (MeSH), Modèles logistiques (MeSH), Mâle (MeSH), Nourrisson (MeSH), Pandémies (prévention et contrôle), Pandémies (statistiques et données numériques), Québec (épidémiologie), Répartition par sexe (MeSH), Répartition par âge (MeSH), Sous-type H1N1 du virus de la grippe A (immunologie), Vaccination (méthodes), Vaccins antigrippaux (administration et posologie), Valeurs de référence (MeSH), Études cas-témoins (MeSH), Études rétrospectives (MeSH).
- MESH :
- administration et posologie : Vaccins antigrippaux.
- immunologie : Grippe humaine, Sous-type H1N1 du virus de la grippe A.
- méthodes : Vaccination.
- prévention et contrôle : Grippe humaine, Pandémies.
- statistiques et données numériques : Hospitalisation, Pandémies.
- virologie : Grippe humaine.
- épidémiologie : Québec.
- Analyse de variance, Analyse multifactorielle, Enfant, Enfant d'âge préscolaire, Femelle, Humains, Incidence, Intervalles de confiance, Modèles logistiques, Mâle, Nourrisson, Répartition par sexe, Répartition par âge, Valeurs de référence, Études cas-témoins, Études rétrospectives.
English descriptors
- KwdEn :
- Age Distribution (MeSH), Analysis of Variance (MeSH), Case-Control Studies (MeSH), Child (MeSH), Child, Preschool (MeSH), Confidence Intervals (MeSH), Female (MeSH), Hospitalization (statistics & numerical data), Humans (MeSH), Incidence (MeSH), Infant (MeSH), Influenza A Virus, H1N1 Subtype (immunology), Influenza Vaccines (administration & dosage), Influenza, Human (immunology), Influenza, Human (prevention & control), Influenza, Human (virology), Logistic Models (MeSH), Male (MeSH), Multivariate Analysis (MeSH), Pandemics (prevention & control), Pandemics (statistics & numerical data), Quebec (epidemiology), Reference Values (MeSH), Retrospective Studies (MeSH), Sex Distribution (MeSH), Vaccination (methods).
- MESH :
- chemical , administration & dosage : Influenza Vaccines.
- geographic , epidemiology : Quebec.
- immunology : Influenza A Virus, H1N1 Subtype, Influenza, Human.
- methods : Vaccination.
- prevention & control : Influenza, Human, Pandemics.
- statistics & numerical data : Hospitalization, Pandemics.
- virology : Influenza, Human.
- Age Distribution, Analysis of Variance, Case-Control Studies, Child, Child, Preschool, Confidence Intervals, Female, Humans, Incidence, Infant, Logistic Models, Male, Multivariate Analysis, Reference Values, Retrospective Studies, Sex Distribution.
Abstract
OBJECTIVE
Young children are generally considered immunologically naive with respect to influenza exposure opportunities; thus, a 2-dose schedule is recommended when a child is first immunized with conventional influenza vaccine lacking adjuvant. We estimated the effectiveness of a single pediatric dose of AS03-adjuvanted vaccine against hospitalization for confirmed pandemic influenza A/H1N1 (pH1N1) infection in children aged 6 months to 9 years during the fall 2009 vaccination campaign.
METHODS
In a matched case-control design, case subjects were children hospitalized for pH1N1 infection in the Fall of 2009, in Quebec, Canada. Controls were nonhospitalized children, matched by age and region of residence. Vaccination status in case subjects and controls was ascertained in relation to the case subject's date of illness onset. Vaccine effectiveness was estimated through conditional logistic regression.
RESULTS
The overall effectiveness of a single pediatric dose of vaccine administered ≥14 days before illness onset was 85% (95% confidence interval [CI]: 61% to 94%), varying according to age category but with wide and overlapping CIs: 92% (95% CI: 51% to 99%) in 6-23 month-old children, 89% (95% CI: 34% to 98%) in 2-4 year-olds, and 79% (95% CI: -31% to 96%) in 5-9 year-olds. Overall vaccine effectiveness for immunization ≥10 days before illness onset was slightly lower at 80% (95% CI: 60% to 90%), with similar variation according to age.
CONCLUSION
In children aged 6 months to 9 years, a single pediatric dose of the AS03-adjuvanted pH1N1 vaccine was highly protective against hospitalization beginning at 10 and 14 days after vaccination.
DOI: 10.1542/peds.2010-3492
PubMed: 21987710
Affiliations:
Links toward previous steps (curation, corpus...)
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Analysis (MeSH)</term><term>Pandemics (prevention & control)</term><term>Pandemics (statistics & numerical data)</term><term>Quebec (epidemiology)</term><term>Reference Values (MeSH)</term><term>Retrospective Studies (MeSH)</term><term>Sex Distribution (MeSH)</term><term>Vaccination (methods)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Analyse de variance (MeSH)</term><term>Analyse multifactorielle (MeSH)</term><term>Enfant (MeSH)</term><term>Enfant d'âge préscolaire (MeSH)</term><term>Femelle (MeSH)</term><term>Grippe humaine (immunologie)</term><term>Grippe humaine (prévention et contrôle)</term><term>Grippe humaine (virologie)</term><term>Hospitalisation (statistiques et données numériques)</term><term>Humains (MeSH)</term><term>Incidence (MeSH)</term><term>Intervalles de confiance (MeSH)</term><term>Modèles logistiques (MeSH)</term><term>Mâle (MeSH)</term><term>Nourrisson (MeSH)</term><term>Pandémies (prévention et contrôle)</term><term>Pandémies (statistiques et 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xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Québec</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Age Distribution</term><term>Analysis of Variance</term><term>Case-Control Studies</term><term>Child</term><term>Child, Preschool</term><term>Confidence Intervals</term><term>Female</term><term>Humans</term><term>Incidence</term><term>Infant</term><term>Logistic Models</term><term>Male</term><term>Multivariate Analysis</term><term>Reference Values</term><term>Retrospective Studies</term><term>Sex Distribution</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Analyse de variance</term><term>Analyse multifactorielle</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Femelle</term><term>Humains</term><term>Incidence</term><term>Intervalles de confiance</term><term>Modèles logistiques</term><term>Mâle</term><term>Nourrisson</term><term>Répartition par sexe</term><term>Répartition par âge</term><term>Valeurs de référence</term><term>Études cas-témoins</term><term>Études rétrospectives</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>OBJECTIVE</b></p><p>Young children are generally considered immunologically naive with respect to influenza exposure opportunities; thus, a 2-dose schedule is recommended when a child is first immunized with conventional influenza vaccine lacking adjuvant. We estimated the effectiveness of a single pediatric dose of AS03-adjuvanted vaccine against hospitalization for confirmed pandemic influenza A/H1N1 (pH1N1) infection in children aged 6 months to 9 years during the fall 2009 vaccination campaign.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>In a matched case-control design, case subjects were children hospitalized for pH1N1 infection in the Fall of 2009, in Quebec, Canada. Controls were nonhospitalized children, matched by age and region of residence. Vaccination status in case subjects and controls was ascertained in relation to the case subject's date of illness onset. Vaccine effectiveness was estimated through conditional logistic regression.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>The overall effectiveness of a single pediatric dose of vaccine administered ≥14 days before illness onset was 85% (95% confidence interval [CI]: 61% to 94%), varying according to age category but with wide and overlapping CIs: 92% (95% CI: 51% to 99%) in 6-23 month-old children, 89% (95% CI: 34% to 98%) in 2-4 year-olds, and 79% (95% CI: -31% to 96%) in 5-9 year-olds. Overall vaccine effectiveness for immunization ≥10 days before illness onset was slightly lower at 80% (95% CI: 60% to 90%), with similar variation according to age.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSION</b></p><p>In children aged 6 months to 9 years, a single pediatric dose of the AS03-adjuvanted pH1N1 vaccine was highly protective against hospitalization beginning at 10 and 14 days after vaccination.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">21987710</PMID><DateCompleted><Year>2012</Year><Month>01</Month><Day>24</Day></DateCompleted><DateRevised><Year>2019</Year><Month>12</Month><Day>10</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1098-4275</ISSN><JournalIssue CitedMedium="Internet"><Volume>128</Volume><Issue>5</Issue><PubDate><Year>2011</Year><Month>Nov</Month></PubDate></JournalIssue><Title>Pediatrics</Title><ISOAbbreviation>Pediatrics</ISOAbbreviation></Journal><ArticleTitle>Effectiveness of pandemic H1N1 vaccine against influenza-related hospitalization in children.</ArticleTitle><Pagination><MedlinePgn>e1084-91</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1542/peds.2010-3492</ELocationID><Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">Young children are generally considered immunologically naive with respect to influenza exposure opportunities; thus, a 2-dose schedule is recommended when a child is first immunized with conventional influenza vaccine lacking adjuvant. We estimated the effectiveness of a single pediatric dose of AS03-adjuvanted vaccine against hospitalization for confirmed pandemic influenza A/H1N1 (pH1N1) infection in children aged 6 months to 9 years during the fall 2009 vaccination campaign.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">In a matched case-control design, case subjects were children hospitalized for pH1N1 infection in the Fall of 2009, in Quebec, Canada. Controls were nonhospitalized children, matched by age and region of residence. Vaccination status in case subjects and controls was ascertained in relation to the case subject's date of illness onset. Vaccine effectiveness was estimated through conditional logistic regression.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">The overall effectiveness of a single pediatric dose of vaccine administered ≥14 days before illness onset was 85% (95% confidence interval [CI]: 61% to 94%), varying according to age category but with wide and overlapping CIs: 92% (95% CI: 51% to 99%) in 6-23 month-old children, 89% (95% CI: 34% to 98%) in 2-4 year-olds, and 79% (95% CI: -31% to 96%) in 5-9 year-olds. Overall vaccine effectiveness for immunization ≥10 days before illness onset was slightly lower at 80% (95% CI: 60% to 90%), with similar variation according to age.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">In children aged 6 months to 9 years, a single pediatric dose of the AS03-adjuvanted pH1N1 vaccine was highly protective against hospitalization beginning at 10 and 14 days after vaccination.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Gilca</LastName><ForeName>Rodica</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Institut National de Santé Publique du Québec, Quebec City, Quebec, Canada. rodica.gilca@ssss.gouv.qc.ca</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Deceuninck</LastName><ForeName>Geneviève</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>De Serres</LastName><ForeName>Gaston</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Boulianne</LastName><ForeName>Nicole</ForeName><Initials>N</Initials></Author><Author ValidYN="Y"><LastName>Sauvageau</LastName><ForeName>Chantal</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Quach</LastName><ForeName>Caroline</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Boucher</LastName><ForeName>François D</ForeName><Initials>FD</Initials></Author><Author ValidYN="Y"><LastName>Skowronski</LastName><ForeName>Danuta M</ForeName><Initials>DM</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D023362">Evaluation Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2011</Year><Month>10</Month><Day>10</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Pediatrics</MedlineTA><NlmUniqueID>0376422</NlmUniqueID><ISSNLinking>0031-4005</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007252">Influenza Vaccines</NameOfSubstance></Chemical></ChemicalList><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D017677" MajorTopicYN="N">Age Distribution</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000704" MajorTopicYN="N">Analysis of Variance</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016022" MajorTopicYN="N">Case-Control Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002648" MajorTopicYN="N">Child</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002675" MajorTopicYN="N">Child, Preschool</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016001" MajorTopicYN="N">Confidence Intervals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006760" MajorTopicYN="N">Hospitalization</DescriptorName><QualifierName UI="Q000706" MajorTopicYN="Y">statistics & numerical data</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015994" MajorTopicYN="N">Incidence</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007223" MajorTopicYN="N">Infant</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D053118" MajorTopicYN="N">Influenza A Virus, H1N1 Subtype</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007252" MajorTopicYN="N">Influenza Vaccines</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007251" MajorTopicYN="N">Influenza, Human</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName><QualifierName UI="Q000517" MajorTopicYN="Y">prevention & control</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016015" MajorTopicYN="N">Logistic Models</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015999" MajorTopicYN="N">Multivariate Analysis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D058873" MajorTopicYN="N">Pandemics</DescriptorName><QualifierName UI="Q000517" MajorTopicYN="Y">prevention & control</QualifierName><QualifierName UI="Q000706" MajorTopicYN="N">statistics & numerical data</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011792" MajorTopicYN="N" Type="Geographic">Quebec</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012016" MajorTopicYN="N">Reference Values</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012189" MajorTopicYN="N">Retrospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017678" MajorTopicYN="N">Sex Distribution</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014611" MajorTopicYN="N">Vaccination</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2011</Year><Month>10</Month><Day>12</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2011</Year><Month>10</Month><Day>12</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2012</Year><Month>1</Month><Day>25</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">21987710</ArticleId><ArticleId IdType="pii">peds.2010-3492</ArticleId><ArticleId IdType="doi">10.1542/peds.2010-3492</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Canada</li></country></list><tree><noCountry><name sortKey="Boucher, Francois D" sort="Boucher, Francois D" uniqKey="Boucher F" first="François D" last="Boucher">François D. Boucher</name><name sortKey="Boulianne, Nicole" sort="Boulianne, Nicole" uniqKey="Boulianne N" first="Nicole" last="Boulianne">Nicole Boulianne</name><name sortKey="De Serres, Gaston" sort="De Serres, Gaston" uniqKey="De Serres G" first="Gaston" last="De Serres">Gaston De Serres</name><name sortKey="Deceuninck, Genevieve" sort="Deceuninck, Genevieve" uniqKey="Deceuninck G" first="Geneviève" last="Deceuninck">Geneviève Deceuninck</name><name sortKey="Quach, Caroline" sort="Quach, Caroline" uniqKey="Quach C" first="Caroline" last="Quach">Caroline Quach</name><name sortKey="Sauvageau, Chantal" sort="Sauvageau, Chantal" uniqKey="Sauvageau C" first="Chantal" last="Sauvageau">Chantal Sauvageau</name><name sortKey="Skowronski, Danuta M" sort="Skowronski, Danuta M" uniqKey="Skowronski D" first="Danuta M" last="Skowronski">Danuta M. Skowronski</name></noCountry><country name="Canada"><noRegion><name sortKey="Gilca, Rodica" sort="Gilca, Rodica" uniqKey="Gilca R" first="Rodica" last="Gilca">Rodica Gilca</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a GrippeCanadaV4
| This area was generated with Dilib version V0.6.35. |  |