Influenza A (H1N1pdm09)-Related Critical Illness and Mortality in Mexico and Canada, 2014.
Identifieur interne : 000154 ( Main/Exploration ); précédent : 000153; suivant : 000155Influenza A (H1N1pdm09)-Related Critical Illness and Mortality in Mexico and Canada, 2014.
Auteurs : Guillermo Dominguez-Cherit ; Alethse De La Torre ; Asgar Rishu ; Ruxandra Pinto ; Silvio A. Amendys-Silva ; Adrián Camacho-Ortiz ; Marco Antonio Silva-Medina ; Carmen Hernández-Cárdenas ; Michel Martínez-Franco ; Alejandro Quesada-Sánchez ; Guadalupe Celia L Pez-Gallegos ; Juan L. Mosqueda-G Mez ; Norma E. Rivera-Martinez ; Fernando Campos-Calder N ; Eduardo Rivero-Sigarroa ; Thierry Hernández-Gilsoul ; Lourdes Espinosa-Pérez ; Alejandro E. Macías ; Dolores M. Lue-Martínez ; Christian Buelna-Cano ; Ana-Sofía Ramírez-García Luna ; Nestor G. Cruz-Ruiz ; Manuel Poblano-Morales ; Fernando Molinar-Ramos ; Martin Hernandez-Torre ; Marco Antonio Le N-Gutiérrez ; Oscar Rosaldo-Abundis ; José Ngel Baltazar-Torres ; Henry T. Stelfox ; Bruce Light ; Philippe Jouvet ; Steve Reynolds ; Richard Hall ; Nikki Shindo ; Nick Daneman ; Robert A. FowlerSource :
- Critical care medicine [ 1530-0293 ] ; 2016.
Descripteurs français
- KwdFr :
- Adulte (MeSH), Adulte d'âge moyen (MeSH), Antiviraux (usage thérapeutique), Antiviraux (économie), Canada (épidémiologie), Dépenses de santé (MeSH), Femelle (MeSH), Grippe humaine (physiopathologie), Grippe humaine (thérapie), Grippe humaine (économie), Grippe humaine (épidémiologie), Hormones corticosurrénaliennes (usage thérapeutique), Hormones corticosurrénaliennes (économie), Humains (MeSH), Insuffisance respiratoire (physiopathologie), Insuffisance respiratoire (thérapie), Maladie grave (thérapie), Maladie grave (épidémiologie), Mexique (épidémiologie), Mâle (MeSH), Oxygénation extracorporelle sur oxygénateur à membrane (méthodes), Oxygénation extracorporelle sur oxygénateur à membrane (économie), Sous-type H1N1 du virus de la grippe A (MeSH), Sujet âgé (MeSH), Unités de soins intensifs (statistiques et données numériques), Ventilation artificielle (méthodes), Ventilation artificielle (économie).
- MESH :
- méthodes : Oxygénation extracorporelle sur oxygénateur à membrane, Ventilation artificielle.
- physiopathologie : Grippe humaine, Insuffisance respiratoire.
- statistiques et données numériques : Unités de soins intensifs.
- thérapie : Grippe humaine, Insuffisance respiratoire, Maladie grave.
- usage thérapeutique : Antiviraux, Hormones corticosurrénaliennes.
- économie : Antiviraux, Grippe humaine, Hormones corticosurrénaliennes, Oxygénation extracorporelle sur oxygénateur à membrane, Ventilation artificielle.
- épidémiologie : Canada, Grippe humaine, Maladie grave, Mexique.
- Adulte, Adulte d'âge moyen, Dépenses de santé, Femelle, Humains, Mâle, Sous-type H1N1 du virus de la grippe A, Sujet âgé.
English descriptors
- KwdEn :
- Adrenal Cortex Hormones (economics), Adrenal Cortex Hormones (therapeutic use), Adult (MeSH), Aged (MeSH), Antiviral Agents (economics), Antiviral Agents (therapeutic use), Canada (epidemiology), Critical Illness (epidemiology), Critical Illness (therapy), Extracorporeal Membrane Oxygenation (economics), Extracorporeal Membrane Oxygenation (methods), Female (MeSH), Health Expenditures (MeSH), Humans (MeSH), Influenza A Virus, H1N1 Subtype (MeSH), Influenza, Human (economics), Influenza, Human (epidemiology), Influenza, Human (physiopathology), Influenza, Human (therapy), Intensive Care Units (statistics & numerical data), Male (MeSH), Mexico (epidemiology), Middle Aged (MeSH), Respiration, Artificial (economics), Respiration, Artificial (methods), Respiratory Insufficiency (physiopathology), Respiratory Insufficiency (therapy).
- MESH :
- chemical , economics : Adrenal Cortex Hormones, Antiviral Agents.
- chemical , therapeutic use : Adrenal Cortex Hormones, Antiviral Agents.
- economics : Extracorporeal Membrane Oxygenation, Influenza, Human, Respiration, Artificial.
- epidemiology : Canada, Critical Illness, Influenza, Human, Mexico.
- methods : Extracorporeal Membrane Oxygenation, Respiration, Artificial.
- physiopathology : Influenza, Human, Respiratory Insufficiency.
- statistics & numerical data : Intensive Care Units.
- therapy : Critical Illness, Influenza, Human, Respiratory Insufficiency.
- Adult, Aged, Female, Health Expenditures, Humans, Influenza A Virus, H1N1 Subtype, Male, Middle Aged.
Abstract
OBJECTIVES
The 2009-2010 influenza A (H1N1pdm09) pandemic caused substantial morbidity and mortality among young patients; however, mortality estimates have been confounded by regional differences in eligibility criteria and inclusion of selected populations. In 2013-2014, H1N1pdm09 became North America's dominant seasonal influenza strain. Our objective was to compare the baseline characteristics, resources, and treatments with outcomes among critically ill patients with influenza A (H1N1pdm09) in Mexican and Canadian hospitals in 2014 using consistent eligibility criteria.
DESIGN
Observational study and a survey of available healthcare setting resources.
SETTING
Twenty-one hospitals, 13 in Mexico and eight in Canada.
PATIENTS
Critically ill patients with confirmed H1N1pdm09 during 2013-2014 influenza season.
INTERVENTIONS
None.
MEASUREMENTS AND MAIN RESULTS
The main outcome measures were 90-day mortality and independent predictors of mortality. Among 165 adult patients with H1N1pdm09-related critical illness between September 2013 and March 2014, mean age was 48.3 years, 64% were males, and nearly all influenza was community acquired. Patients were severely hypoxic (median PaO2-to-FIO2 ratio, 83 mm Hg), 97% received mechanical ventilation, with mean positive end-expiratory pressure of 14 cm H2O at the onset of critical illness and 26.7% received rescue oxygenation therapy with prone ventilation, extracorporeal life support, high-frequency oscillatory ventilation, or inhaled nitric oxide. At 90 days, mortality was 34.6% (13.9% in Canada vs 50.5% in Mexico, p < 0.0001). Independent predictors of mortality included lower presenting PaO2-to-FIO2 ratio (odds ratio, 0.89 per 10-point increase [95% CI, 0.80-0.99]), age (odds ratio, 1.49 per 10 yr increment [95% CI, 1.10-2.02]), and requiring critical care in Mexico (odds ratio, 7.76 [95% CI, 2.02-27.35]). ICUs in Canada generally had more beds, ventilators, healthcare personnel, and rescue oxygenation therapies.
CONCLUSIONS
Influenza A (H1N1pdm09)-related critical illness still predominantly affects relatively young to middle-aged patients and is associated with severe hypoxemic respiratory failure. The local critical care system and available resources may be influential determinants of patient outcome.
DOI: 10.1097/CCM.0000000000001830
PubMed: 27359085
Affiliations:
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Mosqueda-G Mez</name></author><author><name sortKey="Rivera Martinez, Norma E" sort="Rivera Martinez, Norma E" uniqKey="Rivera Martinez N" first="Norma E" last="Rivera-Martinez">Norma E. Rivera-Martinez</name></author><author><name sortKey="Campos Calder N, Fernando" sort="Campos Calder N, Fernando" uniqKey="Campos Calder N F" first="Fernando" last="Campos-Calder N">Fernando Campos-Calder N</name></author><author><name sortKey="Rivero Sigarroa, Eduardo" sort="Rivero Sigarroa, Eduardo" uniqKey="Rivero Sigarroa E" first="Eduardo" last="Rivero-Sigarroa">Eduardo Rivero-Sigarroa</name></author><author><name sortKey="Hernandez Gilsoul, Thierry" sort="Hernandez Gilsoul, Thierry" uniqKey="Hernandez Gilsoul T" first="Thierry" last="Hernández-Gilsoul">Thierry Hernández-Gilsoul</name></author><author><name sortKey="Espinosa Perez, Lourdes" sort="Espinosa Perez, Lourdes" uniqKey="Espinosa Perez L" first="Lourdes" last="Espinosa-Pérez">Lourdes Espinosa-Pérez</name></author><author><name sortKey="Macias, Alejandro E" sort="Macias, Alejandro E" uniqKey="Macias A" first="Alejandro E" last="Macías">Alejandro E. Macías</name></author><author><name sortKey="Lue Martinez, Dolores M" sort="Lue Martinez, Dolores M" uniqKey="Lue Martinez D" first="Dolores M" last="Lue-Martínez">Dolores M. Lue-Martínez</name></author><author><name sortKey="Buelna Cano, Christian" sort="Buelna Cano, Christian" uniqKey="Buelna Cano C" first="Christian" last="Buelna-Cano">Christian Buelna-Cano</name></author><author><name sortKey="Ramirez Garcia Luna, Ana Sofia" sort="Ramirez Garcia Luna, Ana Sofia" uniqKey="Ramirez Garcia Luna A" first="Ana-Sofía" last="Ramírez-García Luna">Ana-Sofía Ramírez-García Luna</name></author><author><name sortKey="Cruz Ruiz, Nestor G" sort="Cruz Ruiz, Nestor G" uniqKey="Cruz Ruiz N" first="Nestor G" last="Cruz-Ruiz">Nestor G. 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Stelfox</name></author><author><name sortKey="Light, Bruce" sort="Light, Bruce" uniqKey="Light B" first="Bruce" last="Light">Bruce Light</name></author><author><name sortKey="Jouvet, Philippe" sort="Jouvet, Philippe" uniqKey="Jouvet P" first="Philippe" last="Jouvet">Philippe Jouvet</name></author><author><name sortKey="Reynolds, Steve" sort="Reynolds, Steve" uniqKey="Reynolds S" first="Steve" last="Reynolds">Steve Reynolds</name></author><author><name sortKey="Hall, Richard" sort="Hall, Richard" uniqKey="Hall R" first="Richard" last="Hall">Richard Hall</name></author><author><name sortKey="Shindo, Nikki" sort="Shindo, Nikki" uniqKey="Shindo N" first="Nikki" last="Shindo">Nikki Shindo</name></author><author><name sortKey="Daneman, Nick" sort="Daneman, Nick" uniqKey="Daneman N" first="Nick" last="Daneman">Nick Daneman</name></author><author><name sortKey="Fowler, Robert A" sort="Fowler, Robert A" uniqKey="Fowler R" first="Robert A" last="Fowler">Robert A. Fowler</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:27359085</idno><idno type="pmid">27359085</idno><idno type="doi">10.1097/CCM.0000000000001830</idno><idno type="wicri:Area/Main/Corpus">000152</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000152</idno><idno type="wicri:Area/Main/Curation">000152</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000152</idno><idno type="wicri:Area/Main/Exploration">000152</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Influenza A (H1N1pdm09)-Related Critical Illness and Mortality in Mexico and Canada, 2014.</title><author><name sortKey="Dominguez Cherit, Guillermo" sort="Dominguez Cherit, Guillermo" uniqKey="Dominguez Cherit G" first="Guillermo" last="Dominguez-Cherit">Guillermo Dominguez-Cherit</name><affiliation><nlm:affiliation>1Department of Critical Care Medicine, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.2Escuela de Medicina, Tecnologico de Monterrey, Monterrey, Mexico.3Department of Hospital Epidemiology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.4Trauma, Emergency and Critical Care, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada.5Department of Critical Care Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada.6Department of Critical Care Medicine, Instituto Nacional de Cancerología, Mexico City, Mexico.7Department of Infectious Diseases, Hospital universitario Dr. José Eleuterio González, Monterrey, Nuevo León, Mexico.8Department of Critical Care Medicine and Emergency, Instituto de Salud del Estado de México, Toluca, Mexico.9Department of Critical Care Medicine, Instituto Nacional de Enfermedades Respiratorias, Mexico City, Mexico.10Department of Critical Care Medicine, Hospital General de Tijuana, Tijuana, Baja California, Mexico.11Department of Critical Care Medicine, Hospital Central Ignacio Morones Prieto, San Luis Potosi, Mexico.12Department of Critical Care Medicine, Hospital General de Uruapan, Uruapan, Michoacan, Mexico.13Department of Infectious Diseases, Hospital General Regional de León, León, Guanajuato, Mexico.14Department of Infectious Diseases, Hospital Regional de Alta Especialidad de Oaxaca, Oaxaca, Mexico.15Department of Critical Care Medicine, Hospital General "Dr. Manuel Gea González," Mexico City, Mexico.16Department of Disasters Response, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.17Department of Critical Care Medicine, Hospital San José Monterrey, Monterrey, Nuevo León, Mexico.18Faculty of Medicine, Universidad de Guanajuato, León, Guanajuato, Mexico.19Department of Critical Care Medicine, Hospital Regional de Alta Especialidad de Oaxaca, </nlm:affiliation><wicri:noCountry>no dot</wicri:noCountry></affiliation></author><author><name sortKey="De La Torre, Alethse" sort="De La Torre, Alethse" uniqKey="De La Torre A" first="Alethse" last="De La Torre">Alethse De La Torre</name></author><author><name sortKey="Rishu, Asgar" sort="Rishu, Asgar" uniqKey="Rishu A" first="Asgar" last="Rishu">Asgar Rishu</name></author><author><name sortKey="Pinto, Ruxandra" sort="Pinto, Ruxandra" uniqKey="Pinto R" first="Ruxandra" last="Pinto">Ruxandra Pinto</name></author><author><name sortKey=" Amendys Silva, Silvio A" sort=" Amendys Silva, Silvio A" uniqKey=" Amendys Silva S" first="Silvio A" last=" Amendys-Silva">Silvio A. Amendys-Silva</name></author><author><name sortKey="Camacho Ortiz, Adrian" sort="Camacho Ortiz, Adrian" uniqKey="Camacho Ortiz A" first="Adrián" last="Camacho-Ortiz">Adrián Camacho-Ortiz</name></author><author><name sortKey="Silva Medina, Marco Antonio" sort="Silva Medina, Marco Antonio" uniqKey="Silva Medina M" first="Marco Antonio" last="Silva-Medina">Marco Antonio Silva-Medina</name></author><author><name sortKey="Hernandez Cardenas, Carmen" sort="Hernandez Cardenas, Carmen" uniqKey="Hernandez Cardenas C" first="Carmen" last="Hernández-Cárdenas">Carmen Hernández-Cárdenas</name></author><author><name sortKey="Martinez Franco, Michel" sort="Martinez Franco, Michel" uniqKey="Martinez Franco M" first="Michel" last="Martínez-Franco">Michel Martínez-Franco</name></author><author><name sortKey="Quesada Sanchez, Alejandro" sort="Quesada Sanchez, Alejandro" uniqKey="Quesada Sanchez A" first="Alejandro" last="Quesada-Sánchez">Alejandro Quesada-Sánchez</name></author><author><name sortKey="L Pez Gallegos, Guadalupe Celia" sort="L Pez Gallegos, Guadalupe Celia" uniqKey="L Pez Gallegos G" first="Guadalupe Celia" last="L Pez-Gallegos">Guadalupe Celia L Pez-Gallegos</name></author><author><name sortKey="Mosqueda G Mez, Juan L" sort="Mosqueda G Mez, Juan L" uniqKey="Mosqueda G Mez J" first="Juan L" last="Mosqueda-G Mez">Juan L. Mosqueda-G Mez</name></author><author><name sortKey="Rivera Martinez, Norma E" sort="Rivera Martinez, Norma E" uniqKey="Rivera Martinez N" first="Norma E" last="Rivera-Martinez">Norma E. Rivera-Martinez</name></author><author><name sortKey="Campos Calder N, Fernando" sort="Campos Calder N, Fernando" uniqKey="Campos Calder N F" first="Fernando" last="Campos-Calder N">Fernando Campos-Calder N</name></author><author><name sortKey="Rivero Sigarroa, Eduardo" sort="Rivero Sigarroa, Eduardo" uniqKey="Rivero Sigarroa E" first="Eduardo" last="Rivero-Sigarroa">Eduardo Rivero-Sigarroa</name></author><author><name sortKey="Hernandez Gilsoul, Thierry" sort="Hernandez Gilsoul, Thierry" uniqKey="Hernandez Gilsoul T" first="Thierry" last="Hernández-Gilsoul">Thierry Hernández-Gilsoul</name></author><author><name sortKey="Espinosa Perez, Lourdes" sort="Espinosa Perez, Lourdes" uniqKey="Espinosa Perez L" first="Lourdes" last="Espinosa-Pérez">Lourdes Espinosa-Pérez</name></author><author><name sortKey="Macias, Alejandro E" sort="Macias, Alejandro E" uniqKey="Macias A" first="Alejandro E" last="Macías">Alejandro E. Macías</name></author><author><name sortKey="Lue Martinez, Dolores M" sort="Lue Martinez, Dolores M" uniqKey="Lue Martinez D" first="Dolores M" last="Lue-Martínez">Dolores M. Lue-Martínez</name></author><author><name sortKey="Buelna Cano, Christian" sort="Buelna Cano, Christian" uniqKey="Buelna Cano C" first="Christian" last="Buelna-Cano">Christian Buelna-Cano</name></author><author><name sortKey="Ramirez Garcia Luna, Ana Sofia" sort="Ramirez Garcia Luna, Ana Sofia" uniqKey="Ramirez Garcia Luna A" first="Ana-Sofía" last="Ramírez-García Luna">Ana-Sofía Ramírez-García Luna</name></author><author><name sortKey="Cruz Ruiz, Nestor G" sort="Cruz Ruiz, Nestor G" uniqKey="Cruz Ruiz N" first="Nestor G" last="Cruz-Ruiz">Nestor G. Cruz-Ruiz</name></author><author><name sortKey="Poblano Morales, Manuel" sort="Poblano Morales, Manuel" uniqKey="Poblano Morales M" first="Manuel" last="Poblano-Morales">Manuel Poblano-Morales</name></author><author><name sortKey="Molinar Ramos, Fernando" sort="Molinar Ramos, Fernando" uniqKey="Molinar Ramos F" first="Fernando" last="Molinar-Ramos">Fernando Molinar-Ramos</name></author><author><name sortKey="Hernandez Torre, Martin" sort="Hernandez Torre, Martin" uniqKey="Hernandez Torre M" first="Martin" last="Hernandez-Torre">Martin Hernandez-Torre</name></author><author><name sortKey="Le N Gutierrez, Marco Antonio" sort="Le N Gutierrez, Marco Antonio" uniqKey="Le N Gutierrez M" first="Marco Antonio" last="Le N-Gutiérrez">Marco Antonio Le N-Gutiérrez</name></author><author><name sortKey="Rosaldo Abundis, Oscar" sort="Rosaldo Abundis, Oscar" uniqKey="Rosaldo Abundis O" first="Oscar" last="Rosaldo-Abundis">Oscar Rosaldo-Abundis</name></author><author><name sortKey="Baltazar Torres, Jose Ngel" sort="Baltazar Torres, Jose Ngel" uniqKey="Baltazar Torres J" first="José Ngel" last="Baltazar-Torres">José Ngel Baltazar-Torres</name></author><author><name sortKey="Stelfox, Henry T" sort="Stelfox, Henry T" uniqKey="Stelfox H" first="Henry T" last="Stelfox">Henry T. Stelfox</name></author><author><name sortKey="Light, Bruce" sort="Light, Bruce" uniqKey="Light B" first="Bruce" last="Light">Bruce Light</name></author><author><name sortKey="Jouvet, Philippe" sort="Jouvet, Philippe" uniqKey="Jouvet P" first="Philippe" last="Jouvet">Philippe Jouvet</name></author><author><name sortKey="Reynolds, Steve" sort="Reynolds, Steve" uniqKey="Reynolds S" first="Steve" last="Reynolds">Steve Reynolds</name></author><author><name sortKey="Hall, Richard" sort="Hall, Richard" uniqKey="Hall R" first="Richard" last="Hall">Richard Hall</name></author><author><name sortKey="Shindo, Nikki" sort="Shindo, Nikki" uniqKey="Shindo N" first="Nikki" last="Shindo">Nikki Shindo</name></author><author><name sortKey="Daneman, Nick" sort="Daneman, Nick" uniqKey="Daneman N" first="Nick" last="Daneman">Nick Daneman</name></author><author><name sortKey="Fowler, Robert A" sort="Fowler, Robert A" uniqKey="Fowler R" first="Robert A" last="Fowler">Robert A. Fowler</name></author></analytic><series><title level="j">Critical care medicine</title><idno type="eISSN">1530-0293</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adrenal Cortex Hormones (economics)</term><term>Adrenal Cortex Hormones (therapeutic use)</term><term>Adult (MeSH)</term><term>Aged (MeSH)</term><term>Antiviral Agents (economics)</term><term>Antiviral Agents (therapeutic use)</term><term>Canada (epidemiology)</term><term>Critical Illness (epidemiology)</term><term>Critical Illness (therapy)</term><term>Extracorporeal Membrane Oxygenation (economics)</term><term>Extracorporeal Membrane Oxygenation (methods)</term><term>Female (MeSH)</term><term>Health Expenditures (MeSH)</term><term>Humans (MeSH)</term><term>Influenza A Virus, H1N1 Subtype (MeSH)</term><term>Influenza, Human (economics)</term><term>Influenza, Human (epidemiology)</term><term>Influenza, Human (physiopathology)</term><term>Influenza, Human (therapy)</term><term>Intensive Care Units (statistics & numerical data)</term><term>Male (MeSH)</term><term>Mexico (epidemiology)</term><term>Middle Aged (MeSH)</term><term>Respiration, Artificial (economics)</term><term>Respiration, Artificial (methods)</term><term>Respiratory Insufficiency (physiopathology)</term><term>Respiratory Insufficiency (therapy)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte (MeSH)</term><term>Adulte d'âge moyen (MeSH)</term><term>Antiviraux (usage thérapeutique)</term><term>Antiviraux (économie)</term><term>Canada (épidémiologie)</term><term>Dépenses de santé (MeSH)</term><term>Femelle (MeSH)</term><term>Grippe humaine (physiopathologie)</term><term>Grippe humaine (thérapie)</term><term>Grippe humaine (économie)</term><term>Grippe humaine (épidémiologie)</term><term>Hormones corticosurrénaliennes (usage thérapeutique)</term><term>Hormones corticosurrénaliennes (économie)</term><term>Humains (MeSH)</term><term>Insuffisance respiratoire (physiopathologie)</term><term>Insuffisance respiratoire (thérapie)</term><term>Maladie grave (thérapie)</term><term>Maladie grave (épidémiologie)</term><term>Mexique (épidémiologie)</term><term>Mâle (MeSH)</term><term>Oxygénation extracorporelle sur oxygénateur à membrane (méthodes)</term><term>Oxygénation extracorporelle sur oxygénateur à membrane (économie)</term><term>Sous-type H1N1 du virus de la grippe A (MeSH)</term><term>Sujet âgé (MeSH)</term><term>Unités de soins intensifs (statistiques et données numériques)</term><term>Ventilation artificielle (méthodes)</term><term>Ventilation artificielle (économie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="economics" xml:lang="en"><term>Adrenal Cortex Hormones</term><term>Antiviral Agents</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Adrenal Cortex Hormones</term><term>Antiviral Agents</term></keywords><keywords scheme="MESH" qualifier="economics" xml:lang="en"><term>Extracorporeal Membrane Oxygenation</term><term>Influenza, Human</term><term>Respiration, Artificial</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Canada</term><term>Critical Illness</term><term>Influenza, Human</term><term>Mexico</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Extracorporeal Membrane Oxygenation</term><term>Respiration, Artificial</term></keywords><keywords scheme="MESH" qualifier="méthodes" xml:lang="fr"><term>Oxygénation extracorporelle sur oxygénateur à membrane</term><term>Ventilation artificielle</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Grippe humaine</term><term>Insuffisance respiratoire</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Influenza, Human</term><term>Respiratory Insufficiency</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Intensive Care Units</term></keywords><keywords scheme="MESH" qualifier="statistiques et données numériques" xml:lang="fr"><term>Unités de soins intensifs</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Critical Illness</term><term>Influenza, Human</term><term>Respiratory Insufficiency</term></keywords><keywords scheme="MESH" qualifier="thérapie" xml:lang="fr"><term>Grippe humaine</term><term>Insuffisance respiratoire</term><term>Maladie grave</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antiviraux</term><term>Hormones corticosurrénaliennes</term></keywords><keywords scheme="MESH" qualifier="économie" xml:lang="fr"><term>Antiviraux</term><term>Grippe humaine</term><term>Hormones corticosurrénaliennes</term><term>Oxygénation extracorporelle sur oxygénateur à membrane</term><term>Ventilation artificielle</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Canada</term><term>Grippe humaine</term><term>Maladie grave</term><term>Mexique</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Female</term><term>Health Expenditures</term><term>Humans</term><term>Influenza A Virus, H1N1 Subtype</term><term>Male</term><term>Middle Aged</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Dépenses de santé</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Sous-type H1N1 du virus de la grippe A</term><term>Sujet âgé</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>OBJECTIVES</b></p><p>The 2009-2010 influenza A (H1N1pdm09) pandemic caused substantial morbidity and mortality among young patients; however, mortality estimates have been confounded by regional differences in eligibility criteria and inclusion of selected populations. In 2013-2014, H1N1pdm09 became North America's dominant seasonal influenza strain. Our objective was to compare the baseline characteristics, resources, and treatments with outcomes among critically ill patients with influenza A (H1N1pdm09) in Mexican and Canadian hospitals in 2014 using consistent eligibility criteria.</p></div><div type="abstract" xml:lang="en"><p><b>DESIGN</b></p><p>Observational study and a survey of available healthcare setting resources.</p></div><div type="abstract" xml:lang="en"><p><b>SETTING</b></p><p>Twenty-one hospitals, 13 in Mexico and eight in Canada.</p></div><div type="abstract" xml:lang="en"><p><b>PATIENTS</b></p><p>Critically ill patients with confirmed H1N1pdm09 during 2013-2014 influenza season.</p></div><div type="abstract" xml:lang="en"><p><b>INTERVENTIONS</b></p><p>None.</p></div><div type="abstract" xml:lang="en"><p><b>MEASUREMENTS AND MAIN RESULTS</b></p><p>The main outcome measures were 90-day mortality and independent predictors of mortality. Among 165 adult patients with H1N1pdm09-related critical illness between September 2013 and March 2014, mean age was 48.3 years, 64% were males, and nearly all influenza was community acquired. Patients were severely hypoxic (median PaO2-to-FIO2 ratio, 83 mm Hg), 97% received mechanical ventilation, with mean positive end-expiratory pressure of 14 cm H2O at the onset of critical illness and 26.7% received rescue oxygenation therapy with prone ventilation, extracorporeal life support, high-frequency oscillatory ventilation, or inhaled nitric oxide. At 90 days, mortality was 34.6% (13.9% in Canada vs 50.5% in Mexico, p < 0.0001). Independent predictors of mortality included lower presenting PaO2-to-FIO2 ratio (odds ratio, 0.89 per 10-point increase [95% CI, 0.80-0.99]), age (odds ratio, 1.49 per 10 yr increment [95% CI, 1.10-2.02]), and requiring critical care in Mexico (odds ratio, 7.76 [95% CI, 2.02-27.35]). ICUs in Canada generally had more beds, ventilators, healthcare personnel, and rescue oxygenation therapies.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b></p><p>Influenza A (H1N1pdm09)-related critical illness still predominantly affects relatively young to middle-aged patients and is associated with severe hypoxemic respiratory failure. The local critical care system and available resources may be influential determinants of patient outcome.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27359085</PMID><DateCompleted><Year>2017</Year><Month>05</Month><Day>15</Day></DateCompleted><DateRevised><Year>2017</Year><Month>09</Month><Day>22</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1530-0293</ISSN><JournalIssue CitedMedium="Internet"><Volume>44</Volume><Issue>10</Issue><PubDate><Year>2016</Year><Month>Oct</Month></PubDate></JournalIssue><Title>Critical care medicine</Title><ISOAbbreviation>Crit. Care Med.</ISOAbbreviation></Journal><ArticleTitle>Influenza A (H1N1pdm09)-Related Critical Illness and Mortality in Mexico and Canada, 2014.</ArticleTitle><Pagination><MedlinePgn>1861-70</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1097/CCM.0000000000001830</ELocationID><Abstract><AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">The 2009-2010 influenza A (H1N1pdm09) pandemic caused substantial morbidity and mortality among young patients; however, mortality estimates have been confounded by regional differences in eligibility criteria and inclusion of selected populations. In 2013-2014, H1N1pdm09 became North America's dominant seasonal influenza strain. Our objective was to compare the baseline characteristics, resources, and treatments with outcomes among critically ill patients with influenza A (H1N1pdm09) in Mexican and Canadian hospitals in 2014 using consistent eligibility criteria.</AbstractText><AbstractText Label="DESIGN" NlmCategory="METHODS">Observational study and a survey of available healthcare setting resources.</AbstractText><AbstractText Label="SETTING" NlmCategory="METHODS">Twenty-one hospitals, 13 in Mexico and eight in Canada.</AbstractText><AbstractText Label="PATIENTS" NlmCategory="METHODS">Critically ill patients with confirmed H1N1pdm09 during 2013-2014 influenza season.</AbstractText><AbstractText Label="INTERVENTIONS" NlmCategory="METHODS">None.</AbstractText><AbstractText Label="MEASUREMENTS AND MAIN RESULTS" NlmCategory="RESULTS">The main outcome measures were 90-day mortality and independent predictors of mortality. Among 165 adult patients with H1N1pdm09-related critical illness between September 2013 and March 2014, mean age was 48.3 years, 64% were males, and nearly all influenza was community acquired. Patients were severely hypoxic (median PaO2-to-FIO2 ratio, 83 mm Hg), 97% received mechanical ventilation, with mean positive end-expiratory pressure of 14 cm H2O at the onset of critical illness and 26.7% received rescue oxygenation therapy with prone ventilation, extracorporeal life support, high-frequency oscillatory ventilation, or inhaled nitric oxide. At 90 days, mortality was 34.6% (13.9% in Canada vs 50.5% in Mexico, p < 0.0001). Independent predictors of mortality included lower presenting PaO2-to-FIO2 ratio (odds ratio, 0.89 per 10-point increase [95% CI, 0.80-0.99]), age (odds ratio, 1.49 per 10 yr increment [95% CI, 1.10-2.02]), and requiring critical care in Mexico (odds ratio, 7.76 [95% CI, 2.02-27.35]). ICUs in Canada generally had more beds, ventilators, healthcare personnel, and rescue oxygenation therapies.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Influenza A (H1N1pdm09)-related critical illness still predominantly affects relatively young to middle-aged patients and is associated with severe hypoxemic respiratory failure. The local critical care system and available resources may be influential determinants of patient outcome.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Dominguez-Cherit</LastName><ForeName>Guillermo</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>1Department of Critical Care Medicine, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.2Escuela de Medicina, Tecnologico de Monterrey, Monterrey, Mexico.3Department of Hospital Epidemiology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.4Trauma, Emergency and Critical Care, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada.5Department of Critical Care Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada.6Department of Critical Care Medicine, Instituto Nacional de Cancerología, Mexico City, Mexico.7Department of Infectious Diseases, Hospital universitario Dr. José Eleuterio González, Monterrey, Nuevo León, Mexico.8Department of Critical Care Medicine and Emergency, Instituto de Salud del Estado de México, Toluca, Mexico.9Department of Critical Care Medicine, Instituto Nacional de Enfermedades Respiratorias, Mexico City, Mexico.10Department of Critical Care Medicine, Hospital General de Tijuana, Tijuana, Baja California, Mexico.11Department of Critical Care Medicine, Hospital Central Ignacio Morones Prieto, San Luis Potosi, Mexico.12Department of Critical Care Medicine, Hospital General de Uruapan, Uruapan, Michoacan, Mexico.13Department of Infectious Diseases, Hospital General Regional de León, León, Guanajuato, Mexico.14Department of Infectious Diseases, Hospital Regional de Alta Especialidad de Oaxaca, Oaxaca, Mexico.15Department of Critical Care Medicine, Hospital General "Dr. Manuel Gea González," Mexico City, Mexico.16Department of Disasters Response, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.17Department of Critical Care Medicine, Hospital San José Monterrey, Monterrey, Nuevo León, Mexico.18Faculty of Medicine, Universidad de Guanajuato, León, Guanajuato, Mexico.19Department of Critical Care Medicine, Hospital Regional de Alta Especialidad de Oaxaca, </Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>De la Torre</LastName><ForeName>Alethse</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Rishu</LastName><ForeName>Asgar</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Pinto</LastName><ForeName>Ruxandra</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Ñamendys-Silva</LastName><ForeName>Silvio A</ForeName><Initials>SA</Initials></Author><Author ValidYN="Y"><LastName>Camacho-Ortiz</LastName><ForeName>Adrián</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Silva-Medina</LastName><ForeName>Marco Antonio</ForeName><Initials>MA</Initials></Author><Author ValidYN="Y"><LastName>Hernández-Cárdenas</LastName><ForeName>Carmen</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Martínez-Franco</LastName><ForeName>Michel</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Quesada-Sánchez</LastName><ForeName>Alejandro</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>López-Gallegos</LastName><ForeName>Guadalupe Celia</ForeName><Initials>GC</Initials></Author><Author ValidYN="Y"><LastName>Mosqueda-Gómez</LastName><ForeName>Juan L</ForeName><Initials>JL</Initials></Author><Author ValidYN="Y"><LastName>Rivera-Martinez</LastName><ForeName>Norma E</ForeName><Initials>NE</Initials></Author><Author ValidYN="Y"><LastName>Campos-Calderón</LastName><ForeName>Fernando</ForeName><Initials>F</Initials></Author><Author ValidYN="Y"><LastName>Rivero-Sigarroa</LastName><ForeName>Eduardo</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Hernández-Gilsoul</LastName><ForeName>Thierry</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Espinosa-Pérez</LastName><ForeName>Lourdes</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Macías</LastName><ForeName>Alejandro E</ForeName><Initials>AE</Initials></Author><Author ValidYN="Y"><LastName>Lue-Martínez</LastName><ForeName>Dolores M</ForeName><Initials>DM</Initials></Author><Author ValidYN="Y"><LastName>Buelna-Cano</LastName><ForeName>Christian</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Ramírez-García Luna</LastName><ForeName>Ana-Sofía</ForeName><Initials>AS</Initials></Author><Author ValidYN="Y"><LastName>Cruz-Ruiz</LastName><ForeName>Nestor G</ForeName><Initials>NG</Initials></Author><Author ValidYN="Y"><LastName>Poblano-Morales</LastName><ForeName>Manuel</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Molinar-Ramos</LastName><ForeName>Fernando</ForeName><Initials>F</Initials></Author><Author ValidYN="Y"><LastName>Hernandez-Torre</LastName><ForeName>Martin</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>León-Gutiérrez</LastName><ForeName>Marco Antonio</ForeName><Initials>MA</Initials></Author><Author ValidYN="Y"><LastName>Rosaldo-Abundis</LastName><ForeName>Oscar</ForeName><Initials>O</Initials></Author><Author ValidYN="Y"><LastName>Baltazar-Torres</LastName><ForeName>José Ángel</ForeName><Initials>JÁ</Initials></Author><Author ValidYN="Y"><LastName>Stelfox</LastName><ForeName>Henry T</ForeName><Initials>HT</Initials></Author><Author ValidYN="Y"><LastName>Light</LastName><ForeName>Bruce</ForeName><Initials>B</Initials></Author><Author ValidYN="Y"><LastName>Jouvet</LastName><ForeName>Philippe</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Reynolds</LastName><ForeName>Steve</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Hall</LastName><ForeName>Richard</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Shindo</LastName><ForeName>Nikki</ForeName><Initials>N</Initials></Author><Author ValidYN="Y"><LastName>Daneman</LastName><ForeName>Nick</ForeName><Initials>N</Initials></Author><Author ValidYN="Y"><LastName>Fowler</LastName><ForeName>Robert A</ForeName><Initials>RA</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>001</GrantID><Agency>World Health Organization</Agency><Country>International</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016448">Multicenter Study</PublicationType><PublicationType UI="D064888">Observational Study</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Crit Care Med</MedlineTA><NlmUniqueID>0355501</NlmUniqueID><ISSNLinking>0090-3493</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000305">Adrenal Cortex Hormones</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000998">Antiviral Agents</NameOfSubstance></Chemical></ChemicalList><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>Crit Care Med. 2016 Oct;44(10):1941-2</RefSource><PMID Version="1">27635487</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000305" MajorTopicYN="N">Adrenal Cortex Hormones</DescriptorName><QualifierName UI="Q000191" MajorTopicYN="N">economics</QualifierName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000998" MajorTopicYN="N">Antiviral Agents</DescriptorName><QualifierName UI="Q000191" MajorTopicYN="N">economics</QualifierName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002170" MajorTopicYN="N">Canada</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016638" MajorTopicYN="N">Critical Illness</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015199" MajorTopicYN="N">Extracorporeal Membrane Oxygenation</DescriptorName><QualifierName UI="Q000191" MajorTopicYN="N">economics</QualifierName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005102" MajorTopicYN="N">Health Expenditures</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D053118" MajorTopicYN="Y">Influenza A Virus, H1N1 Subtype</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007251" MajorTopicYN="N">Influenza, Human</DescriptorName><QualifierName UI="Q000191" MajorTopicYN="N">economics</QualifierName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName><QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007362" MajorTopicYN="N">Intensive Care Units</DescriptorName><QualifierName UI="Q000706" MajorTopicYN="Y">statistics & numerical data</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008800" MajorTopicYN="N">Mexico</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012121" MajorTopicYN="N">Respiration, Artificial</DescriptorName><QualifierName UI="Q000191" MajorTopicYN="N">economics</QualifierName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012131" MajorTopicYN="N">Respiratory Insufficiency</DescriptorName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName><QualifierName UI="Q000628" MajorTopicYN="N">therapy</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>7</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>7</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>5</Month><Day>16</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27359085</ArticleId><ArticleId IdType="doi">10.1097/CCM.0000000000001830</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list></list><tree><noCountry><name sortKey=" Amendys Silva, Silvio A" sort=" Amendys Silva, Silvio A" uniqKey=" Amendys Silva S" first="Silvio A" last=" Amendys-Silva">Silvio A. Amendys-Silva</name><name sortKey="Baltazar Torres, Jose Ngel" sort="Baltazar Torres, Jose Ngel" uniqKey="Baltazar Torres J" first="José Ngel" last="Baltazar-Torres">José Ngel Baltazar-Torres</name><name sortKey="Buelna Cano, Christian" sort="Buelna Cano, Christian" uniqKey="Buelna Cano C" first="Christian" last="Buelna-Cano">Christian Buelna-Cano</name><name sortKey="Camacho Ortiz, Adrian" sort="Camacho Ortiz, Adrian" uniqKey="Camacho Ortiz A" first="Adrián" last="Camacho-Ortiz">Adrián Camacho-Ortiz</name><name sortKey="Campos Calder N, Fernando" sort="Campos Calder N, Fernando" uniqKey="Campos Calder N F" first="Fernando" last="Campos-Calder N">Fernando Campos-Calder N</name><name sortKey="Cruz Ruiz, Nestor G" sort="Cruz Ruiz, Nestor G" uniqKey="Cruz Ruiz N" first="Nestor G" last="Cruz-Ruiz">Nestor G. Cruz-Ruiz</name><name sortKey="Daneman, Nick" sort="Daneman, Nick" uniqKey="Daneman N" first="Nick" last="Daneman">Nick Daneman</name><name sortKey="De La Torre, Alethse" sort="De La Torre, Alethse" uniqKey="De La Torre A" first="Alethse" last="De La Torre">Alethse De La Torre</name><name sortKey="Dominguez Cherit, Guillermo" sort="Dominguez Cherit, Guillermo" uniqKey="Dominguez Cherit G" first="Guillermo" last="Dominguez-Cherit">Guillermo Dominguez-Cherit</name><name sortKey="Espinosa Perez, Lourdes" sort="Espinosa Perez, Lourdes" uniqKey="Espinosa Perez L" first="Lourdes" last="Espinosa-Pérez">Lourdes Espinosa-Pérez</name><name sortKey="Fowler, Robert A" sort="Fowler, Robert A" uniqKey="Fowler R" first="Robert A" last="Fowler">Robert A. Fowler</name><name sortKey="Hall, Richard" sort="Hall, Richard" uniqKey="Hall R" first="Richard" last="Hall">Richard Hall</name><name sortKey="Hernandez Cardenas, Carmen" sort="Hernandez Cardenas, Carmen" uniqKey="Hernandez Cardenas C" first="Carmen" last="Hernández-Cárdenas">Carmen Hernández-Cárdenas</name><name sortKey="Hernandez Gilsoul, Thierry" sort="Hernandez Gilsoul, Thierry" uniqKey="Hernandez Gilsoul T" first="Thierry" last="Hernández-Gilsoul">Thierry Hernández-Gilsoul</name><name sortKey="Hernandez Torre, Martin" sort="Hernandez Torre, Martin" uniqKey="Hernandez Torre M" first="Martin" last="Hernandez-Torre">Martin Hernandez-Torre</name><name sortKey="Jouvet, Philippe" sort="Jouvet, Philippe" uniqKey="Jouvet P" first="Philippe" last="Jouvet">Philippe Jouvet</name><name sortKey="L Pez Gallegos, Guadalupe Celia" sort="L Pez Gallegos, Guadalupe Celia" uniqKey="L Pez Gallegos G" first="Guadalupe Celia" last="L Pez-Gallegos">Guadalupe Celia L Pez-Gallegos</name><name sortKey="Le N Gutierrez, Marco Antonio" sort="Le N Gutierrez, Marco Antonio" uniqKey="Le N Gutierrez M" first="Marco Antonio" last="Le N-Gutiérrez">Marco Antonio Le N-Gutiérrez</name><name sortKey="Light, Bruce" sort="Light, Bruce" uniqKey="Light B" first="Bruce" last="Light">Bruce Light</name><name sortKey="Lue Martinez, Dolores M" sort="Lue Martinez, Dolores M" uniqKey="Lue Martinez D" first="Dolores M" last="Lue-Martínez">Dolores M. Lue-Martínez</name><name sortKey="Macias, Alejandro E" sort="Macias, Alejandro E" uniqKey="Macias A" first="Alejandro E" last="Macías">Alejandro E. Macías</name><name sortKey="Martinez Franco, Michel" sort="Martinez Franco, Michel" uniqKey="Martinez Franco M" first="Michel" last="Martínez-Franco">Michel Martínez-Franco</name><name sortKey="Molinar Ramos, Fernando" sort="Molinar Ramos, Fernando" uniqKey="Molinar Ramos F" first="Fernando" last="Molinar-Ramos">Fernando Molinar-Ramos</name><name sortKey="Mosqueda G Mez, Juan L" sort="Mosqueda G Mez, Juan L" uniqKey="Mosqueda G Mez J" first="Juan L" last="Mosqueda-G Mez">Juan L. Mosqueda-G Mez</name><name sortKey="Pinto, Ruxandra" sort="Pinto, Ruxandra" uniqKey="Pinto R" first="Ruxandra" last="Pinto">Ruxandra Pinto</name><name sortKey="Poblano Morales, Manuel" sort="Poblano Morales, Manuel" uniqKey="Poblano Morales M" first="Manuel" last="Poblano-Morales">Manuel Poblano-Morales</name><name sortKey="Quesada Sanchez, Alejandro" sort="Quesada Sanchez, Alejandro" uniqKey="Quesada Sanchez A" first="Alejandro" last="Quesada-Sánchez">Alejandro Quesada-Sánchez</name><name sortKey="Ramirez Garcia Luna, Ana Sofia" sort="Ramirez Garcia Luna, Ana Sofia" uniqKey="Ramirez Garcia Luna A" first="Ana-Sofía" last="Ramírez-García Luna">Ana-Sofía Ramírez-García Luna</name><name sortKey="Reynolds, Steve" sort="Reynolds, Steve" uniqKey="Reynolds S" first="Steve" last="Reynolds">Steve Reynolds</name><name sortKey="Rishu, Asgar" sort="Rishu, Asgar" uniqKey="Rishu A" first="Asgar" last="Rishu">Asgar Rishu</name><name sortKey="Rivera Martinez, Norma E" sort="Rivera Martinez, Norma E" uniqKey="Rivera Martinez N" first="Norma E" last="Rivera-Martinez">Norma E. Rivera-Martinez</name><name sortKey="Rivero Sigarroa, Eduardo" sort="Rivero Sigarroa, Eduardo" uniqKey="Rivero Sigarroa E" first="Eduardo" last="Rivero-Sigarroa">Eduardo Rivero-Sigarroa</name><name sortKey="Rosaldo Abundis, Oscar" sort="Rosaldo Abundis, Oscar" uniqKey="Rosaldo Abundis O" first="Oscar" last="Rosaldo-Abundis">Oscar Rosaldo-Abundis</name><name sortKey="Shindo, Nikki" sort="Shindo, Nikki" uniqKey="Shindo N" first="Nikki" last="Shindo">Nikki Shindo</name><name sortKey="Silva Medina, Marco Antonio" sort="Silva Medina, Marco Antonio" uniqKey="Silva Medina M" first="Marco Antonio" last="Silva-Medina">Marco Antonio Silva-Medina</name><name sortKey="Stelfox, Henry T" sort="Stelfox, Henry T" uniqKey="Stelfox H" first="Henry T" last="Stelfox">Henry T. Stelfox</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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|texte= Influenza A (H1N1pdm09)-Related Critical Illness and Mortality in Mexico and Canada, 2014.
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