Pre-and post-pandemic trends in antiviral use in hospitalized patients with laboratory-confirmed influenza: 2004/05-2013/14, Toronto, Canada.
Identifieur interne : 000114 ( Main/Corpus ); précédent : 000113; suivant : 000115Pre-and post-pandemic trends in antiviral use in hospitalized patients with laboratory-confirmed influenza: 2004/05-2013/14, Toronto, Canada.
Auteurs : Brenda L. Coleman ; Kazi Hassan ; Karen Green ; Jonathan B. Gubbay ; Kevin Katz ; Tony Mazzulli ; Shelly Mcneil ; Matthew Muller ; Jeff Powis ; David Richardson ; Andrew Simor ; Allison J. McgeerSource :
- Antiviral research [ 1872-9096 ] ; 2017.
English descriptors
- KwdEn :
- Adolescent (MeSH), Adult (MeSH), Aged (MeSH), Aged, 80 and over (MeSH), Antiviral Agents (therapeutic use), Canada (epidemiology), Child (MeSH), Child, Preschool (MeSH), Cohort Studies (MeSH), Female (MeSH), Hospitalization (MeSH), Humans (MeSH), Influenza A Virus, H1N1 Subtype (isolation & purification), Influenza, Human (diagnosis), Influenza, Human (drug therapy), Influenza, Human (epidemiology), Influenza, Human (virology), Logistic Models (MeSH), Male (MeSH), Middle Aged (MeSH), Pandemics (MeSH), Retrospective Studies (MeSH), Risk Factors (MeSH), Seasons (MeSH), Young Adult (MeSH).
- MESH :
- chemical , therapeutic use : Antiviral Agents.
- diagnosis : Influenza, Human.
- drug therapy : Influenza, Human.
- epidemiology : Canada, Influenza, Human.
- isolation & purification : Influenza A Virus, H1N1 Subtype.
- virology : Influenza, Human.
- Adolescent, Adult, Aged, Aged, 80 and over, Child, Child, Preschool, Cohort Studies, Female, Hospitalization, Humans, Logistic Models, Male, Middle Aged, Pandemics, Retrospective Studies, Risk Factors, Seasons, Young Adult.
Abstract
BACKGROUND
Data on factors associated with the use of antiviral medication to treat influenza in both children and adults are limited.
OBJECTIVES
To describe trends in antiviral use, analyze factors associated with antiviral treatment of hospitalized patients with influenza, and to compare use based on guidelines.
STUDY DESIGN
A retrospective observational cohort of hospitalized patients with laboratory confirmed influenza in southern Ontario hospitals for the 2004/05-2013/14 seasons.
RESULTS
Of the 7967 patients, 18% of the 1779 children (<15 years) and 66% of the 6188 adults received antiviral therapy. The percentage treated increased from 29% pre-pandemic to 74% during the pandemic, decreased to 55% in 2011/12 and then increased to 65% in 2013/14. Factors significantly associated with antiviral prescription across all age groups during the non-pandemic seasons include influenza type, disease severity, interval between symptom onset and test sample submission, and clinician suspicion of influenza. Rate of treatment of patients meeting guideline criteria was low for children and moderate for adults.
CONCLUSIONS
Since the pandemic, there has been a sustained increase in the use of antiviral medication for all age groups of hospitalized patients with influenza, but much higher for adults than children. The odds of treatment are higher for patients with more severe disease as well as for those tested within 48 h of symptom onset, both of which are part of the guidelines for treatment with anti-influenza medications.
DOI: 10.1016/j.antiviral.2017.01.025
PubMed: 28179155
Links to Exploration step
pubmed:28179155Le document en format XML
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Electronic address: Brenda.coleman@sinaihealthsystem.ca.</nlm:affiliation></affiliation></author><author><name sortKey="Hassan, Kazi" sort="Hassan, Kazi" uniqKey="Hassan K" first="Kazi" last="Hassan">Kazi Hassan</name><affiliation><nlm:affiliation>Sinai Health System, 600 University Avenue, Toronto, ON M5G1X5, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Green, Karen" sort="Green, Karen" uniqKey="Green K" first="Karen" last="Green">Karen Green</name><affiliation><nlm:affiliation>Sinai Health System, 600 University Avenue, Toronto, ON M5G1X5, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Gubbay, Jonathan B" sort="Gubbay, Jonathan B" uniqKey="Gubbay J" first="Jonathan B" last="Gubbay">Jonathan B. 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Mcgeer</name><affiliation><nlm:affiliation>Sinai Health System, 600 University Avenue, Toronto, ON M5G1X5, Canada; University of Toronto, 155 College Street, Toronto, ON M5T3M7, Canada.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28179155</idno><idno type="pmid">28179155</idno><idno type="doi">10.1016/j.antiviral.2017.01.025</idno><idno type="wicri:Area/Main/Corpus">000114</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000114</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Pre-and post-pandemic trends in antiviral use in hospitalized patients with laboratory-confirmed influenza: 2004/05-2013/14, Toronto, Canada.</title><author><name sortKey="Coleman, Brenda L" sort="Coleman, Brenda L" uniqKey="Coleman B" first="Brenda L" last="Coleman">Brenda L. Coleman</name><affiliation><nlm:affiliation>Sinai Health System, 600 University Avenue, Toronto, ON M5G1X5, Canada; University of Toronto, 155 College Street, Toronto, ON M5T3M7, Canada. Electronic address: Brenda.coleman@sinaihealthsystem.ca.</nlm:affiliation></affiliation></author><author><name sortKey="Hassan, Kazi" sort="Hassan, Kazi" uniqKey="Hassan K" first="Kazi" last="Hassan">Kazi Hassan</name><affiliation><nlm:affiliation>Sinai Health System, 600 University Avenue, Toronto, ON M5G1X5, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Green, Karen" sort="Green, Karen" uniqKey="Green K" first="Karen" last="Green">Karen Green</name><affiliation><nlm:affiliation>Sinai Health System, 600 University Avenue, Toronto, ON M5G1X5, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Gubbay, Jonathan B" sort="Gubbay, Jonathan B" uniqKey="Gubbay J" first="Jonathan B" last="Gubbay">Jonathan B. Gubbay</name><affiliation><nlm:affiliation>Public Health Ontario Laboratories, 661 University Ave., Toronto, ON M5G1M1, Canada; University of Toronto, 155 College Street, Toronto, ON M5T3M7, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Katz, Kevin" sort="Katz, Kevin" uniqKey="Katz K" first="Kevin" last="Katz">Kevin Katz</name><affiliation><nlm:affiliation>North York General Hospital, 4001 Leslie St., North York, ON M2K1E1, Canada; University of Toronto, 155 College Street, Toronto, ON M5T3M7, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Mazzulli, Tony" sort="Mazzulli, Tony" uniqKey="Mazzulli T" first="Tony" last="Mazzulli">Tony Mazzulli</name><affiliation><nlm:affiliation>Sinai Health System, 600 University Avenue, Toronto, ON M5G1X5, Canada; University of Toronto, 155 College Street, Toronto, ON M5T3M7, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Mcneil, Shelly" sort="Mcneil, Shelly" uniqKey="Mcneil S" first="Shelly" last="Mcneil">Shelly Mcneil</name><affiliation><nlm:affiliation>Canadian Centre for Vaccinology, IWK Health Centre, 5850/5980 University Ave., Halifax, NS B3K6R8, Canada; Dalhousie University, 6299 South St, Halifax, NS B3H4R2, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Muller, Matthew" sort="Muller, Matthew" uniqKey="Muller M" first="Matthew" last="Muller">Matthew Muller</name><affiliation><nlm:affiliation>St. Michael's Hospital, 30 Bond St., Toronto, ON M5B1W8, Canada; University of Toronto, 155 College Street, Toronto, ON M5T3M7, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Powis, Jeff" sort="Powis, Jeff" uniqKey="Powis J" first="Jeff" last="Powis">Jeff Powis</name><affiliation><nlm:affiliation>Michael Garron Hospital, 825 Coxwell Ave., East York, ON M4C3E7, Canada; William Osler Health System, 2100 Bovaird Dr. E., Brampton, ON L6R3J7, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Richardson, David" sort="Richardson, David" uniqKey="Richardson D" first="David" last="Richardson">David Richardson</name><affiliation><nlm:affiliation>William Osler Health System, 2100 Bovaird Dr. E., Brampton, ON L6R3J7, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Simor, Andrew" sort="Simor, Andrew" uniqKey="Simor A" first="Andrew" last="Simor">Andrew Simor</name><affiliation><nlm:affiliation>Sunnybrook Health Sciences Centre, 2075 Bayview Ave., Toronto, ON M4N3M5, Canada; University of Toronto, 155 College Street, Toronto, ON M5T3M7, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Mcgeer, Allison J" sort="Mcgeer, Allison J" uniqKey="Mcgeer A" first="Allison J" last="Mcgeer">Allison J. Mcgeer</name><affiliation><nlm:affiliation>Sinai Health System, 600 University Avenue, Toronto, ON M5G1X5, Canada; University of Toronto, 155 College Street, Toronto, ON M5T3M7, Canada.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Antiviral research</title><idno type="eISSN">1872-9096</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent (MeSH)</term><term>Adult (MeSH)</term><term>Aged (MeSH)</term><term>Aged, 80 and over (MeSH)</term><term>Antiviral Agents (therapeutic use)</term><term>Canada (epidemiology)</term><term>Child (MeSH)</term><term>Child, Preschool (MeSH)</term><term>Cohort Studies (MeSH)</term><term>Female (MeSH)</term><term>Hospitalization (MeSH)</term><term>Humans (MeSH)</term><term>Influenza A Virus, H1N1 Subtype (isolation & purification)</term><term>Influenza, Human (diagnosis)</term><term>Influenza, Human (drug therapy)</term><term>Influenza, Human (epidemiology)</term><term>Influenza, Human (virology)</term><term>Logistic Models (MeSH)</term><term>Male (MeSH)</term><term>Middle Aged (MeSH)</term><term>Pandemics (MeSH)</term><term>Retrospective Studies (MeSH)</term><term>Risk Factors (MeSH)</term><term>Seasons (MeSH)</term><term>Young Adult (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiviral Agents</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Canada</term><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Child</term><term>Child, Preschool</term><term>Cohort Studies</term><term>Female</term><term>Hospitalization</term><term>Humans</term><term>Logistic Models</term><term>Male</term><term>Middle Aged</term><term>Pandemics</term><term>Retrospective Studies</term><term>Risk Factors</term><term>Seasons</term><term>Young Adult</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b></p><p>Data on factors associated with the use of antiviral medication to treat influenza in both children and adults are limited.</p></div><div type="abstract" xml:lang="en"><p><b>OBJECTIVES</b></p><p>To describe trends in antiviral use, analyze factors associated with antiviral treatment of hospitalized patients with influenza, and to compare use based on guidelines.</p></div><div type="abstract" xml:lang="en"><p><b>STUDY DESIGN</b></p><p>A retrospective observational cohort of hospitalized patients with laboratory confirmed influenza in southern Ontario hospitals for the 2004/05-2013/14 seasons.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>Of the 7967 patients, 18% of the 1779 children (<15 years) and 66% of the 6188 adults received antiviral therapy. The percentage treated increased from 29% pre-pandemic to 74% during the pandemic, decreased to 55% in 2011/12 and then increased to 65% in 2013/14. Factors significantly associated with antiviral prescription across all age groups during the non-pandemic seasons include influenza type, disease severity, interval between symptom onset and test sample submission, and clinician suspicion of influenza. Rate of treatment of patients meeting guideline criteria was low for children and moderate for adults.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b></p><p>Since the pandemic, there has been a sustained increase in the use of antiviral medication for all age groups of hospitalized patients with influenza, but much higher for adults than children. The odds of treatment are higher for patients with more severe disease as well as for those tested within 48 h of symptom onset, both of which are part of the guidelines for treatment with anti-influenza medications.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">28179155</PMID><DateCompleted><Year>2017</Year><Month>12</Month><Day>19</Day></DateCompleted><DateRevised><Year>2018</Year><Month>02</Month><Day>13</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1872-9096</ISSN><JournalIssue CitedMedium="Internet"><Volume>140</Volume><PubDate><Year>2017</Year><Month>04</Month></PubDate></JournalIssue><Title>Antiviral research</Title><ISOAbbreviation>Antiviral Res.</ISOAbbreviation></Journal><ArticleTitle>Pre-and post-pandemic trends in antiviral use in hospitalized patients with laboratory-confirmed influenza: 2004/05-2013/14, Toronto, Canada.</ArticleTitle><Pagination><MedlinePgn>158-163</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0166-3542(16)30612-X</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.antiviral.2017.01.025</ELocationID><Abstract><AbstractText Label="BACKGROUND">Data on factors associated with the use of antiviral medication to treat influenza in both children and adults are limited.</AbstractText><AbstractText Label="OBJECTIVES">To describe trends in antiviral use, analyze factors associated with antiviral treatment of hospitalized patients with influenza, and to compare use based on guidelines.</AbstractText><AbstractText Label="STUDY DESIGN">A retrospective observational cohort of hospitalized patients with laboratory confirmed influenza in southern Ontario hospitals for the 2004/05-2013/14 seasons.</AbstractText><AbstractText Label="RESULTS">Of the 7967 patients, 18% of the 1779 children (<15 years) and 66% of the 6188 adults received antiviral therapy. The percentage treated increased from 29% pre-pandemic to 74% during the pandemic, decreased to 55% in 2011/12 and then increased to 65% in 2013/14. Factors significantly associated with antiviral prescription across all age groups during the non-pandemic seasons include influenza type, disease severity, interval between symptom onset and test sample submission, and clinician suspicion of influenza. Rate of treatment of patients meeting guideline criteria was low for children and moderate for adults.</AbstractText><AbstractText Label="CONCLUSIONS">Since the pandemic, there has been a sustained increase in the use of antiviral medication for all age groups of hospitalized patients with influenza, but much higher for adults than children. The odds of treatment are higher for patients with more severe disease as well as for those tested within 48 h of symptom onset, both of which are part of the guidelines for treatment with anti-influenza medications.</AbstractText><CopyrightInformation>Copyright © 2017 Elsevier B.V. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Coleman</LastName><ForeName>Brenda L</ForeName><Initials>BL</Initials><AffiliationInfo><Affiliation>Sinai Health System, 600 University Avenue, Toronto, ON M5G1X5, Canada; University of Toronto, 155 College Street, Toronto, ON M5T3M7, Canada. Electronic address: Brenda.coleman@sinaihealthsystem.ca.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hassan</LastName><ForeName>Kazi</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Sinai Health System, 600 University Avenue, Toronto, ON M5G1X5, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Green</LastName><ForeName>Karen</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Sinai Health System, 600 University Avenue, Toronto, ON M5G1X5, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gubbay</LastName><ForeName>Jonathan B</ForeName><Initials>JB</Initials><AffiliationInfo><Affiliation>Public Health Ontario Laboratories, 661 University Ave., Toronto, ON M5G1M1, Canada; University of Toronto, 155 College Street, Toronto, ON M5T3M7, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Katz</LastName><ForeName>Kevin</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>North York General Hospital, 4001 Leslie St., North York, ON M2K1E1, Canada; University of Toronto, 155 College Street, Toronto, ON M5T3M7, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mazzulli</LastName><ForeName>Tony</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Sinai Health System, 600 University Avenue, Toronto, ON M5G1X5, Canada; University of Toronto, 155 College Street, Toronto, ON M5T3M7, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>McNeil</LastName><ForeName>Shelly</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Canadian Centre for Vaccinology, IWK Health Centre, 5850/5980 University Ave., Halifax, NS B3K6R8, Canada; Dalhousie University, 6299 South St, Halifax, NS B3H4R2, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Muller</LastName><ForeName>Matthew</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>St. Michael's Hospital, 30 Bond St., Toronto, ON M5B1W8, Canada; University of Toronto, 155 College Street, Toronto, ON M5T3M7, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Powis</LastName><ForeName>Jeff</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Michael Garron Hospital, 825 Coxwell Ave., East York, ON M4C3E7, Canada; William Osler Health System, 2100 Bovaird Dr. E., Brampton, ON L6R3J7, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Richardson</LastName><ForeName>David</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>William Osler Health System, 2100 Bovaird Dr. E., Brampton, ON L6R3J7, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Simor</LastName><ForeName>Andrew</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Sunnybrook Health Sciences Centre, 2075 Bayview Ave., Toronto, ON M4N3M5, Canada; University of Toronto, 155 College Street, Toronto, ON M5T3M7, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>TIBDN</CollectiveName></Author><Author ValidYN="Y"><LastName>McGeer</LastName><ForeName>Allison J</ForeName><Initials>AJ</Initials><AffiliationInfo><Affiliation>Sinai Health System, 600 University Avenue, Toronto, ON M5G1X5, Canada; University of Toronto, 155 College Street, Toronto, ON M5T3M7, Canada.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><Agency>CIHR</Agency><Country>Canada</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D064888">Observational Study</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>02</Month><Day>06</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Antiviral Res</MedlineTA><NlmUniqueID>8109699</NlmUniqueID><ISSNLinking>0166-3542</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000998">Antiviral Agents</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000998" MajorTopicYN="N">Antiviral Agents</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002170" MajorTopicYN="N">Canada</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002648" MajorTopicYN="N">Child</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002675" MajorTopicYN="N">Child, Preschool</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015331" MajorTopicYN="N">Cohort Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006760" MajorTopicYN="N">Hospitalization</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D053118" MajorTopicYN="N">Influenza A Virus, H1N1 Subtype</DescriptorName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007251" MajorTopicYN="N">Influenza, Human</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName><QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016015" MajorTopicYN="N">Logistic Models</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D058873" MajorTopicYN="Y">Pandemics</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012189" MajorTopicYN="N">Retrospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012307" MajorTopicYN="N">Risk Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012621" MajorTopicYN="N">Seasons</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">Hospital patients</Keyword><Keyword MajorTopicYN="Y">Influenza</Keyword><Keyword MajorTopicYN="Y">Neuraminidase inhibitor</Keyword><Keyword MajorTopicYN="Y">Post-pandemic</Keyword><Keyword MajorTopicYN="Y">Predictors</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>11</Month><Day>11</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2017</Year><Month>01</Month><Day>18</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2017</Year><Month>01</Month><Day>23</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>2</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>12</Month><Day>20</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>2</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">28179155</ArticleId><ArticleId IdType="pii">S0166-3542(16)30612-X</ArticleId><ArticleId IdType="doi">10.1016/j.antiviral.2017.01.025</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/GrippeCanadaV4/Data/Main/Corpus
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Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Corpus/biblio.hfd -nk 000114 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= GrippeCanadaV4
|flux= Main
|étape= Corpus
|type= RBID
|clé= pubmed:28179155
|texte= Pre-and post-pandemic trends in antiviral use in hospitalized patients with laboratory-confirmed influenza: 2004/05-2013/14, Toronto, Canada.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Corpus/RBID.i -Sk "pubmed:28179155" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Corpus/biblio.hfd \
| NlmPubMed2Wicri -a GrippeCanadaV4
| This area was generated with Dilib version V0.6.35. |  |