Antiviral Terpenoid Constituents of Ganoderma pfeifferi.
Identifieur interne : 000523 ( Main/Exploration ); précédent : 000522; suivant : 000524Antiviral Terpenoid Constituents of Ganoderma pfeifferi.
Auteurs : Timo H J. Niedermeyer [Allemagne] ; Ulrike Lindequist ; Renate Mentel ; Dirk Gördes ; Enrico Schmidt ; Kerstin Thurow ; Michael LalkSource :
- Journal of natural products [ 0163-3864 ] ; 2005.
Descripteurs français
- KwdFr :
- Allemagne (MeSH), Antibactériens (composition chimique), Antibactériens (isolement et purification), Antibactériens (pharmacologie), Antifongiques (composition chimique), Antifongiques (isolement et purification), Antifongiques (pharmacologie), Antiviraux (composition chimique), Antiviraux (isolement et purification), Antiviraux (pharmacologie), Ganoderma (composition chimique), Relation structure-activité (MeSH), Simplexvirus (effets des médicaments et des substances chimiques), Structure moléculaire (MeSH), Stérols (composition chimique), Stérols (isolement et purification), Stérols (pharmacologie), Terpènes (composition chimique), Terpènes (isolement et purification), Terpènes (pharmacologie), Tests de sensibilité microbienne (MeSH), Virus de la grippe A (effets des médicaments et des substances chimiques).
- MESH :
- composition chimique : Antibactériens, Antifongiques, Antiviraux, Ganoderma, Stérols, Terpènes.
- effets des médicaments et des substances chimiques : Simplexvirus, Virus de la grippe A.
- isolement et purification : Antibactériens, Antifongiques, Antiviraux, Stérols, Terpènes.
- pharmacologie : Antibactériens, Antifongiques, Antiviraux, Stérols, Terpènes.
- Allemagne, Relation structure-activité, Structure moléculaire, Tests de sensibilité microbienne.
- Wicri :
- geographic : Allemagne.
English descriptors
- KwdEn :
- Anti-Bacterial Agents (chemistry), Anti-Bacterial Agents (isolation & purification), Anti-Bacterial Agents (pharmacology), Antifungal Agents (chemistry), Antifungal Agents (isolation & purification), Antifungal Agents (pharmacology), Antiviral Agents (chemistry), Antiviral Agents (isolation & purification), Antiviral Agents (pharmacology), Ganoderma (chemistry), Germany (MeSH), Influenza A virus (drug effects), Microbial Sensitivity Tests (MeSH), Molecular Structure (MeSH), Simplexvirus (drug effects), Sterols (chemistry), Sterols (isolation & purification), Sterols (pharmacology), Structure-Activity Relationship (MeSH), Terpenes (chemistry), Terpenes (isolation & purification), Terpenes (pharmacology).
- MESH :
- chemical , chemistry : Anti-Bacterial Agents, Antifungal Agents, Antiviral Agents, Sterols, Terpenes.
- chemical , isolation & purification : Anti-Bacterial Agents, Antifungal Agents, Antiviral Agents, Sterols, Terpenes.
- chemical , pharmacology : Anti-Bacterial Agents, Antifungal Agents, Antiviral Agents, Sterols, Terpenes.
- geographic : Germany.
- chemistry : Ganoderma.
- drug effects : Influenza A virus, Simplexvirus.
- Microbial Sensitivity Tests, Molecular Structure, Structure-Activity Relationship.
Abstract
Four sterols and 10 triterpenes were isolated from the fruiting bodies of Ganoderma pfeifferi, including the three new triterpenes 3,7,11-trioxo-5alpha-lanosta-8,24-diene-26-al (lucialdehyde D, 1), 5alpha-lanosta-8,24-diene-26-hydroxy-3,7-dione (ganoderone A, 2), and 5alpha-lanosta-8-ene-24,25-epoxy-26-hydroxy-3,7-dione (ganoderone C, 3). The structures of 1-3 were determined on the basis of spectroscopic evidence. Antibacterial, antifungal, and antiviral activity were studied for some of the isolated compounds. Ganoderone A (2), lucialdehyde B (4), and ergosta-7,22-dien-3beta-ol (7) were found to exhibit potent inhibitory activity against herpes simplex virus.
DOI: 10.1021/np0501886
PubMed: 16378363
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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<term>Anti-Bacterial Agents (pharmacology)</term>
<term>Antifungal Agents (chemistry)</term>
<term>Antifungal Agents (isolation & purification)</term>
<term>Antifungal Agents (pharmacology)</term>
<term>Antiviral Agents (chemistry)</term>
<term>Antiviral Agents (isolation & purification)</term>
<term>Antiviral Agents (pharmacology)</term>
<term>Ganoderma (chemistry)</term>
<term>Germany (MeSH)</term>
<term>Influenza A virus (drug effects)</term>
<term>Microbial Sensitivity Tests (MeSH)</term>
<term>Molecular Structure (MeSH)</term>
<term>Simplexvirus (drug effects)</term>
<term>Sterols (chemistry)</term>
<term>Sterols (isolation & purification)</term>
<term>Sterols (pharmacology)</term>
<term>Structure-Activity Relationship (MeSH)</term>
<term>Terpenes (chemistry)</term>
<term>Terpenes (isolation & purification)</term>
<term>Terpenes (pharmacology)</term>
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<keywords scheme="KwdFr" xml:lang="fr"><term>Allemagne (MeSH)</term>
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<term>Antibactériens (isolement et purification)</term>
<term>Antibactériens (pharmacologie)</term>
<term>Antifongiques (composition chimique)</term>
<term>Antifongiques (isolement et purification)</term>
<term>Antifongiques (pharmacologie)</term>
<term>Antiviraux (composition chimique)</term>
<term>Antiviraux (isolement et purification)</term>
<term>Antiviraux (pharmacologie)</term>
<term>Ganoderma (composition chimique)</term>
<term>Relation structure-activité (MeSH)</term>
<term>Simplexvirus (effets des médicaments et des substances chimiques)</term>
<term>Structure moléculaire (MeSH)</term>
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<term>Stérols (isolement et purification)</term>
<term>Stérols (pharmacologie)</term>
<term>Terpènes (composition chimique)</term>
<term>Terpènes (isolement et purification)</term>
<term>Terpènes (pharmacologie)</term>
<term>Tests de sensibilité microbienne (MeSH)</term>
<term>Virus de la grippe A (effets des médicaments et des substances chimiques)</term>
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<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Anti-Bacterial Agents</term>
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<term>Antiviral Agents</term>
<term>Sterols</term>
<term>Terpenes</term>
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<term>Antifungal Agents</term>
<term>Antiviral Agents</term>
<term>Sterols</term>
<term>Terpenes</term>
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<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Anti-Bacterial Agents</term>
<term>Antifungal Agents</term>
<term>Antiviral Agents</term>
<term>Sterols</term>
<term>Terpenes</term>
</keywords>
<keywords scheme="MESH" type="geographic" xml:lang="en"><term>Germany</term>
</keywords>
<keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Ganoderma</term>
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<keywords scheme="MESH" qualifier="composition chimique" xml:lang="fr"><term>Antibactériens</term>
<term>Antifongiques</term>
<term>Antiviraux</term>
<term>Ganoderma</term>
<term>Stérols</term>
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<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Influenza A virus</term>
<term>Simplexvirus</term>
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<term>Virus de la grippe A</term>
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<term>Antifongiques</term>
<term>Antiviraux</term>
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<term>Terpènes</term>
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<term>Antiviraux</term>
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<term>Terpènes</term>
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<keywords scheme="MESH" xml:lang="en"><term>Microbial Sensitivity Tests</term>
<term>Molecular Structure</term>
<term>Structure-Activity Relationship</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Allemagne</term>
<term>Relation structure-activité</term>
<term>Structure moléculaire</term>
<term>Tests de sensibilité microbienne</term>
</keywords>
<keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Allemagne</term>
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<front><div type="abstract" xml:lang="en">Four sterols and 10 triterpenes were isolated from the fruiting bodies of Ganoderma pfeifferi, including the three new triterpenes 3,7,11-trioxo-5alpha-lanosta-8,24-diene-26-al (lucialdehyde D, 1), 5alpha-lanosta-8,24-diene-26-hydroxy-3,7-dione (ganoderone A, 2), and 5alpha-lanosta-8-ene-24,25-epoxy-26-hydroxy-3,7-dione (ganoderone C, 3). The structures of 1-3 were determined on the basis of spectroscopic evidence. Antibacterial, antifungal, and antiviral activity were studied for some of the isolated compounds. Ganoderone A (2), lucialdehyde B (4), and ergosta-7,22-dien-3beta-ol (7) were found to exhibit potent inhibitory activity against herpes simplex virus.</div>
</front>
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<Title>Journal of natural products</Title>
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<ArticleTitle>Antiviral Terpenoid Constituents of Ganoderma pfeifferi.</ArticleTitle>
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</Pagination>
<Abstract><AbstractText>Four sterols and 10 triterpenes were isolated from the fruiting bodies of Ganoderma pfeifferi, including the three new triterpenes 3,7,11-trioxo-5alpha-lanosta-8,24-diene-26-al (lucialdehyde D, 1), 5alpha-lanosta-8,24-diene-26-hydroxy-3,7-dione (ganoderone A, 2), and 5alpha-lanosta-8-ene-24,25-epoxy-26-hydroxy-3,7-dione (ganoderone C, 3). The structures of 1-3 were determined on the basis of spectroscopic evidence. Antibacterial, antifungal, and antiviral activity were studied for some of the isolated compounds. Ganoderone A (2), lucialdehyde B (4), and ergosta-7,22-dien-3beta-ol (7) were found to exhibit potent inhibitory activity against herpes simplex virus.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Niedermeyer</LastName>
<ForeName>Timo H J</ForeName>
<Initials>TH</Initials>
<AffiliationInfo><Affiliation>Institute of Pharmacy, Ernst-Moritz-Arndt-University, Friedrich-Ludwig-Jahn-Strasse 17, 17487 Greifswald, Germany.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Lindequist</LastName>
<ForeName>Ulrike</ForeName>
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<Author ValidYN="Y"><LastName>Mentel</LastName>
<ForeName>Renate</ForeName>
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<Author ValidYN="Y"><LastName>Gördes</LastName>
<ForeName>Dirk</ForeName>
<Initials>D</Initials>
</Author>
<Author ValidYN="Y"><LastName>Schmidt</LastName>
<ForeName>Enrico</ForeName>
<Initials>E</Initials>
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<Author ValidYN="Y"><LastName>Thurow</LastName>
<ForeName>Kerstin</ForeName>
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<name sortKey="Lindequist, Ulrike" sort="Lindequist, Ulrike" uniqKey="Lindequist U" first="Ulrike" last="Lindequist">Ulrike Lindequist</name>
<name sortKey="Mentel, Renate" sort="Mentel, Renate" uniqKey="Mentel R" first="Renate" last="Mentel">Renate Mentel</name>
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