Effect of Influenza Vaccination of Children on Infection Rate in Hutterite Communities: Follow-Up Study of a Randomized Trial.
Identifieur interne : 000120 ( Main/Corpus ); précédent : 000119; suivant : 000121Effect of Influenza Vaccination of Children on Infection Rate in Hutterite Communities: Follow-Up Study of a Randomized Trial.
Auteurs : Biao Wang ; Margaret L. Russell ; Lorraine Moss ; Kevin Fonseca ; David J D. Earn ; Fred Aoki ; Gregory Horsman ; Paul Van Caeseele ; Khami Chokani ; Mark Vooght ; Lorne Babiuk ; Richard Webby ; Stephen D. Walter ; Mark LoebSource :
- PloS one [ 1932-6203 ] ; 2016.
English descriptors
- KwdEn :
- Adolescent (MeSH), Canada (MeSH), Child (MeSH), Child, Preschool (MeSH), Disease Outbreaks (MeSH), Female (MeSH), Follow-Up Studies (MeSH), Humans (MeSH), Incidence (MeSH), Influenza Vaccines (MeSH), Influenza, Human (epidemiology), Influenza, Human (prevention & control), Male (MeSH), Treatment Outcome (MeSH).
- MESH :
- chemical : Influenza Vaccines.
- epidemiology : Influenza, Human.
- prevention & control : Influenza, Human.
- Adolescent, Canada, Child, Child, Preschool, Disease Outbreaks, Female, Follow-Up Studies, Humans, Incidence, Male, Treatment Outcome.
Abstract
BACKGROUND
An earlier cluster randomized controlled trial (RCT) of Hutterite colonies had shown that if more than 80% of children and adolescents were immunized with influenza vaccine there was a statistically significant reduction in laboratory-confirmed influenza among all unimmunized community members. We assessed the impact of this intervention for two additional influenza seasonal periods.
METHODS
Follow-up data for two influenza seasonal periods of a cluster randomized trial involving 1053 Canadian children and adolescents aged 36 months to 15 years in Season 2 and 1014 in Season 3 who received the study vaccine, and 2805 community members in Season 2 and 2840 in Season 3 who did not receive the study vaccine. Follow-up for Season 2 began November 18, 2009 and ended April 25, 2010 while Season 3 extended from December 6, 2010 and ended May 27, 2011. Children were randomly assigned in a blinded manner according to community membership to receive either inactivated trivalent influenza vaccine or hepatitis A. The primary outcome was confirmed influenza A and B infection using RT-PCR assay. Due to the outbreak of 2009 H1N1 pandemic, data in Season 2 were excluded for analysis.
RESULTS
For an analysis of the combined Season 1 and Season 3 data, among non-recipients (i.e., participants who did not receive study vaccines), 66 of the 2794 (2.4%) participants in the influenza vaccine colonies and 121 of the 2301 (5.3%) participants in the hepatitis A colonies had influenza confirmed by RT-PCR, for a protective effectiveness of 60% (95% CI, 6% to 83%; P = 0.04); among all study participants (i.e., including both those who received study vaccine and those who did not), 125 of the 3806 (3.3%) in the influenza vaccine colonies and 239 of the 3243 (7.4%) in the hepatitis A colonies had influenza confirmed by RT-PCR, for a protective effectiveness of 63% (95% CI, 5% to 85%; P = 0.04).
CONCLUSION
Immunizing children and adolescents with inactivated influenza vaccine can offer a protective effect among unimmunized community members for influenza A and B together when considered over multiple years of seasonal influenza.
TRIAL REGISTRATION
Clinicaltrials.gov NCT00877396.
DOI: 10.1371/journal.pone.0167281
PubMed: 27977707
PubMed Central: PMC5157992
Links to Exploration step
pubmed:27977707Le document en format XML
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<affiliation><nlm:affiliation>Michael G. De- Groote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.</nlm:affiliation>
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<author><name sortKey="Aoki, Fred" sort="Aoki, Fred" uniqKey="Aoki F" first="Fred" last="Aoki">Fred Aoki</name>
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<author><name sortKey="Horsman, Gregory" sort="Horsman, Gregory" uniqKey="Horsman G" first="Gregory" last="Horsman">Gregory Horsman</name>
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<author><name sortKey="Caeseele, Paul Van" sort="Caeseele, Paul Van" uniqKey="Caeseele P" first="Paul Van" last="Caeseele">Paul Van Caeseele</name>
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<author><name sortKey="Babiuk, Lorne" sort="Babiuk, Lorne" uniqKey="Babiuk L" first="Lorne" last="Babiuk">Lorne Babiuk</name>
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<author><name sortKey="Webby, Richard" sort="Webby, Richard" uniqKey="Webby R" first="Richard" last="Webby">Richard Webby</name>
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<author><name sortKey="Loeb, Mark" sort="Loeb, Mark" uniqKey="Loeb M" first="Mark" last="Loeb">Mark Loeb</name>
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<affiliation><nlm:affiliation>Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada.</nlm:affiliation>
</affiliation>
<affiliation><nlm:affiliation>Michael G. De- Groote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.</nlm:affiliation>
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<affiliation><nlm:affiliation>Department of Medicine, McMaster University, Hamilton, Ontario, Canada.</nlm:affiliation>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Effect of Influenza Vaccination of Children on Infection Rate in Hutterite Communities: Follow-Up Study of a Randomized Trial.</title>
<author><name sortKey="Wang, Biao" sort="Wang, Biao" uniqKey="Wang B" first="Biao" last="Wang">Biao Wang</name>
<affiliation><nlm:affiliation>Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Russell, Margaret L" sort="Russell, Margaret L" uniqKey="Russell M" first="Margaret L" last="Russell">Margaret L. Russell</name>
<affiliation><nlm:affiliation>Department of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Moss, Lorraine" sort="Moss, Lorraine" uniqKey="Moss L" first="Lorraine" last="Moss">Lorraine Moss</name>
<affiliation><nlm:affiliation>Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.</nlm:affiliation>
</affiliation>
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<author><name sortKey="Fonseca, Kevin" sort="Fonseca, Kevin" uniqKey="Fonseca K" first="Kevin" last="Fonseca">Kevin Fonseca</name>
<affiliation><nlm:affiliation>Department of Microbiology and Infectious Diseases and Provincial Laboratory for Public Health, University of Calgary, Calgary, Alberta, Canada.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Earn, David J D" sort="Earn, David J D" uniqKey="Earn D" first="David J D" last="Earn">David J D. Earn</name>
<affiliation><nlm:affiliation>Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada.</nlm:affiliation>
</affiliation>
<affiliation><nlm:affiliation>Michael G. De- Groote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.</nlm:affiliation>
</affiliation>
<affiliation><nlm:affiliation>Department of Mathematics and Statistics, McMaster University, Hamilton, Ontario, Canada.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Aoki, Fred" sort="Aoki, Fred" uniqKey="Aoki F" first="Fred" last="Aoki">Fred Aoki</name>
<affiliation><nlm:affiliation>Departments of Medicine, Medical Microbiology and Pharmacology, and Therapeutics, University of Manitoba, Winnipeg, Manitoba, Canada.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Horsman, Gregory" sort="Horsman, Gregory" uniqKey="Horsman G" first="Gregory" last="Horsman">Gregory Horsman</name>
<affiliation><nlm:affiliation>Saskatchewan Disease Control Laboratory, Regina, Saskatchewan, Canada.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Caeseele, Paul Van" sort="Caeseele, Paul Van" uniqKey="Caeseele P" first="Paul Van" last="Caeseele">Paul Van Caeseele</name>
<affiliation><nlm:affiliation>Cadham Provincial Laboratory, Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Chokani, Khami" sort="Chokani, Khami" uniqKey="Chokani K" first="Khami" last="Chokani">Khami Chokani</name>
<affiliation><nlm:affiliation>Saskatchewan Health, Prince Albert Parkland Health Region, Prince Albert, Saskatchewan, Canada.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Vooght, Mark" sort="Vooght, Mark" uniqKey="Vooght M" first="Mark" last="Vooght">Mark Vooght</name>
<affiliation><nlm:affiliation>Saskatchewan Health, Five Hills Health Region, Moose Jaw, Saskatchewan, Canada.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Babiuk, Lorne" sort="Babiuk, Lorne" uniqKey="Babiuk L" first="Lorne" last="Babiuk">Lorne Babiuk</name>
<affiliation><nlm:affiliation>Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Canada.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Webby, Richard" sort="Webby, Richard" uniqKey="Webby R" first="Richard" last="Webby">Richard Webby</name>
<affiliation><nlm:affiliation>St Jude Children's Research Hospital and WHO Collaborating Center, Memphis, Tennessee, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Walter, Stephen D" sort="Walter, Stephen D" uniqKey="Walter S" first="Stephen D" last="Walter">Stephen D. Walter</name>
<affiliation><nlm:affiliation>Department of Microbiology and Infectious Diseases and Provincial Laboratory for Public Health, University of Calgary, Calgary, Alberta, Canada.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Loeb, Mark" sort="Loeb, Mark" uniqKey="Loeb M" first="Mark" last="Loeb">Mark Loeb</name>
<affiliation><nlm:affiliation>Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.</nlm:affiliation>
</affiliation>
<affiliation><nlm:affiliation>Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada.</nlm:affiliation>
</affiliation>
<affiliation><nlm:affiliation>Michael G. De- Groote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.</nlm:affiliation>
</affiliation>
<affiliation><nlm:affiliation>Department of Medicine, McMaster University, Hamilton, Ontario, Canada.</nlm:affiliation>
</affiliation>
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<imprint><date when="2016" type="published">2016</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent (MeSH)</term>
<term>Canada (MeSH)</term>
<term>Child (MeSH)</term>
<term>Child, Preschool (MeSH)</term>
<term>Disease Outbreaks (MeSH)</term>
<term>Female (MeSH)</term>
<term>Follow-Up Studies (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Incidence (MeSH)</term>
<term>Influenza Vaccines (MeSH)</term>
<term>Influenza, Human (epidemiology)</term>
<term>Influenza, Human (prevention & control)</term>
<term>Male (MeSH)</term>
<term>Treatment Outcome (MeSH)</term>
</keywords>
<keywords scheme="MESH" type="chemical" xml:lang="en"><term>Influenza Vaccines</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Influenza, Human</term>
</keywords>
<keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Influenza, Human</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adolescent</term>
<term>Canada</term>
<term>Child</term>
<term>Child, Preschool</term>
<term>Disease Outbreaks</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Humans</term>
<term>Incidence</term>
<term>Male</term>
<term>Treatment Outcome</term>
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<front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b>
</p>
<p>An earlier cluster randomized controlled trial (RCT) of Hutterite colonies had shown that if more than 80% of children and adolescents were immunized with influenza vaccine there was a statistically significant reduction in laboratory-confirmed influenza among all unimmunized community members. We assessed the impact of this intervention for two additional influenza seasonal periods.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>METHODS</b>
</p>
<p>Follow-up data for two influenza seasonal periods of a cluster randomized trial involving 1053 Canadian children and adolescents aged 36 months to 15 years in Season 2 and 1014 in Season 3 who received the study vaccine, and 2805 community members in Season 2 and 2840 in Season 3 who did not receive the study vaccine. Follow-up for Season 2 began November 18, 2009 and ended April 25, 2010 while Season 3 extended from December 6, 2010 and ended May 27, 2011. Children were randomly assigned in a blinded manner according to community membership to receive either inactivated trivalent influenza vaccine or hepatitis A. The primary outcome was confirmed influenza A and B infection using RT-PCR assay. Due to the outbreak of 2009 H1N1 pandemic, data in Season 2 were excluded for analysis.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>RESULTS</b>
</p>
<p>For an analysis of the combined Season 1 and Season 3 data, among non-recipients (i.e., participants who did not receive study vaccines), 66 of the 2794 (2.4%) participants in the influenza vaccine colonies and 121 of the 2301 (5.3%) participants in the hepatitis A colonies had influenza confirmed by RT-PCR, for a protective effectiveness of 60% (95% CI, 6% to 83%; P = 0.04); among all study participants (i.e., including both those who received study vaccine and those who did not), 125 of the 3806 (3.3%) in the influenza vaccine colonies and 239 of the 3243 (7.4%) in the hepatitis A colonies had influenza confirmed by RT-PCR, for a protective effectiveness of 63% (95% CI, 5% to 85%; P = 0.04).</p>
</div>
<div type="abstract" xml:lang="en"><p><b>CONCLUSION</b>
</p>
<p>Immunizing children and adolescents with inactivated influenza vaccine can offer a protective effect among unimmunized community members for influenza A and B together when considered over multiple years of seasonal influenza.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>TRIAL REGISTRATION</b>
</p>
<p>Clinicaltrials.gov NCT00877396.</p>
</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27977707</PMID>
<DateCompleted><Year>2017</Year>
<Month>06</Month>
<Day>29</Day>
</DateCompleted>
<DateRevised><Year>2018</Year>
<Month>11</Month>
<Day>13</Day>
</DateRevised>
<Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Electronic">1932-6203</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>11</Volume>
<Issue>12</Issue>
<PubDate><Year>2016</Year>
</PubDate>
</JournalIssue>
<Title>PloS one</Title>
<ISOAbbreviation>PLoS ONE</ISOAbbreviation>
</Journal>
<ArticleTitle>Effect of Influenza Vaccination of Children on Infection Rate in Hutterite Communities: Follow-Up Study of a Randomized Trial.</ArticleTitle>
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<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">An earlier cluster randomized controlled trial (RCT) of Hutterite colonies had shown that if more than 80% of children and adolescents were immunized with influenza vaccine there was a statistically significant reduction in laboratory-confirmed influenza among all unimmunized community members. We assessed the impact of this intervention for two additional influenza seasonal periods.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">Follow-up data for two influenza seasonal periods of a cluster randomized trial involving 1053 Canadian children and adolescents aged 36 months to 15 years in Season 2 and 1014 in Season 3 who received the study vaccine, and 2805 community members in Season 2 and 2840 in Season 3 who did not receive the study vaccine. Follow-up for Season 2 began November 18, 2009 and ended April 25, 2010 while Season 3 extended from December 6, 2010 and ended May 27, 2011. Children were randomly assigned in a blinded manner according to community membership to receive either inactivated trivalent influenza vaccine or hepatitis A. The primary outcome was confirmed influenza A and B infection using RT-PCR assay. Due to the outbreak of 2009 H1N1 pandemic, data in Season 2 were excluded for analysis.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">For an analysis of the combined Season 1 and Season 3 data, among non-recipients (i.e., participants who did not receive study vaccines), 66 of the 2794 (2.4%) participants in the influenza vaccine colonies and 121 of the 2301 (5.3%) participants in the hepatitis A colonies had influenza confirmed by RT-PCR, for a protective effectiveness of 60% (95% CI, 6% to 83%; P = 0.04); among all study participants (i.e., including both those who received study vaccine and those who did not), 125 of the 3806 (3.3%) in the influenza vaccine colonies and 239 of the 3243 (7.4%) in the hepatitis A colonies had influenza confirmed by RT-PCR, for a protective effectiveness of 63% (95% CI, 5% to 85%; P = 0.04).</AbstractText>
<AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Immunizing children and adolescents with inactivated influenza vaccine can offer a protective effect among unimmunized community members for influenza A and B together when considered over multiple years of seasonal influenza.</AbstractText>
<AbstractText Label="TRIAL REGISTRATION" NlmCategory="BACKGROUND">Clinicaltrials.gov NCT00877396.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Wang</LastName>
<ForeName>Biao</ForeName>
<Initials>B</Initials>
<AffiliationInfo><Affiliation>Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Russell</LastName>
<ForeName>Margaret L</ForeName>
<Initials>ML</Initials>
<AffiliationInfo><Affiliation>Department of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Moss</LastName>
<ForeName>Lorraine</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Fonseca</LastName>
<ForeName>Kevin</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Department of Microbiology and Infectious Diseases and Provincial Laboratory for Public Health, University of Calgary, Calgary, Alberta, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Earn</LastName>
<ForeName>David J D</ForeName>
<Initials>DJ</Initials>
<AffiliationInfo><Affiliation>Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Michael G. De- Groote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Mathematics and Statistics, McMaster University, Hamilton, Ontario, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Aoki</LastName>
<ForeName>Fred</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>Departments of Medicine, Medical Microbiology and Pharmacology, and Therapeutics, University of Manitoba, Winnipeg, Manitoba, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Horsman</LastName>
<ForeName>Gregory</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>Saskatchewan Disease Control Laboratory, Regina, Saskatchewan, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Caeseele</LastName>
<ForeName>Paul Van</ForeName>
<Initials>PV</Initials>
<AffiliationInfo><Affiliation>Cadham Provincial Laboratory, Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chokani</LastName>
<ForeName>Khami</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Saskatchewan Health, Prince Albert Parkland Health Region, Prince Albert, Saskatchewan, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Vooght</LastName>
<ForeName>Mark</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Saskatchewan Health, Five Hills Health Region, Moose Jaw, Saskatchewan, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Babiuk</LastName>
<ForeName>Lorne</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Webby</LastName>
<ForeName>Richard</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>St Jude Children's Research Hospital and WHO Collaborating Center, Memphis, Tennessee, United States of America.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Walter</LastName>
<ForeName>Stephen D</ForeName>
<Initials>SD</Initials>
<AffiliationInfo><Affiliation>Department of Microbiology and Infectious Diseases and Provincial Laboratory for Public Health, University of Calgary, Calgary, Alberta, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Loeb</LastName>
<ForeName>Mark</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Michael G. De- Groote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Medicine, McMaster University, Hamilton, Ontario, Canada.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
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