Pulmonary manifestation of novel swine-origin influenza A (H1N1) virus (S-OIV) infection in immunocompromised patients: initial findings with multidetector computed tomography.
Identifieur interne : 000241 ( Main/Corpus ); précédent : 000240; suivant : 000242Pulmonary manifestation of novel swine-origin influenza A (H1N1) virus (S-OIV) infection in immunocompromised patients: initial findings with multidetector computed tomography.
Auteurs : A. Laqmani ; G. Adam ; M. RegierSource :
- Medical principles and practice : international journal of the Kuwait University, Health Science Centre [ 1423-0151 ] ; 2012.
English descriptors
- KwdEn :
- Adult (MeSH), Aged (MeSH), Animals (MeSH), Disease Progression (MeSH), Female (MeSH), Germany (MeSH), Humans (MeSH), Immunocompromised Host (MeSH), Influenza A Virus, H1N1 Subtype (MeSH), Influenza, Human (diagnosis), Influenza, Human (mortality), Male (MeSH), Middle Aged (MeSH), Multidetector Computed Tomography (MeSH), Pneumonia, Viral (diagnosis), Pneumonia, Viral (mortality), Prognosis (MeSH), Respiration, Artificial (MeSH), Respiratory Distress Syndrome, Adult (MeSH), Respiratory Insufficiency (MeSH), Retrospective Studies (MeSH), Swine (MeSH), Time Factors (MeSH).
- MESH :
- geographic : Germany.
- diagnosis : Influenza, Human, Pneumonia, Viral.
- mortality : Influenza, Human, Pneumonia, Viral.
- Adult, Aged, Animals, Disease Progression, Female, Humans, Immunocompromised Host, Influenza A Virus, H1N1 Subtype, Male, Middle Aged, Multidetector Computed Tomography, Prognosis, Respiration, Artificial, Respiratory Distress Syndrome, Adult, Respiratory Insufficiency, Retrospective Studies, Swine, Time Factors.
Abstract
OBJECTIVE
To describe initial multidetector computed tomographic (MDCT) findings of novel swine-origin influenza A (H1N1) virus (S-OIV) infection in immunocompromised patients and to evaluate whether or not identification of certain abnormalities can help predict patients who are at risk for a severe clinical course.
SUBJECTS AND METHODS
This retrospective study included 13 patients with confirmed S-OIV infection suffering from an underlying immunodeficiency or who were receiving immunosuppressive therapy. All patients underwent MDCT of the thorax due to respiratory distress. All data were read by two independent radiologists who described the type and pattern of opacities, distribution and extent of the abnormalities observed. Adverse outcome measures were defined as acute respiratory distress syndrome with the need for mechanical ventilation, extracorporeal membrane oxygenation or death.
RESULTS
MDCT revealed pulmonary manifestations in 12 (92%) of 13 individuals. Six (50%) patients showed an adverse outcome with development of acute respiratory distress syndrome, 4 of these died. The most common findings were ground-glass opacities (10/12; 83%) and pulmonary consolidation (7/12; 58%) predominantly with a bilateral distribution. Reticular pattern and a tree-in-bud appearance were found in 3/12 (25%), respectively. Bilateral opacities with extensive involvement of the lung parenchyma were most predictive of a severe clinical course.
CONCLUSION
The MDCT scan in immunocompromised patients with confirmed S-OIV infection frequently revealed pulmonary abnormalities, which included ground-glass opacities and consolidations. Therefore, prediction of an adverse clinical outcome could be made in patients with MDCT findings demonstrating bilateral extensive consolidations, often combined with ground-glass opacities.
DOI: 10.1159/000338399
PubMed: 22678192
Links to Exploration step
pubmed:22678192Le document en format XML
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<author><name sortKey="Laqmani, A" sort="Laqmani, A" uniqKey="Laqmani A" first="A" last="Laqmani">A. Laqmani</name>
<affiliation><nlm:affiliation>Center for Radiology and Endoscopy, Department of Diagnostic and Interventional Radiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. a.laqmani @ uke.de</nlm:affiliation>
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</author>
<author><name sortKey="Adam, G" sort="Adam, G" uniqKey="Adam G" first="G" last="Adam">G. Adam</name>
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<author><name sortKey="Regier, M" sort="Regier, M" uniqKey="Regier M" first="M" last="Regier">M. Regier</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Pulmonary manifestation of novel swine-origin influenza A (H1N1) virus (S-OIV) infection in immunocompromised patients: initial findings with multidetector computed tomography.</title>
<author><name sortKey="Laqmani, A" sort="Laqmani, A" uniqKey="Laqmani A" first="A" last="Laqmani">A. Laqmani</name>
<affiliation><nlm:affiliation>Center for Radiology and Endoscopy, Department of Diagnostic and Interventional Radiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. a.laqmani @ uke.de</nlm:affiliation>
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<author><name sortKey="Adam, G" sort="Adam, G" uniqKey="Adam G" first="G" last="Adam">G. Adam</name>
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<author><name sortKey="Regier, M" sort="Regier, M" uniqKey="Regier M" first="M" last="Regier">M. Regier</name>
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<series><title level="j">Medical principles and practice : international journal of the Kuwait University, Health Science Centre</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult (MeSH)</term>
<term>Aged (MeSH)</term>
<term>Animals (MeSH)</term>
<term>Disease Progression (MeSH)</term>
<term>Female (MeSH)</term>
<term>Germany (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Immunocompromised Host (MeSH)</term>
<term>Influenza A Virus, H1N1 Subtype (MeSH)</term>
<term>Influenza, Human (diagnosis)</term>
<term>Influenza, Human (mortality)</term>
<term>Male (MeSH)</term>
<term>Middle Aged (MeSH)</term>
<term>Multidetector Computed Tomography (MeSH)</term>
<term>Pneumonia, Viral (diagnosis)</term>
<term>Pneumonia, Viral (mortality)</term>
<term>Prognosis (MeSH)</term>
<term>Respiration, Artificial (MeSH)</term>
<term>Respiratory Distress Syndrome, Adult (MeSH)</term>
<term>Respiratory Insufficiency (MeSH)</term>
<term>Retrospective Studies (MeSH)</term>
<term>Swine (MeSH)</term>
<term>Time Factors (MeSH)</term>
</keywords>
<keywords scheme="MESH" type="geographic" xml:lang="en"><term>Germany</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Influenza, Human</term>
<term>Pneumonia, Viral</term>
</keywords>
<keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Influenza, Human</term>
<term>Pneumonia, Viral</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Animals</term>
<term>Disease Progression</term>
<term>Female</term>
<term>Humans</term>
<term>Immunocompromised Host</term>
<term>Influenza A Virus, H1N1 Subtype</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Multidetector Computed Tomography</term>
<term>Prognosis</term>
<term>Respiration, Artificial</term>
<term>Respiratory Distress Syndrome, Adult</term>
<term>Respiratory Insufficiency</term>
<term>Retrospective Studies</term>
<term>Swine</term>
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<front><div type="abstract" xml:lang="en"><p><b>OBJECTIVE</b>
</p>
<p>To describe initial multidetector computed tomographic (MDCT) findings of novel swine-origin influenza A (H1N1) virus (S-OIV) infection in immunocompromised patients and to evaluate whether or not identification of certain abnormalities can help predict patients who are at risk for a severe clinical course.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>SUBJECTS AND METHODS</b>
</p>
<p>This retrospective study included 13 patients with confirmed S-OIV infection suffering from an underlying immunodeficiency or who were receiving immunosuppressive therapy. All patients underwent MDCT of the thorax due to respiratory distress. All data were read by two independent radiologists who described the type and pattern of opacities, distribution and extent of the abnormalities observed. Adverse outcome measures were defined as acute respiratory distress syndrome with the need for mechanical ventilation, extracorporeal membrane oxygenation or death.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>RESULTS</b>
</p>
<p>MDCT revealed pulmonary manifestations in 12 (92%) of 13 individuals. Six (50%) patients showed an adverse outcome with development of acute respiratory distress syndrome, 4 of these died. The most common findings were ground-glass opacities (10/12; 83%) and pulmonary consolidation (7/12; 58%) predominantly with a bilateral distribution. Reticular pattern and a tree-in-bud appearance were found in 3/12 (25%), respectively. Bilateral opacities with extensive involvement of the lung parenchyma were most predictive of a severe clinical course.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>CONCLUSION</b>
</p>
<p>The MDCT scan in immunocompromised patients with confirmed S-OIV infection frequently revealed pulmonary abnormalities, which included ground-glass opacities and consolidations. Therefore, prediction of an adverse clinical outcome could be made in patients with MDCT findings demonstrating bilateral extensive consolidations, often combined with ground-glass opacities.</p>
</div>
</front>
</TEI>
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<Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To describe initial multidetector computed tomographic (MDCT) findings of novel swine-origin influenza A (H1N1) virus (S-OIV) infection in immunocompromised patients and to evaluate whether or not identification of certain abnormalities can help predict patients who are at risk for a severe clinical course.</AbstractText>
<AbstractText Label="SUBJECTS AND METHODS" NlmCategory="METHODS">This retrospective study included 13 patients with confirmed S-OIV infection suffering from an underlying immunodeficiency or who were receiving immunosuppressive therapy. All patients underwent MDCT of the thorax due to respiratory distress. All data were read by two independent radiologists who described the type and pattern of opacities, distribution and extent of the abnormalities observed. Adverse outcome measures were defined as acute respiratory distress syndrome with the need for mechanical ventilation, extracorporeal membrane oxygenation or death.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">MDCT revealed pulmonary manifestations in 12 (92%) of 13 individuals. Six (50%) patients showed an adverse outcome with development of acute respiratory distress syndrome, 4 of these died. The most common findings were ground-glass opacities (10/12; 83%) and pulmonary consolidation (7/12; 58%) predominantly with a bilateral distribution. Reticular pattern and a tree-in-bud appearance were found in 3/12 (25%), respectively. Bilateral opacities with extensive involvement of the lung parenchyma were most predictive of a severe clinical course.</AbstractText>
<AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">The MDCT scan in immunocompromised patients with confirmed S-OIV infection frequently revealed pulmonary abnormalities, which included ground-glass opacities and consolidations. Therefore, prediction of an adverse clinical outcome could be made in patients with MDCT findings demonstrating bilateral extensive consolidations, often combined with ground-glass opacities.</AbstractText>
<CopyrightInformation>Copyright © 2012 S. Karger AG, Basel.</CopyrightInformation>
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