Displacement of the Gent/1999 human-like swine H1N2 influenza A virus lineage by novel H1N2 reassortants in Germany.
Identifieur interne : 000004 ( Main/Corpus ); précédent : 000003; suivant : 000005Displacement of the Gent/1999 human-like swine H1N2 influenza A virus lineage by novel H1N2 reassortants in Germany.
Auteurs : Roland Zell ; Marco Groth ; Andi Krumbholz ; Jeannette Lange ; Anja Philipps ; Ralf DürrwaldSource :
- Archives of virology [ 1432-8798 ] ; 2020.
English descriptors
- KwdEn :
- Animals (MeSH), Germany (epidemiology), Humans (MeSH), Influenza A Virus, H1N2 Subtype (classification), Influenza A Virus, H1N2 Subtype (genetics), Influenza A Virus, H1N2 Subtype (isolation & purification), Orthomyxoviridae Infections (epidemiology), Orthomyxoviridae Infections (virology), Phylogeny (MeSH), Prevalence (MeSH), Reassortant Viruses (classification), Reassortant Viruses (genetics), Reassortant Viruses (isolation & purification), Sequence Analysis, RNA (methods), Swine (MeSH).
- MESH :
- geographic , epidemiology : Germany.
- classification : Influenza A Virus, H1N2 Subtype, Reassortant Viruses.
- epidemiology : Orthomyxoviridae Infections.
- genetics : Influenza A Virus, H1N2 Subtype, Reassortant Viruses.
- isolation & purification : Influenza A Virus, H1N2 Subtype, Reassortant Viruses.
- methods : Sequence Analysis, RNA.
- virology : Orthomyxoviridae Infections.
- Animals, Humans, Phylogeny, Prevalence, Swine.
Abstract
A swine influenza survey was conducted between 2003 and 2015 in Germany. During this period, 8122 snout swabs or other respiratory specimens from pigs of 5178 herds, mainly from Germany, were investigated for the presence of swine influenza A virus (S-IAV). In total, 1310 S-IAV isolates were collected. Of this collection, the complete genome of 267 H1N2 S-IAV isolates was sequenced and phylogenetically analyzed. The data demonstrate the incursion of human-like swine H1N2 viruses (Gent/1999-like) in 2000 and prevalent circulation until 2010. From 2008 onward, a sustained and broad change of the genetic constellation of the swine H1N2 subtype commenced. The Gent/1999-like swine H1N2 viruses ceased and several new swine H1N2 reassortants emerged and became prevalent in Germany. Of these, the upsurge of the Diepholz/2008-like, Emmelsbuell/2009-like and Papenburg/2010-like viruses is notable. The data reveal the importance of reassortment events in S-IAV evolution. The strong circulation of S-IAV of different lineages in the swine population throughout the year underlines that pigs are important reservoir hosts.
DOI: 10.1007/s00705-019-04457-w
PubMed: 31696308
Links to Exploration step
pubmed:31696308Le document en format XML
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Fritz Lipmann Institute, 07745, Jena, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Krumbholz, Andi" sort="Krumbholz, Andi" uniqKey="Krumbholz A" first="Andi" last="Krumbholz">Andi Krumbholz</name><affiliation><nlm:affiliation>Section of Experimental Virology, Institute for Medical Microbiology, Jena University Hospital, Friedrich Schiller University Jena, 07745, Jena, Germany.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Institute of Infection Medicine, Kiel University and University Medical Center Schleswig-Holstein, 24105, Kiel, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Lange, Jeannette" sort="Lange, Jeannette" uniqKey="Lange J" first="Jeannette" last="Lange">Jeannette Lange</name><affiliation><nlm:affiliation>Section of Experimental Virology, Institute for Medical Microbiology, Jena University Hospital, Friedrich Schiller University Jena, 07745, Jena, Germany.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Paul-Ehrlich-Institut, 63225, Langen, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Philipps, Anja" sort="Philipps, Anja" uniqKey="Philipps A" first="Anja" last="Philipps">Anja Philipps</name><affiliation><nlm:affiliation>Section of Experimental Virology, Institute for Medical Microbiology, Jena University Hospital, Friedrich Schiller University Jena, 07745, Jena, Germany.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Thermo Fisher Scientific GENEART GmbH, 93059, Regensburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Durrwald, Ralf" sort="Durrwald, Ralf" uniqKey="Durrwald R" first="Ralf" last="Dürrwald">Ralf Dürrwald</name><affiliation><nlm:affiliation>Section of Experimental Virology, Institute for Medical Microbiology, Jena University Hospital, Friedrich Schiller University Jena, 07745, Jena, Germany.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Robert Koch Institute, 13353, Berlin, Germany.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Archives of virology</title><idno type="eISSN">1432-8798</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term><term>Germany (epidemiology)</term><term>Humans (MeSH)</term><term>Influenza A Virus, H1N2 Subtype (classification)</term><term>Influenza A Virus, H1N2 Subtype (genetics)</term><term>Influenza A Virus, H1N2 Subtype (isolation & purification)</term><term>Orthomyxoviridae Infections (epidemiology)</term><term>Orthomyxoviridae Infections (virology)</term><term>Phylogeny (MeSH)</term><term>Prevalence (MeSH)</term><term>Reassortant Viruses (classification)</term><term>Reassortant Viruses (genetics)</term><term>Reassortant Viruses (isolation & purification)</term><term>Sequence Analysis, RNA (methods)</term><term>Swine (MeSH)</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Germany</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Influenza A Virus, H1N2 Subtype</term><term>Reassortant Viruses</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Orthomyxoviridae Infections</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Influenza A Virus, H1N2 Subtype</term><term>Reassortant Viruses</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Influenza A Virus, H1N2 Subtype</term><term>Reassortant Viruses</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Sequence Analysis, RNA</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Orthomyxoviridae Infections</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Humans</term><term>Phylogeny</term><term>Prevalence</term><term>Swine</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A swine influenza survey was conducted between 2003 and 2015 in Germany. During this period, 8122 snout swabs or other respiratory specimens from pigs of 5178 herds, mainly from Germany, were investigated for the presence of swine influenza A virus (S-IAV). In total, 1310 S-IAV isolates were collected. Of this collection, the complete genome of 267 H1N2 S-IAV isolates was sequenced and phylogenetically analyzed. The data demonstrate the incursion of human-like swine H1N2 viruses (Gent/1999-like) in 2000 and prevalent circulation until 2010. From 2008 onward, a sustained and broad change of the genetic constellation of the swine H1N2 subtype commenced. The Gent/1999-like swine H1N2 viruses ceased and several new swine H1N2 reassortants emerged and became prevalent in Germany. Of these, the upsurge of the Diepholz/2008-like, Emmelsbuell/2009-like and Papenburg/2010-like viruses is notable. The data reveal the importance of reassortment events in S-IAV evolution. The strong circulation of S-IAV of different lineages in the swine population throughout the year underlines that pigs are important reservoir hosts.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">31696308</PMID><DateCompleted><Year>2020</Year><Month>01</Month><Day>17</Day></DateCompleted><DateRevised><Year>2020</Year><Month>01</Month><Day>17</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1432-8798</ISSN><JournalIssue CitedMedium="Internet"><Volume>165</Volume><Issue>1</Issue><PubDate><Year>2020</Year><Month>Jan</Month></PubDate></JournalIssue><Title>Archives of virology</Title><ISOAbbreviation>Arch. Virol.</ISOAbbreviation></Journal><ArticleTitle>Displacement of the Gent/1999 human-like swine H1N2 influenza A virus lineage by novel H1N2 reassortants in Germany.</ArticleTitle><Pagination><MedlinePgn>55-67</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1007/s00705-019-04457-w</ELocationID><Abstract><AbstractText>A swine influenza survey was conducted between 2003 and 2015 in Germany. During this period, 8122 snout swabs or other respiratory specimens from pigs of 5178 herds, mainly from Germany, were investigated for the presence of swine influenza A virus (S-IAV). In total, 1310 S-IAV isolates were collected. Of this collection, the complete genome of 267 H1N2 S-IAV isolates was sequenced and phylogenetically analyzed. The data demonstrate the incursion of human-like swine H1N2 viruses (Gent/1999-like) in 2000 and prevalent circulation until 2010. From 2008 onward, a sustained and broad change of the genetic constellation of the swine H1N2 subtype commenced. The Gent/1999-like swine H1N2 viruses ceased and several new swine H1N2 reassortants emerged and became prevalent in Germany. Of these, the upsurge of the Diepholz/2008-like, Emmelsbuell/2009-like and Papenburg/2010-like viruses is notable. The data reveal the importance of reassortment events in S-IAV evolution. The strong circulation of S-IAV of different lineages in the swine population throughout the year underlines that pigs are important reservoir hosts.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Zell</LastName><ForeName>Roland</ForeName><Initials>R</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-8317-2152</Identifier><AffiliationInfo><Affiliation>Section of Experimental Virology, Institute for Medical Microbiology, Jena University Hospital, Friedrich Schiller University Jena, 07745, Jena, Germany. roland.zell@med.uni-jena.de.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Groth</LastName><ForeName>Marco</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>CF DNA Sequencing, Leibniz Institute on Aging, Fritz Lipmann Institute, 07745, Jena, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Krumbholz</LastName><ForeName>Andi</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Section of Experimental Virology, Institute for Medical Microbiology, Jena University Hospital, Friedrich Schiller University Jena, 07745, Jena, Germany.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institute of Infection Medicine, Kiel University and University Medical Center Schleswig-Holstein, 24105, Kiel, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lange</LastName><ForeName>Jeannette</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Section of Experimental Virology, Institute for Medical Microbiology, Jena University Hospital, Friedrich Schiller University Jena, 07745, Jena, Germany.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Paul-Ehrlich-Institut, 63225, Langen, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Philipps</LastName><ForeName>Anja</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Section of Experimental Virology, Institute for Medical Microbiology, Jena University Hospital, Friedrich Schiller University Jena, 07745, Jena, Germany.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Thermo Fisher Scientific GENEART GmbH, 93059, Regensburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dürrwald</LastName><ForeName>Ralf</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Section of Experimental Virology, Institute for Medical Microbiology, Jena University Hospital, Friedrich Schiller University Jena, 07745, Jena, Germany.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Robert Koch Institute, 13353, Berlin, Germany.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>01KI7142</GrantID><Agency>Bundesministerium für 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UI="D005858" MajorTopicYN="N" Type="Geographic">Germany</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D057221" MajorTopicYN="N">Influenza A Virus, H1N2 Subtype</DescriptorName><QualifierName UI="Q000145" MajorTopicYN="Y">classification</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009976" MajorTopicYN="N">Orthomyxoviridae Infections</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010802" MajorTopicYN="N">Phylogeny</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015995" MajorTopicYN="N">Prevalence</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016865" MajorTopicYN="N">Reassortant Viruses</DescriptorName><QualifierName UI="Q000145" MajorTopicYN="Y">classification</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017423" MajorTopicYN="N">Sequence Analysis, RNA</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013552" MajorTopicYN="N">Swine</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2019</Year><Month>08</Month><Day>13</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2019</Year><Month>10</Month><Day>07</Day></PubMedPubDate><PubMedPubDate 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