Age-related prevalence of cross-reactive antibodies against influenza A(H3N2) variant virus, Germany, 2003 to 2010.
Identifieur interne : 000123 ( Main/Corpus ); précédent : 000122; suivant : 000124Age-related prevalence of cross-reactive antibodies against influenza A(H3N2) variant virus, Germany, 2003 to 2010.
Auteurs : B. Blümel ; B. Schweiger ; M. Dehnert ; S. Buda ; A. Reuss ; I. Czogiel ; P. Kamtsiuris ; M. Schlaud ; C. Poethko-Müller ; M. Thamm ; W. HaasSource :
- Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin [ 1560-7917 ] ; 2015.
English descriptors
- KwdEn :
- Adolescent (MeSH), Adult (MeSH), Age Factors (MeSH), Aged (MeSH), Aged, 80 and over (MeSH), Animals (MeSH), Antibodies, Viral (blood), Antibodies, Viral (immunology), Child (MeSH), Child, Preschool (MeSH), Cross Reactions (MeSH), Female (MeSH), Germany (epidemiology), Hemagglutination Inhibition Tests (MeSH), Humans (MeSH), Influenza A Virus, H3N2 Subtype (genetics), Influenza A Virus, H3N2 Subtype (immunology), Influenza, Human (epidemiology), Influenza, Human (immunology), Influenza, Human (prevention & control), Influenza, Human (virology), Male (MeSH), Middle Aged (MeSH), Population Surveillance (MeSH), Prevalence (MeSH), Swine (MeSH), Swine Diseases (epidemiology), Swine Diseases (virology), Vaccination (MeSH), Young Adult (MeSH).
- MESH :
- chemical , blood : Antibodies, Viral.
- chemical , immunology : Antibodies, Viral.
- geographic , epidemiology : Germany.
- epidemiology : Influenza, Human, Swine Diseases.
- genetics : Influenza A Virus, H3N2 Subtype.
- immunology : Influenza A Virus, H3N2 Subtype, Influenza, Human.
- prevention & control : Influenza, Human.
- virology : Influenza, Human, Swine Diseases.
- Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Animals, Child, Child, Preschool, Cross Reactions, Female, Hemagglutination Inhibition Tests, Humans, Male, Middle Aged, Population Surveillance, Prevalence, Swine, Vaccination, Young Adult.
Abstract
To estimate susceptibility to the swine-origin influenza A(H3N2) variant virus (A(H3N2)v) in the German population, we investigated cross-reactive antibodies against this virus and factors associated with seroprotective titre using sera from representative health examination surveys of children and adolescents (n = 815, 2003–06) and adults (n = 600, 2008–10). Antibodies were assessed by haemagglutination inhibition assay (HI); in our study an HI titre ≥ 40 was defined as seroprotective. We investigated associated factors by multivariable logistic regression. Overall, 41% (95% confidence interval (CI): 37–45) of children and adolescents and 39% (95% CI: 34–44) of adults had seroprotective titres. The proportion of people with seroprotective titre was lowest among children younger than 10 years (15%; 95% CI: 7–30) and highest among adults aged 18 to 29 years (59%; 95% CI: 49–67). Prior influenza vaccination was associated with higher odds of having seroprotective titre (odds ratio (OR) for children and adolescents: 3.4; 95% CI: 1.8–6.5; OR for adults: 2.4; 95% CI: 1.7–3.4). Young children showed the highest and young adults the lowest susceptibility to the A(H3N2)v virus. Our results suggest that initial exposure to circulating seasonal influenza viruses may predict long-term cross-reactivity that may be enhanced by seasonal influenza vaccination.
PubMed: 26290488
Links to Exploration step
pubmed:26290488Le document en format XML
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<affiliation><nlm:affiliation>Robert Koch Institute, Berlin, Germany.</nlm:affiliation>
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<author><name sortKey="Schweiger, B" sort="Schweiger, B" uniqKey="Schweiger B" first="B" last="Schweiger">B. Schweiger</name>
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<author><name sortKey="Dehnert, M" sort="Dehnert, M" uniqKey="Dehnert M" first="M" last="Dehnert">M. Dehnert</name>
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<author><name sortKey="Buda, S" sort="Buda, S" uniqKey="Buda S" first="S" last="Buda">S. Buda</name>
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<author><name sortKey="Reuss, A" sort="Reuss, A" uniqKey="Reuss A" first="A" last="Reuss">A. Reuss</name>
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<term>Age Factors (MeSH)</term>
<term>Aged (MeSH)</term>
<term>Aged, 80 and over (MeSH)</term>
<term>Animals (MeSH)</term>
<term>Antibodies, Viral (blood)</term>
<term>Antibodies, Viral (immunology)</term>
<term>Child (MeSH)</term>
<term>Child, Preschool (MeSH)</term>
<term>Cross Reactions (MeSH)</term>
<term>Female (MeSH)</term>
<term>Germany (epidemiology)</term>
<term>Hemagglutination Inhibition Tests (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Influenza A Virus, H3N2 Subtype (genetics)</term>
<term>Influenza A Virus, H3N2 Subtype (immunology)</term>
<term>Influenza, Human (epidemiology)</term>
<term>Influenza, Human (immunology)</term>
<term>Influenza, Human (prevention & control)</term>
<term>Influenza, Human (virology)</term>
<term>Male (MeSH)</term>
<term>Middle Aged (MeSH)</term>
<term>Population Surveillance (MeSH)</term>
<term>Prevalence (MeSH)</term>
<term>Swine (MeSH)</term>
<term>Swine Diseases (epidemiology)</term>
<term>Swine Diseases (virology)</term>
<term>Vaccination (MeSH)</term>
<term>Young Adult (MeSH)</term>
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<term>Swine Diseases</term>
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<front><div type="abstract" xml:lang="en">To estimate susceptibility to the swine-origin influenza A(H3N2) variant virus (A(H3N2)v) in the German population, we investigated cross-reactive antibodies against this virus and factors associated with seroprotective titre using sera from representative health examination surveys of children and adolescents (n = 815, 2003–06) and adults (n = 600, 2008–10). Antibodies were assessed by haemagglutination inhibition assay (HI); in our study an HI titre ≥ 40 was defined as seroprotective. We investigated associated factors by multivariable logistic regression. Overall, 41% (95% confidence interval (CI): 37–45) of children and adolescents and 39% (95% CI: 34–44) of adults had seroprotective titres. The proportion of people with seroprotective titre was lowest among children younger than 10 years (15%; 95% CI: 7–30) and highest among adults aged 18 to 29 years (59%; 95% CI: 49–67). Prior influenza vaccination was associated with higher odds of having seroprotective titre (odds ratio (OR) for children and adolescents: 3.4; 95% CI: 1.8–6.5; OR for adults: 2.4; 95% CI: 1.7–3.4). Young children showed the highest and young adults the lowest susceptibility to the A(H3N2)v virus. Our results suggest that initial exposure to circulating seasonal influenza viruses may predict long-term cross-reactivity that may be enhanced by seasonal influenza vaccination.</div>
</front>
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<Abstract><AbstractText>To estimate susceptibility to the swine-origin influenza A(H3N2) variant virus (A(H3N2)v) in the German population, we investigated cross-reactive antibodies against this virus and factors associated with seroprotective titre using sera from representative health examination surveys of children and adolescents (n = 815, 2003–06) and adults (n = 600, 2008–10). Antibodies were assessed by haemagglutination inhibition assay (HI); in our study an HI titre ≥ 40 was defined as seroprotective. We investigated associated factors by multivariable logistic regression. Overall, 41% (95% confidence interval (CI): 37–45) of children and adolescents and 39% (95% CI: 34–44) of adults had seroprotective titres. The proportion of people with seroprotective titre was lowest among children younger than 10 years (15%; 95% CI: 7–30) and highest among adults aged 18 to 29 years (59%; 95% CI: 49–67). Prior influenza vaccination was associated with higher odds of having seroprotective titre (odds ratio (OR) for children and adolescents: 3.4; 95% CI: 1.8–6.5; OR for adults: 2.4; 95% CI: 1.7–3.4). Young children showed the highest and young adults the lowest susceptibility to the A(H3N2)v virus. Our results suggest that initial exposure to circulating seasonal influenza viruses may predict long-term cross-reactivity that may be enhanced by seasonal influenza vaccination.</AbstractText>
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