Age-specific mortality during the 1918 influenza pandemic: unravelling the mystery of high young adult mortality.
Identifieur interne : 000399 ( Main/Exploration ); précédent : 000398; suivant : 000400Age-specific mortality during the 1918 influenza pandemic: unravelling the mystery of high young adult mortality.
Auteurs : Alain Gagnon [Canada] ; Matthew S. Miller ; Stacey A. Hallman ; Robert Bourbeau ; D Ann Herring ; David J D. Earn ; Joaquín MadrenasSource :
- PloS one [ 1932-6203 ] ; 2013.
Descripteurs français
- KwdFr :
- Adolescent (MeSH), Adulte (MeSH), Adulte d'âge moyen (MeSH), Canada (épidémiologie), Enfant (MeSH), Enfant d'âge préscolaire (MeSH), Femelle (MeSH), Grippe humaine (mortalité), Grippe humaine (épidémiologie), Humains (MeSH), Jeune adulte (MeSH), Mâle (MeSH), Nourrisson (MeSH), Nouveau-né (MeSH), Pandémies (statistiques et données numériques), Répartition par âge (MeSH), Sujet âgé (MeSH), Sujet âgé de 80 ans ou plus (MeSH), États-Unis (épidémiologie).
- MESH :
- mortalité : Grippe humaine.
- statistiques et données numériques : Pandémies.
- épidémiologie : Canada, Grippe humaine, États-Unis.
- Adolescent, Adulte, Adulte d'âge moyen, Enfant, Enfant d'âge préscolaire, Femelle, Humains, Jeune adulte, Mâle, Nourrisson, Nouveau-né, Répartition par âge, Sujet âgé, Sujet âgé de 80 ans ou plus.
- Wicri :
- geographic : Canada, États-Unis.
English descriptors
- KwdEn :
- Adolescent (MeSH), Adult (MeSH), Age Distribution (MeSH), Aged (MeSH), Aged, 80 and over (MeSH), Canada (epidemiology), Child (MeSH), Child, Preschool (MeSH), Female (MeSH), Humans (MeSH), Infant (MeSH), Infant, Newborn (MeSH), Influenza, Human (epidemiology), Influenza, Human (mortality), Male (MeSH), Middle Aged (MeSH), Pandemics (statistics & numerical data), United States (epidemiology), Young Adult (MeSH).
- MESH :
- geographic , epidemiology : Canada, United States.
- epidemiology : Influenza, Human.
- mortality : Influenza, Human.
- statistics & numerical data : Pandemics.
- Adolescent, Adult, Age Distribution, Aged, Aged, 80 and over, Child, Child, Preschool, Female, Humans, Infant, Infant, Newborn, Male, Middle Aged, Young Adult.
Abstract
The worldwide spread of a novel influenza A (H1N1) virus in 2009 showed that influenza remains a significant health threat, even for individuals in the prime of life. This paper focuses on the unusually high young adult mortality observed during the Spanish flu pandemic of 1918. Using historical records from Canada and the U.S., we report a peak of mortality at the exact age of 28 during the pandemic and argue that this increased mortality resulted from an early life exposure to influenza during the previous Russian flu pandemic of 1889-90. We posit that in specific instances, development of immunological memory to an influenza virus strain in early life may lead to a dysregulated immune response to antigenically novel strains encountered in later life, thereby increasing the risk of death. Exposure during critical periods of development could also create holes in the T cell repertoire and impair fetal maturation in general, thereby increasing mortality from infectious diseases later in life. Knowledge of the age-pattern of susceptibility to mortality from influenza could improve crisis management during future influenza pandemics.
DOI: 10.1371/journal.pone.0069586
PubMed: 23940526
PubMed Central: PMC3734171
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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This paper focuses on the unusually high young adult mortality observed during the Spanish flu pandemic of 1918. Using historical records from Canada and the U.S., we report a peak of mortality at the exact age of 28 during the pandemic and argue that this increased mortality resulted from an early life exposure to influenza during the previous Russian flu pandemic of 1889-90. We posit that in specific instances, development of immunological memory to an influenza virus strain in early life may lead to a dysregulated immune response to antigenically novel strains encountered in later life, thereby increasing the risk of death. Exposure during critical periods of development could also create holes in the T cell repertoire and impair fetal maturation in general, thereby increasing mortality from infectious diseases later in life. Knowledge of the age-pattern of susceptibility to mortality from influenza could improve crisis management during future influenza pandemics. </div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">23940526</PMID><DateCompleted><Year>2014</Year><Month>03</Month><Day>05</Day></DateCompleted><DateRevised><Year>2018</Year><Month>11</Month><Day>13</Day></DateRevised><Article PubModel="Electronic-Print"><Journal><ISSN IssnType="Electronic">1932-6203</ISSN><JournalIssue CitedMedium="Internet"><Volume>8</Volume><Issue>8</Issue><PubDate><Year>2013</Year></PubDate></JournalIssue><Title>PloS one</Title><ISOAbbreviation>PLoS ONE</ISOAbbreviation></Journal><ArticleTitle>Age-specific mortality during the 1918 influenza pandemic: unravelling the mystery of high young adult mortality.</ArticleTitle><Pagination><MedlinePgn>e69586</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1371/journal.pone.0069586</ELocationID><Abstract><AbstractText>The worldwide spread of a novel influenza A (H1N1) virus in 2009 showed that influenza remains a significant health threat, even for individuals in the prime of life. This paper focuses on the unusually high young adult mortality observed during the Spanish flu pandemic of 1918. Using historical records from Canada and the U.S., we report a peak of mortality at the exact age of 28 during the pandemic and argue that this increased mortality resulted from an early life exposure to influenza during the previous Russian flu pandemic of 1889-90. We posit that in specific instances, development of immunological memory to an influenza virus strain in early life may lead to a dysregulated immune response to antigenically novel strains encountered in later life, thereby increasing the risk of death. Exposure during critical periods of development could also create holes in the T cell repertoire and impair fetal maturation in general, thereby increasing mortality from infectious diseases later in life. Knowledge of the age-pattern of susceptibility to mortality from influenza could improve crisis management during future influenza pandemics. </AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Gagnon</LastName><ForeName>Alain</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Département de Démographie, Université de Montréal, Montreal, Quebec, Canada. alain.gagnon.4@umontreal.ca</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Miller</LastName><ForeName>Matthew S</ForeName><Initials>MS</Initials></Author><Author ValidYN="Y"><LastName>Hallman</LastName><ForeName>Stacey A</ForeName><Initials>SA</Initials></Author><Author ValidYN="Y"><LastName>Bourbeau</LastName><ForeName>Robert</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Herring</LastName><ForeName>D Ann</ForeName><Initials>DA</Initials></Author><Author ValidYN="Y"><LastName>Earn</LastName><ForeName>David J 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Distribution</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002170" MajorTopicYN="N" Type="Geographic">Canada</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002648" MajorTopicYN="N">Child</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002675" MajorTopicYN="N">Child, Preschool</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007223" MajorTopicYN="N">Infant</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007231" MajorTopicYN="N">Infant, Newborn</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007251" MajorTopicYN="N">Influenza, Human</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000401" MajorTopicYN="Y">mortality</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D058873" MajorTopicYN="N">Pandemics</DescriptorName><QualifierName UI="Q000706" MajorTopicYN="N">statistics & numerical data</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014481" MajorTopicYN="N" Type="Geographic">United States</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D055815" MajorTopicYN="N">Young 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Earn</name><name sortKey="Hallman, Stacey A" sort="Hallman, Stacey A" uniqKey="Hallman S" first="Stacey A" last="Hallman">Stacey A. Hallman</name><name sortKey="Herring, D Ann" sort="Herring, D Ann" uniqKey="Herring D" first="D Ann" last="Herring">D Ann Herring</name><name sortKey="Madrenas, Joaquin" sort="Madrenas, Joaquin" uniqKey="Madrenas J" first="Joaquín" last="Madrenas">Joaquín Madrenas</name><name sortKey="Miller, Matthew S" sort="Miller, Matthew S" uniqKey="Miller M" first="Matthew S" last="Miller">Matthew S. Miller</name></noCountry><country name="Canada"><noRegion><name sortKey="Gagnon, Alain" sort="Gagnon, Alain" uniqKey="Gagnon A" first="Alain" last="Gagnon">Alain Gagnon</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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