Molecular analysis of highly pathogenic avian influenza virus of subtype H5N1 isolated from wild birds and mammals in northern Germany.
Identifieur interne : 000478 ( Main/Corpus ); précédent : 000477; suivant : 000479Molecular analysis of highly pathogenic avian influenza virus of subtype H5N1 isolated from wild birds and mammals in northern Germany.
Auteurs : Siegfried Weber ; Timm Harder ; Elke Starick ; Martin Beer ; Ortrud Werner ; Bernd Hoffmann ; Thomas C. Mettenleiter ; Egbert MundtSource :
- The Journal of general virology [ 0022-1317 ] ; 2007.
English descriptors
- KwdEn :
- Amino Acid Sequence, Amino Acid Substitution, Animals, Animals, Wild (virology), Anseriformes (virology), Cat Diseases (epidemiology), Cat Diseases (virology), Cats, Disease Outbreaks, Germany (epidemiology), Hemagglutinin Glycoproteins, Influenza Virus (genetics), Humans, Influenza A Virus, H5N1 Subtype (classification), Influenza A Virus, H5N1 Subtype (genetics), Influenza A Virus, H5N1 Subtype (isolation & purification), Influenza A Virus, H5N1 Subtype (pathogenicity), Influenza in Birds (virology), Molecular Sequence Data, Neuraminidase (genetics), Orthomyxoviridae Infections (epidemiology), Orthomyxoviridae Infections (veterinary), Orthomyxoviridae Infections (virology), Phylogeny, Sequence Analysis, DNA.
- MESH :
- chemical , genetics : Hemagglutinin Glycoproteins, Influenza Virus, Neuraminidase.
- geographic , epidemiology : Germany.
- classification : Influenza A Virus, H5N1 Subtype.
- epidemiology : Cat Diseases, Orthomyxoviridae Infections.
- genetics : Influenza A Virus, H5N1 Subtype.
- isolation & purification : Influenza A Virus, H5N1 Subtype.
- pathogenicity : Influenza A Virus, H5N1 Subtype.
- veterinary : Orthomyxoviridae Infections.
- virology : Animals, Wild, Anseriformes, Cat Diseases, Influenza in Birds, Orthomyxoviridae Infections.
- Amino Acid Sequence, Amino Acid Substitution, Animals, Cats, Disease Outbreaks, Humans, Molecular Sequence Data, Phylogeny, Sequence Analysis, DNA.
Abstract
Analysis of the full-length sequences of all eight segments of the German wild-bird H5N1 highly pathogenic avian influenza virus index isolate, A/Cygnus cygnus/Germany/R65/2006, and an H5N1 isolate from a cat (A/cat/Germany/R606/2006) obtained during an outbreak in February 2006 revealed a very high similarity between these two sequences. One amino acid substitution in the PA gene, encoding a protein involved in virus RNA replication, and one amino acid substitution in the haemagglutinin (HA) protein were observed. Phylogenetic analyses of the HA and neuraminidase nucleotide sequences showed that avian influenza H5N1 isolates from the Astrakhan region located in southern Russia were the closest relatives. Reassortment events could be excluded in comparison with other 'Qinghai-like' H5N1 viruses. In addition, an H5N1 isolate originating from a single outbreak in poultry in Germany was found to be related closely to the H5N1 viruses circulating at that time in the wild-bird population.
DOI: 10.1099/vir.0.82300-0
PubMed: 17251574
Links to Exploration step
pubmed:17251574Le document en format XML
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Mettenleiter</name></author><author><name sortKey="Mundt, Egbert" sort="Mundt, Egbert" uniqKey="Mundt E" first="Egbert" last="Mundt">Egbert Mundt</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2007">2007</date><idno type="RBID">pubmed:17251574</idno><idno type="pmid">17251574</idno><idno type="doi">10.1099/vir.0.82300-0</idno><idno type="wicri:Area/Main/Corpus">000478</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000478</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Molecular analysis of highly pathogenic avian influenza virus of subtype H5N1 isolated from wild birds and mammals in northern Germany.</title><author><name sortKey="Weber, Siegfried" sort="Weber, Siegfried" uniqKey="Weber S" first="Siegfried" last="Weber">Siegfried Weber</name><affiliation><nlm:affiliation>Institute of Molecular Biology, Friedrich-Loeffler-Institut, 17493 Greifswald-Insel Riems, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Harder, Timm" sort="Harder, Timm" uniqKey="Harder T" first="Timm" last="Harder">Timm Harder</name></author><author><name sortKey="Starick, Elke" sort="Starick, Elke" uniqKey="Starick E" first="Elke" last="Starick">Elke Starick</name></author><author><name sortKey="Beer, Martin" sort="Beer, Martin" uniqKey="Beer M" first="Martin" last="Beer">Martin Beer</name></author><author><name sortKey="Werner, Ortrud" sort="Werner, Ortrud" uniqKey="Werner O" first="Ortrud" last="Werner">Ortrud Werner</name></author><author><name sortKey="Hoffmann, Bernd" sort="Hoffmann, Bernd" uniqKey="Hoffmann B" first="Bernd" last="Hoffmann">Bernd Hoffmann</name></author><author><name sortKey="Mettenleiter, Thomas C" sort="Mettenleiter, Thomas C" uniqKey="Mettenleiter T" first="Thomas C" last="Mettenleiter">Thomas C. Mettenleiter</name></author><author><name sortKey="Mundt, Egbert" sort="Mundt, Egbert" uniqKey="Mundt E" first="Egbert" last="Mundt">Egbert Mundt</name></author></analytic><series><title level="j">The Journal of general virology</title><idno type="ISSN">0022-1317</idno><imprint><date when="2007" type="published">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence</term><term>Amino Acid Substitution</term><term>Animals</term><term>Animals, Wild (virology)</term><term>Anseriformes (virology)</term><term>Cat Diseases (epidemiology)</term><term>Cat Diseases (virology)</term><term>Cats</term><term>Disease Outbreaks</term><term>Germany (epidemiology)</term><term>Hemagglutinin Glycoproteins, Influenza Virus (genetics)</term><term>Humans</term><term>Influenza A Virus, H5N1 Subtype (classification)</term><term>Influenza A Virus, H5N1 Subtype (genetics)</term><term>Influenza A Virus, H5N1 Subtype (isolation & purification)</term><term>Influenza A Virus, H5N1 Subtype (pathogenicity)</term><term>Influenza in Birds (virology)</term><term>Molecular Sequence Data</term><term>Neuraminidase (genetics)</term><term>Orthomyxoviridae Infections (epidemiology)</term><term>Orthomyxoviridae Infections (veterinary)</term><term>Orthomyxoviridae Infections (virology)</term><term>Phylogeny</term><term>Sequence Analysis, DNA</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Hemagglutinin Glycoproteins, Influenza Virus</term><term>Neuraminidase</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Germany</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Influenza A Virus, H5N1 Subtype</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Cat Diseases</term><term>Orthomyxoviridae Infections</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Influenza A Virus, H5N1 Subtype</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Influenza A Virus, H5N1 Subtype</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Influenza A Virus, H5N1 Subtype</term></keywords><keywords scheme="MESH" qualifier="veterinary" xml:lang="en"><term>Orthomyxoviridae Infections</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Animals, Wild</term><term>Anseriformes</term><term>Cat Diseases</term><term>Influenza in Birds</term><term>Orthomyxoviridae Infections</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term><term>Amino Acid Substitution</term><term>Animals</term><term>Cats</term><term>Disease Outbreaks</term><term>Humans</term><term>Molecular Sequence Data</term><term>Phylogeny</term><term>Sequence Analysis, DNA</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Analysis of the full-length sequences of all eight segments of the German wild-bird H5N1 highly pathogenic avian influenza virus index isolate, A/Cygnus cygnus/Germany/R65/2006, and an H5N1 isolate from a cat (A/cat/Germany/R606/2006) obtained during an outbreak in February 2006 revealed a very high similarity between these two sequences. One amino acid substitution in the PA gene, encoding a protein involved in virus RNA replication, and one amino acid substitution in the haemagglutinin (HA) protein were observed. Phylogenetic analyses of the HA and neuraminidase nucleotide sequences showed that avian influenza H5N1 isolates from the Astrakhan region located in southern Russia were the closest relatives. Reassortment events could be excluded in comparison with other 'Qinghai-like' H5N1 viruses. In addition, an H5N1 isolate originating from a single outbreak in poultry in Germany was found to be related closely to the H5N1 viruses circulating at that time in the wild-bird population.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">17251574</PMID><DateCompleted><Year>2007</Year><Month>03</Month><Day>15</Day></DateCompleted><DateRevised><Year>2007</Year><Month>01</Month><Day>25</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0022-1317</ISSN><JournalIssue CitedMedium="Print"><Volume>88</Volume><Issue>Pt 2</Issue><PubDate><Year>2007</Year><Month>Feb</Month></PubDate></JournalIssue><Title>The Journal of general virology</Title><ISOAbbreviation>J. Gen. 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Reassortment events could be excluded in comparison with other 'Qinghai-like' H5N1 viruses. 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PubStatus="entrez"><Year>2007</Year><Month>1</Month><Day>26</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">17251574</ArticleId><ArticleId IdType="pii">88/2/554</ArticleId><ArticleId IdType="doi">10.1099/vir.0.82300-0</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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