Long-lasting cough in an adult German population: incidence, symptoms, and related pathogens.
Identifieur interne : 000036 ( Main/Curation ); précédent : 000035; suivant : 000037Long-lasting cough in an adult German population: incidence, symptoms, and related pathogens.
Auteurs : Raphael Weinberger [Allemagne] ; Marion Riffelmann [Allemagne] ; Nicole Kennerknecht [Allemagne] ; Christel Hül E [Allemagne] ; Martina Littmann [Allemagne] ; Judith O'Brien [Allemagne] ; Rüdiger Von Kries [Allemagne] ; Carl Heinz Wirsing Von König [Allemagne]Source :
- European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology [ 1435-4373 ] ; 2018.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Allemagne (épidémiologie), Anticorps antibactériens (sang), Anticorps antiviraux (sang), Bactéries (immunologie), Bactéries (isolement et purification), Estimation de Kaplan-Meier, Femelle, Humains, Incidence, Infections bactériennes (microbiologie), Infections bactériennes (épidémiologie), Jeune adulte, Maladie chronique, Maladies virales (virologie), Maladies virales (épidémiologie), Mâle, Partie nasale du pharynx (microbiologie), Sujet âgé, Sujet âgé de 80 ans ou plus, Tabagisme (épidémiologie), Toux (microbiologie), Toux (virologie), Toux (épidémiologie), Virus (immunologie), Virus (isolement et purification), Études de cohortes.
- MESH :
- immunologie : Bactéries, Virus.
- isolement et purification : Bactéries, Virus.
- microbiologie : Infections bactériennes, Partie nasale du pharynx, Toux.
- sang : Anticorps antibactériens, Anticorps antiviraux.
- virologie : Maladies virales, Toux.
- épidémiologie : Allemagne, Infections bactériennes, Maladies virales, Tabagisme, Toux.
- Adolescent, Adulte, Adulte d'âge moyen, Estimation de Kaplan-Meier, Femelle, Humains, Incidence, Jeune adulte, Maladie chronique, Mâle, Sujet âgé, Sujet âgé de 80 ans ou plus, Études de cohortes.
English descriptors
- KwdEn :
- Adolescent, Adult, Aged, Aged, 80 and over, Antibodies, Bacterial (blood), Antibodies, Viral (blood), Bacteria (immunology), Bacteria (isolation & purification), Bacterial Infections (epidemiology), Bacterial Infections (microbiology), Chronic Disease, Cohort Studies, Cough (epidemiology), Cough (microbiology), Cough (virology), Female, Germany (epidemiology), Humans, Incidence, Kaplan-Meier Estimate, Male, Middle Aged, Nasopharynx (microbiology), Smoking (epidemiology), Virus Diseases (epidemiology), Virus Diseases (virology), Viruses (immunology), Viruses (isolation & purification), Young Adult.
- MESH :
- chemical , blood : Antibodies, Bacterial, Antibodies, Viral.
- epidemiology : Bacterial Infections, Cough, Germany, Smoking, Virus Diseases.
- immunology : Bacteria, Viruses.
- isolation & purification : Bacteria, Viruses.
- microbiology : Bacterial Infections, Cough, Nasopharynx.
- virology : Cough, Virus Diseases.
- Adolescent, Adult, Aged, Aged, 80 and over, Chronic Disease, Cohort Studies, Female, Humans, Incidence, Kaplan-Meier Estimate, Male, Middle Aged, Young Adult.
Abstract
Studies of the incidence of pertussis in adults have shown that it accounts for only 5-15% cases of prolonged coughing. We assessed the burden of suffering related to prolonged coughing and tried to identify further causative agents. Based on a sentinel study with 35 general practitioners in two German cities (Krefeld, Rostock), with 3,946 patients fulfilling the inclusion criteria, we estimated the incidence of prolonged coughing in adults. In 975 of these outpatients, PCR and/or serology for adenovirus, Bordetella pertussis and B. parapertussis, human metapneumovirus, influenza virus A and rhinovirus, parainfluenza virus, Mycoplasma pneumonia, and respiratory syncytial virus (RSV) were performed. Treatment data were extracted for a subgroup of 138 patients. Descriptive statistics, including Kaplan-Maier curves were generated. Yearly incidence ranged between 1.4 and 2.1% per population in the two cities. Adult patients sought medical attention only after a median of 3 weeks of coughing. Irrespective of smoking and unrelated to the identified pathogens, the median duration of coughing was 6 weeks, with an interquartile range of 4-11 weeks. In 48.3% of patients, possible pathogens were identified, among which adenovirus (15.1%), RSV (7.5%), B. pertussis (5.6%), and influenza viruses (4.0%) were most often found. Symptoms were not indicative of a specific agent and a total of 64% of patients received antibiotics. Prolonged adult coughing requiring medical attention prompts substantial healthcare use. Apart from B. pertussis, a broad range of pathogens was associated with the symptoms. However, patients sought medical attention too late to guide efficacious therapeutic interventions using the diagnostic tests.
DOI: 10.1007/s10096-017-3158-6
PubMed: 29302815
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<term>Antibodies, Viral (blood)</term>
<term>Bacteria (immunology)</term>
<term>Bacteria (isolation & purification)</term>
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<front><div type="abstract" xml:lang="en">Studies of the incidence of pertussis in adults have shown that it accounts for only 5-15% cases of prolonged coughing. We assessed the burden of suffering related to prolonged coughing and tried to identify further causative agents. Based on a sentinel study with 35 general practitioners in two German cities (Krefeld, Rostock), with 3,946 patients fulfilling the inclusion criteria, we estimated the incidence of prolonged coughing in adults. In 975 of these outpatients, PCR and/or serology for adenovirus, Bordetella pertussis and B. parapertussis, human metapneumovirus, influenza virus A and rhinovirus, parainfluenza virus, Mycoplasma pneumonia, and respiratory syncytial virus (RSV) were performed. Treatment data were extracted for a subgroup of 138 patients. Descriptive statistics, including Kaplan-Maier curves were generated. Yearly incidence ranged between 1.4 and 2.1% per population in the two cities. Adult patients sought medical attention only after a median of 3 weeks of coughing. Irrespective of smoking and unrelated to the identified pathogens, the median duration of coughing was 6 weeks, with an interquartile range of 4-11 weeks. In 48.3% of patients, possible pathogens were identified, among which adenovirus (15.1%), RSV (7.5%), B. pertussis (5.6%), and influenza viruses (4.0%) were most often found. Symptoms were not indicative of a specific agent and a total of 64% of patients received antibiotics. Prolonged adult coughing requiring medical attention prompts substantial healthcare use. Apart from B. pertussis, a broad range of pathogens was associated with the symptoms. However, patients sought medical attention too late to guide efficacious therapeutic interventions using the diagnostic tests.</div>
</front>
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<Abstract><AbstractText>Studies of the incidence of pertussis in adults have shown that it accounts for only 5-15% cases of prolonged coughing. We assessed the burden of suffering related to prolonged coughing and tried to identify further causative agents. Based on a sentinel study with 35 general practitioners in two German cities (Krefeld, Rostock), with 3,946 patients fulfilling the inclusion criteria, we estimated the incidence of prolonged coughing in adults. In 975 of these outpatients, PCR and/or serology for adenovirus, Bordetella pertussis and B. parapertussis, human metapneumovirus, influenza virus A and rhinovirus, parainfluenza virus, Mycoplasma pneumonia, and respiratory syncytial virus (RSV) were performed. Treatment data were extracted for a subgroup of 138 patients. Descriptive statistics, including Kaplan-Maier curves were generated. Yearly incidence ranged between 1.4 and 2.1% per population in the two cities. Adult patients sought medical attention only after a median of 3 weeks of coughing. Irrespective of smoking and unrelated to the identified pathogens, the median duration of coughing was 6 weeks, with an interquartile range of 4-11 weeks. In 48.3% of patients, possible pathogens were identified, among which adenovirus (15.1%), RSV (7.5%), B. pertussis (5.6%), and influenza viruses (4.0%) were most often found. Symptoms were not indicative of a specific agent and a total of 64% of patients received antibiotics. Prolonged adult coughing requiring medical attention prompts substantial healthcare use. Apart from B. pertussis, a broad range of pathogens was associated with the symptoms. However, patients sought medical attention too late to guide efficacious therapeutic interventions using the diagnostic tests.</AbstractText>
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