Prospective study of human metapneumovirus infection in children less than 3 years of age.
Identifieur interne : 000524 ( Main/Corpus ); précédent : 000523; suivant : 000525Prospective study of human metapneumovirus infection in children less than 3 years of age.
Auteurs : Brigitte König ; Wolfgang König ; Ralf Arnold ; Herrmann Werchau ; Gabriele Ihorst ; Johannes ForsterSource :
- Journal of clinical microbiology [ 0095-1137 ] ; 2004.
English descriptors
- KwdEn :
- Child, Preschool, Germany (epidemiology), Humans, Infant, Infant, Newborn, Metapneumovirus (isolation & purification), Paramyxoviridae Infections (complications), Paramyxoviridae Infections (epidemiology), Paramyxoviridae Infections (virology), Prospective Studies, Respiratory Syncytial Virus Infections (complications), Respiratory Syncytial Virus Infections (epidemiology), Respiratory Syncytial Virus Infections (virology), Respiratory Syncytial Virus, Human (isolation & purification), Respiratory Tract Infections (epidemiology), Respiratory Tract Infections (physiopathology), Respiratory Tract Infections (virology), Severity of Illness Index.
- MESH :
- geographic , epidemiology : Germany.
- complications : Paramyxoviridae Infections, Respiratory Syncytial Virus Infections.
- epidemiology : Paramyxoviridae Infections, Respiratory Syncytial Virus Infections, Respiratory Tract Infections.
- isolation & purification : Metapneumovirus, Respiratory Syncytial Virus, Human.
- physiopathology : Respiratory Tract Infections.
- virology : Paramyxoviridae Infections, Respiratory Syncytial Virus Infections, Respiratory Tract Infections.
- Child, Preschool, Humans, Infant, Infant, Newborn, Prospective Studies, Severity of Illness Index.
Abstract
Most lower respiratory tract infections (LRTIs) in children under the age of 3 years are due to respiratory syncytial virus (RSV). Epidemiological, host, and viral factors eventually account for the severity of LRTIs, but they do not completely explain it. Human metapneumovirus (hMPV) was recently identified in children with LRTIs. In a population-based prospective multicenter study (the PRI.DE study, conducted in Germany over 2 years), we tested 3,369 nasopharyngeal secretions from children younger than 3 years of age with LRTIs for RSV A and B, influenza viruses (IVs) A and B, and parainfluenza viruses (PIVs) 1 to 3. Of the children requiring intensive care (n = 85), 18% had hMPV infections, and 60% of these children were infected with hMPV in combination with RSV. We did not detect hMPV in a randomly selected subset of RSV-positive nasopharyngeal secretions (n = 120) from children not requiring intensive care support. hMPV was detected in <1% of virus-negative samples from patients without intensive care support (n = 620). Our data support the hypothesis that coinfections with RSV and hMPV are more severe than infections with either RSV or hMPV alone, at least in children younger than 3 years of age.
DOI: 10.1128/JCM.42.10.4632-4635.2004
PubMed: 15472321
Links to Exploration step
pubmed:15472321Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Prospective study of human metapneumovirus infection in children less than 3 years of age.</title><author><name sortKey="Konig, Brigitte" sort="Konig, Brigitte" uniqKey="Konig B" first="Brigitte" last="König">Brigitte König</name><affiliation><nlm:affiliation>Institute of Medical Microbiology, Otto-von-Guericke-University Magdeburg, Magdeburg, Germany. brigitte.koenig@medizin.uni-magdeburg.de</nlm:affiliation></affiliation></author><author><name sortKey="Konig, Wolfgang" sort="Konig, Wolfgang" uniqKey="Konig W" first="Wolfgang" last="König">Wolfgang König</name></author><author><name sortKey="Arnold, Ralf" sort="Arnold, Ralf" uniqKey="Arnold R" first="Ralf" last="Arnold">Ralf Arnold</name></author><author><name sortKey="Werchau, Herrmann" sort="Werchau, Herrmann" uniqKey="Werchau H" first="Herrmann" last="Werchau">Herrmann Werchau</name></author><author><name sortKey="Ihorst, Gabriele" sort="Ihorst, Gabriele" uniqKey="Ihorst G" first="Gabriele" last="Ihorst">Gabriele Ihorst</name></author><author><name sortKey="Forster, Johannes" sort="Forster, Johannes" uniqKey="Forster J" first="Johannes" last="Forster">Johannes Forster</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2004">2004</date><idno type="RBID">pubmed:15472321</idno><idno type="pmid">15472321</idno><idno type="doi">10.1128/JCM.42.10.4632-4635.2004</idno><idno type="wicri:Area/Main/Corpus">000524</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000524</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Prospective study of human metapneumovirus infection in children less than 3 years of age.</title><author><name sortKey="Konig, Brigitte" sort="Konig, Brigitte" uniqKey="Konig B" first="Brigitte" last="König">Brigitte König</name><affiliation><nlm:affiliation>Institute of Medical Microbiology, Otto-von-Guericke-University Magdeburg, Magdeburg, Germany. brigitte.koenig@medizin.uni-magdeburg.de</nlm:affiliation></affiliation></author><author><name sortKey="Konig, Wolfgang" sort="Konig, Wolfgang" uniqKey="Konig W" first="Wolfgang" last="König">Wolfgang König</name></author><author><name sortKey="Arnold, Ralf" sort="Arnold, Ralf" uniqKey="Arnold R" first="Ralf" last="Arnold">Ralf Arnold</name></author><author><name sortKey="Werchau, Herrmann" sort="Werchau, Herrmann" uniqKey="Werchau H" first="Herrmann" last="Werchau">Herrmann Werchau</name></author><author><name sortKey="Ihorst, Gabriele" sort="Ihorst, Gabriele" uniqKey="Ihorst G" first="Gabriele" last="Ihorst">Gabriele Ihorst</name></author><author><name sortKey="Forster, Johannes" sort="Forster, Johannes" uniqKey="Forster J" first="Johannes" last="Forster">Johannes Forster</name></author></analytic><series><title level="j">Journal of clinical microbiology</title><idno type="ISSN">0095-1137</idno><imprint><date when="2004" 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Index</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Germany</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Paramyxoviridae Infections</term><term>Respiratory Syncytial Virus Infections</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Paramyxoviridae Infections</term><term>Respiratory Syncytial Virus Infections</term><term>Respiratory Tract Infections</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Metapneumovirus</term><term>Respiratory Syncytial Virus, Human</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Respiratory Tract Infections</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Paramyxoviridae Infections</term><term>Respiratory Syncytial Virus Infections</term><term>Respiratory Tract Infections</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Child, Preschool</term><term>Humans</term><term>Infant</term><term>Infant, Newborn</term><term>Prospective Studies</term><term>Severity of Illness Index</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Most lower respiratory tract infections (LRTIs) in children under the age of 3 years are due to respiratory syncytial virus (RSV). Epidemiological, host, and viral factors eventually account for the severity of LRTIs, but they do not completely explain it. Human metapneumovirus (hMPV) was recently identified in children with LRTIs. In a population-based prospective multicenter study (the PRI.DE study, conducted in Germany over 2 years), we tested 3,369 nasopharyngeal secretions from children younger than 3 years of age with LRTIs for RSV A and B, influenza viruses (IVs) A and B, and parainfluenza viruses (PIVs) 1 to 3. Of the children requiring intensive care (n = 85), 18% had hMPV infections, and 60% of these children were infected with hMPV in combination with RSV. We did not detect hMPV in a randomly selected subset of RSV-positive nasopharyngeal secretions (n = 120) from children not requiring intensive care support. hMPV was detected in <1% of virus-negative samples from patients without intensive care support (n = 620). Our data support the hypothesis that coinfections with RSV and hMPV are more severe than infections with either RSV or hMPV alone, at least in children younger than 3 years of age.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">15472321</PMID><DateCompleted><Year>2004</Year><Month>12</Month><Day>23</Day></DateCompleted><DateRevised><Year>2018</Year><Month>11</Month><Day>13</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0095-1137</ISSN><JournalIssue CitedMedium="Print"><Volume>42</Volume><Issue>10</Issue><PubDate><Year>2004</Year><Month>Oct</Month></PubDate></JournalIssue><Title>Journal of clinical microbiology</Title><ISOAbbreviation>J. Clin. Microbiol.</ISOAbbreviation></Journal><ArticleTitle>Prospective study of human metapneumovirus infection in children less than 3 years of age.</ArticleTitle><Pagination><MedlinePgn>4632-5</MedlinePgn></Pagination><Abstract><AbstractText>Most lower respiratory tract infections (LRTIs) in children under the age of 3 years are due to respiratory syncytial virus (RSV). Epidemiological, host, and viral factors eventually account for the severity of LRTIs, but they do not completely explain it. Human metapneumovirus (hMPV) was recently identified in children with LRTIs. In a population-based prospective multicenter study (the PRI.DE study, conducted in Germany over 2 years), we tested 3,369 nasopharyngeal secretions from children younger than 3 years of age with LRTIs for RSV A and B, influenza viruses (IVs) A and B, and parainfluenza viruses (PIVs) 1 to 3. Of the children requiring intensive care (n = 85), 18% had hMPV infections, and 60% of these children were infected with hMPV in combination with RSV. We did not detect hMPV in a randomly selected subset of RSV-positive nasopharyngeal secretions (n = 120) from children not requiring intensive care support. hMPV was detected in <1% of virus-negative samples from patients without intensive care support (n = 620). Our data support the hypothesis that coinfections with RSV and hMPV are more severe than infections with either RSV or hMPV alone, at least in children younger than 3 years of age.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>König</LastName><ForeName>Brigitte</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Institute of Medical Microbiology, Otto-von-Guericke-University Magdeburg, Magdeburg, Germany. brigitte.koenig@medizin.uni-magdeburg.de</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>König</LastName><ForeName>Wolfgang</ForeName><Initials>W</Initials></Author><Author ValidYN="Y"><LastName>Arnold</LastName><ForeName>Ralf</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Werchau</LastName><ForeName>Herrmann</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Ihorst</LastName><ForeName>Gabriele</ForeName><Initials>G</Initials></Author><Author 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