Survey about tolerance of the AS03-adjuvanted H1N1 influenza vaccine in children with rheumatic diseases.
Identifieur interne : 000177 ( Main/Corpus ); précédent : 000176; suivant : 000178Survey about tolerance of the AS03-adjuvanted H1N1 influenza vaccine in children with rheumatic diseases.
Auteurs : C. Sengler ; M. Niewerth ; T. Kallinich ; A. Nimtz-Talaska ; M. Haller ; H-I Huppertz ; K. MindenSource :
- Clinical rheumatology [ 1434-9949 ] ; 2014.
English descriptors
- KwdEn :
- Adjuvants, Immunologic (administration & dosage), Adolescent (MeSH), Antirheumatic Agents (therapeutic use), Arthritis, Juvenile (complications), Arthritis, Juvenile (drug therapy), Autoantibodies (chemistry), Child (MeSH), Child, Preschool (MeSH), Databases, Factual (MeSH), Female (MeSH), Germany (MeSH), Health Status (MeSH), Humans (MeSH), Influenza A Virus, H1N1 Subtype (immunology), Influenza Vaccines (administration & dosage), Influenza, Human (immunology), Influenza, Human (prevention & control), Male (MeSH), Methotrexate (therapeutic use), Rheumatic Diseases (complications), Rheumatic Diseases (immunology), Rheumatology (standards), Surveys and Questionnaires (MeSH), Vaccination (MeSH).
- MESH :
- chemical , administration & dosage : Adjuvants, Immunologic, Influenza Vaccines.
- chemical , chemistry : Autoantibodies.
- chemical , therapeutic use : Antirheumatic Agents, Methotrexate.
- geographic : Germany.
- complications : Arthritis, Juvenile, Rheumatic Diseases.
- drug therapy : Arthritis, Juvenile.
- immunology : Influenza A Virus, H1N1 Subtype, Influenza, Human, Rheumatic Diseases.
- prevention & control : Influenza, Human.
- standards : Rheumatology.
- Adolescent, Child, Child, Preschool, Databases, Factual, Female, Health Status, Humans, Male, Surveys and Questionnaires, Vaccination.
Abstract
The objective of this study is to evaluate complications and changes in health status (disease activity and flare) in response to the AS03-adjuvanted H1N1 vaccine in children with rheumatic diseases. We conducted a nationwide survey addressing paediatric rheumatology sites who participated in the national paediatric rheumatology database. Ninety patients were documented-38 % under treatment with biologicals-of whom 18 % suffered from complications (10 % local and 8 % systemic) with no relevant changes in median disease activity or flare rate during 4 weeks following the vaccination. The adjuvanted H1N1 influenza vaccine seems to be adequately tolerated in children with rheumatic diseases.
DOI: 10.1007/s10067-013-2435-8
PubMed: 24288046
Links to Exploration step
pubmed:24288046Le document en format XML
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<affiliation><nlm:affiliation>Epidemiology Unit, German Rheumatism Research Centre Berlin, Leibniz Institute, Charitéplatz 1, 10117, Berlin, Germany, sengler@drfz.de.</nlm:affiliation>
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<author><name sortKey="Niewerth, M" sort="Niewerth, M" uniqKey="Niewerth M" first="M" last="Niewerth">M. Niewerth</name>
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<author><name sortKey="Nimtz Talaska, A" sort="Nimtz Talaska, A" uniqKey="Nimtz Talaska A" first="A" last="Nimtz-Talaska">A. Nimtz-Talaska</name>
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<author><name sortKey="Haller, M" sort="Haller, M" uniqKey="Haller M" first="M" last="Haller">M. Haller</name>
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<author><name sortKey="Huppertz, H I" sort="Huppertz, H I" uniqKey="Huppertz H" first="H-I" last="Huppertz">H-I Huppertz</name>
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<term>Arthritis, Juvenile (complications)</term>
<term>Arthritis, Juvenile (drug therapy)</term>
<term>Autoantibodies (chemistry)</term>
<term>Child (MeSH)</term>
<term>Child, Preschool (MeSH)</term>
<term>Databases, Factual (MeSH)</term>
<term>Female (MeSH)</term>
<term>Germany (MeSH)</term>
<term>Health Status (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Influenza A Virus, H1N1 Subtype (immunology)</term>
<term>Influenza Vaccines (administration & dosage)</term>
<term>Influenza, Human (immunology)</term>
<term>Influenza, Human (prevention & control)</term>
<term>Male (MeSH)</term>
<term>Methotrexate (therapeutic use)</term>
<term>Rheumatic Diseases (complications)</term>
<term>Rheumatic Diseases (immunology)</term>
<term>Rheumatology (standards)</term>
<term>Surveys and Questionnaires (MeSH)</term>
<term>Vaccination (MeSH)</term>
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<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antirheumatic Agents</term>
<term>Methotrexate</term>
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<term>Rheumatic Diseases</term>
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<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term>
<term>Influenza, Human</term>
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<term>Child</term>
<term>Child, Preschool</term>
<term>Databases, Factual</term>
<term>Female</term>
<term>Health Status</term>
<term>Humans</term>
<term>Male</term>
<term>Surveys and Questionnaires</term>
<term>Vaccination</term>
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<front><div type="abstract" xml:lang="en">The objective of this study is to evaluate complications and changes in health status (disease activity and flare) in response to the AS03-adjuvanted H1N1 vaccine in children with rheumatic diseases. We conducted a nationwide survey addressing paediatric rheumatology sites who participated in the national paediatric rheumatology database. Ninety patients were documented-38 % under treatment with biologicals-of whom 18 % suffered from complications (10 % local and 8 % systemic) with no relevant changes in median disease activity or flare rate during 4 weeks following the vaccination. The adjuvanted H1N1 influenza vaccine seems to be adequately tolerated in children with rheumatic diseases. </div>
</front>
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<Abstract><AbstractText>The objective of this study is to evaluate complications and changes in health status (disease activity and flare) in response to the AS03-adjuvanted H1N1 vaccine in children with rheumatic diseases. We conducted a nationwide survey addressing paediatric rheumatology sites who participated in the national paediatric rheumatology database. Ninety patients were documented-38 % under treatment with biologicals-of whom 18 % suffered from complications (10 % local and 8 % systemic) with no relevant changes in median disease activity or flare rate during 4 weeks following the vaccination. The adjuvanted H1N1 influenza vaccine seems to be adequately tolerated in children with rheumatic diseases. </AbstractText>
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