Safe vaccination of children with a virosomal adjuvanted influenza vaccine.
Identifieur interne : 000431 ( Main/Corpus ); précédent : 000430; suivant : 000432Safe vaccination of children with a virosomal adjuvanted influenza vaccine.
Auteurs : Valérie Künzi ; Martin Dornseiff ; Jörg Horwath ; Katharina HartmannSource :
- Vaccine [ 0264-410X ] ; 2009.
English descriptors
- KwdEn :
- Child (MeSH), Child, Preschool (MeSH), Germany (MeSH), Humans (MeSH), Infant (MeSH), Influenza Vaccines (adverse effects), Influenza Vaccines (immunology), Product Surveillance, Postmarketing (MeSH), Surveys and Questionnaires (MeSH), Vaccines, Virosome (adverse effects), Vaccines, Virosome (immunology).
- MESH :
- chemical , adverse effects : Influenza Vaccines, Vaccines, Virosome.
- chemical , immunology : Influenza Vaccines, Vaccines, Virosome.
- geographic : Germany.
- Child, Child, Preschool, Humans, Infant, Product Surveillance, Postmarketing, Surveys and Questionnaires.
Abstract
A post-marketing study was conducted in 26 paediatric practices in Germany to collect safety information on the virosomal adjuvanted influenza vaccine Inflexal V (in Germany marketed as Infectovac Flu). Children aged 6 months to 6 years received one or two doses. Adverse events were documented by parents/legal guardians in a questionnaire for four days after vaccination. The rates of adverse events were low: 14% of vaccine exposures were associated with systemic and 25% with local adverse events. Most symptoms were mild to moderate and resolved within a few days. Nearly 100% of parents/legal guardians would agree to have their child vaccinated again with Inflexal V. Vaccination with Inflexal V was safe, well tolerated and highly accepted by parents/legal guardians.
DOI: 10.1016/j.vaccine.2008.12.008
PubMed: 19114080
Links to Exploration step
pubmed:19114080Le document en format XML
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<author><name sortKey="Kunzi, Valerie" sort="Kunzi, Valerie" uniqKey="Kunzi V" first="Valérie" last="Künzi">Valérie Künzi</name>
<affiliation><nlm:affiliation>Crucell, Berna Biotech Ltd, Rehhagstrasse 79, 3018 Berne, Switzerland. valerie.kuenzi@crucell.ch</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Dornseiff, Martin" sort="Dornseiff, Martin" uniqKey="Dornseiff M" first="Martin" last="Dornseiff">Martin Dornseiff</name>
</author>
<author><name sortKey="Horwath, Jorg" sort="Horwath, Jorg" uniqKey="Horwath J" first="Jörg" last="Horwath">Jörg Horwath</name>
</author>
<author><name sortKey="Hartmann, Katharina" sort="Hartmann, Katharina" uniqKey="Hartmann K" first="Katharina" last="Hartmann">Katharina Hartmann</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Safe vaccination of children with a virosomal adjuvanted influenza vaccine.</title>
<author><name sortKey="Kunzi, Valerie" sort="Kunzi, Valerie" uniqKey="Kunzi V" first="Valérie" last="Künzi">Valérie Künzi</name>
<affiliation><nlm:affiliation>Crucell, Berna Biotech Ltd, Rehhagstrasse 79, 3018 Berne, Switzerland. valerie.kuenzi@crucell.ch</nlm:affiliation>
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<author><name sortKey="Dornseiff, Martin" sort="Dornseiff, Martin" uniqKey="Dornseiff M" first="Martin" last="Dornseiff">Martin Dornseiff</name>
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<author><name sortKey="Horwath, Jorg" sort="Horwath, Jorg" uniqKey="Horwath J" first="Jörg" last="Horwath">Jörg Horwath</name>
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<author><name sortKey="Hartmann, Katharina" sort="Hartmann, Katharina" uniqKey="Hartmann K" first="Katharina" last="Hartmann">Katharina Hartmann</name>
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<series><title level="j">Vaccine</title>
<idno type="ISSN">0264-410X</idno>
<imprint><date when="2009" type="published">2009</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Child (MeSH)</term>
<term>Child, Preschool (MeSH)</term>
<term>Germany (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Infant (MeSH)</term>
<term>Influenza Vaccines (adverse effects)</term>
<term>Influenza Vaccines (immunology)</term>
<term>Product Surveillance, Postmarketing (MeSH)</term>
<term>Surveys and Questionnaires (MeSH)</term>
<term>Vaccines, Virosome (adverse effects)</term>
<term>Vaccines, Virosome (immunology)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Influenza Vaccines</term>
<term>Vaccines, Virosome</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Influenza Vaccines</term>
<term>Vaccines, Virosome</term>
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<keywords scheme="MESH" type="geographic" xml:lang="en"><term>Germany</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Child</term>
<term>Child, Preschool</term>
<term>Humans</term>
<term>Infant</term>
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<front><div type="abstract" xml:lang="en">A post-marketing study was conducted in 26 paediatric practices in Germany to collect safety information on the virosomal adjuvanted influenza vaccine Inflexal V (in Germany marketed as Infectovac Flu). Children aged 6 months to 6 years received one or two doses. Adverse events were documented by parents/legal guardians in a questionnaire for four days after vaccination. The rates of adverse events were low: 14% of vaccine exposures were associated with systemic and 25% with local adverse events. Most symptoms were mild to moderate and resolved within a few days. Nearly 100% of parents/legal guardians would agree to have their child vaccinated again with Inflexal V. Vaccination with Inflexal V was safe, well tolerated and highly accepted by parents/legal guardians.</div>
</front>
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<Title>Vaccine</Title>
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<Abstract><AbstractText>A post-marketing study was conducted in 26 paediatric practices in Germany to collect safety information on the virosomal adjuvanted influenza vaccine Inflexal V (in Germany marketed as Infectovac Flu). Children aged 6 months to 6 years received one or two doses. Adverse events were documented by parents/legal guardians in a questionnaire for four days after vaccination. The rates of adverse events were low: 14% of vaccine exposures were associated with systemic and 25% with local adverse events. Most symptoms were mild to moderate and resolved within a few days. Nearly 100% of parents/legal guardians would agree to have their child vaccinated again with Inflexal V. Vaccination with Inflexal V was safe, well tolerated and highly accepted by parents/legal guardians.</AbstractText>
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<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Künzi</LastName>
<ForeName>Valérie</ForeName>
<Initials>V</Initials>
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<Author ValidYN="Y"><LastName>Horwath</LastName>
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<Author ValidYN="Y"><LastName>Hartmann</LastName>
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<Language>eng</Language>
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<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
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