[Effectiveness of Live Attenuated Influenza Vaccines and Trivalent Inactivated Influenza Vaccines against confirmed Influenza In Children and Adolescents in Saxony-Anhalt, 2012/13].
Identifieur interne : 000120 ( Main/Curation ); précédent : 000119; suivant : 000121[Effectiveness of Live Attenuated Influenza Vaccines and Trivalent Inactivated Influenza Vaccines against confirmed Influenza In Children and Adolescents in Saxony-Anhalt, 2012/13].
Auteurs : N. Hermann [Autriche]Source :
- Gesundheitswesen (Bundesverband der Arzte des Offentlichen Gesundheitsdienstes (Germany)) [ 1439-4421 ] ; 2015.
Descripteurs français
- KwdFr :
- Adolescent, Allemagne (épidémiologie), Enfant, Enfant d'âge préscolaire, Facteurs de risque, Femelle, Grippe humaine (), Grippe humaine (diagnostic), Grippe humaine (épidémiologie), Humains, Mâle, Prévalence, Répartition par sexe, Répartition par âge, Résultat thérapeutique, Vaccins antigrippaux (administration et posologie), Vaccins atténués (administration et posologie), Vaccins inactivés (administration et posologie), Études rétrospectives.
- MESH :
- administration et posologie : Vaccins antigrippaux, Vaccins atténués, Vaccins inactivés.
- diagnostic : Grippe humaine.
- épidémiologie : Allemagne, Grippe humaine.
- Adolescent, Enfant, Enfant d'âge préscolaire, Facteurs de risque, Femelle, Grippe humaine, Humains, Mâle, Prévalence, Répartition par sexe, Répartition par âge, Résultat thérapeutique, Études rétrospectives.
English descriptors
- KwdEn :
- Adolescent, Age Distribution, Child, Child, Preschool, Female, Germany (epidemiology), Humans, Influenza Vaccines (administration & dosage), Influenza, Human (diagnosis), Influenza, Human (epidemiology), Influenza, Human (therapy), Male, Prevalence, Retrospective Studies, Risk Factors, Sex Distribution, Treatment Outcome, Vaccines, Attenuated (administration & dosage), Vaccines, Inactivated (administration & dosage).
- MESH :
- chemical , administration & dosage : Influenza Vaccines, Vaccines, Attenuated, Vaccines, Inactivated.
- diagnosis : Influenza, Human.
- epidemiology : Germany, Influenza, Human.
- therapy : Influenza, Human.
- Adolescent, Age Distribution, Child, Child, Preschool, Female, Humans, Male, Prevalence, Retrospective Studies, Risk Factors, Sex Distribution, Treatment Outcome.
Abstract
Since 2012, there are not only trivalent inactivated influenza vaccines (TIV) but also live attenuated influenza vaccines (LAIV) available for children aged 2-17 years in Germany. The Saxony-Anhalt State Office for Consumer Protection conducted a test-negative case-control-study. The aim of the study was to identify the effectiveness of LAIV and TIV against a confirmed influenza diagnosis in children and adolescents in Saxony-Anhalt in the season 2012/13. The children had nasal swabs taken, which were further diagnosed in a laboratory using the PCR method. 834 patients of 15 voluntarily participating paediatric surgeries in Saxony-Anhalt were analysed by multivariate logistic regression with STATA 12. Controlling for age group, gender and month of the disease's onset showed an effectiveness of all vaccines amongst the 2-17 years old (38% with 95% CI: 0.8-61%; p=0.046). A differentiation according to LAIV and TIV demonstrated a significant effectiveness for LAIV (84%) in children of all ages (95% CI: 45-95%, p=0.004). After stratification for age groups LAIV was proven efficient in children aged 2-6 years (90% with 95% CI: 20-99%, p=0.03), whilst it led to a non-significant result in children aged 7-17 years (74% with 95% CI: -32-95%, p=0.106). There was no significant effectiveness of TIV seen in any age group.The Saxony-Anhalt State Office for Consumer Protection endorses the use of LAIV in children in accordance with the STIKO recommendations, as long as no contraindication is evident.
DOI: 10.1055/s-0035-1554685
PubMed: 26227384
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pubmed:26227384Le document en format XML
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<term>Prévalence</term>
<term>Répartition par sexe</term>
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<front><div type="abstract" xml:lang="en">Since 2012, there are not only trivalent inactivated influenza vaccines (TIV) but also live attenuated influenza vaccines (LAIV) available for children aged 2-17 years in Germany. The Saxony-Anhalt State Office for Consumer Protection conducted a test-negative case-control-study. The aim of the study was to identify the effectiveness of LAIV and TIV against a confirmed influenza diagnosis in children and adolescents in Saxony-Anhalt in the season 2012/13. The children had nasal swabs taken, which were further diagnosed in a laboratory using the PCR method. 834 patients of 15 voluntarily participating paediatric surgeries in Saxony-Anhalt were analysed by multivariate logistic regression with STATA 12. Controlling for age group, gender and month of the disease's onset showed an effectiveness of all vaccines amongst the 2-17 years old (38% with 95% CI: 0.8-61%; p=0.046). A differentiation according to LAIV and TIV demonstrated a significant effectiveness for LAIV (84%) in children of all ages (95% CI: 45-95%, p=0.004). After stratification for age groups LAIV was proven efficient in children aged 2-6 years (90% with 95% CI: 20-99%, p=0.03), whilst it led to a non-significant result in children aged 7-17 years (74% with 95% CI: -32-95%, p=0.106). There was no significant effectiveness of TIV seen in any age group.The Saxony-Anhalt State Office for Consumer Protection endorses the use of LAIV in children in accordance with the STIKO recommendations, as long as no contraindication is evident. </div>
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<Abstract><AbstractText>Since 2012, there are not only trivalent inactivated influenza vaccines (TIV) but also live attenuated influenza vaccines (LAIV) available for children aged 2-17 years in Germany. The Saxony-Anhalt State Office for Consumer Protection conducted a test-negative case-control-study. The aim of the study was to identify the effectiveness of LAIV and TIV against a confirmed influenza diagnosis in children and adolescents in Saxony-Anhalt in the season 2012/13. The children had nasal swabs taken, which were further diagnosed in a laboratory using the PCR method. 834 patients of 15 voluntarily participating paediatric surgeries in Saxony-Anhalt were analysed by multivariate logistic regression with STATA 12. Controlling for age group, gender and month of the disease's onset showed an effectiveness of all vaccines amongst the 2-17 years old (38% with 95% CI: 0.8-61%; p=0.046). A differentiation according to LAIV and TIV demonstrated a significant effectiveness for LAIV (84%) in children of all ages (95% CI: 45-95%, p=0.004). After stratification for age groups LAIV was proven efficient in children aged 2-6 years (90% with 95% CI: 20-99%, p=0.03), whilst it led to a non-significant result in children aged 7-17 years (74% with 95% CI: -32-95%, p=0.106). There was no significant effectiveness of TIV seen in any age group.The Saxony-Anhalt State Office for Consumer Protection endorses the use of LAIV in children in accordance with the STIKO recommendations, as long as no contraindication is evident. </AbstractText>
<CopyrightInformation>© Georg Thieme Verlag KG Stuttgart · New York.</CopyrightInformation>
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